| Definition | Methanobrevibacter smithii ATCC 35061 chromosome, complete genome. |
|---|---|
| Accession | NC_009515 |
| Length | 1,853,160 |
Click here to switch to the map view.
The map label for this gene is ppiB [H]
Identifier: 148643427
GI number: 148643427
Start: 1388083
End: 1388517
Strand: Reverse
Name: ppiB [H]
Synonym: Msm_1367
Alternate gene names: 148643427
Gene position: 1388517-1388083 (Counterclockwise)
Preceding gene: 148643429
Following gene: 148643419
Centisome position: 74.93
GC content: 38.16
Gene sequence:
>435_bases ATGAAAGTTGCAATAATTGAAACTGAAAAAGGAACAATTGAATTGGAATTATTCGAAGAAGATGCTCCAAATACTGTAGC TAACTTTGAAAAACTTATAGAAGAAGGATTTTACGACGGATTAACTTTCCACAGAGTAATACCAAATTTCGTGATTCAAG GAGGCTGTCCTAACGGTAACGGTACAGGAGGACCTGGTTACACCATCAAATGTGAAACCGAAGGAAACCCAAATAAACAT GGAACCGGTGCTCTTTCAATGGCTCATGCAGGAAAAGATACTGGAGGAAGCCAATTTTTCATTACACATTCCCCACAACC ACACTTAGACGGAGTACACACTGTATTTGGTCATGTTATTGGTGACGGTATGGATGTTGTAAATAAAATCCAACAAGGAG ACAAAATGCTCCATTTACATGTTGAAGAAAGATAG
Upstream 100 bases:
>100_bases GCTTCAATAAGTTCATTTGTGTTCATAAAATACTTCCATAAAATACTTATATTAACTATATTTATAGTATTAATGATATT TAAAATTTAAAAGTGATAAA
Downstream 100 bases:
>100_bases TTATTTTTAACTATTCTTTTTCATCATGCTGAATCAAAACTATATTAACACCATTTGGATCAATAACCCTTGCCATCATG CCAACAGATATTCTAGTTGC
Product: peptidyl-prolyl cis-trans isomerase, PpiB
Products: NA
Alternate protein names: PPIase B; Rotamase B [H]
Number of amino acids: Translated: 144; Mature: 144
Protein sequence:
>144_residues MKVAIIETEKGTIELELFEEDAPNTVANFEKLIEEGFYDGLTFHRVIPNFVIQGGCPNGNGTGGPGYTIKCETEGNPNKH GTGALSMAHAGKDTGGSQFFITHSPQPHLDGVHTVFGHVIGDGMDVVNKIQQGDKMLHLHVEER
Sequences:
>Translated_144_residues MKVAIIETEKGTIELELFEEDAPNTVANFEKLIEEGFYDGLTFHRVIPNFVIQGGCPNGNGTGGPGYTIKCETEGNPNKH GTGALSMAHAGKDTGGSQFFITHSPQPHLDGVHTVFGHVIGDGMDVVNKIQQGDKMLHLHVEER >Mature_144_residues MKVAIIETEKGTIELELFEEDAPNTVANFEKLIEEGFYDGLTFHRVIPNFVIQGGCPNGNGTGGPGYTIKCETEGNPNKH GTGALSMAHAGKDTGGSQFFITHSPQPHLDGVHTVFGHVIGDGMDVVNKIQQGDKMLHLHVEER
Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]
COG id: COG0652
COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 PPIase cyclophilin-type domain [H]
Homologues:
Organism=Homo sapiens, GI7706339, Length=128, Percent_Identity=48.4375, Blast_Score=113, Evalue=5e-26, Organism=Homo sapiens, GI24308049, Length=130, Percent_Identity=46.9230769230769, Blast_Score=99, Evalue=2e-21, Organism=Homo sapiens, GI64276486, Length=121, Percent_Identity=40.495867768595, Blast_Score=96, Evalue=1e-20, Organism=Homo sapiens, GI19557636, Length=130, Percent_Identity=43.0769230769231, Blast_Score=96, Evalue=1e-20, Organism=Homo sapiens, GI5031987, Length=128, Percent_Identity=50.78125, Blast_Score=95, Evalue=2e-20, Organism=Homo sapiens, GI4826932, Length=124, Percent_Identity=50, Blast_Score=94, Evalue=3e-20, Organism=Homo sapiens, GI6631100, Length=135, Percent_Identity=46.6666666666667, Blast_Score=94, Evalue=6e-20, Organism=Homo sapiens, GI150418007, Length=127, Percent_Identity=48.8188976377953, Blast_Score=92, Evalue=1e-19, Organism=Homo sapiens, GI4758950, Length=128, Percent_Identity=48.4375, Blast_Score=92, Evalue=1e-19, Organism=Homo sapiens, GI4505991, Length=137, Percent_Identity=49.6350364963504, Blast_Score=92, Evalue=2e-19, Organism=Homo sapiens, GI42560244, Length=143, Percent_Identity=44.0559440559441, Blast_Score=89, Evalue=1e-18, Organism=Homo sapiens, GI10863927, Length=128, Percent_Identity=46.875, Blast_Score=89, Evalue=1e-18, Organism=Homo sapiens, GI310127646, Length=137, Percent_Identity=42.3357664233577, Blast_Score=88, Evalue=2e-18, Organism=Homo sapiens, GI310114371, Length=137, Percent_Identity=42.3357664233577, Blast_Score=88, Evalue=2e-18, Organism=Homo sapiens, GI310119221, Length=137, Percent_Identity=42.3357664233577, Blast_Score=88, Evalue=2e-18, Organism=Homo sapiens, GI5174637, Length=142, Percent_Identity=44.3661971830986, Blast_Score=88, Evalue=2e-18, Organism=Homo sapiens, GI45439316, Length=138, Percent_Identity=43.4782608695652, Blast_Score=88, Evalue=3e-18, Organism=Homo sapiens, GI303305009, Length=137, Percent_Identity=43.7956204379562, Blast_Score=87, Evalue=4e-18, Organism=Homo sapiens, GI22547212, Length=129, Percent_Identity=45.7364341085271, Blast_Score=84, Evalue=4e-17, Organism=Homo sapiens, GI7657473, Length=129, Percent_Identity=45.7364341085271, Blast_Score=84, Evalue=4e-17, Organism=Homo sapiens, GI22547215, Length=129, Percent_Identity=45.7364341085271, Blast_Score=84, Evalue=4e-17, Organism=Homo sapiens, GI5454154, Length=140, Percent_Identity=42.8571428571429, Blast_Score=84, Evalue=6e-17, Organism=Homo sapiens, GI256017253, Length=116, Percent_Identity=46.551724137931, Blast_Score=83, Evalue=8e-17, Organism=Homo sapiens, GI221139811, Length=116, Percent_Identity=46.551724137931, Blast_Score=83, Evalue=8e-17, Organism=Homo sapiens, GI256017251, Length=116, Percent_Identity=46.551724137931, Blast_Score=83, Evalue=8e-17, Organism=Homo sapiens, GI20911035, Length=139, Percent_Identity=38.1294964028777, Blast_Score=81, Evalue=4e-16, Organism=Homo sapiens, GI178057341, Length=116, Percent_Identity=45.6896551724138, Blast_Score=79, Evalue=9e-16, Organism=Homo sapiens, GI209417936, Length=115, Percent_Identity=46.0869565217391, Blast_Score=79, Evalue=1e-15, Organism=Homo sapiens, GI30102944, Length=115, Percent_Identity=46.0869565217391, Blast_Score=79, Evalue=1e-15, Organism=Homo sapiens, GI219842199, Length=115, Percent_Identity=46.0869565217391, Blast_Score=79, Evalue=1e-15, Organism=Homo sapiens, GI310129267, Length=135, Percent_Identity=41.4814814814815, Blast_Score=79, Evalue=1e-15, Organism=Homo sapiens, GI310120620, Length=135, Percent_Identity=41.4814814814815, Blast_Score=79, Evalue=1e-15, Organism=Homo sapiens, GI310110104, Length=135, Percent_Identity=40.7407407407407, Blast_Score=76, Evalue=1e-14, Organism=Homo sapiens, GI169164185, Length=127, Percent_Identity=40.9448818897638, Blast_Score=69, Evalue=1e-12, Organism=Homo sapiens, GI169163623, Length=127, Percent_Identity=40.9448818897638, Blast_Score=69, Evalue=1e-12, Organism=Homo sapiens, GI169163387, Length=127, Percent_Identity=40.9448818897638, Blast_Score=69, Evalue=2e-12, Organism=Homo sapiens, GI310132444, Length=136, Percent_Identity=38.2352941176471, Blast_Score=69, Evalue=2e-12, Organism=Homo sapiens, GI310113152, Length=136, Percent_Identity=38.2352941176471, Blast_Score=69, Evalue=2e-12, Organism=Homo sapiens, GI310127745, Length=122, Percent_Identity=42.6229508196721, Blast_Score=67, Evalue=4e-12, Organism=Homo sapiens, GI310119290, Length=122, Percent_Identity=42.6229508196721, Blast_Score=67, Evalue=4e-12, Organism=Homo sapiens, GI169214050, Length=127, Percent_Identity=40.1574803149606, Blast_Score=67, Evalue=4e-12, Organism=Homo sapiens, GI310114540, Length=124, Percent_Identity=41.9354838709677, Blast_Score=67, Evalue=4e-12, Organism=Homo sapiens, GI239751853, Length=127, Percent_Identity=40.1574803149606, Blast_Score=67, Evalue=5e-12, Organism=Homo sapiens, GI113428306, Length=127, Percent_Identity=40.1574803149606, Blast_Score=67, Evalue=5e-12, Organism=Escherichia coli, GI1789763, Length=135, Percent_Identity=41.4814814814815, Blast_Score=83, Evalue=6e-18, Organism=Escherichia coli, GI1786736, Length=134, Percent_Identity=37.3134328358209, Blast_Score=64, Evalue=5e-12, Organism=Caenorhabditis elegans, GI17539496, Length=133, Percent_Identity=45.8646616541353, Blast_Score=112, Evalue=6e-26, Organism=Caenorhabditis elegans, GI17506311, Length=135, Percent_Identity=48.1481481481481, Blast_Score=100, Evalue=3e-22, Organism=Caenorhabditis elegans, GI17506307, Length=133, Percent_Identity=50.3759398496241, Blast_Score=100, Evalue=3e-22, Organism=Caenorhabditis elegans, GI17552780, Length=132, Percent_Identity=50, Blast_Score=96, Evalue=6e-21, Organism=Caenorhabditis elegans, GI71997782, Length=121, Percent_Identity=42.9752066115703, Blast_Score=95, Evalue=1e-20, Organism=Caenorhabditis elegans, GI17565860, Length=143, Percent_Identity=46.1538461538462, Blast_Score=94, Evalue=2e-20, Organism=Caenorhabditis elegans, GI71980590, Length=129, Percent_Identity=39.5348837209302, Blast_Score=91, Evalue=2e-19, Organism=Caenorhabditis elegans, GI17532641, Length=125, Percent_Identity=40, Blast_Score=91, Evalue=2e-19, Organism=Caenorhabditis elegans, GI71980594, Length=129, Percent_Identity=39.5348837209302, Blast_Score=91, Evalue=2e-19, Organism=Caenorhabditis elegans, GI17539498, Length=128, Percent_Identity=44.53125, Blast_Score=90, Evalue=3e-19, Organism=Caenorhabditis elegans, GI17559074, Length=135, Percent_Identity=44.4444444444444, Blast_Score=90, Evalue=5e-19, Organism=Caenorhabditis elegans, GI17566266, Length=142, Percent_Identity=42.2535211267606, Blast_Score=89, Evalue=9e-19, Organism=Caenorhabditis elegans, GI17532643, Length=133, Percent_Identity=46.6165413533835, Blast_Score=88, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17552782, Length=135, Percent_Identity=42.962962962963, Blast_Score=84, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17551282, Length=135, Percent_Identity=45.1851851851852, Blast_Score=84, Evalue=3e-17, Organism=Caenorhabditis elegans, GI17551284, Length=135, Percent_Identity=45.1851851851852, Blast_Score=84, Evalue=3e-17, Organism=Caenorhabditis elegans, GI17552784, Length=144, Percent_Identity=38.8888888888889, Blast_Score=77, Evalue=2e-15, Organism=Caenorhabditis elegans, GI32563659, Length=141, Percent_Identity=32.6241134751773, Blast_Score=66, Evalue=6e-12, Organism=Saccharomyces cerevisiae, GI6323562, Length=135, Percent_Identity=48.1481481481481, Blast_Score=99, Evalue=2e-22, Organism=Saccharomyces cerevisiae, GI6320359, Length=128, Percent_Identity=47.65625, Blast_Score=96, Evalue=3e-21, Organism=Saccharomyces cerevisiae, GI6321848, Length=135, Percent_Identity=49.6296296296296, Blast_Score=93, Evalue=2e-20, Organism=Saccharomyces cerevisiae, GI6320510, Length=131, Percent_Identity=48.0916030534351, Blast_Score=86, Evalue=2e-18, Organism=Saccharomyces cerevisiae, GI6323246, Length=143, Percent_Identity=44.7552447552448, Blast_Score=84, Evalue=8e-18, Organism=Drosophila melanogaster, GI17986117, Length=128, Percent_Identity=48.4375, Blast_Score=115, Evalue=8e-27, Organism=Drosophila melanogaster, GI19922376, Length=129, Percent_Identity=44.9612403100775, Blast_Score=108, Evalue=1e-24, Organism=Drosophila melanogaster, GI21357249, Length=144, Percent_Identity=36.8055555555556, Blast_Score=101, Evalue=2e-22, Organism=Drosophila melanogaster, GI24650807, Length=135, Percent_Identity=45.1851851851852, Blast_Score=98, Evalue=2e-21, Organism=Drosophila melanogaster, GI20130249, Length=128, Percent_Identity=50, Blast_Score=98, Evalue=2e-21, Organism=Drosophila melanogaster, GI45549139, Length=128, Percent_Identity=50, Blast_Score=96, Evalue=7e-21, Organism=Drosophila melanogaster, GI24664125, Length=128, Percent_Identity=48.4375, Blast_Score=92, Evalue=8e-20, Organism=Drosophila melanogaster, GI21357783, Length=128, Percent_Identity=48.4375, Blast_Score=92, Evalue=8e-20, Organism=Drosophila melanogaster, GI17647301, Length=130, Percent_Identity=45.3846153846154, Blast_Score=89, Evalue=8e-19, Organism=Drosophila melanogaster, GI24586038, Length=142, Percent_Identity=41.5492957746479, Blast_Score=84, Evalue=4e-17, Organism=Drosophila melanogaster, GI24652460, Length=144, Percent_Identity=33.3333333333333, Blast_Score=82, Evalue=2e-16, Organism=Drosophila melanogaster, GI19922912, Length=129, Percent_Identity=45.7364341085271, Blast_Score=81, Evalue=2e-16, Organism=Drosophila melanogaster, GI17136360, Length=130, Percent_Identity=41.5384615384615, Blast_Score=76, Evalue=8e-15, Organism=Drosophila melanogaster, GI21355677, Length=137, Percent_Identity=34.3065693430657, Blast_Score=68, Evalue=2e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR015891 - InterPro: IPR020892 - InterPro: IPR002130 [H]
Pfam domain/function: PF00160 Pro_isomerase [H]
EC number: =5.2.1.8 [H]
Molecular weight: Translated: 15569; Mature: 15569
Theoretical pI: Translated: 5.17; Mature: 5.17
Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.4 %Cys (Translated Protein) 2.8 %Met (Translated Protein) 4.2 %Cys+Met (Translated Protein) 1.4 %Cys (Mature Protein) 2.8 %Met (Mature Protein) 4.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKVAIIETEKGTIELELFEEDAPNTVANFEKLIEEGFYDGLTFHRVIPNFVIQGGCPNGN CEEEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHCHHEEECCCCCCC GTGGPGYTIKCETEGNPNKHGTGALSMAHAGKDTGGSQFFITHSPQPHLDGVHTVFGHVI CCCCCCEEEEEECCCCCCCCCCCEEEECCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHH GDGMDVVNKIQQGDKMLHLHVEER CCCHHHHHHHHCCCEEEEEEEECC >Mature Secondary Structure MKVAIIETEKGTIELELFEEDAPNTVANFEKLIEEGFYDGLTFHRVIPNFVIQGGCPNGN CEEEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHCHHEEECCCCCCC GTGGPGYTIKCETEGNPNKHGTGALSMAHAGKDTGGSQFFITHSPQPHLDGVHTVFGHVI CCCCCCEEEEEECCCCCCCCCCCEEEECCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHH GDGMDVVNKIQQGDKMLHLHVEER CCCHHHHHHHHCCCEEEEEEEECC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 7934829; 8022278; 9384377; 8755892 [H]