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The map label for this gene is ahcY [H]

Identifier: 148642787

GI number: 148642787

Start: 696204

End: 697454

Strand: Reverse

Name: ahcY [H]

Synonym: Msm_0727

Alternate gene names: 148642787

Gene position: 697454-696204 (Counterclockwise)

Preceding gene: 148642790

Following gene: 148642786

Centisome position: 37.64

GC content: 36.53

Gene sequence:

>1251_bases
ATGAGTAAAGTTAAAGATATGTCTCTTGCTAAAGAAGGTATAAGAAAAATTGAATGGGTTCAAAGACACATGCCAGTTCT
TGAACACATCAAAAAAGAATATGAAGAAACTCAACCTTTCAAAGGAATCACTATTGGGTCTTGCCTACATTTAGAACCTA
AAACTATTAATTTAGGTTTAACTTTGCAGGCAGGTGGAGCTGAAGTAGCTATGACTGGATGTAATCCGTTATCCACTCAT
GATGATGCAGTGGCCGGAGCTGCTGATTTAGGTTTGAACATCTACGGTTGGAGAGATCAGGATGATGAAGAATATTATCA
GACTATCAACATGGTTCTTGATCACAAACCTGATGTAATCATTGATGACGGTGCAGATATGATTATGGTTCTTCACAATG
AAAGAACTGATGTTTTAAAACATATTAAAGGAGCATGTGAAGAAACTACTACTGGTGTTCACAGATTGGAAGCTATGCAT
AAAGATGGGGCTTTAAAATTCCCTGTTGTAGCTGTAAATGATGCTTATACCAAATATTTGTTTGATAACAGATATGGTAC
AGGCCAATCCAGTTTTGATGCAATTATGGGAACCACCAATATGTTAATAGCTGGTAAATCTGTTGTTGTATGTGGATATG
GATGGTGCGGTCGTGGAATAGCTTTAAGGGCACAAGGTCTTGGAGCTAATGTTATTGTAACTGAAATCGATCCAATCAGA
GCACTTGAAGCAAGAATGGATGGTTACAGAGTAATGAAAATTAGAGATGCTGTAAAAGAAGCTGATTTAATCATTACTGT
AACTGGTAATATCAATATTATTCATGGTGATGACTTCAAATACATGAAAGACGGCTGTATGTTATGTAACTCCGGTCATT
TTAATGTGGAAATTAATAGACGTGACTTGGAAGCTCAATCAACCAGTGTTCGTGAAGTAAGAGAAAGTATTGAAATGTTT
ACCATGAAAGACGGCAGAAAAATATATCTGCTTGCAGACGGAAGATTAGTAAACTTATCTGCAGCCAGGGGACAAGGACA
CCCTGCAGAAATCATGGACATGAGTTTTGCTGTTCAGGCATTATCTGCAAAATACATTTTAAACAACGATTTGGAAGTCG
GTGTAACTAAAGCTCCTGATGACATTGATTATGAAGTAGCTAATTTAAAACTAAAAGCTATGGATATTGAAATTGATACT
TTATCTGACCGCCAAAAAGAGTATATGTGCAGCTGGAAAGAAGGAACTTAA

Upstream 100 bases:

>100_bases
TTTGTTGCATTATATATTTTTAAAATTATTTATGAATAATAATATTTAATAACCCTCAAATGATATATTATAATATTATT
TAATTTTTATAGGGGATATT

Downstream 100 bases:

>100_bases
GTTTTCTTCTTTGATTTTTTCTTTTTTTTATTTGGATAATATGTCTTATTTCAGATATGTTGACAATGGTGAAGGTCCAA
CTAAGTTATTTATAGGTGGA

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MSKVKDMSLAKEGIRKIEWVQRHMPVLEHIKKEYEETQPFKGITIGSCLHLEPKTINLGLTLQAGGAEVAMTGCNPLSTH
DDAVAGAADLGLNIYGWRDQDDEEYYQTINMVLDHKPDVIIDDGADMIMVLHNERTDVLKHIKGACEETTTGVHRLEAMH
KDGALKFPVVAVNDAYTKYLFDNRYGTGQSSFDAIMGTTNMLIAGKSVVVCGYGWCGRGIALRAQGLGANVIVTEIDPIR
ALEARMDGYRVMKIRDAVKEADLIITVTGNINIIHGDDFKYMKDGCMLCNSGHFNVEINRRDLEAQSTSVREVRESIEMF
TMKDGRKIYLLADGRLVNLSAARGQGHPAEIMDMSFAVQALSAKYILNNDLEVGVTKAPDDIDYEVANLKLKAMDIEIDT
LSDRQKEYMCSWKEGT

Sequences:

>Translated_416_residues
MSKVKDMSLAKEGIRKIEWVQRHMPVLEHIKKEYEETQPFKGITIGSCLHLEPKTINLGLTLQAGGAEVAMTGCNPLSTH
DDAVAGAADLGLNIYGWRDQDDEEYYQTINMVLDHKPDVIIDDGADMIMVLHNERTDVLKHIKGACEETTTGVHRLEAMH
KDGALKFPVVAVNDAYTKYLFDNRYGTGQSSFDAIMGTTNMLIAGKSVVVCGYGWCGRGIALRAQGLGANVIVTEIDPIR
ALEARMDGYRVMKIRDAVKEADLIITVTGNINIIHGDDFKYMKDGCMLCNSGHFNVEINRRDLEAQSTSVREVRESIEMF
TMKDGRKIYLLADGRLVNLSAARGQGHPAEIMDMSFAVQALSAKYILNNDLEVGVTKAPDDIDYEVANLKLKAMDIEIDT
LSDRQKEYMCSWKEGT
>Mature_415_residues
SKVKDMSLAKEGIRKIEWVQRHMPVLEHIKKEYEETQPFKGITIGSCLHLEPKTINLGLTLQAGGAEVAMTGCNPLSTHD
DAVAGAADLGLNIYGWRDQDDEEYYQTINMVLDHKPDVIIDDGADMIMVLHNERTDVLKHIKGACEETTTGVHRLEAMHK
DGALKFPVVAVNDAYTKYLFDNRYGTGQSSFDAIMGTTNMLIAGKSVVVCGYGWCGRGIALRAQGLGANVIVTEIDPIRA
LEARMDGYRVMKIRDAVKEADLIITVTGNINIIHGDDFKYMKDGCMLCNSGHFNVEINRRDLEAQSTSVREVRESIEMFT
MKDGRKIYLLADGRLVNLSAARGQGHPAEIMDMSFAVQALSAKYILNNDLEVGVTKAPDDIDYEVANLKLKAMDIEIDTL
SDRQKEYMCSWKEGT

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=412, Percent_Identity=39.8058252427184, Blast_Score=298, Evalue=8e-81,
Organism=Homo sapiens, GI239937451, Length=391, Percent_Identity=40.4092071611253, Blast_Score=288, Evalue=7e-78,
Organism=Homo sapiens, GI298286489, Length=412, Percent_Identity=35.1941747572816, Blast_Score=274, Evalue=1e-73,
Organism=Homo sapiens, GI195539349, Length=412, Percent_Identity=35.1941747572816, Blast_Score=274, Evalue=1e-73,
Organism=Homo sapiens, GI24308043, Length=412, Percent_Identity=35.1941747572816, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI195539337, Length=412, Percent_Identity=35.1941747572816, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI21361647, Length=412, Percent_Identity=34.7087378640777, Blast_Score=256, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI17506425, Length=416, Percent_Identity=39.6634615384615, Blast_Score=301, Evalue=5e-82,
Organism=Saccharomyces cerevisiae, GI6320882, Length=434, Percent_Identity=38.4792626728111, Blast_Score=288, Evalue=1e-78,
Organism=Drosophila melanogaster, GI24642172, Length=413, Percent_Identity=40.9200968523002, Blast_Score=296, Evalue=3e-80,
Organism=Drosophila melanogaster, GI24656245, Length=403, Percent_Identity=36.7245657568238, Blast_Score=269, Evalue=2e-72,
Organism=Drosophila melanogaster, GI45553385, Length=409, Percent_Identity=35.9413202933985, Blast_Score=258, Evalue=4e-69,
Organism=Drosophila melanogaster, GI45553387, Length=409, Percent_Identity=35.9413202933985, Blast_Score=258, Evalue=4e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 46248; Mature: 46116

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKVKDMSLAKEGIRKIEWVQRHMPVLEHIKKEYEETQPFKGITIGSCLHLEPKTINLGL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCEEEECCCEEEEEE
TLQAGGAEVAMTGCNPLSTHDDAVAGAADLGLNIYGWRDQDDEEYYQTINMVLDHKPDVI
EEECCCCEEEEECCCCCCCCCCHHCCHHHCCEEEEECCCCCHHHHHHHHHHHHCCCCCEE
IDDGADMIMVLHNERTDVLKHIKGACEETTTGVHRLEAMHKDGALKFPVVAVNDAYTKYL
EECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCHHEEHE
FDNRYGTGQSSFDAIMGTTNMLIAGKSVVVCGYGWCGRGIALRAQGLGANVIVTEIDPIR
EECCCCCCCCHHHHHHCCCEEEEECCEEEEECCCCCCCCEEEEECCCCCEEEEECCCCHH
ALEARMDGYRVMKIRDAVKEADLIITVTGNINIIHGDDFKYMKDGCMLCNSGHFNVEINR
HHHHHCCCEEEEEEHHHHCCCCEEEEEECCEEEEECCCCHHHCCCEEEECCCEEEEEEEC
RDLEAQSTSVREVRESIEMFTMKDGRKIYLLADGRLVNLSAARGQGHPAEIMDMSFAVQA
CCCCCHHHHHHHHHHHHHEEEECCCCEEEEEECCEEEEEEECCCCCCCHHHHHHHHHHHH
LSAKYILNNDLEVGVTKAPDDIDYEVANLKLKAMDIEIDTLSDRQKEYMCSWKEGT
HHEEEEECCCCEEEEECCCCCCCEEEEEEEEEEEEEEEECCCCCCHHHEEECCCCC
>Mature Secondary Structure 
SKVKDMSLAKEGIRKIEWVQRHMPVLEHIKKEYEETQPFKGITIGSCLHLEPKTINLGL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCEEEECCCEEEEEE
TLQAGGAEVAMTGCNPLSTHDDAVAGAADLGLNIYGWRDQDDEEYYQTINMVLDHKPDVI
EEECCCCEEEEECCCCCCCCCCHHCCHHHCCEEEEECCCCCHHHHHHHHHHHHCCCCCEE
IDDGADMIMVLHNERTDVLKHIKGACEETTTGVHRLEAMHKDGALKFPVVAVNDAYTKYL
EECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCHHEEHE
FDNRYGTGQSSFDAIMGTTNMLIAGKSVVVCGYGWCGRGIALRAQGLGANVIVTEIDPIR
EECCCCCCCCHHHHHHCCCEEEEECCEEEEECCCCCCCCEEEEECCCCCEEEEECCCCHH
ALEARMDGYRVMKIRDAVKEADLIITVTGNINIIHGDDFKYMKDGCMLCNSGHFNVEINR
HHHHHCCCEEEEEEHHHHCCCCEEEEEECCEEEEECCCCHHHCCCEEEECCCEEEEEEEC
RDLEAQSTSVREVRESIEMFTMKDGRKIYLLADGRLVNLSAARGQGHPAEIMDMSFAVQA
CCCCCHHHHHHHHHHHHHEEEECCCCEEEEEECCEEEEEEECCCCCCCHHHHHHHHHHHH
LSAKYILNNDLEVGVTKAPDDIDYEVANLKLKAMDIEIDTLSDRQKEYMCSWKEGT
HHEEEEECCCCEEEEECCCCCCCEEEEEEEEEEEEEEEECCCCCCHHHEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]