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The map label for this gene is 148642115

Identifier: 148642115

GI number: 148642115

Start: 51065

End: 52171

Strand: Reverse

Name: 148642115

Synonym: Msm_0055

Alternate gene names: NA

Gene position: 52171-51065 (Counterclockwise)

Preceding gene: 148642116

Following gene: 148642114

Centisome position: 2.82

GC content: 33.6

Gene sequence:

>1107_bases
ATGACTCCAAACAAGCCATGGGATGATAAAAAAGAAATGATTACAACTGCATTGGAATCAGGCATCAGCTATGTCTTGGA
TTTAGATGATTATGATAAAATCCAAAAGTTAGGAAATGTAAAAATAGTAGCTAACAGTGATGATGCAGATATTTATCTTG
TTGGAATAAATGGTGAAGGTGACGGATCTTTAATCCTTAGTGAAGATTTAAACCAATCACAAGATTTACAGGAAGCAAAA
AAAGCTAAAAGAGAAGGCAAAACTGTTTGTGCTTATGTAGAAATCACAGATAAAAATCATGAGCAATTAGCTGTCAGTTT
AGGTTCTGTTGCTGATTACATTATTTTAATAAGTACTGACTGGACAGTTATTCCATTGGAAAATATTATTGCAGACCTGC
AGAAAGCAGATGTAAAAATAATAGCTGCAGTAGCCGATGAAGACGGAGCTAAATTGGCTATTGAAACATTGGAACATGGT
ACTGATGGAGTAATATTTGAAGCAAATGATTTTAATCAGATTAAAAAAATAGCACAGTTAGTTGTAGACGCTTCTAAAAT
AAAATATGATTTGAAAGTAGCTACTGTTACTAATGTTAAACCATTAGGTTCAGGTGACAGAGTATGTGTTGACACTACTG
ACATGATGAAACCTGGAGAAGGTATGTTAATCGGATCATATTCCAAATCATTATTTTTAGTACATAGCGAGTCACTTGAA
AGTGAATATGTAGCATCAAGACCATTCAGAGTAAATGCAGGTCCTGTTCAGGCATATGTAATGGTTCCGGGAAATAAAAC
AAGATACCTCTCAGAACTTGTTGCAGGAGACGAAGTTTTAATTGTCAATACAGAAGGTGAAACAAGAACTGCATATGTCG
GAAGAAGTAAAATTGAAAGAAGGCCTTTAATATTGATTGAAGCAGAATATGAAGGCAAAACAATCAGAACACTTCTTCAG
AATGCAGAAACAATTAGAATAGTTGATGCTGATAATAATCCTCTATCCGTAGCTGATATCAAAATAGGGGATAAAGTTAA
AGTATATGTTGAATCAAATGCCAGACATTTTGGTATAGCTATTGATGAAACAATAATTGAACAGTAA

Upstream 100 bases:

>100_bases
TAAAGCTATTTCAGAAGTAGTGCATAATGATTTAGAAGTAAATGAAGCTTTAAAATTCTTGAAATAAGGTGATTTTGTGG
AAAATAAATTCGCTTGGATA

Downstream 100 bases:

>100_bases
GGTGTTTTAATGTCTCAAATCAGATCTTTTTTAGCTATTGATTTAGATGATGATTTTAAACCTAAAGTAAATAAAATCAT
AAAAGAATTTAAAAAGATTG

Product: 3-dehydroquinate synthase

Products: NA

Alternate protein names: DHQ synthase

Number of amino acids: Translated: 368; Mature: 367

Protein sequence:

>368_residues
MTPNKPWDDKKEMITTALESGISYVLDLDDYDKIQKLGNVKIVANSDDADIYLVGINGEGDGSLILSEDLNQSQDLQEAK
KAKREGKTVCAYVEITDKNHEQLAVSLGSVADYIILISTDWTVIPLENIIADLQKADVKIIAAVADEDGAKLAIETLEHG
TDGVIFEANDFNQIKKIAQLVVDASKIKYDLKVATVTNVKPLGSGDRVCVDTTDMMKPGEGMLIGSYSKSLFLVHSESLE
SEYVASRPFRVNAGPVQAYVMVPGNKTRYLSELVAGDEVLIVNTEGETRTAYVGRSKIERRPLILIEAEYEGKTIRTLLQ
NAETIRIVDADNNPLSVADIKIGDKVKVYVESNARHFGIAIDETIIEQ

Sequences:

>Translated_368_residues
MTPNKPWDDKKEMITTALESGISYVLDLDDYDKIQKLGNVKIVANSDDADIYLVGINGEGDGSLILSEDLNQSQDLQEAK
KAKREGKTVCAYVEITDKNHEQLAVSLGSVADYIILISTDWTVIPLENIIADLQKADVKIIAAVADEDGAKLAIETLEHG
TDGVIFEANDFNQIKKIAQLVVDASKIKYDLKVATVTNVKPLGSGDRVCVDTTDMMKPGEGMLIGSYSKSLFLVHSESLE
SEYVASRPFRVNAGPVQAYVMVPGNKTRYLSELVAGDEVLIVNTEGETRTAYVGRSKIERRPLILIEAEYEGKTIRTLLQ
NAETIRIVDADNNPLSVADIKIGDKVKVYVESNARHFGIAIDETIIEQ
>Mature_367_residues
TPNKPWDDKKEMITTALESGISYVLDLDDYDKIQKLGNVKIVANSDDADIYLVGINGEGDGSLILSEDLNQSQDLQEAKK
AKREGKTVCAYVEITDKNHEQLAVSLGSVADYIILISTDWTVIPLENIIADLQKADVKIIAAVADEDGAKLAIETLEHGT
DGVIFEANDFNQIKKIAQLVVDASKIKYDLKVATVTNVKPLGSGDRVCVDTTDMMKPGEGMLIGSYSKSLFLVHSESLES
EYVASRPFRVNAGPVQAYVMVPGNKTRYLSELVAGDEVLIVNTEGETRTAYVGRSKIERRPLILIEAEYEGKTIRTLLQN
AETIRIVDADNNPLSVADIKIGDKVKVYVESNARHFGIAIDETIIEQ

Specific function: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis

COG id: COG1465

COG function: function code E; Predicted alternative 3-dehydroquinate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the archaeal-type DHQ synthase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DHQS_METS3 (A5UJ82)

Other databases:

- EMBL:   CP000678
- RefSeq:   YP_001272628.1
- STRING:   A5UJ82
- GeneID:   5215784
- GenomeReviews:   CP000678_GR
- KEGG:   msi:Msm_0055
- eggNOG:   arNOG05006
- HOGENOM:   HBG670179
- OMA:   DRVCIDT
- ProtClustDB:   PRK02290
- HAMAP:   MF_01244
- InterPro:   IPR002812
- PIRSF:   PIRSF006655
- ProDom:   PD017907

Pfam domain/function: PF01959 DHQS

EC number: NA

Molecular weight: Translated: 40380; Mature: 40249

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPNKPWDDKKEMITTALESGISYVLDLDDYDKIQKLGNVKIVANSDDADIYLVGINGEG
CCCCCCCCCHHHHHHHHHHCCCEEEEECCCHHHHHHCCCEEEEEECCCCEEEEEEECCCC
DGSLILSEDLNQSQDLQEAKKAKREGKTVCAYVEITDKNHEQLAVSLGSVADYIILISTD
CCCEEEECCCCCCHHHHHHHHHHHCCCEEEEEEEEECCCCCEEEEECCCCEEEEEEEECC
WTVIPLENIIADLQKADVKIIAAVADEDGAKLAIETLEHGTDGVIFEANDFNQIKKIAQL
CEEEEHHHHHHHHHHCCEEEEEEEECCCCCEEEEEECCCCCCEEEEECCCHHHHHHHHHH
VVDASKIKYDLKVATVTNVKPLGSGDRVCVDTTDMMKPGEGMLIGSYSKSLFLVHSESLE
HHHHHHEEEEEEEEEEECCCCCCCCCEEEEECHHHCCCCCCEEEECCCCEEEEEECCCCC
SEYVASRPFRVNAGPVQAYVMVPGNKTRYLSELVAGDEVLIVNTEGETRTAYVGRSKIER
CHHHHCCCEEECCCCEEEEEEECCCCHHHHHHHHCCCEEEEEECCCCCEEEEECHHHCCC
RPLILIEAEYEGKTIRTLLQNAETIRIVDADNNPLSVADIKIGDKVKVYVESNARHFGIA
CCEEEEEECCCCHHHHHHHCCCCEEEEEECCCCCEEEEEEEECCEEEEEEECCCEEEEEE
IDETIIEQ
ECHHHHCC
>Mature Secondary Structure 
TPNKPWDDKKEMITTALESGISYVLDLDDYDKIQKLGNVKIVANSDDADIYLVGINGEG
CCCCCCCCHHHHHHHHHHCCCEEEEECCCHHHHHHCCCEEEEEECCCCEEEEEEECCCC
DGSLILSEDLNQSQDLQEAKKAKREGKTVCAYVEITDKNHEQLAVSLGSVADYIILISTD
CCCEEEECCCCCCHHHHHHHHHHHCCCEEEEEEEEECCCCCEEEEECCCCEEEEEEEECC
WTVIPLENIIADLQKADVKIIAAVADEDGAKLAIETLEHGTDGVIFEANDFNQIKKIAQL
CEEEEHHHHHHHHHHCCEEEEEEEECCCCCEEEEEECCCCCCEEEEECCCHHHHHHHHHH
VVDASKIKYDLKVATVTNVKPLGSGDRVCVDTTDMMKPGEGMLIGSYSKSLFLVHSESLE
HHHHHHEEEEEEEEEEECCCCCCCCCEEEEECHHHCCCCCCEEEECCCCEEEEEECCCCC
SEYVASRPFRVNAGPVQAYVMVPGNKTRYLSELVAGDEVLIVNTEGETRTAYVGRSKIER
CHHHHCCCEEECCCCEEEEEEECCCCHHHHHHHHCCCEEEEEECCCCCEEEEECHHHCCC
RPLILIEAEYEGKTIRTLLQNAETIRIVDADNNPLSVADIKIGDKVKVYVESNARHFGIA
CCEEEEEECCCCHHHHHHHCCCCEEEEEECCCCCEEEEEEEECCEEEEEEECCCEEEEEE
IDETIIEQ
ECHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA