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The map label for this gene is proC [H]

Identifier: 148381130

GI number: 148381130

Start: 3387637

End: 3388443

Strand: Reverse

Name: proC [H]

Synonym: CBO3182

Alternate gene names: 148381130

Gene position: 3388443-3387637 (Counterclockwise)

Preceding gene: 148381131

Following gene: 148381129

Centisome position: 87.18

GC content: 33.33

Gene sequence:

>807_bases
ATGAATAAAGTAATTGGATTTATTGGTGCTGGAAATATGGGACAAGCAATGGTTGGGGGAATAGTTAATTCAAAATTAGT
TGGCCCAGAAAATATTATATTATCAGATTTGAATGAAAAGGCATTAGAAGCTGCTAAAGAAAGATTTGGGGTTAGAGTAA
CAACAAATAGCAATGAATTAGCTAAAGAAGTAGATATATTAGTTTTATCTGTAAAACCAAATTTATATCCAATAGTTATA
AAAGGTATAAAAGATAGTGTTAAAAAAGAAGTTATAGTAGTTACTATCGCAGCTGGTAAAGCATTAGAAGATACTGAAAC
TATGTTTGGAAAAAGAATAAAAATAGTTAGAGTAATGCCTAATACTCCTGCATTAGTTGGAGAAGGTATGGCTGCTGTAT
GTCCTAACGATTTGGTTTCTAAAGAGGAAGCTGAAGAAGTCATAAGTATCTTTGAAAGCTTTGGAAAAGCAGAAATAGTG
GAAGAGAAATTGATGGATGCAGTAACTGCAGTAAGTGGTTCATCTCCAGCTTATGTGTATATGTTTATAGAAGCTATGGC
AGATGCAGCTGTGCTAGAAGGTATGCCAAGAGATAAGGCTTATAAATTTGCAGCACAAGCTGTATTAGGATCAGCAAAAA
TGGTTCTAGAAACAGGAATGCATCCAGGTGCATTAAAAGATATGGTTTGTTCACCAGGAGGAACTACAATTGAGGCAGTA
GCAACTCTTGAAAAAAATGGTTTTAGAAATGCAATTATAGAAGCTATGAGAGATTGTGCAATAAAATCTAAAGAAATGTC
TAAATAA

Upstream 100 bases:

>100_bases
ATATATTATTGTAAAGAAAAATAAAAACTAGGAGAAGGAACTAAGATTTATAATTTAAGTCTTTCTCCTAGTAACAAATT
TTTATTAGGAGGAAAGCTAC

Downstream 100 bases:

>100_bases
TACAGTTAGCATTTTTCGTTATCCTATCTTTTAAAGATAGGATAACGAAGAAATATAAAATAAATCACCAAGTTATAGAG
GTAATAATCAGAATATTGCC

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 268; Mature: 268

Protein sequence:

>268_residues
MNKVIGFIGAGNMGQAMVGGIVNSKLVGPENIILSDLNEKALEAAKERFGVRVTTNSNELAKEVDILVLSVKPNLYPIVI
KGIKDSVKKEVIVVTIAAGKALEDTETMFGKRIKIVRVMPNTPALVGEGMAAVCPNDLVSKEEAEEVISIFESFGKAEIV
EEKLMDAVTAVSGSSPAYVYMFIEAMADAAVLEGMPRDKAYKFAAQAVLGSAKMVLETGMHPGALKDMVCSPGGTTIEAV
ATLEKNGFRNAIIEAMRDCAIKSKEMSK

Sequences:

>Translated_268_residues
MNKVIGFIGAGNMGQAMVGGIVNSKLVGPENIILSDLNEKALEAAKERFGVRVTTNSNELAKEVDILVLSVKPNLYPIVI
KGIKDSVKKEVIVVTIAAGKALEDTETMFGKRIKIVRVMPNTPALVGEGMAAVCPNDLVSKEEAEEVISIFESFGKAEIV
EEKLMDAVTAVSGSSPAYVYMFIEAMADAAVLEGMPRDKAYKFAAQAVLGSAKMVLETGMHPGALKDMVCSPGGTTIEAV
ATLEKNGFRNAIIEAMRDCAIKSKEMSK
>Mature_268_residues
MNKVIGFIGAGNMGQAMVGGIVNSKLVGPENIILSDLNEKALEAAKERFGVRVTTNSNELAKEVDILVLSVKPNLYPIVI
KGIKDSVKKEVIVVTIAAGKALEDTETMFGKRIKIVRVMPNTPALVGEGMAAVCPNDLVSKEEAEEVISIFESFGKAEIV
EEKLMDAVTAVSGSSPAYVYMFIEAMADAAVLEGMPRDKAYKFAAQAVLGSAKMVLETGMHPGALKDMVCSPGGTTIEAV
ATLEKNGFRNAIIEAMRDCAIKSKEMSK

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361454, Length=267, Percent_Identity=38.2022471910112, Blast_Score=182, Evalue=2e-46,
Organism=Homo sapiens, GI24797095, Length=266, Percent_Identity=36.4661654135338, Blast_Score=177, Evalue=7e-45,
Organism=Homo sapiens, GI24797097, Length=266, Percent_Identity=36.4661654135338, Blast_Score=177, Evalue=8e-45,
Organism=Homo sapiens, GI198041662, Length=266, Percent_Identity=34.2105263157895, Blast_Score=174, Evalue=9e-44,
Organism=Escherichia coli, GI1786585, Length=268, Percent_Identity=54.8507462686567, Blast_Score=289, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI17569021, Length=262, Percent_Identity=38.5496183206107, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17540664, Length=278, Percent_Identity=37.410071942446, Blast_Score=169, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6320861, Length=279, Percent_Identity=31.8996415770609, Blast_Score=123, Evalue=2e-29,
Organism=Drosophila melanogaster, GI21358587, Length=264, Percent_Identity=36.7424242424242, Blast_Score=183, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24648116, Length=280, Percent_Identity=38.2142857142857, Blast_Score=177, Evalue=6e-45,
Organism=Drosophila melanogaster, GI24647700, Length=169, Percent_Identity=42.603550295858, Blast_Score=147, Evalue=7e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 28531; Mature: 28531

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKVIGFIGAGNMGQAMVGGIVNSKLVGPENIILSDLNEKALEAAKERFGVRVTTNSNEL
CCCEEEEEECCCCCHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHHHCCEEEECCCHHH
AKEVDILVLSVKPNLYPIVIKGIKDSVKKEVIVVTIAAGKALEDTETMFGKRIKIVRVMP
HHEEEEEEEEECCCEEEEEEECCHHHCCCEEEEEEEECCCCCHHHHHHHCCEEEEEEECC
NTPALVGEGMAAVCPNDLVSKEEAEEVISIFESFGKAEIVEEKLMDAVTAVSGSSPAYVY
CCCCHHCCCCHHCCCHHHCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCEEEE
MFIEAMADAAVLEGMPRDKAYKFAAQAVLGSAKMVLETGMHPGALKDMVCSPGGTTIEAV
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCEEHHH
ATLEKNGFRNAIIEAMRDCAIKSKEMSK
HHHHHCCHHHHHHHHHHHHHHCHHCCCC
>Mature Secondary Structure
MNKVIGFIGAGNMGQAMVGGIVNSKLVGPENIILSDLNEKALEAAKERFGVRVTTNSNEL
CCCEEEEEECCCCCHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHHHCCEEEECCCHHH
AKEVDILVLSVKPNLYPIVIKGIKDSVKKEVIVVTIAAGKALEDTETMFGKRIKIVRVMP
HHEEEEEEEEECCCEEEEEEECCHHHCCCEEEEEEEECCCCCHHHHHHHCCEEEEEEECC
NTPALVGEGMAAVCPNDLVSKEEAEEVISIFESFGKAEIVEEKLMDAVTAVSGSSPAYVY
CCCCHHCCCCHHCCCHHHCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCEEEE
MFIEAMADAAVLEGMPRDKAYKFAAQAVLGSAKMVLETGMHPGALKDMVCSPGGTTIEAV
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCEEHHH
ATLEKNGFRNAIIEAMRDCAIKSKEMSK
HHHHHCCHHHHHHHHHHHHHHCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6296787; 9278503 [H]