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The map label for this gene is aas [H]

Identifier: 148360754

GI number: 148360754

Start: 723432

End: 724973

Strand: Direct

Name: aas [H]

Synonym: LPC_2703

Alternate gene names: 148360754

Gene position: 723432-724973 (Clockwise)

Preceding gene: 148360755

Following gene: 148360753

Centisome position: 20.23

GC content: 39.56

Gene sequence:

>1542_bases
ATGTTACCATTCTTAAGTTTGTTTTTTAGACAGTTATATCGAATTCACGTTAAAATAGAAGACAATAATCGTATTCCCTT
AACTTACAGACAGTTCTTGACTCGTTGTTTTATTCTGGGGCGCCAAATTAAAAAGCAAACGGCTATAGGCGAAACGGTCG
GAGTAATGATGCCGACTACTATAGCTGGCATGGTCACTTTTTTTGCTTTACAAGCTTATAGACGAATACCTGCCATGTTG
AATTTTAGCATGGGTTTTTATAACTTATATTCAGCCTGTAATACAGCAAGAATTAAATCAATTTATACTGCAAGGCAATT
CATAGAAACCGCCAAATTAGAACCCTTGGTAGAAGAGTTGCAACAGGCGGGTATAAGAATTCATTATTTAGAAGATTTTA
AATCAACTATTCATTTAGGTAACAAGCTTTCCGGGATATTCAAAGGCTTCTTTCCCACTCTAAGCTACCGTTTTCTTGGT
GACAAAATATCCCCTGATACAACAGGCATAATCCTGTTTACCTCTGGTTCTGAGGGAAAACCCAAAGGGGTTGCTCTTAG
CCATGCCAATATATTGGCTAATTGTTGGCAAATGACTTCCAGAGTCGACTTTACTCCACGAGATGTTTTATTTAATTCCT
TACCTATATTCCATTGTTTTGGCCTTACAGCAGGAAGTGTGCTTCCTTTGGTTAATGGTTTGAATTGTTTTTTCTATCCT
TCCCCTCTTCATTATAAGGTAATTCCTGGATTGGTTTATCAAACAGGGGCTACTATTTTGTTTGGCACAGATACTTTTTT
AACGGGTTATGCAAGGGCCGCGGGCAAACATGATTTCAACAGCGTCCGCTATATCTTCGCTGGCGCCGAGAAAGTGAAAC
CGGAAACCATTAGATACTGGAGCGAAGCGTTTGGGGCAAGAATTTATGAAGGCTATGGTGCTACTGAGGCATCGCCAGTC
ATATCGCTTAATTGTCCGTTGGCATCAGTACCGGGTAGTGTCGGAATGATTTTACCTTTTATGGATTTCAAAGTAGAACC
AGTAGAGGGAATTGTACAAGGCGGGCGTTTAAAATTATGCGGACCCAATATCATGTTAGGTTATCTTGATGAGGATAAAC
CTGGAGTAATTATAGAACCTGAAGATGGTTGGCATGATACGGGAGATATCGTCACCGTGAATGCAGATGGATTCATTACT
ATAGCAGGTCGCGCCAAACGTTTTGCCAAGATTGCTGGTGAAATGGTATCTCTTACAGCGGTGGAAGGAATTGCAGCTTC
AATTTGGCCTGAATTATTACATGCCGCTGTTGTGCAAAAATCTCCAAGAAAGGGGGAGCAAATTTTCTTATTTACTGAAG
CAGAGTATGCAGATAAAGTATCATTTATAAAAAAGGTTAAGGAGAGAGGGCAATCAGAATTGCTGGTTCCTCATATGATT
TATCCGGCATGCCAAATTCCTGTCCTGCCTTCAGGAAAAATTGATTATATAACGCTTGAAAAGCAATTTTTAGAACAGAA
AGAAACCATGGAAACAGTATAA

Upstream 100 bases:

>100_bases
CACAGAATAATTCTATTAATTTATCCACTCCAGACCTCTTGATTCTTATTTTTGTTCTTCGAAAAAACGAATAAGATCAC
AAATGGTCTGGTTTTTCAAT

Downstream 100 bases:

>100_bases
ATGAAATTAATATGGATAGTATTAGCCCTTATTTTAGCCCTTGTTGTCATACTTTATTTATTTCCTCAAATCAATTTTCG
AGAAATGCCGAAGGGGTTAG

Product: hypothetical protein

Products: NA

Alternate protein names: 2-acylglycerophosphoethanolamine acyltransferase; 2-acyl-GPE acyltransferase; Acyl-[acyl-carrier-protein]--phospholipid O-acyltransferase; Acyl-[acyl-carrier-protein] synthetase; Acyl-ACP synthetase; Long-chain-fatty-acid--[acyl-carrier-protein] ligase [H]

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MLPFLSLFFRQLYRIHVKIEDNNRIPLTYRQFLTRCFILGRQIKKQTAIGETVGVMMPTTIAGMVTFFALQAYRRIPAML
NFSMGFYNLYSACNTARIKSIYTARQFIETAKLEPLVEELQQAGIRIHYLEDFKSTIHLGNKLSGIFKGFFPTLSYRFLG
DKISPDTTGIILFTSGSEGKPKGVALSHANILANCWQMTSRVDFTPRDVLFNSLPIFHCFGLTAGSVLPLVNGLNCFFYP
SPLHYKVIPGLVYQTGATILFGTDTFLTGYARAAGKHDFNSVRYIFAGAEKVKPETIRYWSEAFGARIYEGYGATEASPV
ISLNCPLASVPGSVGMILPFMDFKVEPVEGIVQGGRLKLCGPNIMLGYLDEDKPGVIIEPEDGWHDTGDIVTVNADGFIT
IAGRAKRFAKIAGEMVSLTAVEGIAASIWPELLHAAVVQKSPRKGEQIFLFTEAEYADKVSFIKKVKERGQSELLVPHMI
YPACQIPVLPSGKIDYITLEKQFLEQKETMETV

Sequences:

>Translated_513_residues
MLPFLSLFFRQLYRIHVKIEDNNRIPLTYRQFLTRCFILGRQIKKQTAIGETVGVMMPTTIAGMVTFFALQAYRRIPAML
NFSMGFYNLYSACNTARIKSIYTARQFIETAKLEPLVEELQQAGIRIHYLEDFKSTIHLGNKLSGIFKGFFPTLSYRFLG
DKISPDTTGIILFTSGSEGKPKGVALSHANILANCWQMTSRVDFTPRDVLFNSLPIFHCFGLTAGSVLPLVNGLNCFFYP
SPLHYKVIPGLVYQTGATILFGTDTFLTGYARAAGKHDFNSVRYIFAGAEKVKPETIRYWSEAFGARIYEGYGATEASPV
ISLNCPLASVPGSVGMILPFMDFKVEPVEGIVQGGRLKLCGPNIMLGYLDEDKPGVIIEPEDGWHDTGDIVTVNADGFIT
IAGRAKRFAKIAGEMVSLTAVEGIAASIWPELLHAAVVQKSPRKGEQIFLFTEAEYADKVSFIKKVKERGQSELLVPHMI
YPACQIPVLPSGKIDYITLEKQFLEQKETMETV
>Mature_513_residues
MLPFLSLFFRQLYRIHVKIEDNNRIPLTYRQFLTRCFILGRQIKKQTAIGETVGVMMPTTIAGMVTFFALQAYRRIPAML
NFSMGFYNLYSACNTARIKSIYTARQFIETAKLEPLVEELQQAGIRIHYLEDFKSTIHLGNKLSGIFKGFFPTLSYRFLG
DKISPDTTGIILFTSGSEGKPKGVALSHANILANCWQMTSRVDFTPRDVLFNSLPIFHCFGLTAGSVLPLVNGLNCFFYP
SPLHYKVIPGLVYQTGATILFGTDTFLTGYARAAGKHDFNSVRYIFAGAEKVKPETIRYWSEAFGARIYEGYGATEASPV
ISLNCPLASVPGSVGMILPFMDFKVEPVEGIVQGGRLKLCGPNIMLGYLDEDKPGVIIEPEDGWHDTGDIVTVNADGFIT
IAGRAKRFAKIAGEMVSLTAVEGIAASIWPELLHAAVVQKSPRKGEQIFLFTEAEYADKVSFIKKVKERGQSELLVPHMI
YPACQIPVLPSGKIDYITLEKQFLEQKETMETV

Specific function: Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the ATP- dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=438, Percent_Identity=26.9406392694064, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI57165412, Length=459, Percent_Identity=26.797385620915, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI40807491, Length=312, Percent_Identity=26.6025641025641, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI57165410, Length=458, Percent_Identity=25.764192139738, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI187761345, Length=392, Percent_Identity=24.7448979591837, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI187761343, Length=392, Percent_Identity=24.7448979591837, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI42544132, Length=359, Percent_Identity=24.7910863509749, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1789201, Length=499, Percent_Identity=45.6913827655311, Blast_Score=433, Evalue=1e-122,
Organism=Escherichia coli, GI145693145, Length=364, Percent_Identity=27.4725274725275, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1788107, Length=465, Percent_Identity=24.5161290322581, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1786801, Length=313, Percent_Identity=23.3226837060703, Blast_Score=63, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17560308, Length=364, Percent_Identity=26.9230769230769, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17558820, Length=293, Percent_Identity=26.6211604095563, Blast_Score=99, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI71994694, Length=436, Percent_Identity=24.3119266055046, Blast_Score=92, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71994703, Length=436, Percent_Identity=24.3119266055046, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71994690, Length=436, Percent_Identity=24.3119266055046, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI32563687, Length=306, Percent_Identity=25.8169934640523, Blast_Score=89, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6319699, Length=379, Percent_Identity=25.5936675461741, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI18859661, Length=360, Percent_Identity=26.1111111111111, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24581924, Length=363, Percent_Identity=26.1707988980716, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI21355181, Length=502, Percent_Identity=22.9083665338645, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI62472339, Length=385, Percent_Identity=26.2337662337662, Blast_Score=65, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002123
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF01553 Acyltransferase; PF00501 AMP-binding [H]

EC number: =2.3.1.40; =6.2.1.20 [H]

Molecular weight: Translated: 57124; Mature: 57124

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPFLSLFFRQLYRIHVKIEDNNRIPLTYRQFLTRCFILGRQIKKQTAIGETVGVMMPTT
CCCHHHHHHHHHHEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
IAGMVTFFALQAYRRIPAMLNFSMGFYNLYSACNTARIKSIYTARQFIETAKLEPLVEEL
HHHHHHHHHHHHHHHCHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHH
QQAGIRIHYLEDFKSTIHLGNKLSGIFKGFFPTLSYRFLGDKISPDTTGIILFTSGSEGK
HHCCCEEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCC
PKGVALSHANILANCWQMTSRVDFTPRDVLFNSLPIFHCFGLTAGSVLPLVNGLNCFFYP
CCCEEEEHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHCCCCCCHHHHHCCCEEEECC
SPLHYKVIPGLVYQTGATILFGTDTFLTGYARAAGKHDFNSVRYIFAGAEKVKPETIRYW
CCCCEEECCCHHHHCCCEEEEECCHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHH
SEAFGARIYEGYGATEASPVISLNCPLASVPGSVGMILPFMDFKVEPVEGIVQGGRLKLC
HHHHCCEEEECCCCCCCCCEEEECCCHHCCCCCCCEEEECCCCEECCHHHHHCCCEEEEE
GPNIMLGYLDEDKPGVIIEPEDGWHDTGDIVTVNADGFITIAGRAKRFAKIAGEMVSLTA
CCCEEEEEECCCCCCEEECCCCCCCCCCCEEEECCCCEEEECCHHHHHHHHHHHHHHHHH
VEGIAASIWPELLHAAVVQKSPRKGEQIFLFTEAEYADKVSFIKKVKERGQSELLVPHMI
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCEECHHHH
YPACQIPVLPSGKIDYITLEKQFLEQKETMETV
CCCCCCCCCCCCCEEEEEECHHHHHHHHHHCCC
>Mature Secondary Structure
MLPFLSLFFRQLYRIHVKIEDNNRIPLTYRQFLTRCFILGRQIKKQTAIGETVGVMMPTT
CCCHHHHHHHHHHEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
IAGMVTFFALQAYRRIPAMLNFSMGFYNLYSACNTARIKSIYTARQFIETAKLEPLVEEL
HHHHHHHHHHHHHHHCHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHH
QQAGIRIHYLEDFKSTIHLGNKLSGIFKGFFPTLSYRFLGDKISPDTTGIILFTSGSEGK
HHCCCEEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCC
PKGVALSHANILANCWQMTSRVDFTPRDVLFNSLPIFHCFGLTAGSVLPLVNGLNCFFYP
CCCEEEEHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHCCCCCCHHHHHCCCEEEECC
SPLHYKVIPGLVYQTGATILFGTDTFLTGYARAAGKHDFNSVRYIFAGAEKVKPETIRYW
CCCCEEECCCHHHHCCCEEEEECCHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHH
SEAFGARIYEGYGATEASPVISLNCPLASVPGSVGMILPFMDFKVEPVEGIVQGGRLKLC
HHHHCCEEEECCCCCCCCCEEEECCCHHCCCCCCCEEEECCCCEECCHHHHHCCCEEEEE
GPNIMLGYLDEDKPGVIIEPEDGWHDTGDIVTVNADGFITIAGRAKRFAKIAGEMVSLTA
CCCEEEEEECCCCCCEEECCCCCCCCCCCEEEECCCCEEEECCHHHHHHHHHHHHHHHHH
VEGIAASIWPELLHAAVVQKSPRKGEQIFLFTEAEYADKVSFIKKVKERGQSELLVPHMI
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCEECHHHH
YPACQIPVLPSGKIDYITLEKQFLEQKETMETV
CCCCCCCCCCCCCEEEEEECHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA