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The map label for this gene is cvrA [H]

Identifier: 148642678

GI number: 148642678

Start: 597729

End: 598916

Strand: Reverse

Name: cvrA [H]

Synonym: Msm_0618

Alternate gene names: 148642678

Gene position: 598916-597729 (Counterclockwise)

Preceding gene: 148642679

Following gene: 148642677

Centisome position: 32.32

GC content: 32.74

Gene sequence:

>1188_bases
ATGTTTGATGTTCATTTGGTACTGTTGTTTATAGGATTTTTACTTTTAGTCTGTGTATTGTTAAGTAAATTCACAGCTAA
AATCGGTGTTCCCGCATTATTGATTTTTTTAATTGTAGGTTTGATTTTAGACACCAACCAGGTTATATCATCATCGATAA
CGAATTATAATATGATTCAATCGATAAGTATTTTTGCTCTGATTATTATCATGTTTTCGGGGGGTTTGGACACTGAACTT
GCCAACATTAAAAGAGTAACATGGGAAGGAATCTCTTTATCTACCGTCGGTGTTTTTATTACTGCAATTGTTGTAGGAAT
ACTGGTTCATTTACTATTCGGGTTAGGATGGTTGGATTCATTTTTAATAGGTTCAATTATATCTTCTACAGATGCTGCAG
CAGTGTTTTCAATTTTTAAAACACAAAAGTTACATATTAAAGATAATTTGGATCACATGCTTGAGTTAGAAAGTGCTACA
AACGATCCTATGGCTTATATACTTGTAACATCAGTGATTTATTTAATAATTCATCCTGAGACATCTATGTTGCTTCTAAT
ATTTAATTTCTTTAAATCACTGGCTTTAGGTTTAATAATGGGAGCAATTTTAGGTAAAGGATTTTCAAAATTGCTTGCAA
GGATTAAATTAAGCGTTGAGGGATTGTATCCGGTACTGTTATTGTCTGCAGCTATTCTTTCATTTGCAGCTACTGAAGTT
GTTGGGGGAAATGGATTCCTGTCAGTATATATTGCGGCAGTAATAATAGGTAATTGTAAAATCAAATATAAATATACTCA
ATTATCCTTTTTCGAAGGTATTGCATGGATTATGCAGATTGTGATGTTTGTATTACTTGGTGCATTTTCATCAATAAAGG
AACTTATACCTATGTTAATTCCGGCAATATGGATTGCAATGATACTGACATTTGTGGCAAGGCCAATTGCAGTACTGATA
TCTTTGGCTCCATTTGATATAGACAGACCTTCAAAGGCGTTTGTTTCATGGGCAGGAATTAAAGGGGCAGTACCTATTGT
ATTTGCATTTTATCCATTGGTACATGGTATTTATAATGCACAAATGATATTTGATATTGTAATGGTTGTTACTTGTATTT
CAGTACTGGTACAGGGATCTACTCTTAAATTTATGGCTGGACACCTTAAAGTATTAAAAGAGGAATAA

Upstream 100 bases:

>100_bases
TAATGCTTATAAATGTTAAAATTAAAAGTTTATATTAGCTGTTATATTTTTTTTAGTAATGGCGATTTTAATCTAAATTT
TTTGAAATAATTTGATATTT

Downstream 100 bases:

>100_bases
TATGAATTATGATGTAGTTATAGCACGTTATGGTGAAATTGGTTTAAAAAGCTCAAAAGTAAGAGCACGTTTTGAGCGCA
AATTGGTTAAAAATATTAAA

Product: pH regulator (monovalent cation:H+ antiporter)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MFDVHLVLLFIGFLLLVCVLLSKFTAKIGVPALLIFLIVGLILDTNQVISSSITNYNMIQSISIFALIIIMFSGGLDTEL
ANIKRVTWEGISLSTVGVFITAIVVGILVHLLFGLGWLDSFLIGSIISSTDAAAVFSIFKTQKLHIKDNLDHMLELESAT
NDPMAYILVTSVIYLIIHPETSMLLLIFNFFKSLALGLIMGAILGKGFSKLLARIKLSVEGLYPVLLLSAAILSFAATEV
VGGNGFLSVYIAAVIIGNCKIKYKYTQLSFFEGIAWIMQIVMFVLLGAFSSIKELIPMLIPAIWIAMILTFVARPIAVLI
SLAPFDIDRPSKAFVSWAGIKGAVPIVFAFYPLVHGIYNAQMIFDIVMVVTCISVLVQGSTLKFMAGHLKVLKEE

Sequences:

>Translated_395_residues
MFDVHLVLLFIGFLLLVCVLLSKFTAKIGVPALLIFLIVGLILDTNQVISSSITNYNMIQSISIFALIIIMFSGGLDTEL
ANIKRVTWEGISLSTVGVFITAIVVGILVHLLFGLGWLDSFLIGSIISSTDAAAVFSIFKTQKLHIKDNLDHMLELESAT
NDPMAYILVTSVIYLIIHPETSMLLLIFNFFKSLALGLIMGAILGKGFSKLLARIKLSVEGLYPVLLLSAAILSFAATEV
VGGNGFLSVYIAAVIIGNCKIKYKYTQLSFFEGIAWIMQIVMFVLLGAFSSIKELIPMLIPAIWIAMILTFVARPIAVLI
SLAPFDIDRPSKAFVSWAGIKGAVPIVFAFYPLVHGIYNAQMIFDIVMVVTCISVLVQGSTLKFMAGHLKVLKEE
>Mature_395_residues
MFDVHLVLLFIGFLLLVCVLLSKFTAKIGVPALLIFLIVGLILDTNQVISSSITNYNMIQSISIFALIIIMFSGGLDTEL
ANIKRVTWEGISLSTVGVFITAIVVGILVHLLFGLGWLDSFLIGSIISSTDAAAVFSIFKTQKLHIKDNLDHMLELESAT
NDPMAYILVTSVIYLIIHPETSMLLLIFNFFKSLALGLIMGAILGKGFSKLLARIKLSVEGLYPVLLLSAAILSFAATEV
VGGNGFLSVYIAAVIIGNCKIKYKYTQLSFFEGIAWIMQIVMFVLLGAFSSIKELIPMLIPAIWIAMILTFVARPIAVLI
SLAPFDIDRPSKAFVSWAGIKGAVPIVFAFYPLVHGIYNAQMIFDIVMVVTCISVLVQGSTLKFMAGHLKVLKEE

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG3263

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI87081854, Length=364, Percent_Identity=36.2637362637363, Blast_Score=226, Evalue=2e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 43121; Mature: 43121

Theoretical pI: Translated: 8.08; Mature: 8.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDVHLVLLFIGFLLLVCVLLSKFTAKIGVPALLIFLIVGLILDTNQVISSSITNYNMIQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHH
SISIFALIIIMFSGGLDTELANIKRVTWEGISLSTVGVFITAIVVGILVHLLFGLGWLDS
HHHHHHHHHHHHCCCCCHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLIGSIISSTDAAAVFSIFKTQKLHIKDNLDHMLELESATNDPMAYILVTSVIYLIIHPE
HHHHHHHHCCHHHHHHHHHHHHHEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCC
TSMLLLIFNFFKSLALGLIMGAILGKGFSKLLARIKLSVEGLYPVLLLSAAILSFAATEV
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGGNGFLSVYIAAVIIGNCKIKYKYTQLSFFEGIAWIMQIVMFVLLGAFSSIKELIPMLI
CCCCHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PAIWIAMILTFVARPIAVLISLAPFDIDRPSKAFVSWAGIKGAVPIVFAFYPLVHGIYNA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
QMIFDIVMVVTCISVLVQGSTLKFMAGHLKVLKEE
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFDVHLVLLFIGFLLLVCVLLSKFTAKIGVPALLIFLIVGLILDTNQVISSSITNYNMIQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHH
SISIFALIIIMFSGGLDTELANIKRVTWEGISLSTVGVFITAIVVGILVHLLFGLGWLDS
HHHHHHHHHHHHCCCCCHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLIGSIISSTDAAAVFSIFKTQKLHIKDNLDHMLELESATNDPMAYILVTSVIYLIIHPE
HHHHHHHHCCHHHHHHHHHHHHHEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCC
TSMLLLIFNFFKSLALGLIMGAILGKGFSKLLARIKLSVEGLYPVLLLSAAILSFAATEV
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGGNGFLSVYIAAVIIGNCKIKYKYTQLSFFEGIAWIMQIVMFVLLGAFSSIKELIPMLI
CCCCHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PAIWIAMILTFVARPIAVLISLAPFDIDRPSKAFVSWAGIKGAVPIVFAFYPLVHGIYNA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
QMIFDIVMVVTCISVLVQGSTLKFMAGHLKVLKEE
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]