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The map label for this gene is fabFn [H]

Identifier: 148361022

GI number: 148361022

Start: 455865

End: 457142

Strand: Direct

Name: fabFn [H]

Synonym: LPC_2982

Alternate gene names: 148361022

Gene position: 455865-457142 (Clockwise)

Preceding gene: 148361023

Following gene: 148361021

Centisome position: 12.75

GC content: 41.31

Gene sequence:

>1278_bases
ATGAGTCAAGCGAATAGAGTATTTATTACTGGTCGCAGCGCTCTAACTGCCTCTGGTGCAACAGCTGATGAAACTTGGAA
TGCAATCATTTCTGGCCAGTGTGGAATAGATGAAATTAATTTTTGGGAATTATCTGAATGGTCGCATCGTTTGGGCGGGG
AAATAAAAGATTTCCAACCTTCCAAGATGCTTCCTGATAGAAAATTAATAAAAGTTATTTCTCGTCAAGATATAATGGGA
ATCAATGCGGCAGTGCAAGCTGTTGAGCACAGTAAAATGATTGCTTACAGAGATAGCCTGGCAGATGCTGATTTATTTAA
TGAACAAACCGCCATTTATGTTGGTTCTCCAGGGAATAAGTATTTTCAACAATATGACTTTATACCTTTGTTGGCCAAAA
CCCATGGAGATATGCGTAGCTTTGCAAATCAGTTGTTTGATGAAGTGCATCCTATGTGGTTATTGAGGATTTTACCTAAT
AATGTGCTTGCCTATACAGGTATTACCTATGGCTTTAAAGGTCCAAATCACAATGTAACGAATCATGCGGTAGGTGGTAC
ACAAGCGATTTTGGAAGCGTACCATGCCATACGTAGCGGGCAGGCAGAACGCGCGGTTGTGGTTGCCTATGATATAGGCA
CAGAACCTCAAGGCTTATTTTATTATGAAAAATTGGGTGTGGTAAGTAATCGTCATTTAAAACCTTTTGATAAAGAGCAT
GACGGTACCATTCTTGCTGAAGGTGCTGCGGCCCTTGTATTGGAAAGTGAAGCCAGTGTGAAGTCTAGGGCTGCGACTTG
TTATGGCGAGATAGTTGGTGGTTTATCCGCTTCTGAAGCAACAGGATTATTTTCTATTGAAGCAGATGGGCAACATTTGG
CTTCATTGATGAGGCAGACATTAAGCACATCAGGAATAAGTTCTGAGGAAATAGGGTTAATAGTAACCCATGGTAATGGA
AACAGTAAATCAGATGACAGTGAAGCTCTGGCTATCAAATCAGTATTCAAACAAGAAGAAGTTCCTGCGACCGCTTTTAA
ATGGTCCATGGGACATACTTTATGCGCCTCTGGAGTATTGGATGCGGTATTAACTACATATGCCCTTGAAACCAAATGCG
TGCCGGGGATCGCTAATTTTCAACAAATTGCCCCGACGTGTGAAGGCTTGTCAGTAAGTCGTGAGCATAGAGAGACAATA
TCTAATTCCTATGCCATGATGATCAACCGAGGGTTTGCCAGTATGAATGTATGTTTGGTGATCAAAGCTTGTGAATAA

Upstream 100 bases:

>100_bases
TGAAAAATCTTTAGGGGTAGTATTATCTAATTCGTTTGGTTTTGGAGGTTCTAATAGCTGCTTGTTATTTAAACATCCAG
AATTCGAGGAGGCAAAATAA

Downstream 100 bases:

>100_bases
TTTAGCTCAACAAATAGAAGCATTACCCATTACACTGGCGGGACGTTTTATTTATCGGTTTTTGCCATACAGGCGCCGGT
TGATTTTTTCCAATATTAGC

Product: 3-oxoacyl-(acyl carrier protein) synthase II, N- terminal

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MSQANRVFITGRSALTASGATADETWNAIISGQCGIDEINFWELSEWSHRLGGEIKDFQPSKMLPDRKLIKVISRQDIMG
INAAVQAVEHSKMIAYRDSLADADLFNEQTAIYVGSPGNKYFQQYDFIPLLAKTHGDMRSFANQLFDEVHPMWLLRILPN
NVLAYTGITYGFKGPNHNVTNHAVGGTQAILEAYHAIRSGQAERAVVVAYDIGTEPQGLFYYEKLGVVSNRHLKPFDKEH
DGTILAEGAAALVLESEASVKSRAATCYGEIVGGLSASEATGLFSIEADGQHLASLMRQTLSTSGISSEEIGLIVTHGNG
NSKSDDSEALAIKSVFKQEEVPATAFKWSMGHTLCASGVLDAVLTTYALETKCVPGIANFQQIAPTCEGLSVSREHRETI
SNSYAMMINRGFASMNVCLVIKACE

Sequences:

>Translated_425_residues
MSQANRVFITGRSALTASGATADETWNAIISGQCGIDEINFWELSEWSHRLGGEIKDFQPSKMLPDRKLIKVISRQDIMG
INAAVQAVEHSKMIAYRDSLADADLFNEQTAIYVGSPGNKYFQQYDFIPLLAKTHGDMRSFANQLFDEVHPMWLLRILPN
NVLAYTGITYGFKGPNHNVTNHAVGGTQAILEAYHAIRSGQAERAVVVAYDIGTEPQGLFYYEKLGVVSNRHLKPFDKEH
DGTILAEGAAALVLESEASVKSRAATCYGEIVGGLSASEATGLFSIEADGQHLASLMRQTLSTSGISSEEIGLIVTHGNG
NSKSDDSEALAIKSVFKQEEVPATAFKWSMGHTLCASGVLDAVLTTYALETKCVPGIANFQQIAPTCEGLSVSREHRETI
SNSYAMMINRGFASMNVCLVIKACE
>Mature_424_residues
SQANRVFITGRSALTASGATADETWNAIISGQCGIDEINFWELSEWSHRLGGEIKDFQPSKMLPDRKLIKVISRQDIMGI
NAAVQAVEHSKMIAYRDSLADADLFNEQTAIYVGSPGNKYFQQYDFIPLLAKTHGDMRSFANQLFDEVHPMWLLRILPNN
VLAYTGITYGFKGPNHNVTNHAVGGTQAILEAYHAIRSGQAERAVVVAYDIGTEPQGLFYYEKLGVVSNRHLKPFDKEHD
GTILAEGAAALVLESEASVKSRAATCYGEIVGGLSASEATGLFSIEADGQHLASLMRQTLSTSGISSEEIGLIVTHGNGN
SKSDDSEALAIKSVFKQEEVPATAFKWSMGHTLCASGVLDAVLTTYALETKCVPGIANFQQIAPTCEGLSVSREHRETIS
NSYAMMINRGFASMNVCLVIKACE

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=394, Percent_Identity=26.6497461928934, Blast_Score=114, Evalue=1e-25,
Organism=Escherichia coli, GI1787337, Length=425, Percent_Identity=27.0588235294118, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI1788663, Length=444, Percent_Identity=21.8468468468468, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71983541, Length=447, Percent_Identity=21.4765100671141, Blast_Score=101, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI71983535, Length=262, Percent_Identity=22.9007633587786, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI212642053, Length=280, Percent_Identity=24.6428571428571, Blast_Score=78, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6320904, Length=455, Percent_Identity=22.8571428571429, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24644341, Length=441, Percent_Identity=25.8503401360544, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI221330659, Length=264, Percent_Identity=23.1060606060606, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI19920632, Length=264, Percent_Identity=23.1060606060606, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24581345, Length=244, Percent_Identity=25, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 46155; Mature: 46023

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQANRVFITGRSALTASGATADETWNAIISGQCGIDEINFWELSEWSHRLGGEIKDFQP
CCCCCEEEEECCCEEEECCCCCCCCCHHEEECCCCCCCCCCEEHHHHHHHHCCCCCCCCC
SKMLPDRKLIKVISRQDIMGINAAVQAVEHSKMIAYRDSLADADLFNEQTAIYVGSPGNK
CCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCEEEEEECCCHH
YFQQYDFIPLLAKTHGDMRSFANQLFDEVHPMWLLRILPNNVLAYTGITYGFKGPNHNVT
HHHHCCCCHHHHHCCCHHHHHHHHHHHHHCHHHEEHHCCCCEEEECCEEECCCCCCCCCC
NHAVGGTQAILEAYHAIRSGQAERAVVVAYDIGTEPQGLFYYEKLGVVSNRHLKPFDKEH
CCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCEEEEEHHCCCCCCCCCCCCCCC
DGTILAEGAAALVLESEASVKSRAATCYGEIVGGLSASEATGLFSIEADGQHLASLMRQT
CCEEEECCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCHHHHHHHHHHH
LSTSGISSEEIGLIVTHGNGNSKSDDSEALAIKSVFKQEEVPATAFKWSMGHTLCASGVL
HHHCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCHHEEECCCHHHHHHHHH
DAVLTTYALETKCVPGIANFQQIAPTCEGLSVSREHRETISNSYAMMINRGFASMNVCLV
HHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHCCEEEEEECCCCCCEEEEE
IKACE
EEECC
>Mature Secondary Structure 
SQANRVFITGRSALTASGATADETWNAIISGQCGIDEINFWELSEWSHRLGGEIKDFQP
CCCCEEEEECCCEEEECCCCCCCCCHHEEECCCCCCCCCCEEHHHHHHHHCCCCCCCCC
SKMLPDRKLIKVISRQDIMGINAAVQAVEHSKMIAYRDSLADADLFNEQTAIYVGSPGNK
CCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCEEEEEECCCHH
YFQQYDFIPLLAKTHGDMRSFANQLFDEVHPMWLLRILPNNVLAYTGITYGFKGPNHNVT
HHHHCCCCHHHHHCCCHHHHHHHHHHHHHCHHHEEHHCCCCEEEECCEEECCCCCCCCCC
NHAVGGTQAILEAYHAIRSGQAERAVVVAYDIGTEPQGLFYYEKLGVVSNRHLKPFDKEH
CCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCEEEEEHHCCCCCCCCCCCCCCC
DGTILAEGAAALVLESEASVKSRAATCYGEIVGGLSASEATGLFSIEADGQHLASLMRQT
CCEEEECCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCHHHHHHHHHHH
LSTSGISSEEIGLIVTHGNGNSKSDDSEALAIKSVFKQEEVPATAFKWSMGHTLCASGVL
HHHCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCHHEEECCCHHHHHHHHH
DAVLTTYALETKCVPGIANFQQIAPTCEGLSVSREHRETISNSYAMMINRGFASMNVCLV
HHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHCCEEEEEECCCCCCEEEEE
IKACE
EEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231; 11152607 [H]