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The map label for this gene is murC

Identifier: 148652337

GI number: 148652337

Start: 627401

End: 628831

Strand: Direct

Name: murC

Synonym: PsycPRwf_0525

Alternate gene names: 148652337

Gene position: 627401-628831 (Clockwise)

Preceding gene: 148652336

Following gene: 148652338

Centisome position: 21.06

GC content: 47.38

Gene sequence:

>1431_bases
ATGTCAAAATCAGCCCTGCCAAAAAGATTAATCGAAATTCCAGAAATGCGCCGCATTAAAAGCATTCACTTTATCGGCGT
GGGTGGTGCAGGGATGTGCGGGATTGCTGAGGTAATGAAAAACCAAGGCTATGGTGTTAGTGGCTCAGACATTAAAGAAA
GTCCGGTAACCAAGCGCTTACAAAGCTTGGGAATTGAAGTATTTATCGGTCATGACTCAAAAAATATTGCCAATGCCGAC
GTGGTCGTGGTCTCTTCTGCCATTGATCGCGAGAATCCTGAGATTCAGGCTGCTCTAAAAGCACAATTACCCGTGGTACG
CCGTGCTGATATGCTGGGTGAATTAATGCGTTATCGTCATGGCATCGCCGTGGCCGGTGCCCATGGTAAGACGACAACCA
CGAGCTTGCTGACCATGATGATGACAGAGGCCGGGTTTGATCCTACCTATGTTATCGGTGGTAAACTTAATGCTTCAGGA
AAAAATGCTTCGCTGGGTGAAAGCCGCTATTTAATTGCAGAAGCTGATGAGTCAGATGCTTCATTTTTGACCCTGCATCC
TATGGCTGCTATTGTGACCAATATTGACCAAGATCATATGGATACTTACGGTAATAGCTTTGATAAATTAAAAGCCGCTT
ACATCCAGTTTTTACAAAATATGCCGTTTTATGGTCTGGCTGTGGTCTGCGGTGATGATAAAGAGCTGTTCGATATGATT
GATGATATTGGTCGCCCAGTATTAACTTTCGGCTTAGAGCCGCACAACAATGTGCAGGCCACCAATGTACGTGTTGATGG
CACTAAAACTCACTTCACCGTGCTGCGTAAAGACCGTGAGCCATTGGAATTAACGTTAAACATTCCAGGGCAACACAACG
TACTTAACGCCTTAGCTGCCATTACTATGGCCACCGATGAGGGGGTGAATGATGATGCTATTAAACGGGCGTTGGCAAAG
TTTGCTGGGGTAGGTCGCCGCTTTGAGCAGCAAGCTTGCGTGGCCAAAGATGACGGTGATGTTTTATTAATTGATGACTA
TGGTCATCATCCAGTAGAGGTGGCAGCGACTATTAAAGCGGCGCGCGCCAGTTATCCTGAGCGCCGTTTGGTGATGTTAT
TCCAGCCGCACCGTTACAGCCGTACTCGTGATTGTTATGATGACTTTGTGGCGGTATTATCACAAGTGGATGTGCTGCTA
TTGCTGGATGTGTATAGTGCCGGTGAAGCGCCAATTGTGGGCGCTGATACCAAGTCATTGGCTCGTAGTATCCGCTTGCG
CGGTGAAGTTGAGCCGGTTGTGGTGGATAAAGATGAGCTGGCCCCTGTGATGCAGCGGGTGCTACAAGCGGGTGATATGC
TCATTACACAAGGCGCAGGCAACGTAGGTCAGCTAAGCCAACAATTAGCGGCCAATAACCTGTATCTTTAA

Upstream 100 bases:

>100_bases
TATTACCGTAAAACCTATTTTAAACGGTATTTAGCTCATTACTAGGTAGCTGTTATTTCTACCAAATATTTATTGTCATT
TTTTATTGAAAGAGAACCCT

Downstream 100 bases:

>100_bases
GCCAACACTAATCCTTGAAGATTATGATTAGTGTTTGAAGTAATTTTTATCTATACTATTTACGTTGTGACTAAGCTGAC
TGGTCTTATTGGCCTTGCTG

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 476; Mature: 475

Protein sequence:

>476_residues
MSKSALPKRLIEIPEMRRIKSIHFIGVGGAGMCGIAEVMKNQGYGVSGSDIKESPVTKRLQSLGIEVFIGHDSKNIANAD
VVVVSSAIDRENPEIQAALKAQLPVVRRADMLGELMRYRHGIAVAGAHGKTTTTSLLTMMMTEAGFDPTYVIGGKLNASG
KNASLGESRYLIAEADESDASFLTLHPMAAIVTNIDQDHMDTYGNSFDKLKAAYIQFLQNMPFYGLAVVCGDDKELFDMI
DDIGRPVLTFGLEPHNNVQATNVRVDGTKTHFTVLRKDREPLELTLNIPGQHNVLNALAAITMATDEGVNDDAIKRALAK
FAGVGRRFEQQACVAKDDGDVLLIDDYGHHPVEVAATIKAARASYPERRLVMLFQPHRYSRTRDCYDDFVAVLSQVDVLL
LLDVYSAGEAPIVGADTKSLARSIRLRGEVEPVVVDKDELAPVMQRVLQAGDMLITQGAGNVGQLSQQLAANNLYL

Sequences:

>Translated_476_residues
MSKSALPKRLIEIPEMRRIKSIHFIGVGGAGMCGIAEVMKNQGYGVSGSDIKESPVTKRLQSLGIEVFIGHDSKNIANAD
VVVVSSAIDRENPEIQAALKAQLPVVRRADMLGELMRYRHGIAVAGAHGKTTTTSLLTMMMTEAGFDPTYVIGGKLNASG
KNASLGESRYLIAEADESDASFLTLHPMAAIVTNIDQDHMDTYGNSFDKLKAAYIQFLQNMPFYGLAVVCGDDKELFDMI
DDIGRPVLTFGLEPHNNVQATNVRVDGTKTHFTVLRKDREPLELTLNIPGQHNVLNALAAITMATDEGVNDDAIKRALAK
FAGVGRRFEQQACVAKDDGDVLLIDDYGHHPVEVAATIKAARASYPERRLVMLFQPHRYSRTRDCYDDFVAVLSQVDVLL
LLDVYSAGEAPIVGADTKSLARSIRLRGEVEPVVVDKDELAPVMQRVLQAGDMLITQGAGNVGQLSQQLAANNLYL
>Mature_475_residues
SKSALPKRLIEIPEMRRIKSIHFIGVGGAGMCGIAEVMKNQGYGVSGSDIKESPVTKRLQSLGIEVFIGHDSKNIANADV
VVVSSAIDRENPEIQAALKAQLPVVRRADMLGELMRYRHGIAVAGAHGKTTTTSLLTMMMTEAGFDPTYVIGGKLNASGK
NASLGESRYLIAEADESDASFLTLHPMAAIVTNIDQDHMDTYGNSFDKLKAAYIQFLQNMPFYGLAVVCGDDKELFDMID
DIGRPVLTFGLEPHNNVQATNVRVDGTKTHFTVLRKDREPLELTLNIPGQHNVLNALAAITMATDEGVNDDAIKRALAKF
AGVGRRFEQQACVAKDDGDVLLIDDYGHHPVEVAATIKAARASYPERRLVMLFQPHRYSRTRDCYDDFVAVLSQVDVLLL
LDVYSAGEAPIVGADTKSLARSIRLRGEVEPVVVDKDELAPVMQRVLQAGDMLITQGAGNVGQLSQQLAANNLYL

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=476, Percent_Identity=54.4117647058823, Blast_Score=486, Evalue=1e-138,
Organism=Escherichia coli, GI1790680, Length=468, Percent_Identity=28.2051282051282, Blast_Score=164, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_PSYWF (A5WCT9)

Other databases:

- EMBL:   CP000713
- RefSeq:   YP_001279430.1
- ProteinModelPortal:   A5WCT9
- SMR:   A5WCT9
- STRING:   A5WCT9
- GeneID:   5205496
- GenomeReviews:   CP000713_GR
- KEGG:   prw:PsycPRwf_0525
- eggNOG:   COG0773
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- ProtClustDB:   PRK00421
- BioCyc:   PSP56811:PSYCPRWF_0525-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 51793; Mature: 51662

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKSALPKRLIEIPEMRRIKSIHFIGVGGAGMCGIAEVMKNQGYGVSGSDIKESPVTKRL
CCCCHHHHHHHCCCHHHHHCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHH
QSLGIEVFIGHDSKNIANADVVVVSSAIDRENPEIQAALKAQLPVVRRADMLGELMRYRH
HHCCEEEEEECCCCCCCCCCEEEEEHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHC
GIAVAGAHGKTTTTSLLTMMMTEAGFDPTYVIGGKLNASGKNASLGESRYLIAEADESDA
CEEEECCCCCHHHHHHHHHHHHHCCCCCEEEECCEECCCCCCCCCCCCEEEEEECCCCCC
SFLTLHPMAAIVTNIDQDHMDTYGNSFDKLKAAYIQFLQNMPFYGLAVVCGDDKELFDMI
CEEEECHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHH
DDIGRPVLTFGLEPHNNVQATNVRVDGTKTHFTVLRKDREPLELTLNIPGQHNVLNALAA
HHCCCCEEEECCCCCCCEEEEEEEECCCCEEEEEEECCCCCEEEEEECCCCHHHHHHHHH
ITMATDEGVNDDAIKRALAKFAGVGRRFEQQACVAKDDGDVLLIDDYGHHPVEVAATIKA
HHEECCCCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHH
ARASYPERRLVMLFQPHRYSRTRDCYDDFVAVLSQVDVLLLLDVYSAGEAPIVGADTKSL
HHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEHHCCCCCCEECCCHHHH
ARSIRLRGEVEPVVVDKDELAPVMQRVLQAGDMLITQGAGNVGQLSQQLAANNLYL
HHHHHHCCCCCEEEECHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SKSALPKRLIEIPEMRRIKSIHFIGVGGAGMCGIAEVMKNQGYGVSGSDIKESPVTKRL
CCCHHHHHHHCCCHHHHHCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHH
QSLGIEVFIGHDSKNIANADVVVVSSAIDRENPEIQAALKAQLPVVRRADMLGELMRYRH
HHCCEEEEEECCCCCCCCCCEEEEEHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHC
GIAVAGAHGKTTTTSLLTMMMTEAGFDPTYVIGGKLNASGKNASLGESRYLIAEADESDA
CEEEECCCCCHHHHHHHHHHHHHCCCCCEEEECCEECCCCCCCCCCCCEEEEEECCCCCC
SFLTLHPMAAIVTNIDQDHMDTYGNSFDKLKAAYIQFLQNMPFYGLAVVCGDDKELFDMI
CEEEECHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHH
DDIGRPVLTFGLEPHNNVQATNVRVDGTKTHFTVLRKDREPLELTLNIPGQHNVLNALAA
HHCCCCEEEECCCCCCCEEEEEEEECCCCEEEEEEECCCCCEEEEEECCCCHHHHHHHHH
ITMATDEGVNDDAIKRALAKFAGVGRRFEQQACVAKDDGDVLLIDDYGHHPVEVAATIKA
HHEECCCCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHH
ARASYPERRLVMLFQPHRYSRTRDCYDDFVAVLSQVDVLLLLDVYSAGEAPIVGADTKSL
HHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEHHCCCCCCEECCCHHHH
ARSIRLRGEVEPVVVDKDELAPVMQRVLQAGDMLITQGAGNVGQLSQQLAANNLYL
HHHHHHCCCCCEEEECHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA