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The map label for this gene is rmlD [C]

Identifier: 148360589

GI number: 148360589

Start: 936589

End: 937473

Strand: Direct

Name: rmlD [C]

Synonym: LPC_2535

Alternate gene names: 148360589

Gene position: 936589-937473 (Clockwise)

Preceding gene: 148360590

Following gene: 148360588

Centisome position: 26.19

GC content: 37.85

Gene sequence:

>885_bases
ATGAAAATATTGGTTACAGGTGCTAATGGGCAAGTTGGTACCGAGATTATCAAGCGATTTTCTTCCTCTGAGCATGAAGT
ATATGCTTGTACCAGAGATATTCTAGATTGTTCCAAACTCGAACGGGTTCATGATGTGTTATTGGAAATCAAACCGGATC
TTATCATTAATGCAGCAGCCTATACGGCTGTAGATAAGGCTGAGGATGAACCTGATTTGGCTCATATTGTGAACGCCGAG
TTTGTCTGTCACCTGGTGAATTATTGTAGCTTGAAAAACATCCCCTTGATCCATCTTTCAACTGATTATGTATTTGATGG
AGAAAAGGAGGGAGCCTATCATGAAACCGATATTCCGCATCCAGTAAGTACCTATGGGCGCACGAAATGGGAAGGAGAAC
AGGCTATTTTATCCCAACTTAAAAAGTATATTATTTTGCGAGTTAGCTGGGTATTTGGTGAACAAGGGAAAAATTTTGTA
AAAACGATTTTAAATTTGGCTTCCAGCAGAAAAGAATTGAATATTGTTTCAGATCAATGGGGAAGGCCTACTTCAGCTCG
CGATATAGCAAGAGTACTATTTGAAATAGTACAGAAAATCAGACATTCTTCCTTTGACTATTGGGGGCTTTACCATTATG
CAGGGCAGGGTGTTACCAATTGGCATGAATTTGCAAACGTATTTCTTAATATGGCAAAAGAGAAACAGCTTCTCTTGACT
TTAACCGATTTAAATCCAATTAAGTCAGAAGAATATCCTACTAGGGCAACAAGGCCTAAAAATTCGGTACTCGATACAAC
AAAGATAGAAACAATATTGGGTATAAAAAGCTGTAGTTGGAAAAATGATTTGCCAGATGTTATCGACCATTTTACAAAAA
AGTAA

Upstream 100 bases:

>100_bases
TTGGCCATTAGGAGAGCAAGTTCAATTGTCTCCAAAAGACGCTGCAGCCAAGCCTTTAAGTTTAATAGATGCTGAACTTT
TACCGAGATATCAAACCTAA

Downstream 100 bases:

>100_bases
GAATCACACTATGAAAAATCAGATGAACAATCTTTTGGTAACTGGAGCTGCGGGCTTTATAGGAAGTAATTTTGTTAAAT
TTATGAACGATAAATACCCG

Product: dTDP-6-deoxy-L-mannose dehydrogenase RmlD

Products: NA

Alternate protein names: dTDP-4-keto-L-rhamnose reductase; dTDP-6-deoxy-L-lyxo-4-hexulose reductase; dTDP-6-deoxy-L-mannose dehydrogenase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MKILVTGANGQVGTEIIKRFSSSEHEVYACTRDILDCSKLERVHDVLLEIKPDLIINAAAYTAVDKAEDEPDLAHIVNAE
FVCHLVNYCSLKNIPLIHLSTDYVFDGEKEGAYHETDIPHPVSTYGRTKWEGEQAILSQLKKYIILRVSWVFGEQGKNFV
KTILNLASSRKELNIVSDQWGRPTSARDIARVLFEIVQKIRHSSFDYWGLYHYAGQGVTNWHEFANVFLNMAKEKQLLLT
LTDLNPIKSEEYPTRATRPKNSVLDTTKIETILGIKSCSWKNDLPDVIDHFTKK

Sequences:

>Translated_294_residues
MKILVTGANGQVGTEIIKRFSSSEHEVYACTRDILDCSKLERVHDVLLEIKPDLIINAAAYTAVDKAEDEPDLAHIVNAE
FVCHLVNYCSLKNIPLIHLSTDYVFDGEKEGAYHETDIPHPVSTYGRTKWEGEQAILSQLKKYIILRVSWVFGEQGKNFV
KTILNLASSRKELNIVSDQWGRPTSARDIARVLFEIVQKIRHSSFDYWGLYHYAGQGVTNWHEFANVFLNMAKEKQLLLT
LTDLNPIKSEEYPTRATRPKNSVLDTTKIETILGIKSCSWKNDLPDVIDHFTKK
>Mature_294_residues
MKILVTGANGQVGTEIIKRFSSSEHEVYACTRDILDCSKLERVHDVLLEIKPDLIINAAAYTAVDKAEDEPDLAHIVNAE
FVCHLVNYCSLKNIPLIHLSTDYVFDGEKEGAYHETDIPHPVSTYGRTKWEGEQAILSQLKKYIILRVSWVFGEQGKNFV
KTILNLASSRKELNIVSDQWGRPTSARDIARVLFEIVQKIRHSSFDYWGLYHYAGQGVTNWHEFANVFLNMAKEKQLLLT
LTDLNPIKSEEYPTRATRPKNSVLDTTKIETILGIKSCSWKNDLPDVIDHFTKK

Specific function: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose. RmlD uses NADH and NADPH nearly equally well [H]

COG id: COG1091

COG function: function code M; dTDP-4-dehydrorhamnose reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose reductase family [H]

Homologues:

Organism=Homo sapiens, GI33519455, Length=313, Percent_Identity=29.3929712460064, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI11034825, Length=313, Percent_Identity=29.3929712460064, Blast_Score=112, Evalue=4e-25,
Organism=Escherichia coli, GI1788352, Length=288, Percent_Identity=36.8055555555556, Blast_Score=191, Evalue=4e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005913
- InterPro:   IPR016040 [H]

Pfam domain/function: PF04321 RmlD_sub_bind [H]

EC number: =1.1.1.133 [H]

Molecular weight: Translated: 33508; Mature: 33508

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILVTGANGQVGTEIIKRFSSSEHEVYACTRDILDCSKLERVHDVLLEIKPDLIINAAA
CEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHH
YTAVDKAEDEPDLAHIVNAEFVCHLVNYCSLKNIPLIHLSTDYVFDGEKEGAYHETDIPH
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCEEECCCCCCCCCCCCCCC
PVSTYGRTKWEGEQAILSQLKKYIILRVSWVFGEQGKNFVKTILNLASSRKELNIVSDQW
CHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEHHCCC
GRPTSARDIARVLFEIVQKIRHSSFDYWGLYHYAGQGVTNWHEFANVFLNMAKEKQLLLT
CCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEE
LTDLNPIKSEEYPTRATRPKNSVLDTTKIETILGIKSCSWKNDLPDVIDHFTKK
EECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MKILVTGANGQVGTEIIKRFSSSEHEVYACTRDILDCSKLERVHDVLLEIKPDLIINAAA
CEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHH
YTAVDKAEDEPDLAHIVNAEFVCHLVNYCSLKNIPLIHLSTDYVFDGEKEGAYHETDIPH
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCEEECCCCCCCCCCCCCCC
PVSTYGRTKWEGEQAILSQLKKYIILRVSWVFGEQGKNFVKTILNLASSRKELNIVSDQW
CHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEHHCCC
GRPTSARDIARVLFEIVQKIRHSSFDYWGLYHYAGQGVTNWHEFANVFLNMAKEKQLLLT
CCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEE
LTDLNPIKSEEYPTRATRPKNSVLDTTKIETILGIKSCSWKNDLPDVIDHFTKK
EECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]