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The map label for this gene is hisC

Identifier: 148642713

GI number: 148642713

Start: 633580

End: 634680

Strand: Reverse

Name: hisC

Synonym: Msm_0653

Alternate gene names: 148642713

Gene position: 634680-633580 (Counterclockwise)

Preceding gene: 148642714

Following gene: 148642712

Centisome position: 34.25

GC content: 31.79

Gene sequence:

>1101_bases
ATGAAACCAAGGGCAATAGTTAGTGAAATGGATTCCTATGTTCCAGGTAAATCTCAGGATGAGATAGCTAGTGAATTCAA
CTTAAATAAAGATGATATAATTAAATTAGGATCTAATGAAAATCCATTTGGCCCATCTGCTAAAGCTATTGAAGCTATCG
GAAAAGAATGTAAAAACATAAACAGATATCCAGAATCAGTTTTAAACGAGCTTCAACAAGAATTAGCCAATTATTCTGGG
GTTAAACAATCTCAGGTTATTATTGGTGGTGATGGTGCTGATGAAATCATTGATGTTTTAGCTAAAACATTTATTGACGA
AGGTGATGAGTTTATTGTACCTCTACCTTCTTACATGTATTATGAGTATTTATTGCAGCAATACGGTGCTCGTCCGGTTT
ATGCTAAATGGAATTTGGAAGAAAACAAATTGGATACAGATTCAATTTTAAATTCTATAAACAATAAAACAAAAATGATT
TTCTTATGCACACCAAATAATCCTACAGGTACTTTAATTGATGAAAAGGATATTAGGGATATAGCCTCTGGAAATCCTGA
TGTTCTGATTGTTGTAGATGAAGCCTACTTTGAGTATGCTGAAGTTACAAATAAGGATTTGATTAATGAATTTGACAATA
TTTTCATTATCAGAACCATGTCTAAAGTAATGGGATTGGCTGGAATGAGAATGGGTTATGGTTTAGCTTGCAGTGAGATT
ATTGAATATATGCACAGAATTAAACCGGTATTTTCTCTAACAAGATTGTCTTATGTAGCTGCTCTTAATACTTTGAGGGA
TAAGAACTACATTGAAACATCTATTGAAAAAGGTATTGAAAGCAGGGAATATCTTTATAATGAACTGTCAAAAATCGATT
CATTGAATGTTTTCCCGTCTAAATCTAATTTCATGTTAATTGGCATAAAAGACACAGGATTTACAGCATCTGAATTTGCA
TTTGAACTTATGAAAAAAGGTGTTATTGTAAGGGACTGCACATCATTTAAAGGATTGGATGAATATTGGATTAGGATAAG
TATCTGTACTTTAGAAGAGGATAAAAAATTCATAGACATTGTAAAAGAGGTATTATCCTAA

Upstream 100 bases:

>100_bases
CAAACTAATAAAGGAAGTTACTCCTGAACAAATTGAACATATTCAAGAAAATGCAGATAATTACAAAAAACTTTCAAAAC
AATATAAATAAGGTTAAAAA

Downstream 100 bases:

>100_bases
TGTATGTAGGCGGAACTGTAATTTCTTCTGTTGAATTTCATGGAAATATGTCTTTAGTTATTTTCATGTCAAAATGTCCT
CTTGCTTGCCGTTATTGTCA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MKPRAIVSEMDSYVPGKSQDEIASEFNLNKDDIIKLGSNENPFGPSAKAIEAIGKECKNINRYPESVLNELQQELANYSG
VKQSQVIIGGDGADEIIDVLAKTFIDEGDEFIVPLPSYMYYEYLLQQYGARPVYAKWNLEENKLDTDSILNSINNKTKMI
FLCTPNNPTGTLIDEKDIRDIASGNPDVLIVVDEAYFEYAEVTNKDLINEFDNIFIIRTMSKVMGLAGMRMGYGLACSEI
IEYMHRIKPVFSLTRLSYVAALNTLRDKNYIETSIEKGIESREYLYNELSKIDSLNVFPSKSNFMLIGIKDTGFTASEFA
FELMKKGVIVRDCTSFKGLDEYWIRISICTLEEDKKFIDIVKEVLS

Sequences:

>Translated_366_residues
MKPRAIVSEMDSYVPGKSQDEIASEFNLNKDDIIKLGSNENPFGPSAKAIEAIGKECKNINRYPESVLNELQQELANYSG
VKQSQVIIGGDGADEIIDVLAKTFIDEGDEFIVPLPSYMYYEYLLQQYGARPVYAKWNLEENKLDTDSILNSINNKTKMI
FLCTPNNPTGTLIDEKDIRDIASGNPDVLIVVDEAYFEYAEVTNKDLINEFDNIFIIRTMSKVMGLAGMRMGYGLACSEI
IEYMHRIKPVFSLTRLSYVAALNTLRDKNYIETSIEKGIESREYLYNELSKIDSLNVFPSKSNFMLIGIKDTGFTASEFA
FELMKKGVIVRDCTSFKGLDEYWIRISICTLEEDKKFIDIVKEVLS
>Mature_366_residues
MKPRAIVSEMDSYVPGKSQDEIASEFNLNKDDIIKLGSNENPFGPSAKAIEAIGKECKNINRYPESVLNELQQELANYSG
VKQSQVIIGGDGADEIIDVLAKTFIDEGDEFIVPLPSYMYYEYLLQQYGARPVYAKWNLEENKLDTDSILNSINNKTKMI
FLCTPNNPTGTLIDEKDIRDIASGNPDVLIVVDEAYFEYAEVTNKDLINEFDNIFIIRTMSKVMGLAGMRMGYGLACSEI
IEYMHRIKPVFSLTRLSYVAALNTLRDKNYIETSIEKGIESREYLYNELSKIDSLNVFPSKSNFMLIGIKDTGFTASEFA
FELMKKGVIVRDCTSFKGLDEYWIRISICTLEEDKKFIDIVKEVLS

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Homo sapiens, GI95147551, Length=324, Percent_Identity=21.2962962962963, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI169881279, Length=324, Percent_Identity=21.2962962962963, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI56713254, Length=164, Percent_Identity=28.0487804878049, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI56713256, Length=164, Percent_Identity=28.0487804878049, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1788332, Length=318, Percent_Identity=30.188679245283, Blast_Score=134, Evalue=9e-33,
Organism=Caenorhabditis elegans, GI17567369, Length=235, Percent_Identity=23.4042553191489, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322075, Length=370, Percent_Identity=26.4864864864865, Blast_Score=112, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_METS3 (A5UKY0)

Other databases:

- EMBL:   CP000678
- RefSeq:   YP_001273226.1
- ProteinModelPortal:   A5UKY0
- SMR:   A5UKY0
- STRING:   A5UKY0
- GeneID:   5216093
- GenomeReviews:   CP000678_GR
- KEGG:   msi:Msm_0653
- eggNOG:   arNOG04897
- HOGENOM:   HBG646350
- OMA:   YDIAARR
- ProtClustDB:   PRK00950
- HAMAP:   MF_01023
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 41485; Mature: 41485

Theoretical pI: Translated: 4.41; Mature: 4.41

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPRAIVSEMDSYVPGKSQDEIASEFNLNKDDIIKLGSNENPFGPSAKAIEAIGKECKNI
CCCHHHHHHHHHCCCCCCHHHHHHHCCCCHHHEEEECCCCCCCCCCHHHHHHHHHHHHHH
NRYPESVLNELQQELANYSGVKQSQVIIGGDGADEIIDVLAKTFIDEGDEFIVPLPSYMY
HCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCEEEECHHHHH
YEYLLQQYGARPVYAKWNLEENKLDTDSILNSINNKTKMIFLCTPNNPTGTLIDEKDIRD
HHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHH
IASGNPDVLIVVDEAYFEYAEVTNKDLINEFDNIFIIRTMSKVMGLAGMRMGYGLACSEI
HHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHCEEEHHHHHHHHHHHHHHHCCCCCHHHH
IEYMHRIKPVFSLTRLSYVAALNTLRDKNYIETSIEKGIESREYLYNELSKIDSLNVFPS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCC
KSNFMLIGIKDTGFTASEFAFELMKKGVIVRDCTSFKGLDEYWIRISICTLEEDKKFIDI
CCCEEEEEECCCCCCHHHHHHHHHHCCCEEEECCCCCCCCEEEEEEEEEEECCCHHHHHH
VKEVLS
HHHHHC
>Mature Secondary Structure
MKPRAIVSEMDSYVPGKSQDEIASEFNLNKDDIIKLGSNENPFGPSAKAIEAIGKECKNI
CCCHHHHHHHHHCCCCCCHHHHHHHCCCCHHHEEEECCCCCCCCCCHHHHHHHHHHHHHH
NRYPESVLNELQQELANYSGVKQSQVIIGGDGADEIIDVLAKTFIDEGDEFIVPLPSYMY
HCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCEEEECHHHHH
YEYLLQQYGARPVYAKWNLEENKLDTDSILNSINNKTKMIFLCTPNNPTGTLIDEKDIRD
HHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHH
IASGNPDVLIVVDEAYFEYAEVTNKDLINEFDNIFIIRTMSKVMGLAGMRMGYGLACSEI
HHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHCEEEHHHHHHHHHHHHHHHCCCCCHHHH
IEYMHRIKPVFSLTRLSYVAALNTLRDKNYIETSIEKGIESREYLYNELSKIDSLNVFPS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCC
KSNFMLIGIKDTGFTASEFAFELMKKGVIVRDCTSFKGLDEYWIRISICTLEEDKKFIDI
CCCEEEEEECCCCCCHHHHHHHHHHCCCEEEECCCCCCCCEEEEEEEEEEECCCHHHHHH
VKEVLS
HHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA