Click here to switch to the map view.

The map label for this gene is fabFc [H]

Identifier: 148361023

GI number: 148361023

Start: 454572

End: 455864

Strand: Direct

Name: fabFc [H]

Synonym: LPC_2983

Alternate gene names: 148361023

Gene position: 454572-455864 (Clockwise)

Preceding gene: 148361024

Following gene: 148361022

Centisome position: 12.71

GC content: 44.01

Gene sequence:

>1293_bases
ATGAAACGACGAGTTGCTATTACAGGTCTAGGGGTTGTTTCGCCTCTAGGAAATGATGTATCCACCACTTGGAACAATTT
GATCGCCGGCTATTCTGGCATAGATAGTATCAAGCAGTTTGATGCCAGTGCTTTTCCTACCACTATTGCTGCTGAAGTAA
AGAACTTTTCACCTGATACGTCTATTTCGGGAAAGCATACACGATTTATCATGTCTTTTACTCATTTTGCATTGGAAGCT
GCACGCCAGGCTTTTGAGGATGCTTCTATCTTCCCTACCAAGCAAACATCCGATCGGTGGGGAATTGTAACAGGCAGTGG
GATGATGACGGCCGAGTTTGAGTATTTAACGCGGTTTCAACAAACTTGTGCTGCAGACGGTGAAATTGATTGGGGAAAGC
TGCAATCTAATAGCAGGGATTTCTATAATTTGGTTGATTTTGGTAAAACCACTTCAAACTCTGGTCTTTCCTTATTAATA
CAACAATATGGGATTACTGGTTATGCCTCTTCTGTCCATACGGCCTGCGCTTCAGGAGGCCAAGCCTTGGGATTGGCAAT
GCAGGTGATTCGTCGTGGCGAGGCAGATTTTATGTTGGCAGGTGGATTTGATTCCATGATTAATCCTTTGGGTTTGTCGA
GTTTTTGTCTTTTGGGTGCCTTATCAACTTATAATGAGACTCCGCAAACGGCAAGTCGCCCCTTTGATGCGACACGCAAT
GGTTTTGTCCTGGGTGAAGGAGCTGCCTTTTTGATCCTTGAAGAATGGAGTAAAGCAAAAGCTCGTGGGGCAAAAATCTA
TGCTGAACTGGCTGGAGAGGGGAATTCTTTGAGCTCCTACCGAATAACTGATTCACATCCCAACGGCGATGGTGCTATTC
AAGCGATTAAACGTGCGTTGGAAGATGCCGGGGTTCAACCACGGGATGTCGATTATATTAACGCGCATGGTACATCCACT
AAAATGAATGATTTAAGTGAAACCAATGCAATCAAAGTTGTCTTCGGGGATAGGATCGCCAATTTACCTGTTAGCTCTAC
CAAAAGCCAAACGGGGCATTTAATCGCAGCGGCGGGAGCACTTGAAGCGGTATTGTCAGTTAAATCCATAGAACAGGCGC
AAGTCCCCAAAACAGCGAATTTAAAAACACCTGATCCGGAGTGTGATTTGGATTATGTTGTTGATGGCCCACGTGAAAAA
TCTTTAGGGGTAGTATTATCTAATTCGTTTGGTTTTGGAGGTTCTAATAGCTGCTTGTTATTTAAACATCCAGAATTCGA
GGAGGCAAAATAA

Upstream 100 bases:

>100_bases
CAAATGGATGATGAATTAATACTGTCTTATAGGTGTGAGGTTGATGGCAAGCGGGTATGTGTTGTCGACATAGTGCTTAT
CCCAAAAGGTAAATGAGGTT

Downstream 100 bases:

>100_bases
ATGAGTCAAGCGAATAGAGTATTTATTACTGGTCGCAGCGCTCTAACTGCCTCTGGTGCAACAGCTGATGAAACTTGGAA
TGCAATCATTTCTGGCCAGT

Product: 3-oxoacyl-(acyl carrier protein) synthase II, C- terminal

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MKRRVAITGLGVVSPLGNDVSTTWNNLIAGYSGIDSIKQFDASAFPTTIAAEVKNFSPDTSISGKHTRFIMSFTHFALEA
ARQAFEDASIFPTKQTSDRWGIVTGSGMMTAEFEYLTRFQQTCAADGEIDWGKLQSNSRDFYNLVDFGKTTSNSGLSLLI
QQYGITGYASSVHTACASGGQALGLAMQVIRRGEADFMLAGGFDSMINPLGLSSFCLLGALSTYNETPQTASRPFDATRN
GFVLGEGAAFLILEEWSKAKARGAKIYAELAGEGNSLSSYRITDSHPNGDGAIQAIKRALEDAGVQPRDVDYINAHGTST
KMNDLSETNAIKVVFGDRIANLPVSSTKSQTGHLIAAAGALEAVLSVKSIEQAQVPKTANLKTPDPECDLDYVVDGPREK
SLGVVLSNSFGFGGSNSCLLFKHPEFEEAK

Sequences:

>Translated_430_residues
MKRRVAITGLGVVSPLGNDVSTTWNNLIAGYSGIDSIKQFDASAFPTTIAAEVKNFSPDTSISGKHTRFIMSFTHFALEA
ARQAFEDASIFPTKQTSDRWGIVTGSGMMTAEFEYLTRFQQTCAADGEIDWGKLQSNSRDFYNLVDFGKTTSNSGLSLLI
QQYGITGYASSVHTACASGGQALGLAMQVIRRGEADFMLAGGFDSMINPLGLSSFCLLGALSTYNETPQTASRPFDATRN
GFVLGEGAAFLILEEWSKAKARGAKIYAELAGEGNSLSSYRITDSHPNGDGAIQAIKRALEDAGVQPRDVDYINAHGTST
KMNDLSETNAIKVVFGDRIANLPVSSTKSQTGHLIAAAGALEAVLSVKSIEQAQVPKTANLKTPDPECDLDYVVDGPREK
SLGVVLSNSFGFGGSNSCLLFKHPEFEEAK
>Mature_430_residues
MKRRVAITGLGVVSPLGNDVSTTWNNLIAGYSGIDSIKQFDASAFPTTIAAEVKNFSPDTSISGKHTRFIMSFTHFALEA
ARQAFEDASIFPTKQTSDRWGIVTGSGMMTAEFEYLTRFQQTCAADGEIDWGKLQSNSRDFYNLVDFGKTTSNSGLSLLI
QQYGITGYASSVHTACASGGQALGLAMQVIRRGEADFMLAGGFDSMINPLGLSSFCLLGALSTYNETPQTASRPFDATRN
GFVLGEGAAFLILEEWSKAKARGAKIYAELAGEGNSLSSYRITDSHPNGDGAIQAIKRALEDAGVQPRDVDYINAHGTST
KMNDLSETNAIKVVFGDRIANLPVSSTKSQTGHLIAAAGALEAVLSVKSIEQAQVPKTANLKTPDPECDLDYVVDGPREK
SLGVVLSNSFGFGGSNSCLLFKHPEFEEAK

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=431, Percent_Identity=38.2830626450116, Blast_Score=264, Evalue=2e-70,
Organism=Homo sapiens, GI223972627, Length=142, Percent_Identity=46.4788732394366, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI41872631, Length=433, Percent_Identity=28.175519630485, Blast_Score=122, Evalue=9e-28,
Organism=Escherichia coli, GI1787337, Length=422, Percent_Identity=41.7061611374408, Blast_Score=293, Evalue=1e-80,
Organism=Escherichia coli, GI1788663, Length=428, Percent_Identity=34.5794392523364, Blast_Score=201, Evalue=6e-53,
Organism=Caenorhabditis elegans, GI71983541, Length=427, Percent_Identity=29.9765807962529, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI71983535, Length=264, Percent_Identity=34.8484848484849, Blast_Score=165, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI212642053, Length=385, Percent_Identity=28.5714285714286, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17550940, Length=260, Percent_Identity=29.2307692307692, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320904, Length=459, Percent_Identity=32.8976034858388, Blast_Score=206, Evalue=4e-54,
Organism=Drosophila melanogaster, GI24644341, Length=435, Percent_Identity=38.3908045977011, Blast_Score=273, Evalue=2e-73,
Organism=Drosophila melanogaster, GI221330659, Length=443, Percent_Identity=26.1851015801354, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI19920632, Length=443, Percent_Identity=26.1851015801354, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24581345, Length=444, Percent_Identity=24.3243243243243, Blast_Score=106, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 45958; Mature: 45958

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRRVAITGLGVVSPLGNDVSTTWNNLIAGYSGIDSIKQFDASAFPTTIAAEVKNFSPDT
CCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHCCCCCC
SISGKHTRFIMSFTHFALEAARQAFEDASIFPTKQTSDRWGIVTGSGMMTAEFEYLTRFQ
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCEEHHHHHHHHHH
QTCAADGEIDWGKLQSNSRDFYNLVDFGKTTSNSGLSLLIQQYGITGYASSVHTACASGG
HHHCCCCCCCHHHCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCC
QALGLAMQVIRRGEADFMLAGGFDSMINPLGLSSFCLLGALSTYNETPQTASRPFDATRN
HHHHHHHHHHHCCCCCEEEECCHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
GFVLGEGAAFLILEEWSKAKARGAKIYAELAGEGNSLSSYRITDSHPNGDGAIQAIKRAL
CEEEECCCEEEEEECHHHHHHCCCEEEEEECCCCCCCCEEEEECCCCCCCHHHHHHHHHH
EDAGVQPRDVDYINAHGTSTKMNDLSETNAIKVVFGDRIANLPVSSTKSQTGHLIAAAGA
HHCCCCCCCCCEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEHHH
LEAVLSVKSIEQAQVPKTANLKTPDPECDLDYVVDGPREKSLGVVLSNSFGFGGSNSCLL
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCCCCCCEEEEECCCCCCCCCCEEE
FKHPEFEEAK
EECCCCCCCC
>Mature Secondary Structure
MKRRVAITGLGVVSPLGNDVSTTWNNLIAGYSGIDSIKQFDASAFPTTIAAEVKNFSPDT
CCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHCCCCCC
SISGKHTRFIMSFTHFALEAARQAFEDASIFPTKQTSDRWGIVTGSGMMTAEFEYLTRFQ
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCEEHHHHHHHHHH
QTCAADGEIDWGKLQSNSRDFYNLVDFGKTTSNSGLSLLIQQYGITGYASSVHTACASGG
HHHCCCCCCCHHHCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCC
QALGLAMQVIRRGEADFMLAGGFDSMINPLGLSSFCLLGALSTYNETPQTASRPFDATRN
HHHHHHHHHHHCCCCCEEEECCHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
GFVLGEGAAFLILEEWSKAKARGAKIYAELAGEGNSLSSYRITDSHPNGDGAIQAIKRAL
CEEEECCCEEEEEECHHHHHHCCCEEEEEECCCCCCCCEEEEECCCCCCCHHHHHHHHHH
EDAGVQPRDVDYINAHGTSTKMNDLSETNAIKVVFGDRIANLPVSSTKSQTGHLIAAAGA
HHCCCCCCCCCEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEHHH
LEAVLSVKSIEQAQVPKTANLKTPDPECDLDYVVDGPREKSLGVVLSNSFGFGGSNSCLL
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCCCCCCEEEEECCCCCCCCCCEEE
FKHPEFEEAK
EECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]