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The map label for this gene is bcr [H]

Identifier: 148361151

GI number: 148361151

Start: 3383082

End: 3384281

Strand: Direct

Name: bcr [H]

Synonym: LPC_3125

Alternate gene names: 148361151

Gene position: 3383082-3384281 (Clockwise)

Preceding gene: 148361150

Following gene: 148361152

Centisome position: 94.59

GC content: 41.42

Gene sequence:

>1200_bases
ATGTTTATCCGCAACCTGCAACTTTTTATCGTTGTCGCCTCTTGCATACTGGTTTTAATTGGCACAGATATTTTGTTACC
CAGCCTGCCTAACATTGCTCACTCACTGTCTGTCTCATCAAATGAAGCCAAAATGCTCATTTCCATTTTCATGATAGGAC
AATTTTCTACAGTTCTTATTTGGGGCGTTATTGCCGACCGGCTAGGCAGAAGAAAAACATTATTTCTGGGGATGCTTATT
TTCTTTATTGGCTCAATCTTCAGTTTAAAAGCCGATTCAATTCAGTTGTTACTGGCTTGTCGATTCTTGCAAGGTACTGG
CGCAGTAGTTGTCCCTGTTGCAGGTTGGGCTTTAGTCCAGGATCTCTTCCCCAAAGACGAAGGAGCTCGCATCATGACCT
GGATTGGGACACTGACTGCAGTGATTCCACTCTTTGCCCCCGCATTAGGGGGACAATTGGATGTGTTATATGGTTGGCGC
TCAAATCTTTATTGTATCGCATTTTACTCTTTCATTTTATGCGTCATTATGCTGTTTTTACCCAGAACTATCCCTGTGCA
AAAAACGACGACTGCTGACCTGAAGGAAACACTAAGCATTTACATTCGAATTATAAAAAACAAAACATTTATTTCCTATA
TCGCACTATTTGGTTTATTAAATTGTGGTGAATGGTGCTTCCTGACAGTTGCTCCATTTTATTATTCGCATGCGCATATT
GCTGCTGACACCATGGGGATATTATTAATGATTACTTCCATGGGATTTGTCTGTGGATCTTTACTGGCCTCCCGCTTATT
TAATCGCCTGGGGATTGATAAAATCATAGCATTGGGAATTCAGTTGGCTGTAATGAGCAGCCTGATGTTGTTAATAGGAG
AATACTTTCACTGGAGCAAACACCAACTCTATAATGCCATAACTATCGGCGTCTATATTCTAAGTTCAGCCTTGCTATGG
GGCGCAACCACATCCAGAGCCTTGCAATGCTTCGATGATTGCAGAGGCTCGGCTTCTGCGATTCGTAGTTTAATCTTACT
GTGCTTCGCTGCTTTTGGTACTTATTCCGGCCGCCTGGTTAATCATAATAGCCTGTTCCCTGTTGGATTGTTCTTACTTT
TTATAGCCTTCATTGCGTTCATTGTTTTCAATAATAAGGAATTGAAAACAGAACGGCATATGGAAGGCATACCCATTTAA

Upstream 100 bases:

>100_bases
GATGCTTTAAAAAAATACTTTTTATAGAATATTTAATTAATTTTTGCTATTATTGCTGCGGATAAATACATCAAATACGT
CCTTTTCTTAAGAGTTCAAT

Downstream 100 bases:

>100_bases
CTTAAAAAGCAAATACTTAACAATATAATTCTTGACGGAACCACCATAGCTCAGCACAATGAACATAGAATTCAGGGATC
TCAATGAACTCTCTGCCCAG

Product: major facilitator superfamily transporter protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Sulfonamide resistance protein [H]

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MFIRNLQLFIVVASCILVLIGTDILLPSLPNIAHSLSVSSNEAKMLISIFMIGQFSTVLIWGVIADRLGRRKTLFLGMLI
FFIGSIFSLKADSIQLLLACRFLQGTGAVVVPVAGWALVQDLFPKDEGARIMTWIGTLTAVIPLFAPALGGQLDVLYGWR
SNLYCIAFYSFILCVIMLFLPRTIPVQKTTTADLKETLSIYIRIIKNKTFISYIALFGLLNCGEWCFLTVAPFYYSHAHI
AADTMGILLMITSMGFVCGSLLASRLFNRLGIDKIIALGIQLAVMSSLMLLIGEYFHWSKHQLYNAITIGVYILSSALLW
GATTSRALQCFDDCRGSASAIRSLILLCFAAFGTYSGRLVNHNSLFPVGLFLLFIAFIAFIVFNNKELKTERHMEGIPI

Sequences:

>Translated_399_residues
MFIRNLQLFIVVASCILVLIGTDILLPSLPNIAHSLSVSSNEAKMLISIFMIGQFSTVLIWGVIADRLGRRKTLFLGMLI
FFIGSIFSLKADSIQLLLACRFLQGTGAVVVPVAGWALVQDLFPKDEGARIMTWIGTLTAVIPLFAPALGGQLDVLYGWR
SNLYCIAFYSFILCVIMLFLPRTIPVQKTTTADLKETLSIYIRIIKNKTFISYIALFGLLNCGEWCFLTVAPFYYSHAHI
AADTMGILLMITSMGFVCGSLLASRLFNRLGIDKIIALGIQLAVMSSLMLLIGEYFHWSKHQLYNAITIGVYILSSALLW
GATTSRALQCFDDCRGSASAIRSLILLCFAAFGTYSGRLVNHNSLFPVGLFLLFIAFIAFIVFNNKELKTERHMEGIPI
>Mature_399_residues
MFIRNLQLFIVVASCILVLIGTDILLPSLPNIAHSLSVSSNEAKMLISIFMIGQFSTVLIWGVIADRLGRRKTLFLGMLI
FFIGSIFSLKADSIQLLLACRFLQGTGAVVVPVAGWALVQDLFPKDEGARIMTWIGTLTAVIPLFAPALGGQLDVLYGWR
SNLYCIAFYSFILCVIMLFLPRTIPVQKTTTADLKETLSIYIRIIKNKTFISYIALFGLLNCGEWCFLTVAPFYYSHAHI
AADTMGILLMITSMGFVCGSLLASRLFNRLGIDKIIALGIQLAVMSSLMLLIGEYFHWSKHQLYNAITIGVYILSSALLW
GATTSRALQCFDDCRGSASAIRSLILLCFAAFGTYSGRLVNHNSLFPVGLFLLFIAFIAFIVFNNKELKTERHMEGIPI

Specific function: Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance. Probable membrane translocase [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=266, Percent_Identity=26.6917293233083, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI48994889, Length=244, Percent_Identity=25.4098360655738, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790146, Length=178, Percent_Identity=30.3370786516854, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI87082312, Length=192, Percent_Identity=27.0833333333333, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1790794, Length=193, Percent_Identity=24.8704663212435, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1787065, Length=265, Percent_Identity=21.8867924528302, Blast_Score=65, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR004734 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 44178; Mature: 44178

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFIRNLQLFIVVASCILVLIGTDILLPSLPNIAHSLSVSSNEAKMLISIFMIGQFSTVLI
CCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
WGVIADRLGRRKTLFLGMLIFFIGSIFSLKADSIQLLLACRFLQGTGAVVVPVAGWALVQ
HHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEECHHHHHHH
DLFPKDEGARIMTWIGTLTAVIPLFAPALGGQLDVLYGWRSNLYCIAFYSFILCVIMLFL
HHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHC
PRTIPVQKTTTADLKETLSIYIRIIKNKTFISYIALFGLLNCGEWCFLTVAPFYYSHAHI
CCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHEEEHHHHHHHHHH
AADTMGILLMITSMGFVCGSLLASRLFNRLGIDKIIALGIQLAVMSSLMLLIGEYFHWSK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
HQLYNAITIGVYILSSALLWGATTSRALQCFDDCRGSASAIRSLILLCFAAFGTYSGRLV
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEE
NHNSLFPVGLFLLFIAFIAFIVFNNKELKTERHMEGIPI
CCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCC
>Mature Secondary Structure
MFIRNLQLFIVVASCILVLIGTDILLPSLPNIAHSLSVSSNEAKMLISIFMIGQFSTVLI
CCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
WGVIADRLGRRKTLFLGMLIFFIGSIFSLKADSIQLLLACRFLQGTGAVVVPVAGWALVQ
HHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEECHHHHHHH
DLFPKDEGARIMTWIGTLTAVIPLFAPALGGQLDVLYGWRSNLYCIAFYSFILCVIMLFL
HHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHC
PRTIPVQKTTTADLKETLSIYIRIIKNKTFISYIALFGLLNCGEWCFLTVAPFYYSHAHI
CCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHEEEHHHHHHHHHH
AADTMGILLMITSMGFVCGSLLASRLFNRLGIDKIIALGIQLAVMSSLMLLIGEYFHWSK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
HQLYNAITIGVYILSSALLWGATTSRALQCFDDCRGSASAIRSLILLCFAAFGTYSGRLV
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEE
NHNSLFPVGLFLLFIAFIAFIVFNNKELKTERHMEGIPI
CCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8486276; 9278503; 2694948 [H]