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The map label for this gene is era

Identifier: 148380897

GI number: 148380897

Start: 3136967

End: 3137857

Strand: Reverse

Name: era

Synonym: CBO2946

Alternate gene names: 148380897

Gene position: 3137857-3136967 (Counterclockwise)

Preceding gene: 148380898

Following gene: 148380896

Centisome position: 80.73

GC content: 28.17

Gene sequence:

>891_bases
ATGTTTAAATCAGGATTTGTAACCATAGTAGGAAGACCTAATGTAGGAAAATCAACGTTATTAAATGCCATAATGAAAGA
GAAACTTTCTATAGTTTCATGCAGACCCCAGACTACAAGAAACAATATACAAACAATATTAACAGAAGATAATTACCAAC
TTGTATTTGTTGATACGCCAGGAATACATAAGCCTAAGCATAAGTTAGGAGAGTATATGGTGAAATCAGCATCAGAAGCT
ATGAAGGATGTGGATTTAGTACTTTTTTTAATAAATCCAGATGAAAAGCCTGGTAGAGGAGATTTGTTTATAATAGAACA
ATTAAAAGAAGTAAAAGTACCAGTATTTTTAGTTTTAAATAAAATAGATGAAAATCCACAAGAAAAAGTAGCAGAGACTT
TAAAAACATATTCAGAACTTATGGAGTTTGAAGAAATAATACCTATATCTGCACTAAAAGGTAAAAATATTGATTTACTT
AAAGAATTAATGTTTAAATATATACCAGAGGGACCACAATATTATCCAGAAGATATGATAATAGATCAAAATGAAAGATT
TATAGTGGCAGAGATAGTAAGGGAAAAAGCTTTAAGACTTTTATCAGAAGAAGTTCCTCATGGTATAGCTGTAGAAATAC
TTCAAATGAAGAAAAATGAAAAAGGAACTTATCACATAGAAGGTAATATATTATGTGAAAAAAATTCTCATAAACCTATA
ATTATAGGTAAAGGTGGTAGTAAATTAAAGAAAATATCTCAATATGCAAGACAGGATATAGAAGCTTTTCTTCAAAGTAA
AGTATATATAAGACTTTGGGTTAAAGTAAAAGAAGAGTGGAGAGATAACCAAAGTTTATTAAAAGAATTAGGTTATAAAA
ATATGAAATAG

Upstream 100 bases:

>100_bases
AGTGAAAGATAAAAATAATTATGAAATAAAGAAACTAGATGAAATTTTACCAGGAGCTTTTACTAAAAAAGATCTAATAA
AATAGACGAGGAGATAAAAT

Downstream 100 bases:

>100_bases
AACTGAAATAAATAATATAGGGAGTTGATTTTCTGTCACTATATAAAACTAGGGCTGTAGTAATAAAAACTCAAGAATTT
AAAGAAGCAGATAAATTAGT

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MFKSGFVTIVGRPNVGKSTLLNAIMKEKLSIVSCRPQTTRNNIQTILTEDNYQLVFVDTPGIHKPKHKLGEYMVKSASEA
MKDVDLVLFLINPDEKPGRGDLFIIEQLKEVKVPVFLVLNKIDENPQEKVAETLKTYSELMEFEEIIPISALKGKNIDLL
KELMFKYIPEGPQYYPEDMIIDQNERFIVAEIVREKALRLLSEEVPHGIAVEILQMKKNEKGTYHIEGNILCEKNSHKPI
IIGKGGSKLKKISQYARQDIEAFLQSKVYIRLWVKVKEEWRDNQSLLKELGYKNMK

Sequences:

>Translated_296_residues
MFKSGFVTIVGRPNVGKSTLLNAIMKEKLSIVSCRPQTTRNNIQTILTEDNYQLVFVDTPGIHKPKHKLGEYMVKSASEA
MKDVDLVLFLINPDEKPGRGDLFIIEQLKEVKVPVFLVLNKIDENPQEKVAETLKTYSELMEFEEIIPISALKGKNIDLL
KELMFKYIPEGPQYYPEDMIIDQNERFIVAEIVREKALRLLSEEVPHGIAVEILQMKKNEKGTYHIEGNILCEKNSHKPI
IIGKGGSKLKKISQYARQDIEAFLQSKVYIRLWVKVKEEWRDNQSLLKELGYKNMK
>Mature_296_residues
MFKSGFVTIVGRPNVGKSTLLNAIMKEKLSIVSCRPQTTRNNIQTILTEDNYQLVFVDTPGIHKPKHKLGEYMVKSASEA
MKDVDLVLFLINPDEKPGRGDLFIIEQLKEVKVPVFLVLNKIDENPQEKVAETLKTYSELMEFEEIIPISALKGKNIDLL
KELMFKYIPEGPQYYPEDMIIDQNERFIVAEIVREKALRLLSEEVPHGIAVEILQMKKNEKGTYHIEGNILCEKNSHKPI
IIGKGGSKLKKISQYARQDIEAFLQSKVYIRLWVKVKEEWRDNQSLLKELGYKNMK

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell membrane; Peripheral membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain

Homologues:

Organism=Homo sapiens, GI24307899, Length=322, Percent_Identity=27.3291925465839, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1788919, Length=296, Percent_Identity=42.9054054054054, Blast_Score=247, Evalue=7e-67,
Organism=Escherichia coli, GI87082120, Length=163, Percent_Identity=33.1288343558282, Blast_Score=75, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6323665, Length=90, Percent_Identity=34.4444444444444, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ERA_CLOB1 (A7FXK1)

Other databases:

- EMBL:   CP000726
- RefSeq:   YP_001385205.1
- ProteinModelPortal:   A7FXK1
- SMR:   A7FXK1
- STRING:   A7FXK1
- GeneID:   5396359
- GenomeReviews:   CP000726_GR
- KEGG:   cba:CLB_2909
- eggNOG:   COG1159
- HOGENOM:   HBG561652
- OMA:   AKDWQRD
- ProtClustDB:   PRK00089
- BioCyc:   CBOT441770:CLB_2909-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00367
- InterPro:   IPR005662
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:3.30.300.20
- TIGRFAMs:   TIGR00436
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1; SSF54814 KH_prok

EC number: NA

Molecular weight: Translated: 34090; Mature: 34090

Theoretical pI: Translated: 8.87; Mature: 8.87

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKSGFVTIVGRPNVGKSTLLNAIMKEKLSIVSCRPQTTRNNIQTILTEDNYQLVFVDTP
CCCCCEEEEEECCCCCHHHHHHHHHHHHHHHEECCCCCCCCCEEEEEECCCEEEEEEECC
GIHKPKHKLGEYMVKSASEAMKDVDLVLFLINPDEKPGRGDLFIIEQLKEVKVPVFLVLN
CCCCHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCEEHEEHHHHCCCCHHEEEE
KIDENPQEKVAETLKTYSELMEFEEIIPISALKGKNIDLLKELMFKYIPEGPQYYPEDMI
HHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHCCCCCCCCCCCEE
IDQNERFIVAEIVREKALRLLSEEVPHGIAVEILQMKKNEKGTYHIEGNILCEKNSHKPI
ECCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEECEEEEECCCCCCE
IIGKGGSKLKKISQYARQDIEAFLQSKVYIRLWVKVKEEWRDNQSLLKELGYKNMK
EEECCCHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEHHHHCCCHHHHHHCCCCCCC
>Mature Secondary Structure
MFKSGFVTIVGRPNVGKSTLLNAIMKEKLSIVSCRPQTTRNNIQTILTEDNYQLVFVDTP
CCCCCEEEEEECCCCCHHHHHHHHHHHHHHHEECCCCCCCCCEEEEEECCCEEEEEEECC
GIHKPKHKLGEYMVKSASEAMKDVDLVLFLINPDEKPGRGDLFIIEQLKEVKVPVFLVLN
CCCCHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCEEHEEHHHHCCCCHHEEEE
KIDENPQEKVAETLKTYSELMEFEEIIPISALKGKNIDLLKELMFKYIPEGPQYYPEDMI
HHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHCCCCCCCCCCCEE
IDQNERFIVAEIVREKALRLLSEEVPHGIAVEILQMKKNEKGTYHIEGNILCEKNSHKPI
ECCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEECEEEEECCCCCCE
IIGKGGSKLKKISQYARQDIEAFLQSKVYIRLWVKVKEEWRDNQSLLKELGYKNMK
EEECCCHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEHHHHCCCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA