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The map label for this gene is coaBC [H]

Identifier: 148643109

GI number: 148643109

Start: 1011274

End: 1011780

Strand: Reverse

Name: coaBC [H]

Synonym: Msm_1049

Alternate gene names: 148643109

Gene position: 1011780-1011274 (Counterclockwise)

Preceding gene: 148643110

Following gene: 148643108

Centisome position: 54.6

GC content: 33.14

Gene sequence:

>507_bases
ATGATTATATTATGTGTTACTGGCAGTATTGCCGCTACTGAATCTATTAAATTAGCTAGGGAACTTAAAAGAAATGATAT
GGAAGTTAAATGTTTTATGAGCGAAGCTGCTTGCGATATTATCACTCCAAATGCTATGGAATTTGCAACAGGTAATGAAG
TGGTAACCAGGTTGACTGGTAAGATTGAGCATGTTAAATATTCACAAGAGGATTTGATATTAGTTGCTCCAGCTACTGCG
AATACCATAAGCAAATTTGCATATAAGCTAGCTGATGACCCAATCTCTACACTTTTGATTACAGCATATGGACATGACAC
TCCAATTTTGTTCGTTCCGTCAATGCATGATTCAATGTTTAAGGCTATTAAAGACAATATTGATAAAATTAAAGAAGAGG
GTTCTGCTTCATTTATCAAACCTAAAATGGATGAAGGCAAAGCAAAATTCCCAGATAAAGAAGATATAGTTTTAGAAGCA
TTAAGAACAATTAATTTAAATAAATGA

Upstream 100 bases:

>100_bases
AATTGATAAATTTAATGAAAATCTAAATTCATTTAATTATATTTTAGAAAATATGCAAATTGGTGCATAATTCTTTTTAT
TTTTTTTTAGAGGTATTTTC

Downstream 100 bases:

>100_bases
GGTGGTTTTATCCACGAAAAAGTTTTAATAAGTATGGGTGGAACTTATGAACCTATTGATCCGATAAGGGGAATAACCAA
CAAATCCTCTGGAAAAATGG

Product: phosphopantothenoylcysteine synthetase/decarboxylase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 168; Mature: 168

Protein sequence:

>168_residues
MIILCVTGSIAATESIKLARELKRNDMEVKCFMSEAACDIITPNAMEFATGNEVVTRLTGKIEHVKYSQEDLILVAPATA
NTISKFAYKLADDPISTLLITAYGHDTPILFVPSMHDSMFKAIKDNIDKIKEEGSASFIKPKMDEGKAKFPDKEDIVLEA
LRTINLNK

Sequences:

>Translated_168_residues
MIILCVTGSIAATESIKLARELKRNDMEVKCFMSEAACDIITPNAMEFATGNEVVTRLTGKIEHVKYSQEDLILVAPATA
NTISKFAYKLADDPISTLLITAYGHDTPILFVPSMHDSMFKAIKDNIDKIKEEGSASFIKPKMDEGKAKFPDKEDIVLEA
LRTINLNK
>Mature_168_residues
MIILCVTGSIAATESIKLARELKRNDMEVKCFMSEAACDIITPNAMEFATGNEVVTRLTGKIEHVKYSQEDLILVAPATA
NTISKFAYKLADDPISTLLITAYGHDTPILFVPSMHDSMFKAIKDNIDKIKEEGSASFIKPKMDEGKAKFPDKEDIVLEA
LRTINLNK

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Escherichia coli, GI87082301, Length=143, Percent_Identity=31.4685314685315, Blast_Score=72, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 18583; Mature: 18583

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIILCVTGSIAATESIKLARELKRNDMEVKCFMSEAACDIITPNAMEFATGNEVVTRLTG
CEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCEECCCCEEECCCHHHHHHHHC
KIEHVKYSQEDLILVAPATANTISKFAYKLADDPISTLLITAYGHDTPILFVPSMHDSMF
HHHEEEECCCCEEEEECCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEECCCHHHHH
KAIKDNIDKIKEEGSASFIKPKMDEGKAKFPDKEDIVLEALRTINLNK
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIILCVTGSIAATESIKLARELKRNDMEVKCFMSEAACDIITPNAMEFATGNEVVTRLTG
CEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCEECCCCEEECCCHHHHHHHHC
KIEHVKYSQEDLILVAPATANTISKFAYKLADDPISTLLITAYGHDTPILFVPSMHDSMF
HHHEEEECCCCEEEEECCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEECCCHHHHH
KAIKDNIDKIKEEGSASFIKPKMDEGKAKFPDKEDIVLEALRTINLNK
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]