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The map label for this gene is nadC [H]

Identifier: 148360546

GI number: 148360546

Start: 992685

End: 993527

Strand: Direct

Name: nadC [H]

Synonym: LPC_2488

Alternate gene names: 148360546

Gene position: 992685-993527 (Clockwise)

Preceding gene: 148360547

Following gene: 148360545

Centisome position: 27.76

GC content: 39.62

Gene sequence:

>843_bases
ATGAATAATGTTTTATCGCAAGTTATATTTGATGTAAAACGTGCTTTGCAAGAGGACGTGGGCAATGGTGATGTTACTGC
GGCTTTGTTGCCTCAGCAGCTGATTGTAGAAGCAGAAATTATATCAAGAGAACCTATGCTTGTTTGTGGGCAGCCCTGGG
TAAATGAGGTTTTTAAGCAAGTTGATAATACAGTTGAAATGGAGTGGCGGGTTTCTGAAGGAGATTTTTTAAGCACGCCA
GCTACTTTATGTATTATTCATGGTACTGCCAGTAGTATTTTAACGGCAGAGCGTACTGCGTTAAATTTTTTGCAAACCCT
TTCAGCTACTGCAACACAAACTTATTACTATGTTCAGAAATTAAAAGGTACCAAGGCAAAGCTGTTAGACACACGCAAAA
CAATTCCAGGACTTCGGTTAGCGCAAAAATACGCTGTCTATTGTGGTGGCGGGTTAAATCATCGTATGGGACTTTATGAT
GCGTTTCTAATCAAAGAAAATCATATCAAAGCCTGTGGTTCAGTTGCTCATGCTATCAGTCTGGCAAGGAAAACCGATAA
ACACTTACTGGTTGAGATTGAAGTGGAAACCCTTGAGGAGTTGCAAGAGGCTTTGGATGCTCACCCTGACAGGATATTAT
TGGATAATTTCACTCAAGATATGCTTGAGCAAGCAGTCAAAATGAATCATCCCAAGTACTGTGAATTGGAAGCCTCTGGC
GGCATTAATATCAATAATATTGCAGACATTGCTCAAACCGGAGTGGATTTTATTTCAGTTGGATCCATCACCAAATCAAT
TCAAGCAATTGATTTGAGCTTATTGATTAGGGAAACATTATGA

Upstream 100 bases:

>100_bases
ATCTGTTTACCGCAATTGTATTGATGATCATGATCACAACCTTTATTGCGCCACCTTTATTAAAGATGCGATATGCCAAA
CCAAAAGAGGATAGGAATGC

Downstream 100 bases:

>100_bases
GCCCAAGTATTGTTTTTACCGGGGGAGGCACTGCCGGACATGTAACGCCTAATATCGCTTTGATTAAGGAATTTCGAAAA
GAAGGCTGGAATGTAGAATA

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MNNVLSQVIFDVKRALQEDVGNGDVTAALLPQQLIVEAEIISREPMLVCGQPWVNEVFKQVDNTVEMEWRVSEGDFLSTP
ATLCIIHGTASSILTAERTALNFLQTLSATATQTYYYVQKLKGTKAKLLDTRKTIPGLRLAQKYAVYCGGGLNHRMGLYD
AFLIKENHIKACGSVAHAISLARKTDKHLLVEIEVETLEELQEALDAHPDRILLDNFTQDMLEQAVKMNHPKYCELEASG
GININNIADIAQTGVDFISVGSITKSIQAIDLSLLIRETL

Sequences:

>Translated_280_residues
MNNVLSQVIFDVKRALQEDVGNGDVTAALLPQQLIVEAEIISREPMLVCGQPWVNEVFKQVDNTVEMEWRVSEGDFLSTP
ATLCIIHGTASSILTAERTALNFLQTLSATATQTYYYVQKLKGTKAKLLDTRKTIPGLRLAQKYAVYCGGGLNHRMGLYD
AFLIKENHIKACGSVAHAISLARKTDKHLLVEIEVETLEELQEALDAHPDRILLDNFTQDMLEQAVKMNHPKYCELEASG
GININNIADIAQTGVDFISVGSITKSIQAIDLSLLIRETL
>Mature_280_residues
MNNVLSQVIFDVKRALQEDVGNGDVTAALLPQQLIVEAEIISREPMLVCGQPWVNEVFKQVDNTVEMEWRVSEGDFLSTP
ATLCIIHGTASSILTAERTALNFLQTLSATATQTYYYVQKLKGTKAKLLDTRKTIPGLRLAQKYAVYCGGGLNHRMGLYD
AFLIKENHIKACGSVAHAISLARKTDKHLLVEIEVETLEELQEALDAHPDRILLDNFTQDMLEQAVKMNHPKYCELEASG
GININNIADIAQTGVDFISVGSITKSIQAIDLSLLIRETL

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=269, Percent_Identity=33.457249070632, Blast_Score=135, Evalue=5e-32,
Organism=Escherichia coli, GI1786299, Length=272, Percent_Identity=50.3676470588235, Blast_Score=234, Evalue=4e-63,
Organism=Saccharomyces cerevisiae, GI6321162, Length=279, Percent_Identity=36.9175627240143, Blast_Score=151, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 30955; Mature: 30955

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNVLSQVIFDVKRALQEDVGNGDVTAALLPQQLIVEAEIISREPMLVCGQPWVNEVFKQ
CCHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHH
VDNTVEMEWRVSEGDFLSTPATLCIIHGTASSILTAERTALNFLQTLSATATQTYYYVQK
CCCCEEEEEEECCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKGTKAKLLDTRKTIPGLRLAQKYAVYCGGGLNHRMGLYDAFLIKENHIKACGSVAHAIS
HCCCHHHHHHHHHCCCCHHHHHHHHEEECCCCCCCCCHHHHEEEECCHHHHHHHHHHHHH
LARKTDKHLLVEIEVETLEELQEALDAHPDRILLDNFTQDMLEQAVKMNHPKYCELEASG
HHHHCCCEEEEEEEHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCCCEEEEECCC
GININNIADIAQTGVDFISVGSITKSIQAIDLSLLIRETL
CCCCHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNNVLSQVIFDVKRALQEDVGNGDVTAALLPQQLIVEAEIISREPMLVCGQPWVNEVFKQ
CCHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHH
VDNTVEMEWRVSEGDFLSTPATLCIIHGTASSILTAERTALNFLQTLSATATQTYYYVQK
CCCCEEEEEEECCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKGTKAKLLDTRKTIPGLRLAQKYAVYCGGGLNHRMGLYDAFLIKENHIKACGSVAHAIS
HCCCHHHHHHHHHCCCCHHHHHHHHEEECCCCCCCCCHHHHEEEECCHHHHHHHHHHHHH
LARKTDKHLLVEIEVETLEELQEALDAHPDRILLDNFTQDMLEQAVKMNHPKYCELEASG
HHHHCCCEEEEEEEHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCCCEEEEECCC
GININNIADIAQTGVDFISVGSITKSIQAIDLSLLIRETL
CCCCHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 2430961; 8419294 [H]