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The map label for this gene is folP [H]

Identifier: 148361107

GI number: 148361107

Start: 3325834

End: 3326709

Strand: Reverse

Name: folP [H]

Synonym: LPC_3081

Alternate gene names: 148361107

Gene position: 3326709-3325834 (Counterclockwise)

Preceding gene: 148361108

Following gene: 148361106

Centisome position: 93.02

GC content: 40.07

Gene sequence:

>876_bases
GTGAATTCTGAACAGTTCCTCGGTTGGCTTGAGCGAAAGAGCCAACCTGCTTCTTCCTTGGTTTTTGAAAAGCCGTTAAT
TATGGGTGTGCTAAATGTTACCTCTGATTCATTTTATGATGGTGGCAAGTATCTGTCTGTGGATAGAGCTTATGAGCAAG
CCATACAATTAATTGCATGTGGAGCTGATCTCATTGATATTGGTGGGGAATCAACCAAACCCGGTGCTCCGCCAGTCCCT
TTAGATGTTGAACTATCAAGAGTTCTTCCCATAATCAAACAACTTCGTGCGTTCACAGATGTGTGTATTTCTATTGATAC
AAATAAGCCAGAAGTGATGGAAGCGGCAATTAATGCTGGTGCGCATGTTATAAATGATGTTTATGCTTTAAGAAGGGATG
GTGCTCTGAATGTTGCTGCACAATTAGATGTTCCTGTCTGTTTAATGCACATGAAAGGAGAGCCGCGAACCATGCAAGAA
AATCCTTCTTACCCAGAAGGGATAATGAAGGAATTACAGCATTTTTTTGAAGAACGCATCGATAAATGCCAGAAAGCCGG
GCTGAATAGGAATAAATTAATTCTTGACCCTGGCTTTGGTTTTGGAAAGCGCGTTCAAGATAACCTACAATTAATTTATC
ATCTGAACGAATTGCATTCTTTTGGATTGCCAATTCTTTTGGGCGTTTCACGCAAAAGCACAATTGGTGCCGTGTTGAAT
ACTGAGGTTGAACAACGTTTGATTGGAAGTATTACGCTAGGGATATATGCGGCTCTTAAAGGCACTGCAATTATCAGGAC
ACATGATGTAGATGAAACGAATCAAGCATTAACTATGATTAATGCAATTTATCAAGCTGCTAAAGAAATCAGTTAA

Upstream 100 bases:

>100_bases
CAGTTAATGATGCTCCTGCAAAACCTATTAATGGTGAAACAATAGAAAATCCGGCAGAAGGGCATTAATTTTATCAGTAG
CTATTTATCGAGAGTACCCT

Downstream 100 bases:

>100_bases
TAGCTCATGAGATGATCAGAAGATGACTGAGACTGGAAAAATTAAATAATAAGGTAGGTAAGGATGAGTCAACGTAAATA
TTTTGGTACGGATGGAATAC

Product: 7,8-dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MNSEQFLGWLERKSQPASSLVFEKPLIMGVLNVTSDSFYDGGKYLSVDRAYEQAIQLIACGADLIDIGGESTKPGAPPVP
LDVELSRVLPIIKQLRAFTDVCISIDTNKPEVMEAAINAGAHVINDVYALRRDGALNVAAQLDVPVCLMHMKGEPRTMQE
NPSYPEGIMKELQHFFEERIDKCQKAGLNRNKLILDPGFGFGKRVQDNLQLIYHLNELHSFGLPILLGVSRKSTIGAVLN
TEVEQRLIGSITLGIYAALKGTAIIRTHDVDETNQALTMINAIYQAAKEIS

Sequences:

>Translated_291_residues
MNSEQFLGWLERKSQPASSLVFEKPLIMGVLNVTSDSFYDGGKYLSVDRAYEQAIQLIACGADLIDIGGESTKPGAPPVP
LDVELSRVLPIIKQLRAFTDVCISIDTNKPEVMEAAINAGAHVINDVYALRRDGALNVAAQLDVPVCLMHMKGEPRTMQE
NPSYPEGIMKELQHFFEERIDKCQKAGLNRNKLILDPGFGFGKRVQDNLQLIYHLNELHSFGLPILLGVSRKSTIGAVLN
TEVEQRLIGSITLGIYAALKGTAIIRTHDVDETNQALTMINAIYQAAKEIS
>Mature_291_residues
MNSEQFLGWLERKSQPASSLVFEKPLIMGVLNVTSDSFYDGGKYLSVDRAYEQAIQLIACGADLIDIGGESTKPGAPPVP
LDVELSRVLPIIKQLRAFTDVCISIDTNKPEVMEAAINAGAHVINDVYALRRDGALNVAAQLDVPVCLMHMKGEPRTMQE
NPSYPEGIMKELQHFFEERIDKCQKAGLNRNKLILDPGFGFGKRVQDNLQLIYHLNELHSFGLPILLGVSRKSTIGAVLN
TEVEQRLIGSITLGIYAALKGTAIIRTHDVDETNQALTMINAIYQAAKEIS

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=269, Percent_Identity=47.2118959107807, Blast_Score=266, Evalue=2e-72,
Organism=Saccharomyces cerevisiae, GI6324073, Length=316, Percent_Identity=27.2151898734177, Blast_Score=112, Evalue=9e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 32019; Mature: 32019

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSEQFLGWLERKSQPASSLVFEKPLIMGVLNVTSDSFYDGGKYLSVDRAYEQAIQLIAC
CCCHHHHHHHHHCCCCHHHHHHHCHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHC
GADLIDIGGESTKPGAPPVPLDVELSRVLPIIKQLRAFTDVCISIDTNKPEVMEAAINAG
CCHHEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHCC
AHVINDVYALRRDGALNVAAQLDVPVCLMHMKGEPRTMQENPSYPEGIMKELQHFFEERI
HHHHHHHHHHHCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
DKCQKAGLNRNKLILDPGFGFGKRVQDNLQLIYHLNELHSFGLPILLGVSRKSTIGAVLN
HHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHH
TEVEQRLIGSITLGIYAALKGTAIIRTHDVDETNQALTMINAIYQAAKEIS
HHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNSEQFLGWLERKSQPASSLVFEKPLIMGVLNVTSDSFYDGGKYLSVDRAYEQAIQLIAC
CCCHHHHHHHHHCCCCHHHHHHHCHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHC
GADLIDIGGESTKPGAPPVPLDVELSRVLPIIKQLRAFTDVCISIDTNKPEVMEAAINAG
CCHHEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHCC
AHVINDVYALRRDGALNVAAQLDVPVCLMHMKGEPRTMQENPSYPEGIMKELQHFFEERI
HHHHHHHHHHHCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
DKCQKAGLNRNKLILDPGFGFGKRVQDNLQLIYHLNELHSFGLPILLGVSRKSTIGAVLN
HHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHH
TEVEQRLIGSITLGIYAALKGTAIIRTHDVDETNQALTMINAIYQAAKEIS
HHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]