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The map label for this gene is ggt [H]

Identifier: 148360796

GI number: 148360796

Start: 679676

End: 681400

Strand: Direct

Name: ggt [H]

Synonym: LPC_2751

Alternate gene names: 148360796

Gene position: 679676-681400 (Clockwise)

Preceding gene: 148360797

Following gene: 148360787

Centisome position: 19.0

GC content: 41.39

Gene sequence:

>1725_bases
ATGAAAGATCATTATAAATGGCTGAGTTGTTTATTTTTTTTAATTTGTAATATTTATCAGGTTAATGCAAAAACATTTCC
GCAACACCCGCCTGGATATGCTGTAGCAAGTGCCCACCCTTTGGCAACTCATGCCGGTTTAGAGATTTTGGCGGCAGGAG
GAAATGCTTTTGATGCTGCAGTTGCGGTAGCTGCTGCCCTGGCAGTAGTCGAGCCATATCATTCGGGACTTGGAGGAGGA
GGTTTTTGGCTACTTCATCAAGAAAAGGAACATTTAAACCTCTTTATTGATGGCAGGGAGGTAGCTCCTCTGGCCGCAAG
TAAGGATATGTATTTGGCTCCTGATGGCCAAGTGATTCCCGGCCTTTCTCTAAATGGTGGTTTATCTGCGGCCATACCTG
GACAGCCAGCTGCCCTGGTTTATATAGCCAAGAACTATGGACGTCTTCCGCTTAGCAAGACATTAGCTCCAGCTATTAAG
CTTGCGGAAGAGGGTTTTCCTGTAGATCCTCAATTTCGTTATTTCTCCACTCTGGATGATAGATTGGAAAACTTGAAGAA
ATATCCCGATACCGCCGCTATTTTTTTAAAGAATGGTCAGCCTTTTGAAATTGGAGAAAAACTTGTTCAAAAAGATTTGG
CAAAAACACTCAGATTGATAGCCAAGTACGGAAATGCCGGATTTTATTCAGGAGAAACGGCTTCTCTGCTAGTTCAAGGT
GTCAATGCGGCAGGTGGAATTTGGTCTCTTGATGATCTGGCTCAATATAAAATTAAAGTGAGGCCACCTTTAATTAGTGC
TTATCATAATATGTTAATTATCACAGCTCCTCTGCCTTCGGCCGGTGGAGTGGCATTGGTAACCATGCTCAATATATTAT
CCAAATTTCCTTTGTCTTCATTTCCCAAATTAAAATGGGTTCATTACGTCGTTGAATCGATGAGATTGGCTTATTGGCAA
AGAGATCAATTTCTGGGTGATCCTGATTTTATTAAGGTTCCACTTGATAAATTGATTTCCTCGGATAATGCGAAACAATT
AAGCCGCTTGATTTCACCAAATAAAGCGATTGATAGTAAAGTCTTGCAAGGCTCAGTTCCGACGGGAAAACACTCAAATA
CCTCACATATTTCGATTATTGATACGGAAGGAAATCGTGTTGCTGCAACAATGACAATTAATTACATTTTTGGCTCCAGC
GTAGTTGCGAAGGGAACAGGGGTATTATTAAATGATGAAATGGACGATTTTTCTACTAAAGTGGGTGAGCAAAATGTCTT
TGGTTTAGTGGGAAGTGAGCGCAATGCCATTGAACCAAGAAAAAGGCCGCTATCCAGCATGGCTCCAACCTTCCTGGAGA
TGCCAGGGCGTGTAGCTATCCTGGGGACTCCTGGAGGAAGCCGTATTCCTACTATGGTTTTACTTGCCTCACTATTATTT
TATGATGGGTATGGAGCTATCAGTATGGTTTCAGCCATGCGATTTCATCATCAATATTTACCAGATGTTTTGCAATTTGA
GCCTGATACTTTCCCAAGTTCAATTCAACAGGGTTTACAAGCTATGGGATACCATTTAATGCCATTGAAACAATATTATG
GAGATATGCAAGCCATTACATGGGACAAAGAAAGTAATGTCTTAACGGCTGCTTCTGATCCAAGACATATTGGTTTAGCT
GCTGCGATATCTAATATGGCATATGGGTATGGGGTTAATTACTAG

Upstream 100 bases:

>100_bases
TATATCTCATCCACTTTAGTTCGTGAAATTGCAGCCTTAAATGGTGATATTTCTCAATTTGTTCCGCCCAATGTAGTTAG
AGAATTAAAAAAGAGACAAA

Downstream 100 bases:

>100_bases
AATACATTTTTAAAATGAATCGGCCAGCTACACTTGGTGCGTAAATTGTTAGTGCTGAATAAAGCAATCAAAATCAATAT
TTGTTTTATGATTTTTGTTA

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 574; Mature: 574

Protein sequence:

>574_residues
MKDHYKWLSCLFFLICNIYQVNAKTFPQHPPGYAVASAHPLATHAGLEILAAGGNAFDAAVAVAAALAVVEPYHSGLGGG
GFWLLHQEKEHLNLFIDGREVAPLAASKDMYLAPDGQVIPGLSLNGGLSAAIPGQPAALVYIAKNYGRLPLSKTLAPAIK
LAEEGFPVDPQFRYFSTLDDRLENLKKYPDTAAIFLKNGQPFEIGEKLVQKDLAKTLRLIAKYGNAGFYSGETASLLVQG
VNAAGGIWSLDDLAQYKIKVRPPLISAYHNMLIITAPLPSAGGVALVTMLNILSKFPLSSFPKLKWVHYVVESMRLAYWQ
RDQFLGDPDFIKVPLDKLISSDNAKQLSRLISPNKAIDSKVLQGSVPTGKHSNTSHISIIDTEGNRVAATMTINYIFGSS
VVAKGTGVLLNDEMDDFSTKVGEQNVFGLVGSERNAIEPRKRPLSSMAPTFLEMPGRVAILGTPGGSRIPTMVLLASLLF
YDGYGAISMVSAMRFHHQYLPDVLQFEPDTFPSSIQQGLQAMGYHLMPLKQYYGDMQAITWDKESNVLTAASDPRHIGLA
AAISNMAYGYGVNY

Sequences:

>Translated_574_residues
MKDHYKWLSCLFFLICNIYQVNAKTFPQHPPGYAVASAHPLATHAGLEILAAGGNAFDAAVAVAAALAVVEPYHSGLGGG
GFWLLHQEKEHLNLFIDGREVAPLAASKDMYLAPDGQVIPGLSLNGGLSAAIPGQPAALVYIAKNYGRLPLSKTLAPAIK
LAEEGFPVDPQFRYFSTLDDRLENLKKYPDTAAIFLKNGQPFEIGEKLVQKDLAKTLRLIAKYGNAGFYSGETASLLVQG
VNAAGGIWSLDDLAQYKIKVRPPLISAYHNMLIITAPLPSAGGVALVTMLNILSKFPLSSFPKLKWVHYVVESMRLAYWQ
RDQFLGDPDFIKVPLDKLISSDNAKQLSRLISPNKAIDSKVLQGSVPTGKHSNTSHISIIDTEGNRVAATMTINYIFGSS
VVAKGTGVLLNDEMDDFSTKVGEQNVFGLVGSERNAIEPRKRPLSSMAPTFLEMPGRVAILGTPGGSRIPTMVLLASLLF
YDGYGAISMVSAMRFHHQYLPDVLQFEPDTFPSSIQQGLQAMGYHLMPLKQYYGDMQAITWDKESNVLTAASDPRHIGLA
AAISNMAYGYGVNY
>Mature_574_residues
MKDHYKWLSCLFFLICNIYQVNAKTFPQHPPGYAVASAHPLATHAGLEILAAGGNAFDAAVAVAAALAVVEPYHSGLGGG
GFWLLHQEKEHLNLFIDGREVAPLAASKDMYLAPDGQVIPGLSLNGGLSAAIPGQPAALVYIAKNYGRLPLSKTLAPAIK
LAEEGFPVDPQFRYFSTLDDRLENLKKYPDTAAIFLKNGQPFEIGEKLVQKDLAKTLRLIAKYGNAGFYSGETASLLVQG
VNAAGGIWSLDDLAQYKIKVRPPLISAYHNMLIITAPLPSAGGVALVTMLNILSKFPLSSFPKLKWVHYVVESMRLAYWQ
RDQFLGDPDFIKVPLDKLISSDNAKQLSRLISPNKAIDSKVLQGSVPTGKHSNTSHISIIDTEGNRVAATMTINYIFGSS
VVAKGTGVLLNDEMDDFSTKVGEQNVFGLVGSERNAIEPRKRPLSSMAPTFLEMPGRVAILGTPGGSRIPTMVLLASLLF
YDGYGAISMVSAMRFHHQYLPDVLQFEPDTFPSSIQQGLQAMGYHLMPLKQYYGDMQAITWDKESNVLTAASDPRHIGLA
AAISNMAYGYGVNY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=537, Percent_Identity=31.4711359404097, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI73915090, Length=537, Percent_Identity=31.4711359404097, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI73915096, Length=537, Percent_Identity=31.4711359404097, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI73915094, Length=537, Percent_Identity=31.4711359404097, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI113429326, Length=532, Percent_Identity=30.0751879699248, Blast_Score=193, Evalue=4e-49,
Organism=Homo sapiens, GI113429324, Length=527, Percent_Identity=30.1707779886148, Blast_Score=192, Evalue=6e-49,
Organism=Homo sapiens, GI109148539, Length=585, Percent_Identity=29.4017094017094, Blast_Score=146, Evalue=6e-35,
Organism=Homo sapiens, GI153266885, Length=563, Percent_Identity=26.8206039076377, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI153266901, Length=565, Percent_Identity=26.9026548672566, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI153266907, Length=563, Percent_Identity=25.5772646536412, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI30581157, Length=188, Percent_Identity=36.1702127659575, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI30581155, Length=188, Percent_Identity=36.1702127659575, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI218505805, Length=191, Percent_Identity=34.5549738219895, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI310124095, Length=191, Percent_Identity=30.3664921465969, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1789856, Length=533, Percent_Identity=40.3377110694184, Blast_Score=347, Evalue=1e-96,
Organism=Caenorhabditis elegans, GI212646519, Length=514, Percent_Identity=34.4357976653696, Blast_Score=221, Evalue=8e-58,
Organism=Caenorhabditis elegans, GI72000294, Length=514, Percent_Identity=34.4357976653696, Blast_Score=221, Evalue=8e-58,
Organism=Caenorhabditis elegans, GI17542894, Length=495, Percent_Identity=33.1313131313131, Blast_Score=194, Evalue=8e-50,
Organism=Caenorhabditis elegans, GI17506189, Length=523, Percent_Identity=30.5927342256214, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI193208245, Length=505, Percent_Identity=30.4950495049505, Blast_Score=192, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI193208247, Length=508, Percent_Identity=30.511811023622, Blast_Score=192, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI72001497, Length=382, Percent_Identity=24.869109947644, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI72001495, Length=270, Percent_Identity=24.8148148148148, Blast_Score=76, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6323330, Length=506, Percent_Identity=29.0513833992095, Blast_Score=140, Evalue=6e-34,
Organism=Drosophila melanogaster, GI161077496, Length=510, Percent_Identity=32.5490196078431, Blast_Score=215, Evalue=8e-56,
Organism=Drosophila melanogaster, GI18859893, Length=500, Percent_Identity=33, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI161077880, Length=552, Percent_Identity=30.4347826086957, Blast_Score=201, Evalue=2e-51,
Organism=Drosophila melanogaster, GI161077878, Length=552, Percent_Identity=30.4347826086957, Blast_Score=201, Evalue=2e-51,
Organism=Drosophila melanogaster, GI45551474, Length=552, Percent_Identity=30.4347826086957, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24642670, Length=552, Percent_Identity=30.4347826086957, Blast_Score=200, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24642666, Length=552, Percent_Identity=30.4347826086957, Blast_Score=200, Evalue=3e-51,
Organism=Drosophila melanogaster, GI18859741, Length=499, Percent_Identity=27.0541082164329, Blast_Score=134, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 62291; Mature: 62291

Theoretical pI: Translated: 7.83; Mature: 7.83

Prosite motif: PS00462 G_GLU_TRANSPEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDHYKWLSCLFFLICNIYQVNAKTFPQHPPGYAVASAHPLATHAGLEILAAGGNAFDAA
CCCHHHHHHHHHHHHHHHEEECCCCCCCCCCCCEEECCCCCHHHCCEEEEEECCCHHHHH
VAVAAALAVVEPYHSGLGGGGFWLLHQEKEHLNLFIDGREVAPLAASKDMYLAPDGQVIP
HHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEECCCEECCCCCCCCEEECCCCCCCC
GLSLNGGLSAAIPGQPAALVYIAKNYGRLPLSKTLAPAIKLAEEGFPVDPQFRYFSTLDD
CCCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
RLENLKKYPDTAAIFLKNGQPFEIGEKLVQKDLAKTLRLIAKYGNAGFYSGETASLLVQG
HHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHEEC
VNAAGGIWSLDDLAQYKIKVRPPLISAYHNMLIITAPLPSAGGVALVTMLNILSKFPLSS
CCCCCCCCCHHHHHHEEEEECCCHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCC
FPKLKWVHYVVESMRLAYWQRDQFLGDPDFIKVPLDKLISSDNAKQLSRLISPNKAIDSK
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHCCCCHHHHHHHHCCCHHHHHH
VLQGSVPTGKHSNTSHISIIDTEGNRVAATMTINYIFGSSVVAKGTGVLLNDEMDDFSTK
HHCCCCCCCCCCCCCEEEEEECCCCEEEEEEEEEEEECCCEEECCCCEEECCCHHHHHHH
VGEQNVFGLVGSERNAIEPRKRPLSSMAPTFLEMPGRVAILGTPGGSRIPTMVLLASLLF
CCCCCEEEEECCCCCCCCCHHCCHHHHCCHHHHCCCCEEEEECCCCCCCHHHHHHHHHHH
YDGYGAISMVSAMRFHHQYLPDVLQFEPDTFPSSIQQGLQAMGYHLMPLKQYYGDMQAIT
HCCCCHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHCCCCCEEHHHHCCCCEEEE
WDKESNVLTAASDPRHIGLAAAISNMAYGYGVNY
ECCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKDHYKWLSCLFFLICNIYQVNAKTFPQHPPGYAVASAHPLATHAGLEILAAGGNAFDAA
CCCHHHHHHHHHHHHHHHEEECCCCCCCCCCCCEEECCCCCHHHCCEEEEEECCCHHHHH
VAVAAALAVVEPYHSGLGGGGFWLLHQEKEHLNLFIDGREVAPLAASKDMYLAPDGQVIP
HHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEECCCEECCCCCCCCEEECCCCCCCC
GLSLNGGLSAAIPGQPAALVYIAKNYGRLPLSKTLAPAIKLAEEGFPVDPQFRYFSTLDD
CCCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
RLENLKKYPDTAAIFLKNGQPFEIGEKLVQKDLAKTLRLIAKYGNAGFYSGETASLLVQG
HHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHEEC
VNAAGGIWSLDDLAQYKIKVRPPLISAYHNMLIITAPLPSAGGVALVTMLNILSKFPLSS
CCCCCCCCCHHHHHHEEEEECCCHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCC
FPKLKWVHYVVESMRLAYWQRDQFLGDPDFIKVPLDKLISSDNAKQLSRLISPNKAIDSK
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHCCCCHHHHHHHHCCCHHHHHH
VLQGSVPTGKHSNTSHISIIDTEGNRVAATMTINYIFGSSVVAKGTGVLLNDEMDDFSTK
HHCCCCCCCCCCCCCEEEEEECCCCEEEEEEEEEEEECCCEEECCCCEEECCCHHHHHHH
VGEQNVFGLVGSERNAIEPRKRPLSSMAPTFLEMPGRVAILGTPGGSRIPTMVLLASLLF
CCCCCEEEEECCCCCCCCCHHCCHHHHCCHHHHCCCCEEEEECCCCCCCHHHHHHHHHHH
YDGYGAISMVSAMRFHHQYLPDVLQFEPDTFPSSIQQGLQAMGYHLMPLKQYYGDMQAIT
HCCCCHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHCCCCCEEHHHHCCCCEEEE
WDKESNVLTAASDPRHIGLAAAISNMAYGYGVNY
ECCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7765305 [H]