Click here to switch to the map view.

The map label for this gene is truD [H]

Identifier: 148643216

GI number: 148643216

Start: 1134937

End: 1136199

Strand: Reverse

Name: truD [H]

Synonym: Msm_1156

Alternate gene names: 148643216

Gene position: 1136199-1134937 (Counterclockwise)

Preceding gene: 148643217

Following gene: 148643215

Centisome position: 61.31

GC content: 33.65

Gene sequence:

>1263_bases
ATGTTAAATGCTAATACTTATGTAACTAATGAGAAAGGGATTGGCGGAACTATTAGAAATCAGTATGAAGATTTTTATGT
TGAAGAAATCCCTGAAATGACTCCAACTGGTGAAGGGCCTAATATTTGGATTTGGATTGAGAAAGTAGGTAGGACTACTT
TAGATGTTGTTTTGGATATTGCAAGAGATTTACATATTAGTAGAAAAAGAATGGGCTTTGCAGGAATGAAAGATAAAAAA
GCCCGTACCCGTCAGTGGATTTGCATATCTAATATGGAATCTGAAGAACAGTTCAGGCAAGTTAAGGATTTGGAAGGAAC
CATTTATAAAACTGATTTTTTAAAGGTTGTTCGTGGACGTAAAAAACTTAGGATGGGACAGCTAAAGGGAAATAAATTCC
AAATTCTTATTCGGGATATTGATGATATTGAAAAAAGTGCTGAAATAGCTAATAACATTTTAAAGGAATTGGAAGTTACT
GGTGTTCCTAATTACTTTGGCTGGCAAAGATTTGGTAAGCCAAGAACAAACACTCACTTGGTAGGTGAAGCTTTAGTTCA
AAATGATTTAAAAGAAGCTGTTAGAAGATACATTGGAAATCCTACAAGTGAAGAACATGAAGAAAACCAAAAAGCAAGAC
AAGCTTATGATGATGGAAATTTGGAAGAATCTTTGGAATTGATGAGTAAAGGAATGCGTTATGAGAAAATGATGGTTCGT
GAACTGATTAAATATGCTAAAAAAGGACCATTAGATGATAAAGCTTATAAAAATGCCTTGCATGCACTTCCAAAACCTCT
CCAAAGGATGTTTGTCCATGCATATCAATCTTATTTATTTAATGATGCAGTTAGCAGAAGGGTAGCTATGGGAATTAACA
GATATGTTGAAGGAGACATTATCATTGACAATGAAGAGAGAATAGTTCGTGATAAAACTCCTGAAGAGTTCCAAAACTTA
ATTGATAATTTTGAAGCTAATCCTACTTCTCCATTATATGGAACTAAAGTACCTTTTGCCGGTGGTGAAGTTGGTGAAAT
GGAAAAATCAGTTTTAAATAGCTATAATTTAACTAAAGAAGACTTTGAAGTTCCTAAAATGCCTCGTTTAGGAAGTCATG
GTTTAAGAAGGTCTATGAGAATTCAAGTTTGGGATGCTTCAGCTATTCCAACAGATGAAGGTGTTTTAACTGAATTTTCA
ATAAATAAAGGTTCTTATGCTACAGCTGTTTTAAGGGAAGTCATGAAAAAAGATGTTGTTTAG

Upstream 100 bases:

>100_bases
CGATGGTGTAGTTTGGATAACACATAGGACTGCGGATCCTATTCCCCGGGTTCAAATCCCGGTCGGGGCATTATATAATT
TTTTTAAATTCCGTGATACA

Downstream 100 bases:

>100_bases
ATTTATGGCTCTTTTTTCATTTTTTAAATTTTTAATAAATTCATTAAAATCATTTATGCATGATTTTTTTTGGTTTTGAA
ATTTTCATATAATTCATTTT

Product: tRNA pseudouridine synthase D, TruD

Products: NA

Alternate protein names: tRNA pseudouridylate synthase D; tRNA-uridine isomerase D [H]

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MLNANTYVTNEKGIGGTIRNQYEDFYVEEIPEMTPTGEGPNIWIWIEKVGRTTLDVVLDIARDLHISRKRMGFAGMKDKK
ARTRQWICISNMESEEQFRQVKDLEGTIYKTDFLKVVRGRKKLRMGQLKGNKFQILIRDIDDIEKSAEIANNILKELEVT
GVPNYFGWQRFGKPRTNTHLVGEALVQNDLKEAVRRYIGNPTSEEHEENQKARQAYDDGNLEESLELMSKGMRYEKMMVR
ELIKYAKKGPLDDKAYKNALHALPKPLQRMFVHAYQSYLFNDAVSRRVAMGINRYVEGDIIIDNEERIVRDKTPEEFQNL
IDNFEANPTSPLYGTKVPFAGGEVGEMEKSVLNSYNLTKEDFEVPKMPRLGSHGLRRSMRIQVWDASAIPTDEGVLTEFS
INKGSYATAVLREVMKKDVV

Sequences:

>Translated_420_residues
MLNANTYVTNEKGIGGTIRNQYEDFYVEEIPEMTPTGEGPNIWIWIEKVGRTTLDVVLDIARDLHISRKRMGFAGMKDKK
ARTRQWICISNMESEEQFRQVKDLEGTIYKTDFLKVVRGRKKLRMGQLKGNKFQILIRDIDDIEKSAEIANNILKELEVT
GVPNYFGWQRFGKPRTNTHLVGEALVQNDLKEAVRRYIGNPTSEEHEENQKARQAYDDGNLEESLELMSKGMRYEKMMVR
ELIKYAKKGPLDDKAYKNALHALPKPLQRMFVHAYQSYLFNDAVSRRVAMGINRYVEGDIIIDNEERIVRDKTPEEFQNL
IDNFEANPTSPLYGTKVPFAGGEVGEMEKSVLNSYNLTKEDFEVPKMPRLGSHGLRRSMRIQVWDASAIPTDEGVLTEFS
INKGSYATAVLREVMKKDVV
>Mature_420_residues
MLNANTYVTNEKGIGGTIRNQYEDFYVEEIPEMTPTGEGPNIWIWIEKVGRTTLDVVLDIARDLHISRKRMGFAGMKDKK
ARTRQWICISNMESEEQFRQVKDLEGTIYKTDFLKVVRGRKKLRMGQLKGNKFQILIRDIDDIEKSAEIANNILKELEVT
GVPNYFGWQRFGKPRTNTHLVGEALVQNDLKEAVRRYIGNPTSEEHEENQKARQAYDDGNLEESLELMSKGMRYEKMMVR
ELIKYAKKGPLDDKAYKNALHALPKPLQRMFVHAYQSYLFNDAVSRRVAMGINRYVEGDIIIDNEERIVRDKTPEEFQNL
IDNFEANPTSPLYGTKVPFAGGEVGEMEKSVLNSYNLTKEDFEVPKMPRLGSHGLRRSMRIQVWDASAIPTDEGVLTEFS
INKGSYATAVLREVMKKDVV

Specific function: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs [H]

COG id: COG0585

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRUD domain [H]

Homologues:

Organism=Homo sapiens, GI148762985, Length=381, Percent_Identity=26.7716535433071, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI148762961, Length=381, Percent_Identity=26.7716535433071, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI148762948, Length=381, Percent_Identity=26.7716535433071, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI50727002, Length=417, Percent_Identity=23.021582733813, Blast_Score=96, Evalue=4e-20,
Organism=Escherichia coli, GI1789102, Length=175, Percent_Identity=37.1428571428571, Blast_Score=96, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17557232, Length=389, Percent_Identity=24.6786632390745, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324817, Length=282, Percent_Identity=29.7872340425532, Blast_Score=111, Evalue=3e-25,
Organism=Drosophila melanogaster, GI21355799, Length=258, Percent_Identity=27.1317829457364, Blast_Score=82, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020103
- InterPro:   IPR001656
- InterPro:   IPR020119
- InterPro:   IPR011760 [H]

Pfam domain/function: PF01142 TruD [H]

EC number: NA

Molecular weight: Translated: 48318; Mature: 48318

Theoretical pI: Translated: 7.72; Mature: 7.72

Prosite motif: PS50984 TRUD ; PS01268 UPF0024

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNANTYVTNEKGIGGTIRNQYEDFYVEEIPEMTPTGEGPNIWIWIEKVGRTTLDVVLDI
CCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEHHCCHHHHHHHHH
ARDLHISRKRMGFAGMKDKKARTRQWICISNMESEEQFRQVKDLEGTIYKTDFLKVVRGR
HHHHHHHHHHCCCCCCCCCHHHHHEEEEECCCCHHHHHHHHHHCCCCEEHHHHHHHHHHH
KKLRMGQLKGNKFQILIRDIDDIEKSAEIANNILKELEVTGVPNYFGWQRFGKPRTNTHL
HHHHHHCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCHHH
VGEALVQNDLKEAVRRYIGNPTSEEHEENQKARQAYDDGNLEESLELMSKGMRYEKMMVR
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHH
ELIKYAKKGPLDDKAYKNALHALPKPLQRMFVHAYQSYLFNDAVSRRVAMGINRYVEGDI
HHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
IIDNEERIVRDKTPEEFQNLIDNFEANPTSPLYGTKVPFAGGEVGEMEKSVLNSYNLTKE
EECCCCHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHH
DFEVPKMPRLGSHGLRRSMRIQVWDASAIPTDEGVLTEFSINKGSYATAVLREVMKKDVV
HCCCCCCCCCCCHHHCCCCEEEEEECCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLNANTYVTNEKGIGGTIRNQYEDFYVEEIPEMTPTGEGPNIWIWIEKVGRTTLDVVLDI
CCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEHHCCHHHHHHHHH
ARDLHISRKRMGFAGMKDKKARTRQWICISNMESEEQFRQVKDLEGTIYKTDFLKVVRGR
HHHHHHHHHHCCCCCCCCCHHHHHEEEEECCCCHHHHHHHHHHCCCCEEHHHHHHHHHHH
KKLRMGQLKGNKFQILIRDIDDIEKSAEIANNILKELEVTGVPNYFGWQRFGKPRTNTHL
HHHHHHCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCHHH
VGEALVQNDLKEAVRRYIGNPTSEEHEENQKARQAYDDGNLEESLELMSKGMRYEKMMVR
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHH
ELIKYAKKGPLDDKAYKNALHALPKPLQRMFVHAYQSYLFNDAVSRRVAMGINRYVEGDI
HHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
IIDNEERIVRDKTPEEFQNLIDNFEANPTSPLYGTKVPFAGGEVGEMEKSVLNSYNLTKE
EECCCCHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHH
DFEVPKMPRLGSHGLRRSMRIQVWDASAIPTDEGVLTEFSINKGSYATAVLREVMKKDVV
HCCCCCCCCCCCHHHCCCCEEEEEECCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]