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The map label for this gene is uvrB [H]

Identifier: 148381328

GI number: 148381328

Start: 3627045

End: 3629042

Strand: Reverse

Name: uvrB [H]

Synonym: CBO3387

Alternate gene names: 148381328

Gene position: 3629042-3627045 (Counterclockwise)

Preceding gene: 148381329

Following gene: 148381327

Centisome position: 93.37

GC content: 29.48

Gene sequence:

>1998_bases
ATGAATAAGATGAACCAATTTAAGGTAATTTCAAAATTTAATCCTACAGGAGATCAACCTAAAGCTATAAAATCTATTGC
TAAAGGCATAGAAAAAAGAGAAAAATTTCAAACTTTAATAGGCGTGACCGGATCAGGTAAAACTTTTACTATGGCAAATA
TTATAGAAAAAGTTCAAAAGCCTACCTTAGTTTTAGCTCATAATAAAACACTGGCAGCACAATTATGCTCAGAATTTAGA
GAGTTTTTTCCTAATAATGCAGTAGAATATTTTGTATCTTATTATGATTATTATCAACCAGAAGCATACGTAGCTCAAAG
TGATACATATATAGAAAAAGATGCATCTATAAATGATGAAATAGATAAATTAAGGCACTCAGCCACATCAGCTTTATTTG
AAAGAAAAGATGTAATAATTGTTGCTTCTGTATCTTGTATATATGGACTTGGTAATCCAGAAGAGTATAAAAAGTTAACT
ATATCGTTAAGAGAAGGTATGGAGAAGGATAGAGATGAAATAATTAAAAAATTAGTAGAAATACAATATGAAAGAAATGA
CATAGATTTTTCTAGAGGTACTTTTAGAGTAAAAGGTGATGTTTTAGATATTTTTCCTGCTTCATCTAGTAGCAAAGCAG
TAAGAGTAGAATTTTTTGGTGACGAAATAGATAGAATAAAAGAATTTGATGTTTTAACAGGAGAAACTATAACTAAGTTA
AAACATATATCTATATTCCCAGCATCTCACTTTGCAACTTCAAAGGATAGACTGGAAGTTGCTATAAAAGATATAGAAGA
AGAGCTAGAAGAAAGAGTAAAAGAATTAGTATCTCAGGATAAAATATTAGAGGCTCAAAGATTAAAGCAGAGAACTAATT
TTGATATAGAAATGATGAGAGAAGTTGGATACTGTACAGGCATTGAAAATTATTCAAGAGTGTTAGATGGAAGAGCAAAA
GGAACACCACCTCAGACCCTTTTAGATTATTTTCCACAGGATTTTCTTCTTTTTATAGATGAAAGTCATGTAACTTTGCC
ACAGGTAAAAGCTATGCAGGCAGGAGATAAATCTAGAAAAGATTCTTTGGTGGAATATGGATTCAGGTTGCCTTGTGCCT
ATGATAATAGGCCTCTTACCTTTAAGGAATTTGAAAATAAATTAAATCAAGTAGTTTTTGTAAGTGCTACACCAGCAAAA
TATGAATTAGAATATTCAACTAACACAGCAGAGCAAGTAATAAGGCCTACAGGACTTTTAGATCCTGAAATAATTGTAAA
ACCAGTAAAGGGACAGATAGACGACTTATATACTAGCATACAAGAAACAATTAAAAGAGGATTTAGAATTCTAGTAACTA
CATTAACAAAAAAAATGGCAGAAGACTTGACTGATTATTTAAAAGAAATGGGAGTAAAAACTAGATATTTACATTCAGAT
ATAGATACTATAGAAAGAATGAAAATAATACATGATCTTAGAAAAGGAGAATTTCATGTTTTAGTAGGAATAAACTTACT
AAGAGAAGGATTGGATATACCAGAAGTAGCTTTAGTTACAATATTAGATGCAGATAAAGAGGGATTTTTAAGATCAGAAA
CATCTCTTATACAGACTGTCGGAAGAGCAGCAAGAAACTCTGAAAGTAAGGTAATTATGTATGGGGATGTTATAACCAAA
TCCATGGAAAAGACTATAAAAGAAACTAATAGAAGAAGAAAAATACAAATGGAATATAATGAAGAACATGGAATTGTTCC
TAAAACTATAATAAAAGATATAAGAGAAGTAATTCAAATAAGTGATATAGCAGAGGAAAGAAAAGAATATGACAATTTAA
ATGAAGCATTAAAATCTTATAATAATGATATAGATAAATTAATAGAGAAATATGAAGAAGAAATGAAAGAGGCAGCACAA
AATTTACAGTTTGAAAAAGCGGCTCATTTGAGAGATGTAATATACAAATTAAAAAAAGATAAAGAAACAGAACTTTAA

Upstream 100 bases:

>100_bases
GTATTTGTACCTAAAAATGTACCTAAAAATACATCTGTAATAAAAGTTAAAAGTGAAAAATTTCAAGACATATTAGAAAA
AATTAAAAACAAAGATAAGG

Downstream 100 bases:

>100_bases
GGAGTGTAATAACAAATAATGAAGGATAAAATTATTATTAAAGGCGCTAAGGTTAATAATTTAAAAAATATAAATCTTCA
GTTGCCGAGAGATAAGTATA

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 665; Mature: 665

Protein sequence:

>665_residues
MNKMNQFKVISKFNPTGDQPKAIKSIAKGIEKREKFQTLIGVTGSGKTFTMANIIEKVQKPTLVLAHNKTLAAQLCSEFR
EFFPNNAVEYFVSYYDYYQPEAYVAQSDTYIEKDASINDEIDKLRHSATSALFERKDVIIVASVSCIYGLGNPEEYKKLT
ISLREGMEKDRDEIIKKLVEIQYERNDIDFSRGTFRVKGDVLDIFPASSSSKAVRVEFFGDEIDRIKEFDVLTGETITKL
KHISIFPASHFATSKDRLEVAIKDIEEELEERVKELVSQDKILEAQRLKQRTNFDIEMMREVGYCTGIENYSRVLDGRAK
GTPPQTLLDYFPQDFLLFIDESHVTLPQVKAMQAGDKSRKDSLVEYGFRLPCAYDNRPLTFKEFENKLNQVVFVSATPAK
YELEYSTNTAEQVIRPTGLLDPEIIVKPVKGQIDDLYTSIQETIKRGFRILVTTLTKKMAEDLTDYLKEMGVKTRYLHSD
IDTIERMKIIHDLRKGEFHVLVGINLLREGLDIPEVALVTILDADKEGFLRSETSLIQTVGRAARNSESKVIMYGDVITK
SMEKTIKETNRRRKIQMEYNEEHGIVPKTIIKDIREVIQISDIAEERKEYDNLNEALKSYNNDIDKLIEKYEEEMKEAAQ
NLQFEKAAHLRDVIYKLKKDKETEL

Sequences:

>Translated_665_residues
MNKMNQFKVISKFNPTGDQPKAIKSIAKGIEKREKFQTLIGVTGSGKTFTMANIIEKVQKPTLVLAHNKTLAAQLCSEFR
EFFPNNAVEYFVSYYDYYQPEAYVAQSDTYIEKDASINDEIDKLRHSATSALFERKDVIIVASVSCIYGLGNPEEYKKLT
ISLREGMEKDRDEIIKKLVEIQYERNDIDFSRGTFRVKGDVLDIFPASSSSKAVRVEFFGDEIDRIKEFDVLTGETITKL
KHISIFPASHFATSKDRLEVAIKDIEEELEERVKELVSQDKILEAQRLKQRTNFDIEMMREVGYCTGIENYSRVLDGRAK
GTPPQTLLDYFPQDFLLFIDESHVTLPQVKAMQAGDKSRKDSLVEYGFRLPCAYDNRPLTFKEFENKLNQVVFVSATPAK
YELEYSTNTAEQVIRPTGLLDPEIIVKPVKGQIDDLYTSIQETIKRGFRILVTTLTKKMAEDLTDYLKEMGVKTRYLHSD
IDTIERMKIIHDLRKGEFHVLVGINLLREGLDIPEVALVTILDADKEGFLRSETSLIQTVGRAARNSESKVIMYGDVITK
SMEKTIKETNRRRKIQMEYNEEHGIVPKTIIKDIREVIQISDIAEERKEYDNLNEALKSYNNDIDKLIEKYEEEMKEAAQ
NLQFEKAAHLRDVIYKLKKDKETEL
>Mature_665_residues
MNKMNQFKVISKFNPTGDQPKAIKSIAKGIEKREKFQTLIGVTGSGKTFTMANIIEKVQKPTLVLAHNKTLAAQLCSEFR
EFFPNNAVEYFVSYYDYYQPEAYVAQSDTYIEKDASINDEIDKLRHSATSALFERKDVIIVASVSCIYGLGNPEEYKKLT
ISLREGMEKDRDEIIKKLVEIQYERNDIDFSRGTFRVKGDVLDIFPASSSSKAVRVEFFGDEIDRIKEFDVLTGETITKL
KHISIFPASHFATSKDRLEVAIKDIEEELEERVKELVSQDKILEAQRLKQRTNFDIEMMREVGYCTGIENYSRVLDGRAK
GTPPQTLLDYFPQDFLLFIDESHVTLPQVKAMQAGDKSRKDSLVEYGFRLPCAYDNRPLTFKEFENKLNQVVFVSATPAK
YELEYSTNTAEQVIRPTGLLDPEIIVKPVKGQIDDLYTSIQETIKRGFRILVTTLTKKMAEDLTDYLKEMGVKTRYLHSD
IDTIERMKIIHDLRKGEFHVLVGINLLREGLDIPEVALVTILDADKEGFLRSETSLIQTVGRAARNSESKVIMYGDVITK
SMEKTIKETNRRRKIQMEYNEEHGIVPKTIIKDIREVIQISDIAEERKEYDNLNEALKSYNNDIDKLIEKYEEEMKEAAQ
NLQFEKAAHLRDVIYKLKKDKETEL

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=663, Percent_Identity=56.7119155354449, Blast_Score=758, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=229, Percent_Identity=24.0174672489083, Blast_Score=67, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 76592; Mature: 76592

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKMNQFKVISKFNPTGDQPKAIKSIAKGIEKREKFQTLIGVTGSGKTFTMANIIEKVQK
CCCCHHEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCEEHHHHHHHHHCC
PTLVLAHNKTLAAQLCSEFREFFPNNAVEYFVSYYDYYQPEAYVAQSDTYIEKDASINDE
CEEEEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCCCEECCCCCCCHH
IDKLRHSATSALFERKDVIIVASVSCIYGLGNPEEYKKLTISLREGMEKDRDEIIKKLVE
HHHHHHHHHHHHHHCCCEEEEEEHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHH
IQYERNDIDFSRGTFRVKGDVLDIFPASSSSKAVRVEFFGDEIDRIKEFDVLTGETITKL
HHHCCCCCCCCCCEEEEECCEEEEECCCCCCCEEEEEECCCHHHHHHHHHCCCCHHHHHH
KHISIFPASHFATSKDRLEVAIKDIEEELEERVKELVSQDKILEAQRLKQRTNFDIEMMR
HHEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
EVGYCTGIENYSRVLDGRAKGTPPQTLLDYFPQDFLLFIDESHVTLPQVKAMQAGDKSRK
HHHHHCCHHHHHHHHCCCCCCCCHHHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCCHHH
DSLVEYGFRLPCAYDNRPLTFKEFENKLNQVVFVSATPAKYELEYSTNTAEQVIRPTGLL
HHHHHCCCCCCCCCCCCCCCHHHHHHHHCEEEEEEECCCEEEEEECCCHHHHHHCCCCCC
DPEIIVKPVKGQIDDLYTSIQETIKRGFRILVTTLTKKMAEDLTDYLKEMGVKTRYLHSD
CHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
IDTIERMKIIHDLRKGEFHVLVGINLLREGLDIPEVALVTILDADKEGFLRSETSLIQTV
HHHHHHHHHHHHHCCCCEEEEEEHHHHHCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHH
GRAARNSESKVIMYGDVITKSMEKTIKETNRRRKIQMEYNEEHGIVPKTIIKDIREVIQI
HHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCHHHHHHHHHHHHHH
SDIAEERKEYDNLNEALKSYNNDIDKLIEKYEEEMKEAAQNLQFEKAAHLRDVIYKLKKD
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
KETEL
CCCCC
>Mature Secondary Structure
MNKMNQFKVISKFNPTGDQPKAIKSIAKGIEKREKFQTLIGVTGSGKTFTMANIIEKVQK
CCCCHHEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCEEHHHHHHHHHCC
PTLVLAHNKTLAAQLCSEFREFFPNNAVEYFVSYYDYYQPEAYVAQSDTYIEKDASINDE
CEEEEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCCCEECCCCCCCHH
IDKLRHSATSALFERKDVIIVASVSCIYGLGNPEEYKKLTISLREGMEKDRDEIIKKLVE
HHHHHHHHHHHHHHCCCEEEEEEHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHH
IQYERNDIDFSRGTFRVKGDVLDIFPASSSSKAVRVEFFGDEIDRIKEFDVLTGETITKL
HHHCCCCCCCCCCEEEEECCEEEEECCCCCCCEEEEEECCCHHHHHHHHHCCCCHHHHHH
KHISIFPASHFATSKDRLEVAIKDIEEELEERVKELVSQDKILEAQRLKQRTNFDIEMMR
HHEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
EVGYCTGIENYSRVLDGRAKGTPPQTLLDYFPQDFLLFIDESHVTLPQVKAMQAGDKSRK
HHHHHCCHHHHHHHHCCCCCCCCHHHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCCHHH
DSLVEYGFRLPCAYDNRPLTFKEFENKLNQVVFVSATPAKYELEYSTNTAEQVIRPTGLL
HHHHHCCCCCCCCCCCCCCCHHHHHHHHCEEEEEEECCCEEEEEECCCHHHHHHCCCCCC
DPEIIVKPVKGQIDDLYTSIQETIKRGFRILVTTLTKKMAEDLTDYLKEMGVKTRYLHSD
CHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
IDTIERMKIIHDLRKGEFHVLVGINLLREGLDIPEVALVTILDADKEGFLRSETSLIQTV
HHHHHHHHHHHHHCCCCEEEEEEHHHHHCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHH
GRAARNSESKVIMYGDVITKSMEKTIKETNRRRKIQMEYNEEHGIVPKTIIKDIREVIQI
HHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCHHHHHHHHHHHHHH
SDIAEERKEYDNLNEALKSYNNDIDKLIEKYEEEMKEAAQNLQFEKAAHLRDVIYKLKKD
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
KETEL
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA