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The map label for this gene is mraY [C]

Identifier: 148642126

GI number: 148642126

Start: 64182

End: 65198

Strand: Reverse

Name: mraY [C]

Synonym: Msm_0066

Alternate gene names: 148642126

Gene position: 65198-64182 (Counterclockwise)

Preceding gene: 148642128

Following gene: 148642125

Centisome position: 3.52

GC content: 34.41

Gene sequence:

>1017_bases
ATGATGTTATTCCCACAACTTCCGTTGTACGCAATAGCAATAATTTGTGGTATTTTATCTTTTTTAGTAACAAGATTATC
AATGCCTAGAATTATTAGAAAATTAGAAAAGGCAGATATTGTAGGTAAGGACCTGCATAAATCATGGAAGCCGATTGTGG
CTGAAATGGGTGGATTTGGTATCCTATTTGGATTTATAATAGGTATTTTTTCAGGAATATGTATGCATGACATTCTTACA
TTTCCGTTATGCATTGTTTTAATTGTAATTCTTCTTGTAGGGATTATAGGTATTGCTGATGATTTGCTTGTGCTTTCATC
AAAAGAAAAGCTGTTCCTATTGTTTTTGGCAGGTATTCCTTTAATATGGGCAGCACCTCCAAATGTTGGAATTGTATATC
TTATTTGTATTCCGATAGCTATTTCAATCGGATCCAATTTAACCAATATGCTGGCAGGTTTAAATGGAATTGAATCAGGG
CTTGGAATAATTGCACTTACCTCTTTAACAATATCCTGTATTATTTTGGGAAAATATGATGTTACAATTATCAGTATGAG
TATGCTTGGAGCTTTAATAGCTTTCCTGTACTTTAACAAATATCCTGCAAAGATTTTCCCTGGAGATACTGGAACTTTAA
TTATAGGGGCAACAATTGTTTCAATAGCTTTTATAGGTCGTGTAAAATTAATTGCTTTGATTGTGCTTTTGCCTAACATT
ATTGATGCAGCCCTTAAATTTTACAGTGCAGGAGTTATGGAAAGGCAACAGTTCAAACCGACTCAGGTAGATGAAAATGG
AAATCTGGTAAGGCCTGAAGTCGGATTCAAATCTTTAATCAGGCTTGTACTGCGAAAACCGATTCCTGAAAAGCAGGCAG
TTAAAATAATTTGGGCTATTGGAATTGTTTGCGGATTAATCGGTATAATTGTTGCAATAGTAATGCCTGATGTGCTTCAA
AACCAGACATTGGCTAATTTCATGCAGATTAAGGAATTCTTTTATCAGTTAGGATGA

Upstream 100 bases:

>100_bases
ATTTATTTTAAATAGATTTAGTTGGAATAGTGAACTTTAGCTAGTTTTATCATAAATTTATTATTCTATAAGTGATAAAA
ATATTTATAAAGTGATTATT

Downstream 100 bases:

>100_bases
TTTGAATGAAACCGTATGTTATTTTAAATGCAGCTATGACACTGGACGGAAAAATAGCCACTAAAACTGGCAGTTCCAAT
ATTTCAGGTGAAAAAGATTT

Product: N-acetylglucosamine-1-phosphate transferase

Products: UMP; N-acetyl-D-glucosaminyl-diphosphodolichol

Alternate protein names: NA

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MMLFPQLPLYAIAIICGILSFLVTRLSMPRIIRKLEKADIVGKDLHKSWKPIVAEMGGFGILFGFIIGIFSGICMHDILT
FPLCIVLIVILLVGIIGIADDLLVLSSKEKLFLLFLAGIPLIWAAPPNVGIVYLICIPIAISIGSNLTNMLAGLNGIESG
LGIIALTSLTISCIILGKYDVTIISMSMLGALIAFLYFNKYPAKIFPGDTGTLIIGATIVSIAFIGRVKLIALIVLLPNI
IDAALKFYSAGVMERQQFKPTQVDENGNLVRPEVGFKSLIRLVLRKPIPEKQAVKIIWAIGIVCGLIGIIVAIVMPDVLQ
NQTLANFMQIKEFFYQLG

Sequences:

>Translated_338_residues
MMLFPQLPLYAIAIICGILSFLVTRLSMPRIIRKLEKADIVGKDLHKSWKPIVAEMGGFGILFGFIIGIFSGICMHDILT
FPLCIVLIVILLVGIIGIADDLLVLSSKEKLFLLFLAGIPLIWAAPPNVGIVYLICIPIAISIGSNLTNMLAGLNGIESG
LGIIALTSLTISCIILGKYDVTIISMSMLGALIAFLYFNKYPAKIFPGDTGTLIIGATIVSIAFIGRVKLIALIVLLPNI
IDAALKFYSAGVMERQQFKPTQVDENGNLVRPEVGFKSLIRLVLRKPIPEKQAVKIIWAIGIVCGLIGIIVAIVMPDVLQ
NQTLANFMQIKEFFYQLG
>Mature_338_residues
MMLFPQLPLYAIAIICGILSFLVTRLSMPRIIRKLEKADIVGKDLHKSWKPIVAEMGGFGILFGFIIGIFSGICMHDILT
FPLCIVLIVILLVGIIGIADDLLVLSSKEKLFLLFLAGIPLIWAAPPNVGIVYLICIPIAISIGSNLTNMLAGLNGIESG
LGIIALTSLTISCIILGKYDVTIISMSMLGALIAFLYFNKYPAKIFPGDTGTLIIGATIVSIAFIGRVKLIALIVLLPNI
IDAALKFYSAGVMERQQFKPTQVDENGNLVRPEVGFKSLIRLVLRKPIPEKQAVKIIWAIGIVCGLIGIIVAIVMPDVLQ
NQTLANFMQIKEFFYQLG

Specific function: First Step Of The Lipid Cycle Reactions In The Biosynthesis Of The Cell Wall Peptidoglycan. [C]

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family [H]

Homologues:

Organism=Homo sapiens, GI42794009, Length=285, Percent_Identity=24.9122807017544, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319720, Length=290, Percent_Identity=26.8965517241379, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19921214, Length=286, Percent_Identity=27.6223776223776, Blast_Score=75, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000715 [H]

Pfam domain/function: PF00953 Glycos_transf_4 [H]

EC number: 2.7.8.15

Molecular weight: Translated: 36752; Mature: 36752

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMLFPQLPLYAIAIICGILSFLVTRLSMPRIIRKLEKADIVGKDLHKSWKPIVAEMGGFG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHH
ILFGFIIGIFSGICMHDILTFPLCIVLIVILLVGIIGIADDLLVLSSKEKLFLLFLAGIP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCC
LIWAAPPNVGIVYLICIPIAISIGSNLTNMLAGLNGIESGLGIIALTSLTISCIILGKYD
EEEECCCCCCEEHHHHHHHHHHHCCHHHHHHHCCHHHHHCHHHHHHHHHHHHHEEECCCC
VTIISMSMLGALIAFLYFNKYPAKIFPGDTGTLIIGATIVSIAFIGRVKLIALIVLLPNI
HHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IDAALKFYSAGVMERQQFKPTQVDENGNLVRPEVGFKSLIRLVLRKPIPEKQAVKIIWAI
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHH
GIVCGLIGIIVAIVMPDVLQNQTLANFMQIKEFFYQLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MMLFPQLPLYAIAIICGILSFLVTRLSMPRIIRKLEKADIVGKDLHKSWKPIVAEMGGFG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHH
ILFGFIIGIFSGICMHDILTFPLCIVLIVILLVGIIGIADDLLVLSSKEKLFLLFLAGIP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCC
LIWAAPPNVGIVYLICIPIAISIGSNLTNMLAGLNGIESGLGIIALTSLTISCIILGKYD
EEEECCCCCCEEHHHHHHHHHHHCCHHHHHHHCCHHHHHCHHHHHHHHHHHHHEEECCCC
VTIISMSMLGALIAFLYFNKYPAKIFPGDTGTLIIGATIVSIAFIGRVKLIALIVLLPNI
HHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IDAALKFYSAGVMERQQFKPTQVDENGNLVRPEVGFKSLIRLVLRKPIPEKQAVKIIWAI
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHH
GIVCGLIGIIVAIVMPDVLQNQTLANFMQIKEFFYQLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-glucosamine; dolichyl phosphate

Specific reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]