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The map label for this gene is gltP [H]

Identifier: 148652178

GI number: 148652178

Start: 438256

End: 439629

Strand: Direct

Name: gltP [H]

Synonym: PsycPRwf_0366

Alternate gene names: 148652178

Gene position: 438256-439629 (Clockwise)

Preceding gene: 148652176

Following gene: 148652179

Centisome position: 14.71

GC content: 44.32

Gene sequence:

>1374_bases
ATGTGGAAAAATATGGGTTTAACCAGTAAGATTCTGGTGGCTATGTTATTGGGTATCATCCTAGGGTTGATTTTTAACTA
TACAGGATTGAATGCCGAAGGTGGGTTTGTTAATACCTATCTAGTAAATGGCTTATTTAGTATTGTCGGTAAGCTGTTTG
TAAACTCACTAAAAATGTTGGTGGTACCCTTGGTTCTTATCTCACTTATTTGTGGGGTATGTGGTATTGGCGACATCCGT
CTATTGGGCCGTATCGGTACCAAAACCTTCTTTATTTATATGGTCACCACAGCTATTGCTATTGCAACTGCTATTGGCCT
CGGCTCAATCTTTGGTATCGGTAAAGGCATGAACCTAAAGCCTGAGAATGCCTTTGAAGCCAAAGATGCACCACCATTGA
TTGATGTTTTCTCAAATATTATTCCCTCTAACCCAATCAGTGCCATGGCCAATGGCGATATGCTGTCTATCATTTTCTTC
GCCATCTTAATTGGGGTGAGTATCTTGATGGTGGGCAAGCCGGCCAAAGGTCTGGTACAAAGCCTAGAGCTGATTAATGA
AGTTATCTTGAAAATGGTAACCATCATTATGAACCTAGCGCCTTACGGGGTGTTTGCCTTGTTGGTCCAAGCCATGTCTG
ATTTAGGCTTAGACTTGATGCTCTCGTTATTTGGTTATGTCGCCGTGTTGGTTGGCTCTTTGGCTTTCCACTTCTTCGTC
ACCATGATGATTATCCTAAAGCTTACCTCCGGATTATCGGTGAGAACCTTTTTATCAAAAATGCGCGAAGTGCAGATCTT
TGCCTTTAGTACGTCAAGCTCAAATGCCACCATCCCCGTTAGCTTACGCACAGTGACCAAGCGTATGGGTGTGGATAACT
CGGTGGCGTCATTTACCATTCCTTTTGGTGCGACCATCAACATGGATGGTACGGCCATTATGCAGGGTACCGCCACTATC
TTTATCGCCAATTTATATGGTGTTGATTTAAGTGTGGGCCAGTATTTGATGGTTATCCTAATGTCAGTACTGGCTTCAGT
CGGGACAGCTGGGGTACCTGGTGTGGGCCTGATCATGCTATCGATGGTGTTTGCTCAAGTGGGTCTGCCTATCGAAGGTA
TCGGTCTTATCTTAGGTGTAGACCGTCTGCTTGATATGTTACGTACTGCAGTAAACGTCGGTGGTGATGCGGCTGTGACT
GCCATTGTGGCAAAAGCAGAAGGCAAGATGGACATTGATGTGTATAACGATCCTGAAGCGGGTACTAAAGAGGTATTCGA
TGGCCACATTGATCCAGAAAGCGAGCAAGAGTTTGCTAATGTGATGAGTGATGGCATTATGGGCAGCGAGTATGATGACC
TAAAAAAAGGCTAA

Upstream 100 bases:

>100_bases
TTGATTCGGCAGACCATGATTAGTAAGGGATTGATAAGTTATTGTTTTTTAATGATGGTCAAACAACTTGCTAGACAGGT
CTTGCTTTAAGGACAAAGTT

Downstream 100 bases:

>100_bases
GCACTCACGGTAACTCATAAAAAAAGCCCCAATTGGGGCTTTTTTTGTGTCTGGGCTGATTTAGCGGCTACCTAAAATTC
AAGCAGATAGCCTTTATCAC

Product: sodium:dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MWKNMGLTSKILVAMLLGIILGLIFNYTGLNAEGGFVNTYLVNGLFSIVGKLFVNSLKMLVVPLVLISLICGVCGIGDIR
LLGRIGTKTFFIYMVTTAIAIATAIGLGSIFGIGKGMNLKPENAFEAKDAPPLIDVFSNIIPSNPISAMANGDMLSIIFF
AILIGVSILMVGKPAKGLVQSLELINEVILKMVTIIMNLAPYGVFALLVQAMSDLGLDLMLSLFGYVAVLVGSLAFHFFV
TMMIILKLTSGLSVRTFLSKMREVQIFAFSTSSSNATIPVSLRTVTKRMGVDNSVASFTIPFGATINMDGTAIMQGTATI
FIANLYGVDLSVGQYLMVILMSVLASVGTAGVPGVGLIMLSMVFAQVGLPIEGIGLILGVDRLLDMLRTAVNVGGDAAVT
AIVAKAEGKMDIDVYNDPEAGTKEVFDGHIDPESEQEFANVMSDGIMGSEYDDLKKG

Sequences:

>Translated_457_residues
MWKNMGLTSKILVAMLLGIILGLIFNYTGLNAEGGFVNTYLVNGLFSIVGKLFVNSLKMLVVPLVLISLICGVCGIGDIR
LLGRIGTKTFFIYMVTTAIAIATAIGLGSIFGIGKGMNLKPENAFEAKDAPPLIDVFSNIIPSNPISAMANGDMLSIIFF
AILIGVSILMVGKPAKGLVQSLELINEVILKMVTIIMNLAPYGVFALLVQAMSDLGLDLMLSLFGYVAVLVGSLAFHFFV
TMMIILKLTSGLSVRTFLSKMREVQIFAFSTSSSNATIPVSLRTVTKRMGVDNSVASFTIPFGATINMDGTAIMQGTATI
FIANLYGVDLSVGQYLMVILMSVLASVGTAGVPGVGLIMLSMVFAQVGLPIEGIGLILGVDRLLDMLRTAVNVGGDAAVT
AIVAKAEGKMDIDVYNDPEAGTKEVFDGHIDPESEQEFANVMSDGIMGSEYDDLKKG
>Mature_457_residues
MWKNMGLTSKILVAMLLGIILGLIFNYTGLNAEGGFVNTYLVNGLFSIVGKLFVNSLKMLVVPLVLISLICGVCGIGDIR
LLGRIGTKTFFIYMVTTAIAIATAIGLGSIFGIGKGMNLKPENAFEAKDAPPLIDVFSNIIPSNPISAMANGDMLSIIFF
AILIGVSILMVGKPAKGLVQSLELINEVILKMVTIIMNLAPYGVFALLVQAMSDLGLDLMLSLFGYVAVLVGSLAFHFFV
TMMIILKLTSGLSVRTFLSKMREVQIFAFSTSSSNATIPVSLRTVTKRMGVDNSVASFTIPFGATINMDGTAIMQGTATI
FIANLYGVDLSVGQYLMVILMSVLASVGTAGVPGVGLIMLSMVFAQVGLPIEGIGLILGVDRLLDMLRTAVNVGGDAAVT
AIVAKAEGKMDIDVYNDPEAGTKEVFDGHIDPESEQEFANVMSDGIMGSEYDDLKKG

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI40254478, Length=462, Percent_Identity=31.3852813852814, Blast_Score=169, Evalue=6e-42,
Organism=Homo sapiens, GI169790839, Length=445, Percent_Identity=29.2134831460674, Blast_Score=161, Evalue=9e-40,
Organism=Homo sapiens, GI194239697, Length=472, Percent_Identity=27.1186440677966, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI66773030, Length=505, Percent_Identity=27.9207920792079, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI21314632, Length=393, Percent_Identity=30.0254452926209, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI4827012, Length=265, Percent_Identity=34.7169811320755, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI5032093, Length=373, Percent_Identity=31.3672922252011, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI223468566, Length=257, Percent_Identity=33.4630350194552, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI223468564, Length=248, Percent_Identity=33.8709677419355, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI301601644, Length=149, Percent_Identity=36.9127516778523, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI262359914, Length=382, Percent_Identity=26.9633507853403, Blast_Score=110, Evalue=2e-24,
Organism=Escherichia coli, GI1790514, Length=449, Percent_Identity=35.1893095768374, Blast_Score=245, Evalue=5e-66,
Organism=Escherichia coli, GI1789947, Length=439, Percent_Identity=27.3348519362187, Blast_Score=164, Evalue=8e-42,
Organism=Escherichia coli, GI1788024, Length=406, Percent_Identity=29.064039408867, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1789473, Length=382, Percent_Identity=27.2251308900524, Blast_Score=99, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI71983099, Length=427, Percent_Identity=33.2552693208431, Blast_Score=207, Evalue=7e-54,
Organism=Caenorhabditis elegans, GI71983106, Length=427, Percent_Identity=33.2552693208431, Blast_Score=207, Evalue=7e-54,
Organism=Caenorhabditis elegans, GI17537407, Length=435, Percent_Identity=34.0229885057471, Blast_Score=199, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI71996953, Length=451, Percent_Identity=29.7117516629712, Blast_Score=171, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI193206505, Length=463, Percent_Identity=28.0777537796976, Blast_Score=154, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI17541374, Length=433, Percent_Identity=27.0207852193995, Blast_Score=149, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI193206654, Length=413, Percent_Identity=27.6029055690073, Blast_Score=141, Evalue=7e-34,
Organism=Drosophila melanogaster, GI24583025, Length=432, Percent_Identity=28.4722222222222, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI17137668, Length=432, Percent_Identity=28.4722222222222, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24583023, Length=432, Percent_Identity=28.4722222222222, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI281360481, Length=512, Percent_Identity=26.7578125, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI281360483, Length=512, Percent_Identity=26.5625, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI17137666, Length=512, Percent_Identity=26.5625, Blast_Score=124, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 48407; Mature: 48407

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.9 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWKNMGLTSKILVAMLLGIILGLIFNYTGLNAEGGFVNTYLVNGLFSIVGKLFVNSLKML
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VVPLVLISLICGVCGIGDIRLLGRIGTKTFFIYMVTTAIAIATAIGLGSIFGIGKGMNLK
HHHHHHHHHHHHHCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PENAFEAKDAPPLIDVFSNIIPSNPISAMANGDMLSIIFFAILIGVSILMVGKPAKGLVQ
CCCCCCCCCCCCHHHHHHHHCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHH
SLELINEVILKMVTIIMNLAPYGVFALLVQAMSDLGLDLMLSLFGYVAVLVGSLAFHFFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
TMMIILKLTSGLSVRTFLSKMREVQIFAFSTSSSNATIPVSLRTVTKRMGVDNSVASFTI
HHHHHHHHHCCCHHHHHHHHHHHEEEEEEECCCCCCEEEEHHHHHHHHHCCCCCCCEEEE
PFGATINMDGTAIMQGTATIFIANLYGVDLSVGQYLMVILMSVLASVGTAGVPGVGLIML
CCCCEECCCCCEEEECCCEEEEEEHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
SMVFAQVGLPIEGIGLILGVDRLLDMLRTAVNVGGDAAVTAIVAKAEGKMDIDVYNDPEA
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEECCCCCC
GTKEVFDGHIDPESEQEFANVMSDGIMGSEYDDLKKG
CCHHHHCCCCCCCHHHHHHHHHHCCCCCCCCHHHCCC
>Mature Secondary Structure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CCHHHHCCCCCCCHHHHHHHHHHCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]