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The map label for this gene is hmgA [H]

Identifier: 148642287

GI number: 148642287

Start: 215756

End: 216958

Strand: Reverse

Name: hmgA [H]

Synonym: Msm_0227

Alternate gene names: 148642287

Gene position: 216958-215756 (Counterclockwise)

Preceding gene: 148642288

Following gene: 148642286

Centisome position: 11.71

GC content: 36.33

Gene sequence:

>1203_bases
ATGAATTCTAAAGAAATTATTGATAAATTGTTAAATGGTGAAATGAAATTATACCAGGTAGACAAATATGTTTCACCAAA
AGAGGCTACAGATATTAGAAGGGAATTTATAGAAAAAACAGCAGGCTGTGAATTACCGCATATGGCTAATTATTCTTTAG
ACATGGAAAGGGCATCTGCAAGAAACATTGAAAATCCAATTGGAACAATCCAGCTTCCTGTAGGTGTAGCCGGACCGTTA
AAAATCAACGGAGATTACTGTAAAAGAGAGGTTTATGTTCCGTTAGCTACATCTGAAGGAGCACTTGTAGCATCAATTAA
CAGAGGTGCATCAACAATTACATCATCTGGAGGAGTAAATGCTCATGTTATTTCAGATATTATGACCAGAGCACCGGTAA
TTAAAACCTCTTCAGCAAGTGATGCTTTAAAAATTAAACAATGGTTTATTGATAATTTCCAAGAACTTAAAGAAATTGCA
GAATCCACCACATCTCATGGTAAGCTTTTAAAAATTGATCCGATTCTAATTGTTGGAACTTATGTTTATCCACGTTTTGT
TTACTCTACTGGAGACAGTATGGGTATGAACATGGTTACTATTGCTTCAGAAAAGATTTTAGATAAATTGGCTGATGAAA
CAACTGGAAGACACATTGCATTAAGCGGAAATGTATGTGTTGATAAAAAGCCTGCGGCAATTAACATGATTGAAGGAAGG
GGAAAAAGTATTGTTGCAGATATTTTAATTCCTGAAGAAATAGTAAATAAAAAACTTAAAACAACTGCTGAAGCTATTGA
AGAAGTAAATATAGCTAAAAATTTAATAGGATCTGCAGCAGCAGGTTCTATGGCATATAATGCTCATTATGCAAATATGG
TTGCAGCTATCTTTTTGGCAACAGGTCAGGATGCAGCTCATGCAGTGGAAGGTTCTTTAGGTATTACAACAGCTGAAAAC
AGAAACGGAGATTTGTATTTCTCAGTAAACCTTCCGGATGTACCGATAGCTACTGTTGGTGGAGGTACAAGCTTAGAAAC
TGCTCATGAGGGTTTGGATATTCTTGGTGTTGCAGGTTCCAATAAGGCTCGTGAATTTGGTGAAATTGTTGCAGCTACTG
TTTTGGCTGGAGAATTATCTTTAGTTGGTGCTCTTGCAGCAGGTCATTTAGCTAGAGCTCATCAGGAACTTGGAAGAGGA
TAA

Upstream 100 bases:

>100_bases
AGGTACTGCAGAAAGTAAAATTAATGCATTAACTGATGCCGGTGTAAGTGTAGCTAAAATGCCATCAGAAATTGTAGATT
TAGTAAGGAAGTCAATTTAA

Downstream 100 bases:

>100_bases
TATGGATGAAAATATATTTTATCCAGAATTAACTTTAGAAACTGATGATATTATAATGGAATTGGCTATAAAAAAAGATT
ATTCTAAAATCAGAGATTCA

Product: hydroxymethylglutaryl-CoA (HMG-CoA) reductase, HmgA

Products: NA

Alternate protein names: HMG-CoA reductase [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MNSKEIIDKLLNGEMKLYQVDKYVSPKEATDIRREFIEKTAGCELPHMANYSLDMERASARNIENPIGTIQLPVGVAGPL
KINGDYCKREVYVPLATSEGALVASINRGASTITSSGGVNAHVISDIMTRAPVIKTSSASDALKIKQWFIDNFQELKEIA
ESTTSHGKLLKIDPILIVGTYVYPRFVYSTGDSMGMNMVTIASEKILDKLADETTGRHIALSGNVCVDKKPAAINMIEGR
GKSIVADILIPEEIVNKKLKTTAEAIEEVNIAKNLIGSAAAGSMAYNAHYANMVAAIFLATGQDAAHAVEGSLGITTAEN
RNGDLYFSVNLPDVPIATVGGGTSLETAHEGLDILGVAGSNKAREFGEIVAATVLAGELSLVGALAAGHLARAHQELGRG

Sequences:

>Translated_400_residues
MNSKEIIDKLLNGEMKLYQVDKYVSPKEATDIRREFIEKTAGCELPHMANYSLDMERASARNIENPIGTIQLPVGVAGPL
KINGDYCKREVYVPLATSEGALVASINRGASTITSSGGVNAHVISDIMTRAPVIKTSSASDALKIKQWFIDNFQELKEIA
ESTTSHGKLLKIDPILIVGTYVYPRFVYSTGDSMGMNMVTIASEKILDKLADETTGRHIALSGNVCVDKKPAAINMIEGR
GKSIVADILIPEEIVNKKLKTTAEAIEEVNIAKNLIGSAAAGSMAYNAHYANMVAAIFLATGQDAAHAVEGSLGITTAEN
RNGDLYFSVNLPDVPIATVGGGTSLETAHEGLDILGVAGSNKAREFGEIVAATVLAGELSLVGALAAGHLARAHQELGRG
>Mature_400_residues
MNSKEIIDKLLNGEMKLYQVDKYVSPKEATDIRREFIEKTAGCELPHMANYSLDMERASARNIENPIGTIQLPVGVAGPL
KINGDYCKREVYVPLATSEGALVASINRGASTITSSGGVNAHVISDIMTRAPVIKTSSASDALKIKQWFIDNFQELKEIA
ESTTSHGKLLKIDPILIVGTYVYPRFVYSTGDSMGMNMVTIASEKILDKLADETTGRHIALSGNVCVDKKPAAINMIEGR
GKSIVADILIPEEIVNKKLKTTAEAIEEVNIAKNLIGSAAAGSMAYNAHYANMVAAIFLATGQDAAHAVEGSLGITTAEN
RNGDLYFSVNLPDVPIATVGGGTSLETAHEGLDILGVAGSNKAREFGEIVAATVLAGELSLVGALAAGHLARAHQELGRG

Specific function: Converts HMG-CoA to mevalonate [H]

COG id: COG1257

COG function: function code I; Hydroxymethylglutaryl-CoA reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA reductase family [H]

Homologues:

Organism=Homo sapiens, GI4557643, Length=414, Percent_Identity=44.4444444444444, Blast_Score=299, Evalue=4e-81,
Organism=Homo sapiens, GI196049380, Length=291, Percent_Identity=48.4536082474227, Blast_Score=247, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI25144592, Length=407, Percent_Identity=43.7346437346437, Blast_Score=290, Evalue=6e-79,
Organism=Saccharomyces cerevisiae, GI6323565, Length=418, Percent_Identity=41.6267942583732, Blast_Score=281, Evalue=2e-76,
Organism=Saccharomyces cerevisiae, GI6323483, Length=419, Percent_Identity=41.0501193317422, Blast_Score=277, Evalue=2e-75,
Organism=Drosophila melanogaster, GI281362379, Length=391, Percent_Identity=40.920716112532, Blast_Score=228, Evalue=6e-60,
Organism=Drosophila melanogaster, GI45553469, Length=391, Percent_Identity=40.920716112532, Blast_Score=228, Evalue=6e-60,
Organism=Drosophila melanogaster, GI24649399, Length=391, Percent_Identity=40.920716112532, Blast_Score=228, Evalue=6e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002202
- InterPro:   IPR023074
- InterPro:   IPR023076
- InterPro:   IPR004554
- InterPro:   IPR009023
- InterPro:   IPR009029 [H]

Pfam domain/function: PF00368 HMG-CoA_red [H]

EC number: =1.1.1.34 [H]

Molecular weight: Translated: 42421; Mature: 42421

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00066 HMG_COA_REDUCTASE_1 ; PS50065 HMG_COA_REDUCTASE_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSKEIIDKLLNGEMKLYQVDKYVSPKEATDIRREFIEKTAGCELPHMANYSLDMERASA
CCHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHH
RNIENPIGTIQLPVGVAGPLKINGDYCKREVYVPLATSEGALVASINRGASTITSSGGVN
CCCCCCCCEEEECCCCCCCEEECCCCCCEEEEEEEECCCCCEEEEECCCCCCEECCCCCC
AHVISDIMTRAPVIKTSSASDALKIKQWFIDNFQELKEIAESTTSHGKLLKIDPILIVGT
HHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCEEEEEC
YVYPRFVYSTGDSMGMNMVTIASEKILDKLADETTGRHIALSGNVCVDKKPAAINMIEGR
HHHHEEEEECCCCCCCEEEEHHHHHHHHHHHHHCCCCEEEEECCEEECCCCCEEEEECCC
GKSIVADILIPEEIVNKKLKTTAEAIEEVNIAKNLIGSAAAGSMAYNAHYANMVAAIFLA
CCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCEEHHHHHHHHHHHHHC
TGQDAAHAVEGSLGITTAENRNGDLYFSVNLPDVPIATVGGGTSLETAHEGLDILGVAGS
CCCCHHHHHCCCCCEEECCCCCCCEEEEECCCCCCEEEECCCCCHHHHHCCCEEEEECCC
NKAREFGEIVAATVLAGELSLVGALAAGHLARAHQELGRG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNSKEIIDKLLNGEMKLYQVDKYVSPKEATDIRREFIEKTAGCELPHMANYSLDMERASA
CCHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHH
RNIENPIGTIQLPVGVAGPLKINGDYCKREVYVPLATSEGALVASINRGASTITSSGGVN
CCCCCCCCEEEECCCCCCCEEECCCCCCEEEEEEEECCCCCEEEEECCCCCCEECCCCCC
AHVISDIMTRAPVIKTSSASDALKIKQWFIDNFQELKEIAESTTSHGKLLKIDPILIVGT
HHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCEEEEEC
YVYPRFVYSTGDSMGMNMVTIASEKILDKLADETTGRHIALSGNVCVDKKPAAINMIEGR
HHHHEEEEECCCCCCCEEEEHHHHHHHHHHHHHCCCCEEEEECCEEECCCCCEEEEECCC
GKSIVADILIPEEIVNKKLKTTAEAIEEVNIAKNLIGSAAAGSMAYNAHYANMVAAIFLA
CCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCEEHHHHHHHHHHHHHC
TGQDAAHAVEGSLGITTAENRNGDLYFSVNLPDVPIATVGGGTSLETAHEGLDILGVAGS
CCCCHHHHHCCCCCEEECCCCCCCEEEEECCCCCCEEEECCCCCHHHHHCCCEEEEECCC
NKAREFGEIVAATVLAGELSLVGALAAGHLARAHQELGRG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]