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The map label for this gene is pol [H]

Identifier: 148643101

GI number: 148643101

Start: 1003159

End: 1004946

Strand: Reverse

Name: pol [H]

Synonym: Msm_1041

Alternate gene names: 148643101

Gene position: 1004946-1003159 (Counterclockwise)

Preceding gene: 148643102

Following gene: 148643096

Centisome position: 54.23

GC content: 32.1

Gene sequence:

>1788_bases
ATGGAAAAAAACGTTGTTATTTTAGATATTGACTATGTTACTTATGAAAACAAGCCTGTAATCCGTTTATTTTCAAAAGA
TAAGGATAAAAACATTGTTTTGTTAGATGACACCTTTGAGCCTTATTTGTATGTTGCTCCTAAAGATGATGATAAAGAGT
GTCAAAAACAGATTCTTGATACTTTAGATGATGTGCATATTGAAGAAGTTATTAAAAAGGATTTTCAGGTGGAAAAAACA
TTTTTAAAAGTGACTTTTTTAAATCCTCAGGAATTAGCTAAAAACAGGGATGCTTTACGTGATTTGGACTCTGTGGATCA
TATAAGGGAACATGATATTCCATTTTACAGAAGATATTTAATTGATCGTGATGTTATTCCAATGACTGAGGTTAAAGCCT
GCGGGGAAAAAATTGATTCATTTTTAAATTTGGATTCTAAAAAACACGATTTGGAAATTATTAAACTTACCAAACCTCTT
GAAAGAGTGAATGATGATTTGCAGGACTTTAGAATTTTAAGTTTTGATTTGGAAGTTAGAAATCCTCATGGGATGCCAAA
TTCTGAAGTTGATGAGATAATCATGATTGGAGTAGCCAGTAATTTTGGAATAAATCAGGTTATTTCAACCAAAACAAATT
CTGAAGATAGGGATGATTTTGTTAATCAGGTAGAATCTGAAAAGGAAATGATTGAAACATTTATTGATATAGTTAAAAAA
AGCAATGTTGATATTATTGTAGGATATAATTCTGATAATTTTGACCTTCCATATCTTAAAGACAGAGCTAAACTTTATGG
TTTGGAGTTGGATTTGGGAATGGATGATTCTAATATTAAATTTATTCGAAGGGGTTTTGCAAATGCAGCTTCTTTTAAAG
GACTGATTCATGTTGATTTATATCTTGTTATGAGAAGATACATGACTTTGGAGAGATATACTTTAGAGAGAGTATACTAT
GAATTATTTGGTGAGGAAAAAATCGATGTTCCTGGAGAACACATCTGGGAGTACTGGGACAGTGATTCAACTGAATTAGA
TGATTTGTTTGATTATTCTTTAGATGATGTTGTATCTACATTAAAAATCGCTCAGCAAACACTTCCGCTTAACCTGGAAC
TTACTCGTATTGTTGGTCAGCCTCTTTTTGACTTAAGCCGTATGGCTACGGGTCAACAGGCTGAATGGTTTTTAGTTAAG
GAAGCATATTTTGACAATGAGATTGTACCAAATAAACCTGGAGGTTCAAACTTTGCACTTAGAGCTGCTGAGGAAGACAA
TGAAGGAGGATATGTTAAGGAACCCGAAATTGGATTGCATGAAAATTTAGTCCAGTTCGATTTCAGAAGTCTGTATCCCA
GCATAATTATTTCAAAAAACATTTCTCCTGACGTGCTGGTTATTGGAGATGTTGAAAATAGACAGGATTACAATATTTCT
CCGGAACATGATTTAAAATTTAAAAAAGAGCCAAAAGGTTTTATTCCGTCAGTTATAGCTAAAATTCTTAATGAAAGATT
TAAAATTAAAAAAGCCATGAAAGCATCTGTTGATCCAACTGAAAAAAAGACTTTAGATGTGCAACAGCAGGCTATAAAAC
GTTTAGCTAATACTATGTATGGTATTTATGGTTTTCCTCGCTTCAGATGGTACTCTTATGAATGTGCAAAAGCTATTACT
TCATGGGGTAGGCAATATATTAAAAGAGCAATGAAAAAAGCGGAAGATTATGGTTTTTATGCAATATATGCAGACACTGA
TGGTTTTTATGCTAAATATAAAAAATAA

Upstream 100 bases:

>100_bases
AATTGTAGGGTTTATTTTAGGTCCATTAATACTGGGTATAACTTATGCTGTTTTAGATAACTTTAGAATAGAACTTAATA
AAAGCAAAGGGGAATAAACA

Downstream 100 bases:

>100_bases
GGAAGAATAAATATTATTCTTCTAAATATGAATCAAAGTCAATATCTAAATCGTCGCAGATTTCTTTCAATTGTTCGTAT
AATTTTTCATCTATTTCCAT

Product: DNA-dependent DNA polymerase I, PolB1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 595; Mature: 595

Protein sequence:

>595_residues
MEKNVVILDIDYVTYENKPVIRLFSKDKDKNIVLLDDTFEPYLYVAPKDDDKECQKQILDTLDDVHIEEVIKKDFQVEKT
FLKVTFLNPQELAKNRDALRDLDSVDHIREHDIPFYRRYLIDRDVIPMTEVKACGEKIDSFLNLDSKKHDLEIIKLTKPL
ERVNDDLQDFRILSFDLEVRNPHGMPNSEVDEIIMIGVASNFGINQVISTKTNSEDRDDFVNQVESEKEMIETFIDIVKK
SNVDIIVGYNSDNFDLPYLKDRAKLYGLELDLGMDDSNIKFIRRGFANAASFKGLIHVDLYLVMRRYMTLERYTLERVYY
ELFGEEKIDVPGEHIWEYWDSDSTELDDLFDYSLDDVVSTLKIAQQTLPLNLELTRIVGQPLFDLSRMATGQQAEWFLVK
EAYFDNEIVPNKPGGSNFALRAAEEDNEGGYVKEPEIGLHENLVQFDFRSLYPSIIISKNISPDVLVIGDVENRQDYNIS
PEHDLKFKKEPKGFIPSVIAKILNERFKIKKAMKASVDPTEKKTLDVQQQAIKRLANTMYGIYGFPRFRWYSYECAKAIT
SWGRQYIKRAMKKAEDYGFYAIYADTDGFYAKYKK

Sequences:

>Translated_595_residues
MEKNVVILDIDYVTYENKPVIRLFSKDKDKNIVLLDDTFEPYLYVAPKDDDKECQKQILDTLDDVHIEEVIKKDFQVEKT
FLKVTFLNPQELAKNRDALRDLDSVDHIREHDIPFYRRYLIDRDVIPMTEVKACGEKIDSFLNLDSKKHDLEIIKLTKPL
ERVNDDLQDFRILSFDLEVRNPHGMPNSEVDEIIMIGVASNFGINQVISTKTNSEDRDDFVNQVESEKEMIETFIDIVKK
SNVDIIVGYNSDNFDLPYLKDRAKLYGLELDLGMDDSNIKFIRRGFANAASFKGLIHVDLYLVMRRYMTLERYTLERVYY
ELFGEEKIDVPGEHIWEYWDSDSTELDDLFDYSLDDVVSTLKIAQQTLPLNLELTRIVGQPLFDLSRMATGQQAEWFLVK
EAYFDNEIVPNKPGGSNFALRAAEEDNEGGYVKEPEIGLHENLVQFDFRSLYPSIIISKNISPDVLVIGDVENRQDYNIS
PEHDLKFKKEPKGFIPSVIAKILNERFKIKKAMKASVDPTEKKTLDVQQQAIKRLANTMYGIYGFPRFRWYSYECAKAIT
SWGRQYIKRAMKKAEDYGFYAIYADTDGFYAKYKK
>Mature_595_residues
MEKNVVILDIDYVTYENKPVIRLFSKDKDKNIVLLDDTFEPYLYVAPKDDDKECQKQILDTLDDVHIEEVIKKDFQVEKT
FLKVTFLNPQELAKNRDALRDLDSVDHIREHDIPFYRRYLIDRDVIPMTEVKACGEKIDSFLNLDSKKHDLEIIKLTKPL
ERVNDDLQDFRILSFDLEVRNPHGMPNSEVDEIIMIGVASNFGINQVISTKTNSEDRDDFVNQVESEKEMIETFIDIVKK
SNVDIIVGYNSDNFDLPYLKDRAKLYGLELDLGMDDSNIKFIRRGFANAASFKGLIHVDLYLVMRRYMTLERYTLERVYY
ELFGEEKIDVPGEHIWEYWDSDSTELDDLFDYSLDDVVSTLKIAQQTLPLNLELTRIVGQPLFDLSRMATGQQAEWFLVK
EAYFDNEIVPNKPGGSNFALRAAEEDNEGGYVKEPEIGLHENLVQFDFRSLYPSIIISKNISPDVLVIGDVENRQDYNIS
PEHDLKFKKEPKGFIPSVIAKILNERFKIKKAMKASVDPTEKKTLDVQQQAIKRLANTMYGIYGFPRFRWYSYECAKAIT
SWGRQYIKRAMKKAEDYGFYAIYADTDGFYAKYKK

Specific function: Thought To Be Involved In DNA Repair And/Or Mutagenesis. [C]

COG id: COG0417

COG function: function code L; DNA polymerase elongation subunit (family B)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA polymerase type-B family [H]

Homologues:

Organism=Homo sapiens, GI156616275, Length=569, Percent_Identity=25.3075571177504, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI106507301, Length=414, Percent_Identity=27.0531400966184, Blast_Score=117, Evalue=3e-26,
Organism=Escherichia coli, GI1786246, Length=439, Percent_Identity=26.879271070615, Blast_Score=111, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17559488, Length=467, Percent_Identity=27.8372591006424, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI32565317, Length=409, Percent_Identity=25.4278728606357, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17507143, Length=385, Percent_Identity=24.9350649350649, Blast_Score=80, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6320101, Length=643, Percent_Identity=25.0388802488336, Blast_Score=152, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6324227, Length=493, Percent_Identity=24.1379310344828, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6325090, Length=409, Percent_Identity=25.1833740831296, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324067, Length=483, Percent_Identity=22.360248447205, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24664937, Length=678, Percent_Identity=26.5486725663717, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24648780, Length=396, Percent_Identity=24.2424242424242, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24649301, Length=381, Percent_Identity=23.6220472440945, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006172
- InterPro:   IPR017964
- InterPro:   IPR006133
- InterPro:   IPR006134
- InterPro:   IPR023211
- InterPro:   IPR012337 [H]

Pfam domain/function: PF00136 DNA_pol_B; PF03104 DNA_pol_B_exo [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 69332; Mature: 69332

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS00116 DNA_POLYMERASE_B

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKNVVILDIDYVTYENKPVIRLFSKDKDKNIVLLDDTFEPYLYVAPKDDDKECQKQILD
CCCCEEEEEEEEEEECCCCEEEEECCCCCCCEEEEECCCCCEEEECCCCCHHHHHHHHHH
TLDDVHIEEVIKKDFQVEKTFLKVTFLNPQELAKNRDALRDLDSVDHIREHDIPFYRRYL
HHHHHHHHHHHHHHHHEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
IDRDVIPMTEVKACGEKIDSFLNLDSKKHDLEIIKLTKPLERVNDDLQDFRILSFDLEVR
HCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHCCCHHHCEEEEEEEEEC
NPHGMPNSEVDEIIMIGVASNFGINQVISTKTNSEDRDDFVNQVESEKEMIETFIDIVKK
CCCCCCCCCCCCEEEEEEECCCCCCHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
SNVDIIVGYNSDNFDLPYLKDRAKLYGLELDLGMDDSNIKFIRRGFANAASFKGLIHVDL
CCCEEEEEECCCCCCCCHHHCCHHEEEEEEECCCCCCCHHHHHHHHCCHHHCCCHHHHHH
YLVMRRYMTLERYTLERVYYELFGEEKIDVPGEHIWEYWDSDSTELDDLFDYSLDDVVST
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHCCCHHHHHHH
LKIAQQTLPLNLELTRIVGQPLFDLSRMATGQQAEWFLVKEAYFDNEIVPNKPGGSNFAL
HHHHHHHCCCCEEEHHHHCCCHHHHHHHCCCCCCCEEEEEEHHCCCCCCCCCCCCCCEEE
RAAEEDNEGGYVKEPEIGLHENLVQFDFRSLYPSIIISKNISPDVLVIGDVENRQDYNIS
EECCCCCCCCEEECCCCCHHHHHHHHHHHHHCCEEEEECCCCCCEEEEECCCCCCCCCCC
PEHDLKFKKEPKGFIPSVIAKILNERFKIKKAMKASVDPTEKKTLDVQQQAIKRLANTMY
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
GIYGFPRFRWYSYECAKAITSWGRQYIKRAMKKAEDYGFYAIYADTDGFYAKYKK
HHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEECCC
>Mature Secondary Structure
MEKNVVILDIDYVTYENKPVIRLFSKDKDKNIVLLDDTFEPYLYVAPKDDDKECQKQILD
CCCCEEEEEEEEEEECCCCEEEEECCCCCCCEEEEECCCCCEEEECCCCCHHHHHHHHHH
TLDDVHIEEVIKKDFQVEKTFLKVTFLNPQELAKNRDALRDLDSVDHIREHDIPFYRRYL
HHHHHHHHHHHHHHHHEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
IDRDVIPMTEVKACGEKIDSFLNLDSKKHDLEIIKLTKPLERVNDDLQDFRILSFDLEVR
HCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHCCCHHHCEEEEEEEEEC
NPHGMPNSEVDEIIMIGVASNFGINQVISTKTNSEDRDDFVNQVESEKEMIETFIDIVKK
CCCCCCCCCCCCEEEEEEECCCCCCHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
SNVDIIVGYNSDNFDLPYLKDRAKLYGLELDLGMDDSNIKFIRRGFANAASFKGLIHVDL
CCCEEEEEECCCCCCCCHHHCCHHEEEEEEECCCCCCCHHHHHHHHCCHHHCCCHHHHHH
YLVMRRYMTLERYTLERVYYELFGEEKIDVPGEHIWEYWDSDSTELDDLFDYSLDDVVST
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHCCCHHHHHHH
LKIAQQTLPLNLELTRIVGQPLFDLSRMATGQQAEWFLVKEAYFDNEIVPNKPGGSNFAL
HHHHHHHCCCCEEEHHHHCCCHHHHHHHCCCCCCCEEEEEEHHCCCCCCCCCCCCCCEEE
RAAEEDNEGGYVKEPEIGLHENLVQFDFRSLYPSIIISKNISPDVLVIGDVENRQDYNIS
EECCCCCCCCEEECCCCCHHHHHHHHHHHHHCCEEEEECCCCCCEEEEECCCCCCCCCCC
PEHDLKFKKEPKGFIPSVIAKILNERFKIKKAMKASVDPTEKKTLDVQQQAIKRLANTMY
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
GIYGFPRFRWYSYECAKAITSWGRQYIKRAMKKAEDYGFYAIYADTDGFYAKYKK
HHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]