BacMap

Definition	Methanobrevibacter smithii ATCC 35061 chromosome, complete genome.
Accession	NC_009515
Length	1,853,160

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The map label for this gene is psmA

Identifier: 148642305

GI number: 148642305

Start: 230518

End: 231270

Strand: Reverse

Name: psmA

Synonym: Msm_0245

Alternate gene names: 148642305

Gene position: 231270-230518 (Counterclockwise)

Preceding gene: 148642306

Following gene: 148642304

Centisome position: 12.48

GC content: 33.86

Gene sequence:

>753_bases
ATGCAACCTTTACAAAATGCTGGATATGATAGGGCAATTACTGTATTTAGCCCAGATGGAAGACTTTTCCAAGTAGAATA
TGCAAGAGAAGCTGTTAAAAGAGGAACCACTTCAATAGGAATTAAATGTTCTGAAGGTATTGTTTTAGCAGTTGATAAAA
GAACTACTTCTAATTTAGTTGAAGCAACATCTATTGAAAAAATATTCAAAATAGATGAACATATTGGAGCAGCAACTTCA
GGTCTTGTTGCTGATGCTAGAGCTTTAGTTGAAAGAGCAAGAGTGGAAGCTCAAATAAATAAAATCACATACAGTGAACC
TATTAGGGTAGATAGCTTATCTAAAAAATTATGTGATATGTTACAGATGTATACTCAAAACGGTGGGGTAAGGCCATTCG
GTTCTGCTTTAATCATTGGTGGAGTATATGACGGTATTTGCAAATTATTCGAAACAGATCCTAGTGGAGCATTAATTGAA
TATAAAGCAACTGCTATTGGATCAGGCAGATCTGCAGCTATGGATATCTTTGAAGATCAATATAAAGATGACATGAATTT
AAATGAAGCTATTAATTTAGCACTAACAGCAATCAATGAAGCAACTGAACATGAAACTACTGCAAACAATGTTGAAATTG
CTGTTATTAAATGTGGTGAAGAAGTATACACTAAACTTTCTCAGGAAGAAGTACAGACTTTCATTGATGAGGTTGTATCT
GAAGAAGAAAGTGAAGAGGAAAGTGAAGAATAA

Upstream 100 bases:

>100_bases
ATTTCATGGAGAATTTGGTTTATTTTTTAAAATAATTGTATTTTTATAGTAGTTGAACTTAAGTTTATTATAATATTAAA
AAAATGTGAGGTATTAATTT

Downstream 100 bases:

>100_bases
ATAATTAATTGGTTAGGGGTTTTTTCAATGGTAAATGTAGATGAAGCAATAATAGCTAAATATGAATATTGTGGGGAACA
TTTTGAAATATTGGTCGATC

Product: proteasome subunit alpha

Products: NA

Alternate protein names: 20S proteasome alpha subunit; Proteasome core protein PsmA

Number of amino acids: Translated: 250; Mature: 250

Protein sequence:

>250_residues
MQPLQNAGYDRAITVFSPDGRLFQVEYAREAVKRGTTSIGIKCSEGIVLAVDKRTTSNLVEATSIEKIFKIDEHIGAATS
GLVADARALVERARVEAQINKITYSEPIRVDSLSKKLCDMLQMYTQNGGVRPFGSALIIGGVYDGICKLFETDPSGALIE
YKATAIGSGRSAAMDIFEDQYKDDMNLNEAINLALTAINEATEHETTANNVEIAVIKCGEEVYTKLSQEEVQTFIDEVVS
EEESEEESEE

Sequences:

>Translated_250_residues
MQPLQNAGYDRAITVFSPDGRLFQVEYAREAVKRGTTSIGIKCSEGIVLAVDKRTTSNLVEATSIEKIFKIDEHIGAATS
GLVADARALVERARVEAQINKITYSEPIRVDSLSKKLCDMLQMYTQNGGVRPFGSALIIGGVYDGICKLFETDPSGALIE
YKATAIGSGRSAAMDIFEDQYKDDMNLNEAINLALTAINEATEHETTANNVEIAVIKCGEEVYTKLSQEEVQTFIDEVVS
EEESEEESEE
>Mature_250_residues
MQPLQNAGYDRAITVFSPDGRLFQVEYAREAVKRGTTSIGIKCSEGIVLAVDKRTTSNLVEATSIEKIFKIDEHIGAATS
GLVADARALVERARVEAQINKITYSEPIRVDSLSKKLCDMLQMYTQNGGVRPFGSALIIGGVYDGICKLFETDPSGALIE
YKATAIGSGRSAAMDIFEDQYKDDMNLNEAINLALTAINEATEHETTANNVEIAVIKCGEEVYTKLSQEEVQTFIDEVVS
EEESEEESEE

Specific function: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation

COG id: COG0638

COG function: function code O; 20S proteasome, alpha and beta subunits

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase T1A family

Homologues:

Organism=Homo sapiens, GI23110942, Length=240, Percent_Identity=42.5, Blast_Score=198, Evalue=3e-51,
Organism=Homo sapiens, GI68303563, Length=230, Percent_Identity=42.6086956521739, Blast_Score=189, Evalue=2e-48,
Organism=Homo sapiens, GI4506181, Length=228, Percent_Identity=40.3508771929825, Blast_Score=184, Evalue=5e-47,
Organism=Homo sapiens, GI68303561, Length=236, Percent_Identity=41.5254237288136, Blast_Score=182, Evalue=3e-46,
Organism=Homo sapiens, GI4506189, Length=230, Percent_Identity=40, Blast_Score=181, Evalue=6e-46,
Organism=Homo sapiens, GI156713442, Length=233, Percent_Identity=38.6266094420601, Blast_Score=156, Evalue=2e-38,
Organism=Homo sapiens, GI4506185, Length=233, Percent_Identity=38.6266094420601, Blast_Score=156, Evalue=2e-38,
Organism=Homo sapiens, GI68303565, Length=230, Percent_Identity=38.2608695652174, Blast_Score=151, Evalue=5e-37,
Organism=Homo sapiens, GI23110944, Length=230, Percent_Identity=32.6086956521739, Blast_Score=144, Evalue=7e-35,
Organism=Homo sapiens, GI4506183, Length=248, Percent_Identity=34.2741935483871, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI23110939, Length=246, Percent_Identity=34.1463414634146, Blast_Score=134, Evalue=6e-32,
Organism=Homo sapiens, GI23110935, Length=233, Percent_Identity=34.7639484978541, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI4506179, Length=233, Percent_Identity=34.7639484978541, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI156713444, Length=166, Percent_Identity=36.7469879518072, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI221316716, Length=105, Percent_Identity=41.9047619047619, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI4506191, Length=208, Percent_Identity=29.3269230769231, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI4506203, Length=186, Percent_Identity=30.1075268817204, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI73747875, Length=211, Percent_Identity=23.2227488151659, Blast_Score=65, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17508493, Length=250, Percent_Identity=42, Blast_Score=194, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI17508491, Length=233, Percent_Identity=43.3476394849785, Blast_Score=193, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI25143215, Length=231, Percent_Identity=37.6623376623377, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17562790, Length=227, Percent_Identity=36.5638766519824, Blast_Score=146, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI17562788, Length=241, Percent_Identity=29.4605809128631, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71998965, Length=237, Percent_Identity=33.3333333333333, Blast_Score=114, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17562792, Length=241, Percent_Identity=29.045643153527, Blast_Score=111, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6321692, Length=257, Percent_Identity=41.2451361867704, Blast_Score=182, Evalue=6e-47,
Organism=Saccharomyces cerevisiae, GI6321574, Length=228, Percent_Identity=42.5438596491228, Blast_Score=180, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6324535, Length=238, Percent_Identity=38.655462184874, Blast_Score=172, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6323547, Length=211, Percent_Identity=38.8625592417062, Blast_Score=157, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6324938, Length=214, Percent_Identity=41.1214953271028, Blast_Score=156, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6323974, Length=213, Percent_Identity=36.150234741784, Blast_Score=123, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6321427, Length=233, Percent_Identity=30.9012875536481, Blast_Score=108, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6324731, Length=218, Percent_Identity=27.5229357798165, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24654391, Length=242, Percent_Identity=40.9090909090909, Blast_Score=196, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24654389, Length=242, Percent_Identity=40.9090909090909, Blast_Score=196, Evalue=1e-50,
Organism=Drosophila melanogaster, GI17933602, Length=217, Percent_Identity=39.63133640553, Blast_Score=177, Evalue=5e-45,
Organism=Drosophila melanogaster, GI17737927, Length=230, Percent_Identity=37.3913043478261, Blast_Score=173, Evalue=1e-43,
Organism=Drosophila melanogaster, GI21356137, Length=215, Percent_Identity=40, Blast_Score=171, Evalue=4e-43,
Organism=Drosophila melanogaster, GI19922898, Length=171, Percent_Identity=43.2748538011696, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI281360341, Length=239, Percent_Identity=30.5439330543933, Blast_Score=143, Evalue=9e-35,
Organism=Drosophila melanogaster, GI24586406, Length=239, Percent_Identity=30.5439330543933, Blast_Score=143, Evalue=9e-35,
Organism=Drosophila melanogaster, GI24586400, Length=239, Percent_Identity=30.5439330543933, Blast_Score=143, Evalue=9e-35,
Organism=Drosophila melanogaster, GI24586402, Length=239, Percent_Identity=30.5439330543933, Blast_Score=143, Evalue=9e-35,
Organism=Drosophila melanogaster, GI17136420, Length=239, Percent_Identity=35.1464435146443, Blast_Score=140, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24651571, Length=176, Percent_Identity=35.7954545454545, Blast_Score=121, Evalue=6e-28,
Organism=Drosophila melanogaster, GI19921232, Length=230, Percent_Identity=33.4782608695652, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24652204, Length=189, Percent_Identity=36.5079365079365, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI17737405, Length=184, Percent_Identity=36.4130434782609, Blast_Score=107, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24584895, Length=207, Percent_Identity=28.0193236714976, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24639979, Length=198, Percent_Identity=26.7676767676768, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28573221, Length=187, Percent_Identity=26.7379679144385, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI20130281, Length=184, Percent_Identity=24.4565217391304, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PSA_METS3 (A5UJS2)

Other databases:

- EMBL:   CP000678
- RefSeq:   YP_001272818.1
- ProteinModelPortal:   A5UJS2
- SMR:   A5UJS2
- STRING:   A5UJS2
- GeneID:   5216609
- GenomeReviews:   CP000678_GR
- KEGG:   msi:Msm_0245
- eggNOG:   arNOG04565
- HOGENOM:   HBG499923
- OMA:   IFQIDDH
- ProtClustDB:   PRK03996
- GO:   GO:0005737
- HAMAP:   MF_00289_A
- InterPro:   IPR019982
- InterPro:   IPR000426
- InterPro:   IPR001353
- SMART:   SM00948
- TIGRFAMs:   TIGR03633

Pfam domain/function: PF00227 Proteasome; PF10584 Proteasome_A_N

EC number: =3.4.25.1

Molecular weight: Translated: 27376; Mature: 27376

Theoretical pI: Translated: 4.21; Mature: 4.21

Prosite motif: PS00388 PROTEASOME_A_1; PS51475 PROTEASOME_A_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPLQNAGYDRAITVFSPDGRLFQVEYAREAVKRGTTSIGIKCSEGIVLAVDKRTTSNLV
CCCCCCCCCCCEEEEECCCCCEEEEHHHHHHHHCCCCEEEEEECCCEEEEECCCCHHHHH
EATSIEKIFKIDEHIGAATSGLVADARALVERARVEAQINKITYSEPIRVDSLSKKLCDM
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
LQMYTQNGGVRPFGSALIIGGVYDGICKLFETDPSGALIEYKATAIGSGRSAAMDIFEDQ
HHHHHHCCCCCCCCCEEEECHHHHHHHHHHCCCCCCCEEEEEEEECCCCCHHHHHHHHHH
YKDDMNLNEAINLALTAINEATEHETTANNVEIAVIKCGEEVYTKLSQEEVQTFIDEVVS
HCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHC
EEESEEESEE
CCCCHHCCCC
>Mature Secondary Structure
MQPLQNAGYDRAITVFSPDGRLFQVEYAREAVKRGTTSIGIKCSEGIVLAVDKRTTSNLV
CCCCCCCCCCCEEEEECCCCCEEEEHHHHHHHHCCCCEEEEEECCCEEEEECCCCHHHHH
EATSIEKIFKIDEHIGAATSGLVADARALVERARVEAQINKITYSEPIRVDSLSKKLCDM
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
LQMYTQNGGVRPFGSALIIGGVYDGICKLFETDPSGALIEYKATAIGSGRSAAMDIFEDQ
HHHHHHCCCCCCCCCEEEECHHHHHHHHHHCCCCCCCEEEEEEEECCCCCHHHHHHHHHH
YKDDMNLNEAINLALTAINEATEHETTANNVEIAVIKCGEEVYTKLSQEEVQTFIDEVVS
HCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHC
EEESEEESEE
CCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA