| Definition | Clostridium botulinum A str. ATCC 3502, complete genome. |
|---|---|
| Accession | NC_009495 |
| Length | 3,886,916 |
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The map label for this gene is gutD [H]
Identifier: 148381353
GI number: 148381353
Start: 3654628
End: 3655413
Strand: Reverse
Name: gutD [H]
Synonym: CBO3413
Alternate gene names: 148381353
Gene position: 3655413-3654628 (Counterclockwise)
Preceding gene: 148381354
Following gene: 148381352
Centisome position: 94.04
GC content: 28.88
Gene sequence:
>786_bases GTGAATTTTAAAGAAAAAACTGTTATAATAACAGGAGGAGCTCAAAGTTTAGGAGAATATATTGCTTATAGCTTTGCTGA AAAAGGTGCTAATATAGTAATTGCAGATATAAATTATGAACAGGCTAATAAAGTATCTCAAAATATAATAAACAAATATA AAGTAAGATCTATAGCAGTTAAAGTTGATGTTTGTAAAGAAGAGGAAGTTAAAAATCTTATAAAAAATACAATAGATAAT TTTAGTAAAATAGATATTTTAATTTGTAATGCTGGAGTAGTTTATAGTACAAAGGTTACTGAGCTGCCTAAAGAAAAATG GGACAATATATTAAATGTAAATTTAACAGGATATTTTTTATGTGCAAAAGAGGCTGCAAAGGAGATGGTGAAGAGAAAAC AAGGAGTTATTATCGATATAAATTCTAAATCAGGTAAAAAAGGAAGTTTGCATAACTGTGCTTATTCTGCATCAAAATTT GGAGCTATAGGTTTAACTCAAAGTTTAGCATTGGATTTAGCGGAGGATGGAATAAGAGTTAATGCAGTTTGTTCAGGTAA TTTATTAGACTCGCCTATGTGGAAAAATGGCTTATATGAACAATATGCTAAAAAATTAAATATACCTAAAGAAAAAGTTA GACAAGCATATATAGATAAGGTACCTTTAAAAAGAGGCTGTACTTATGAGGATGTAAGTAATCTAGTATTATTTTTAAGT TCAAAAGAAGCTTCATATATGACTGGACAGGCTGTAAACGTTACGGGTGGTCAAGAAATGAGATAA
Upstream 100 bases:
>100_bases TTACCAGGAAGCTTATATTTAGAAGATAAAGAAATAAAAGAAATAAAAGAAGGAACTGTAATAGAAGTTGAAAGACCTTA GTTAGAAAAGGAGGGATACT
Downstream 100 bases:
>100_bases AATATATTTTTAGGAGATAAATTATGTTAGATACAATAATTTTTGATATGGATGGGGTAATAATAGACACAGAACCTTTA TCCTTTGAAACTAGTAAAAT
Product: sorbitol-6-phosphate dehydrogenase
Products: NA
Alternate protein names: Glucitol-6-phosphate dehydrogenase; Ketosephosphate reductase [H]
Number of amino acids: Translated: 261; Mature: 261
Protein sequence:
>261_residues MNFKEKTVIITGGAQSLGEYIAYSFAEKGANIVIADINYEQANKVSQNIINKYKVRSIAVKVDVCKEEEVKNLIKNTIDN FSKIDILICNAGVVYSTKVTELPKEKWDNILNVNLTGYFLCAKEAAKEMVKRKQGVIIDINSKSGKKGSLHNCAYSASKF GAIGLTQSLALDLAEDGIRVNAVCSGNLLDSPMWKNGLYEQYAKKLNIPKEKVRQAYIDKVPLKRGCTYEDVSNLVLFLS SKEASYMTGQAVNVTGGQEMR
Sequences:
>Translated_261_residues MNFKEKTVIITGGAQSLGEYIAYSFAEKGANIVIADINYEQANKVSQNIINKYKVRSIAVKVDVCKEEEVKNLIKNTIDN FSKIDILICNAGVVYSTKVTELPKEKWDNILNVNLTGYFLCAKEAAKEMVKRKQGVIIDINSKSGKKGSLHNCAYSASKF GAIGLTQSLALDLAEDGIRVNAVCSGNLLDSPMWKNGLYEQYAKKLNIPKEKVRQAYIDKVPLKRGCTYEDVSNLVLFLS SKEASYMTGQAVNVTGGQEMR >Mature_261_residues MNFKEKTVIITGGAQSLGEYIAYSFAEKGANIVIADINYEQANKVSQNIINKYKVRSIAVKVDVCKEEEVKNLIKNTIDN FSKIDILICNAGVVYSTKVTELPKEKWDNILNVNLTGYFLCAKEAAKEMVKRKQGVIIDINSKSGKKGSLHNCAYSASKF GAIGLTQSLALDLAEDGIRVNAVCSGNLLDSPMWKNGLYEQYAKKLNIPKEKVRQAYIDKVPLKRGCTYEDVSNLVLFLS SKEASYMTGQAVNVTGGQEMR
Specific function: Sorbitol metabolism. [C]
COG id: COG1028
COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI19923817, Length=264, Percent_Identity=32.1969696969697, Blast_Score=135, Evalue=4e-32, Organism=Homo sapiens, GI15277342, Length=270, Percent_Identity=28.5185185185185, Blast_Score=115, Evalue=5e-26, Organism=Homo sapiens, GI66933014, Length=261, Percent_Identity=32.183908045977, Blast_Score=111, Evalue=8e-25, Organism=Homo sapiens, GI59889578, Length=238, Percent_Identity=29.4117647058824, Blast_Score=103, Evalue=1e-22, Organism=Homo sapiens, GI32483357, Length=260, Percent_Identity=28.0769230769231, Blast_Score=103, Evalue=2e-22, Organism=Homo sapiens, GI40254992, Length=256, Percent_Identity=28.125, Blast_Score=100, Evalue=1e-21, Organism=Homo sapiens, GI4504505, Length=189, Percent_Identity=29.6296296296296, Blast_Score=100, Evalue=1e-21, Organism=Homo sapiens, GI31542939, Length=193, Percent_Identity=27.979274611399, Blast_Score=88, Evalue=8e-18, Organism=Homo sapiens, GI5031737, Length=257, Percent_Identity=28.0155642023346, Blast_Score=87, Evalue=2e-17, Organism=Homo sapiens, GI10190704, Length=256, Percent_Identity=24.21875, Blast_Score=86, Evalue=2e-17, Organism=Homo sapiens, GI4758504, Length=209, Percent_Identity=30.622009569378, Blast_Score=86, Evalue=3e-17, Organism=Homo sapiens, GI210032110, Length=181, Percent_Identity=27.0718232044199, Blast_Score=79, Evalue=4e-15, Organism=Homo sapiens, GI126723750, Length=264, Percent_Identity=26.1363636363636, Blast_Score=79, Evalue=6e-15, Organism=Homo sapiens, GI83715985, Length=191, Percent_Identity=30.3664921465969, Blast_Score=77, Evalue=2e-14, Organism=Homo sapiens, GI109715829, Length=267, Percent_Identity=26.5917602996255, Blast_Score=76, Evalue=2e-14, Organism=Homo sapiens, GI33667109, Length=190, Percent_Identity=29.4736842105263, Blast_Score=76, Evalue=4e-14, Organism=Homo sapiens, GI4503817, Length=171, Percent_Identity=29.2397660818713, Blast_Score=75, Evalue=5e-14, Organism=Homo sapiens, GI40807363, Length=203, Percent_Identity=27.5862068965517, Blast_Score=75, Evalue=7e-14, Organism=Homo sapiens, GI226371731, Length=180, Percent_Identity=28.3333333333333, Blast_Score=74, Evalue=1e-13, Organism=Homo sapiens, GI224922801, Length=175, Percent_Identity=26.2857142857143, Blast_Score=74, Evalue=2e-13, Organism=Homo sapiens, GI25282469, Length=224, Percent_Identity=26.3392857142857, Blast_Score=73, Evalue=2e-13, Organism=Homo sapiens, GI142976729, Length=197, Percent_Identity=26.3959390862944, Blast_Score=73, Evalue=2e-13, Organism=Homo sapiens, GI4503301, Length=264, Percent_Identity=25.7575757575758, Blast_Score=73, Evalue=3e-13, Organism=Homo sapiens, GI40254986, Length=163, Percent_Identity=30.0613496932515, Blast_Score=72, Evalue=4e-13, Organism=Homo sapiens, GI7705925, Length=253, Percent_Identity=24.1106719367589, Blast_Score=71, Evalue=1e-12, Organism=Homo sapiens, GI126723191, Length=180, Percent_Identity=26.6666666666667, Blast_Score=69, Evalue=5e-12, Organism=Homo sapiens, GI7706318, Length=188, Percent_Identity=23.4042553191489, Blast_Score=64, Evalue=1e-10, Organism=Escherichia coli, GI1789057, Length=257, Percent_Identity=46.3035019455253, Blast_Score=236, Evalue=1e-63, Organism=Escherichia coli, GI87082100, Length=258, Percent_Identity=33.7209302325581, Blast_Score=127, Evalue=1e-30, Organism=Escherichia coli, GI1787335, Length=260, Percent_Identity=28.8461538461538, Blast_Score=126, Evalue=1e-30, Organism=Escherichia coli, GI87082160, Length=264, Percent_Identity=29.9242424242424, Blast_Score=119, Evalue=2e-28, Organism=Escherichia coli, GI1787905, Length=262, Percent_Identity=30.9160305343511, Blast_Score=119, Evalue=3e-28, Organism=Escherichia coli, GI1790717, Length=252, Percent_Identity=26.984126984127, Blast_Score=114, Evalue=4e-27, Organism=Escherichia coli, GI1788459, Length=254, Percent_Identity=31.8897637795276, Blast_Score=114, Evalue=6e-27, Organism=Escherichia coli, GI1789208, Length=263, Percent_Identity=26.9961977186312, Blast_Score=106, Evalue=1e-24, Organism=Escherichia coli, GI2367175, Length=258, Percent_Identity=28.2945736434109, Blast_Score=106, Evalue=1e-24, Organism=Escherichia coli, GI1786812, Length=273, Percent_Identity=26.007326007326, Blast_Score=93, Evalue=1e-20, Organism=Escherichia coli, GI1789378, Length=261, Percent_Identity=24.1379310344828, Blast_Score=88, Evalue=5e-19, Organism=Escherichia coli, GI2367365, Length=255, Percent_Identity=25.8823529411765, Blast_Score=85, Evalue=5e-18, Organism=Escherichia coli, GI1787526, Length=212, Percent_Identity=23.1132075471698, Blast_Score=77, Evalue=1e-15, Organism=Caenorhabditis elegans, GI17555706, Length=260, Percent_Identity=31.9230769230769, Blast_Score=125, Evalue=1e-29, Organism=Caenorhabditis elegans, GI25147288, Length=257, Percent_Identity=30.7392996108949, Blast_Score=115, Evalue=3e-26, Organism=Caenorhabditis elegans, GI17561402, Length=263, Percent_Identity=27.7566539923954, Blast_Score=105, Evalue=2e-23, Organism=Caenorhabditis elegans, GI71994600, Length=254, Percent_Identity=29.1338582677165, Blast_Score=100, Evalue=8e-22, Organism=Caenorhabditis elegans, GI17562904, Length=268, Percent_Identity=28.3582089552239, Blast_Score=97, Evalue=8e-21, Organism=Caenorhabditis elegans, GI17560676, Length=260, Percent_Identity=24.6153846153846, Blast_Score=96, Evalue=2e-20, Organism=Caenorhabditis elegans, GI115534694, Length=260, Percent_Identity=29.6153846153846, Blast_Score=95, Evalue=3e-20, Organism=Caenorhabditis elegans, GI17564282, Length=192, Percent_Identity=31.7708333333333, Blast_Score=94, Evalue=5e-20, Organism=Caenorhabditis elegans, GI17562908, Length=270, Percent_Identity=25.9259259259259, Blast_Score=94, Evalue=6e-20, Organism=Caenorhabditis elegans, GI193203115, Length=249, Percent_Identity=29.3172690763052, Blast_Score=94, Evalue=7e-20, Organism=Caenorhabditis elegans, GI193203117, Length=248, Percent_Identity=30.241935483871, Blast_Score=94, Evalue=7e-20, Organism=Caenorhabditis elegans, GI17562910, Length=267, Percent_Identity=27.7153558052434, Blast_Score=94, Evalue=8e-20, Organism=Caenorhabditis elegans, GI17560150, Length=268, Percent_Identity=27.6119402985075, Blast_Score=91, Evalue=5e-19, Organism=Caenorhabditis elegans, GI17544670, Length=282, Percent_Identity=27.6595744680851, Blast_Score=91, Evalue=7e-19, Organism=Caenorhabditis elegans, GI17559104, Length=268, Percent_Identity=28.3582089552239, Blast_Score=90, Evalue=1e-18, Organism=Caenorhabditis elegans, GI71994604, Length=253, Percent_Identity=26.0869565217391, Blast_Score=90, Evalue=1e-18, Organism=Caenorhabditis elegans, GI17536025, Length=259, Percent_Identity=26.2548262548263, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17560332, Length=281, Percent_Identity=27.4021352313167, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17508895, Length=184, Percent_Identity=27.7173913043478, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17531453, Length=276, Percent_Identity=26.0869565217391, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI193204405, Length=273, Percent_Identity=24.9084249084249, Blast_Score=89, Evalue=3e-18, Organism=Caenorhabditis elegans, GI17538182, Length=200, Percent_Identity=30, Blast_Score=88, Evalue=4e-18, Organism=Caenorhabditis elegans, GI17562906, Length=270, Percent_Identity=23.7037037037037, Blast_Score=88, Evalue=5e-18, Organism=Caenorhabditis elegans, GI17536651, Length=262, Percent_Identity=26.7175572519084, Blast_Score=87, Evalue=7e-18, Organism=Caenorhabditis elegans, GI17562990, Length=264, Percent_Identity=25.7575757575758, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17563726, Length=271, Percent_Identity=28.4132841328413, Blast_Score=85, Evalue=3e-17, Organism=Caenorhabditis elegans, GI72000259, Length=264, Percent_Identity=26.8939393939394, Blast_Score=85, Evalue=3e-17, Organism=Caenorhabditis elegans, GI17560220, Length=273, Percent_Identity=25.2747252747253, Blast_Score=84, Evalue=8e-17, Organism=Caenorhabditis elegans, GI17568967, Length=189, Percent_Identity=29.6296296296296, Blast_Score=82, Evalue=2e-16, Organism=Caenorhabditis elegans, GI17567345, Length=270, Percent_Identity=25.5555555555556, Blast_Score=77, Evalue=6e-15, Organism=Caenorhabditis elegans, GI17561272, Length=242, Percent_Identity=24.7933884297521, Blast_Score=71, Evalue=6e-13, Organism=Caenorhabditis elegans, GI17508651, Length=261, Percent_Identity=26.8199233716475, Blast_Score=71, Evalue=7e-13, Organism=Caenorhabditis elegans, GI71982365, Length=189, Percent_Identity=27.5132275132275, Blast_Score=66, Evalue=2e-11, Organism=Caenorhabditis elegans, GI17538480, Length=273, Percent_Identity=24.9084249084249, Blast_Score=65, Evalue=3e-11, Organism=Caenorhabditis elegans, GI71997099, Length=191, Percent_Identity=28.2722513089005, Blast_Score=65, Evalue=4e-11, Organism=Caenorhabditis elegans, GI17538486, Length=278, Percent_Identity=25.1798561151079, Blast_Score=64, Evalue=5e-11, Organism=Caenorhabditis elegans, GI17555612, Length=203, Percent_Identity=28.0788177339901, Blast_Score=64, Evalue=8e-11, Organism=Saccharomyces cerevisiae, GI6322861, Length=252, Percent_Identity=30.1587301587302, Blast_Score=95, Evalue=1e-20, Organism=Saccharomyces cerevisiae, GI6324126, Length=259, Percent_Identity=29.3436293436293, Blast_Score=89, Evalue=6e-19, Organism=Saccharomyces cerevisiae, GI6323882, Length=244, Percent_Identity=24.1803278688525, Blast_Score=71, Evalue=2e-13, Organism=Saccharomyces cerevisiae, GI6320089, Length=193, Percent_Identity=27.979274611399, Blast_Score=65, Evalue=8e-12, Organism=Drosophila melanogaster, GI28571526, Length=259, Percent_Identity=30.1158301158301, Blast_Score=119, Evalue=3e-27, Organism=Drosophila melanogaster, GI21355319, Length=257, Percent_Identity=31.5175097276265, Blast_Score=116, Evalue=1e-26, Organism=Drosophila melanogaster, GI24639444, Length=255, Percent_Identity=27.4509803921569, Blast_Score=116, Evalue=2e-26, Organism=Drosophila melanogaster, GI24644339, Length=259, Percent_Identity=30.1158301158301, Blast_Score=115, Evalue=2e-26, Organism=Drosophila melanogaster, GI21357041, Length=259, Percent_Identity=28.1853281853282, Blast_Score=112, Evalue=3e-25, Organism=Drosophila melanogaster, GI23397609, Length=260, Percent_Identity=27.6923076923077, Blast_Score=102, Evalue=3e-22, Organism=Drosophila melanogaster, GI17737361, Length=270, Percent_Identity=26.6666666666667, Blast_Score=96, Evalue=3e-20, Organism=Drosophila melanogaster, GI18859837, Length=189, Percent_Identity=26.4550264550265, Blast_Score=83, Evalue=2e-16, Organism=Drosophila melanogaster, GI24581726, Length=184, Percent_Identity=29.8913043478261, Blast_Score=78, Evalue=5e-15, Organism=Drosophila melanogaster, GI21357673, Length=186, Percent_Identity=28.494623655914, Blast_Score=77, Evalue=8e-15, Organism=Drosophila melanogaster, GI21355631, Length=178, Percent_Identity=26.9662921348315, Blast_Score=77, Evalue=9e-15, Organism=Drosophila melanogaster, GI24649181, Length=165, Percent_Identity=27.2727272727273, Blast_Score=77, Evalue=1e-14, Organism=Drosophila melanogaster, GI24644337, Length=262, Percent_Identity=26.7175572519084, Blast_Score=72, Evalue=5e-13, Organism=Drosophila melanogaster, GI21358495, Length=184, Percent_Identity=26.0869565217391, Blast_Score=69, Evalue=3e-12, Organism=Drosophila melanogaster, GI28571387, Length=168, Percent_Identity=27.9761904761905, Blast_Score=69, Evalue=3e-12, Organism=Drosophila melanogaster, GI24584744, Length=180, Percent_Identity=26.6666666666667, Blast_Score=68, Evalue=6e-12, Organism=Drosophila melanogaster, GI28574402, Length=180, Percent_Identity=26.6666666666667, Blast_Score=68, Evalue=7e-12, Organism=Drosophila melanogaster, GI24643142, Length=254, Percent_Identity=24.4094488188976, Blast_Score=67, Evalue=1e-11, Organism=Drosophila melanogaster, GI24647946, Length=227, Percent_Identity=27.3127753303965, Blast_Score=67, Evalue=2e-11, Organism=Drosophila melanogaster, GI45553409, Length=227, Percent_Identity=27.3127753303965, Blast_Score=67, Evalue=2e-11, Organism=Drosophila melanogaster, GI24647948, Length=227, Percent_Identity=27.3127753303965, Blast_Score=67, Evalue=2e-11, Organism=Drosophila melanogaster, GI221510726, Length=167, Percent_Identity=29.940119760479, Blast_Score=66, Evalue=2e-11, Organism=Drosophila melanogaster, GI161076933, Length=180, Percent_Identity=25, Blast_Score=65, Evalue=6e-11, Organism=Drosophila melanogaster, GI24584748, Length=180, Percent_Identity=25, Blast_Score=65, Evalue=6e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: =1.1.1.140 [H]
Molecular weight: Translated: 28857; Mature: 28857
Theoretical pI: Translated: 9.22; Mature: 9.22
Prosite motif: PS00061 ADH_SHORT ; PS00189 LIPOYL
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
2.3 %Cys (Translated Protein) 1.9 %Met (Translated Protein) 4.2 %Cys+Met (Translated Protein) 2.3 %Cys (Mature Protein) 1.9 %Met (Mature Protein) 4.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNFKEKTVIITGGAQSLGEYIAYSFAEKGANIVIADINYEQANKVSQNIINKYKVRSIAV CCCCCEEEEEECCHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHEEEEEE KVDVCKEEEVKNLIKNTIDNFSKIDILICNAGVVYSTKVTELPKEKWDNILNVNLTGYFL EEECCCHHHHHHHHHHHHCCCCEEEEEEECCCEEEECHHHHCCHHHCCCEEEEEEEEEEE CAKEAAKEMVKRKQGVIIDINSKSGKKGSLHNCAYSASKFGAIGLTQSLALDLAEDGIRV EHHHHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHCHHHCCCCCCHHHHHHHHHCCCEEE NAVCSGNLLDSPMWKNGLYEQYAKKLNIPKEKVRQAYIDKVPLKRGCTYEDVSNLVLFLS EEEEECCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHCCEEEEEE SKEASYMTGQAVNVTGGQEMR CCCCCEECCCEEEECCCCCCC >Mature Secondary Structure MNFKEKTVIITGGAQSLGEYIAYSFAEKGANIVIADINYEQANKVSQNIINKYKVRSIAV CCCCCEEEEEECCHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHEEEEEE KVDVCKEEEVKNLIKNTIDNFSKIDILICNAGVVYSTKVTELPKEKWDNILNVNLTGYFL EEECCCHHHHHHHHHHHHCCCCEEEEEEECCCEEEECHHHHCCHHHCCCEEEEEEEEEEE CAKEAAKEMVKRKQGVIIDINSKSGKKGSLHNCAYSASKFGAIGLTQSLALDLAEDGIRV EHHHHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHCHHHCCCCCCHHHHHHHHHCCCEEE NAVCSGNLLDSPMWKNGLYEQYAKKLNIPKEKVRQAYIDKVPLKRGCTYEDVSNLVLFLS EEEEECCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHCCEEEEEE SKEASYMTGQAVNVTGGQEMR CCCCCEECCCEEEECCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 3553176; 9205837; 9278503; 6384188 [H]