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The map label for this gene is deaD [C]

Identifier: 148643247

GI number: 148643247

Start: 1168992

End: 1171310

Strand: Reverse

Name: deaD [C]

Synonym: Msm_1187

Alternate gene names: 148643247

Gene position: 1171310-1168992 (Counterclockwise)

Preceding gene: 148643248

Following gene: 148643245

Centisome position: 63.21

GC content: 33.38

Gene sequence:

>2319_bases
ATGGCACATTATATTGACCACCCTTTAATAAAATCTAATGCTATCGAGGCCAGGTTATATCAACAGGTTTTAGCTGCTGA
TGTTTTAAAAAAAGGAAATACAATGATTGTTGCACCTACAGCATTAGGTAAAACTATAGTAGCTACTTTAGTAGCGGCAG
ATAGATTGGAAAAAGTTAAAAACTCTAAAATATTGGTATTGGCTCCAAGTAAACCATTAGCTATACAGCATGAATCTACT
TTTAAAGAATTTTTGACTGTTCCTTGTTCATCAATTACTGGTGCTGTTAAAACTGATGAAAGGGTTAAAAGGTGGGAAGA
ATCTCAAATAATCTGTGCAACTCCGCAAACTGTTGAATCTGACTTATTAAAAGGAAGATATTCTCTAAAAGATGTGTCTT
TAGTTGTTTTTGATGAATGTCATCACGGTGTTGGCTCTTATTCTTACGTATATTTGGCTTCAAGATATGTTAAAGAATCC
AAATTTAACTTAATTTTAGGACTGACAGCTTCTCCAGGTTCTGATAAGGAAAAAATAAAAGAAGTTTGTGATAATTTATA
TATTCAAAGTATTGTAGTTAAAACTGAAGAGGATAATGATGTAAGACCTTATTTTAATCCGGTTGCAATAGATTGGGTTA
GGGTTAAAATGAGTTCTGAGTTGGAAAAAATTAAAACACATGTTGATAAAGCTCTTAAGATTCGTCTTAAAGGCCTTAAA
AATATGGGAGTTATTAGAACAGTTTCCGTTAACAAATTGGATATATTAAAAGCAAGAGGAAGAGTTCAAAGTGCAATTGC
AAGGTCTGTAAATCCTAAAAAGGAATGTTTCCAAGCTATTTCTATTTTAAGTGCGGTTATTAATATACAGCATTCTCAGG
AACTTATTGAAACACAAGGAGTAGTTACATTTAACAAATATGTGGCAAGATTGCGTAAGAAGAAAACAAAAGCTGCCAAA
TCATTAATTCAGGATCCTAATTTTGGTAAGGCTATTTATCTTGCAAGGGAGGCTGAAAAACATGGTTTGGAACATCCTAA
ACTTAAAAAGGTAACTGACATTATTAAAAAAGAATTGGGACAAAACGGTCAAACTAAATTGCAGTCTGACAGATATGTTA
AAGATGCTGACCAAAAATCCTCAAAAATAATGGTTTTTACTCAGTATAGGGATTCACTTGAAATGATTCATCAGAAACTT
GAAAAAGAAGGAATTAAATCCGCCAAGTTCTTTGGTCAGGCTTCAAGAGATGGTGAAAAAGGATTAACTCAAAAGGAACA
AAAAGAAATCATTAAAGCCTTTAAAATTGGTGAATATGATGTACTTCTCTCAACAAGTGTAGCTGAAGAAGGAATTGATA
TTCCTGCTGTTGATTTGGTTATTCTTTATGAACCTGTTCCGTCTGAAGTTAGAATGATCCAAAGAAGGGGAAGGACTGGC
CGTAAACGTTCAGGTCGTGTGAAAGTTCTTATTACAAATGGAACCAGAGATGAAGGTTATTATTGGGCTTCAGTTAATAA
GGAACGCAGGATGAAACATCAGTTAATTGATCCTGATGTATTGGAAGAGTTAAATTCCAATGCTATTGAAAGAATGGAAA
ATGAAAAAAGGGTAAAGGTTTTAGATCCTACTCCTAAAAAAGAAGAACTTCCGGTTGTTTTTGCAGATACTCGTGAAGGT
AATTCAAAGGTTATACGTCATTTATCTGAAATGGAAATTGATGTTAAAGTTCAGGCAATGGCTGTTGGTGATTATCAGGT
AAGTGATGAAGTTGTTATAGAACGTAAAACAGCTAAGGACTTTGTTGATTCAATTGTTGACAAAAGACTATTTAAACAGG
CAAGATCTTTAATGGAGGAATTTAAACGTCCGTTAATTATTCTTGAAGGAGATGACTTGTATAATGGTATGATTAATCCG
AATGCAATTAGAGGTTCGATAGCTTCAATAGCTCTGGACTTTGGAATTAGTATTATACCAACAAGAAATGCTCAGGACAC
TGCAGCAATGATTAAAAGAATAGCTATTAGGGAGCAAAGTGGTGAAAAAACACCAATTCAAATAAGAACAGACAAAAAAC
CTGTTAACTTGTGGGAGCAGCAGCTGTTTATAATAGAATCCCTTCCAAATATAGGTCCTGTTAATGCTAAAAACTTATTG
GAGCATTTTGGAACAGTAGCTAATATTATTAACGCGTCTGAGAGTCAGCTTCAGGAAGTTGAAGGTATTGGTAAAAAAAC
AGCAGCCAATATTCGTAAGGTAGTTGATTCCAAGTATTTATATTTCCAAAATGAAATTAAAGAAAAAAAATTATTGTAG

Upstream 100 bases:

>100_bases
ACAAGTTTTTTTACTTTAAAATTAAATCGTGCTGTTTTTATAATTAGTTTTCATGTGCTCTTATTAAACATTTATAAACA
TTTAATTACTATGTTCTATC

Downstream 100 bases:

>100_bases
GAAACTTGAAGGTAATTTAACCTTCAATCTCCCAAATCTTCACTATGTACTGGAGTATAATATTTTTCAGCTACAAATGT
AGGTAAAATAGCACTTAATA

Product: Hef nuclease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 772; Mature: 771

Protein sequence:

>772_residues
MAHYIDHPLIKSNAIEARLYQQVLAADVLKKGNTMIVAPTALGKTIVATLVAADRLEKVKNSKILVLAPSKPLAIQHEST
FKEFLTVPCSSITGAVKTDERVKRWEESQIICATPQTVESDLLKGRYSLKDVSLVVFDECHHGVGSYSYVYLASRYVKES
KFNLILGLTASPGSDKEKIKEVCDNLYIQSIVVKTEEDNDVRPYFNPVAIDWVRVKMSSELEKIKTHVDKALKIRLKGLK
NMGVIRTVSVNKLDILKARGRVQSAIARSVNPKKECFQAISILSAVINIQHSQELIETQGVVTFNKYVARLRKKKTKAAK
SLIQDPNFGKAIYLAREAEKHGLEHPKLKKVTDIIKKELGQNGQTKLQSDRYVKDADQKSSKIMVFTQYRDSLEMIHQKL
EKEGIKSAKFFGQASRDGEKGLTQKEQKEIIKAFKIGEYDVLLSTSVAEEGIDIPAVDLVILYEPVPSEVRMIQRRGRTG
RKRSGRVKVLITNGTRDEGYYWASVNKERRMKHQLIDPDVLEELNSNAIERMENEKRVKVLDPTPKKEELPVVFADTREG
NSKVIRHLSEMEIDVKVQAMAVGDYQVSDEVVIERKTAKDFVDSIVDKRLFKQARSLMEEFKRPLIILEGDDLYNGMINP
NAIRGSIASIALDFGISIIPTRNAQDTAAMIKRIAIREQSGEKTPIQIRTDKKPVNLWEQQLFIIESLPNIGPVNAKNLL
EHFGTVANIINASESQLQEVEGIGKKTAANIRKVVDSKYLYFQNEIKEKKLL

Sequences:

>Translated_772_residues
MAHYIDHPLIKSNAIEARLYQQVLAADVLKKGNTMIVAPTALGKTIVATLVAADRLEKVKNSKILVLAPSKPLAIQHEST
FKEFLTVPCSSITGAVKTDERVKRWEESQIICATPQTVESDLLKGRYSLKDVSLVVFDECHHGVGSYSYVYLASRYVKES
KFNLILGLTASPGSDKEKIKEVCDNLYIQSIVVKTEEDNDVRPYFNPVAIDWVRVKMSSELEKIKTHVDKALKIRLKGLK
NMGVIRTVSVNKLDILKARGRVQSAIARSVNPKKECFQAISILSAVINIQHSQELIETQGVVTFNKYVARLRKKKTKAAK
SLIQDPNFGKAIYLAREAEKHGLEHPKLKKVTDIIKKELGQNGQTKLQSDRYVKDADQKSSKIMVFTQYRDSLEMIHQKL
EKEGIKSAKFFGQASRDGEKGLTQKEQKEIIKAFKIGEYDVLLSTSVAEEGIDIPAVDLVILYEPVPSEVRMIQRRGRTG
RKRSGRVKVLITNGTRDEGYYWASVNKERRMKHQLIDPDVLEELNSNAIERMENEKRVKVLDPTPKKEELPVVFADTREG
NSKVIRHLSEMEIDVKVQAMAVGDYQVSDEVVIERKTAKDFVDSIVDKRLFKQARSLMEEFKRPLIILEGDDLYNGMINP
NAIRGSIASIALDFGISIIPTRNAQDTAAMIKRIAIREQSGEKTPIQIRTDKKPVNLWEQQLFIIESLPNIGPVNAKNLL
EHFGTVANIINASESQLQEVEGIGKKTAANIRKVVDSKYLYFQNEIKEKKLL
>Mature_771_residues
AHYIDHPLIKSNAIEARLYQQVLAADVLKKGNTMIVAPTALGKTIVATLVAADRLEKVKNSKILVLAPSKPLAIQHESTF
KEFLTVPCSSITGAVKTDERVKRWEESQIICATPQTVESDLLKGRYSLKDVSLVVFDECHHGVGSYSYVYLASRYVKESK
FNLILGLTASPGSDKEKIKEVCDNLYIQSIVVKTEEDNDVRPYFNPVAIDWVRVKMSSELEKIKTHVDKALKIRLKGLKN
MGVIRTVSVNKLDILKARGRVQSAIARSVNPKKECFQAISILSAVINIQHSQELIETQGVVTFNKYVARLRKKKTKAAKS
LIQDPNFGKAIYLAREAEKHGLEHPKLKKVTDIIKKELGQNGQTKLQSDRYVKDADQKSSKIMVFTQYRDSLEMIHQKLE
KEGIKSAKFFGQASRDGEKGLTQKEQKEIIKAFKIGEYDVLLSTSVAEEGIDIPAVDLVILYEPVPSEVRMIQRRGRTGR
KRSGRVKVLITNGTRDEGYYWASVNKERRMKHQLIDPDVLEELNSNAIERMENEKRVKVLDPTPKKEELPVVFADTREGN
SKVIRHLSEMEIDVKVQAMAVGDYQVSDEVVIERKTAKDFVDSIVDKRLFKQARSLMEEFKRPLIILEGDDLYNGMINPN
AIRGSIASIALDFGISIIPTRNAQDTAAMIKRIAIREQSGEKTPIQIRTDKKPVNLWEQQLFIIESLPNIGPVNAKNLLE
HFGTVANIINASESQLQEVEGIGKKTAANIRKVVDSKYLYFQNEIKEKKLL

Specific function: Has A Helix-Destabilizing Activity. Plays A Key Role In Optimal Cell Growth At Low Temperature And Is Required For Normal Cell Division. Suppressor Of A Mutant Defective In Rpsb Gene For Ribosomal Protein S2. [C]

COG id: COG1111

COG function: function code L; ERCC4-like helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 helicase C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI74959747, Length=511, Percent_Identity=28.1800391389432, Blast_Score=213, Evalue=4e-55,
Organism=Homo sapiens, GI149408122, Length=532, Percent_Identity=23.8721804511278, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI27886568, Length=162, Percent_Identity=32.0987654320988, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI27881482, Length=175, Percent_Identity=30.8571428571429, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI4885217, Length=344, Percent_Identity=23.2558139534884, Blast_Score=73, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6322192, Length=618, Percent_Identity=28.1553398058252, Blast_Score=186, Evalue=1e-47,
Organism=Drosophila melanogaster, GI116008407, Length=530, Percent_Identity=27.3584905660377, Blast_Score=198, Evalue=9e-51,
Organism=Drosophila melanogaster, GI17977678, Length=160, Percent_Identity=28.75, Blast_Score=69, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR020819
- InterPro:   IPR006166
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR011335
- InterPro:   IPR010994 [H]

Pfam domain/function: PF00270 DEAD; PF02732 ERCC4; PF00271 Helicase_C; PF00633 HHH [H]

EC number: =3.6.4.13 [H]

Molecular weight: Translated: 87116; Mature: 86985

Theoretical pI: Translated: 9.92; Mature: 9.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHYIDHPLIKSNAIEARLYQQVLAADVLKKGNTMIVAPTALGKTIVATLVAADRLEKVK
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHHHC
NSKILVLAPSKPLAIQHESTFKEFLTVPCSSITGAVKTDERVKRWEESQIICATPQTVES
CCEEEEEECCCCCEECCHHHHHHHHHCCHHHHCCCCCCHHHHHHHCCCCEEEECCCHHHH
DLLKGRYSLKDVSLVVFDECHHGVGSYSYVYLASRYVKESKFNLILGLTASPGSDKEKIK
HHHCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHH
EVCDNLYIQSIVVKTEEDNDVRPYFNPVAIDWVRVKMSSELEKIKTHVDKALKIRLKGLK
HHHHHHHHHHEEEEECCCCCCCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCC
NMGVIRTVSVNKLDILKARGRVQSAIARSVNPKKECFQAISILSAVINIQHSQELIETQG
CCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VVTFNKYVARLRKKKTKAAKSLIQDPNFGKAIYLAREAEKHGLEHPKLKKVTDIIKKELG
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHCCCCCCHHHHHHHHHHHHHC
QNGQTKLQSDRYVKDADQKSSKIMVFTQYRDSLEMIHQKLEKEGIKSAKFFGQASRDGEK
CCCCCCCCCCCCHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCC
GLTQKEQKEIIKAFKIGEYDVLLSTSVAEEGIDIPAVDLVILYEPVPSEVRMIQRRGRTG
CCCHHHHHHHHHHHCCCCEEEEEEHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHCCCCC
RKRSGRVKVLITNGTRDEGYYWASVNKERRMKHQLIDPDVLEELNSNAIERMENEKRVKV
CCCCCEEEEEEECCCCCCCEEEEECCHHHHHHHHCCCHHHHHHHCHHHHHHHCCCCCEEE
LDPTPKKEELPVVFADTREGNSKVIRHLSEMEIDVKVQAMAVGDYQVSDEVVIERKTAKD
ECCCCCCCCCCEEEECCCCCCHHHHHHHHHCCEEEEEEEEEECCEECCCHHEEEHHHHHH
FVDSIVDKRLFKQARSLMEEFKRPLIILEGDDLYNGMINPNAIRGSIASIALDFGISIIP
HHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHCCCCCCHHHHHHHHHHHHHCCEEEEE
TRNAQDTAAMIKRIAIREQSGEKTPIQIRTDKKPVNLWEQQLFIIESLPNIGPVNAKNLL
CCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCHHHHH
EHFGTVANIINASESQLQEVEGIGKKTAANIRKVVDSKYLYFQNEIKEKKLL
HHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHCHHHEEHHHHHHHCCC
>Mature Secondary Structure 
AHYIDHPLIKSNAIEARLYQQVLAADVLKKGNTMIVAPTALGKTIVATLVAADRLEKVK
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHHHC
NSKILVLAPSKPLAIQHESTFKEFLTVPCSSITGAVKTDERVKRWEESQIICATPQTVES
CCEEEEEECCCCCEECCHHHHHHHHHCCHHHHCCCCCCHHHHHHHCCCCEEEECCCHHHH
DLLKGRYSLKDVSLVVFDECHHGVGSYSYVYLASRYVKESKFNLILGLTASPGSDKEKIK
HHHCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHH
EVCDNLYIQSIVVKTEEDNDVRPYFNPVAIDWVRVKMSSELEKIKTHVDKALKIRLKGLK
HHHHHHHHHHEEEEECCCCCCCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCC
NMGVIRTVSVNKLDILKARGRVQSAIARSVNPKKECFQAISILSAVINIQHSQELIETQG
CCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VVTFNKYVARLRKKKTKAAKSLIQDPNFGKAIYLAREAEKHGLEHPKLKKVTDIIKKELG
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHCCCCCCHHHHHHHHHHHHHC
QNGQTKLQSDRYVKDADQKSSKIMVFTQYRDSLEMIHQKLEKEGIKSAKFFGQASRDGEK
CCCCCCCCCCCCHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCC
GLTQKEQKEIIKAFKIGEYDVLLSTSVAEEGIDIPAVDLVILYEPVPSEVRMIQRRGRTG
CCCHHHHHHHHHHHCCCCEEEEEEHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHCCCCC
RKRSGRVKVLITNGTRDEGYYWASVNKERRMKHQLIDPDVLEELNSNAIERMENEKRVKV
CCCCCEEEEEEECCCCCCCEEEEECCHHHHHHHHCCCHHHHHHHCHHHHHHHCCCCCEEE
LDPTPKKEELPVVFADTREGNSKVIRHLSEMEIDVKVQAMAVGDYQVSDEVVIERKTAKD
ECCCCCCCCCCEEEECCCCCCHHHHHHHHHCCEEEEEEEEEECCEECCCHHEEEHHHHHH
FVDSIVDKRLFKQARSLMEEFKRPLIILEGDDLYNGMINPNAIRGSIASIALDFGISIIP
HHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHCCCCCCHHHHHHHHHHHHHCCEEEEE
TRNAQDTAAMIKRIAIREQSGEKTPIQIRTDKKPVNLWEQQLFIIESLPNIGPVNAKNLL
CCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCHHHHH
EHFGTVANIINASESQLQEVEGIGKKTAANIRKVVDSKYLYFQNEIKEKKLL
HHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHCHHHEEHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]