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The map label for this gene is lmxE [H]

Identifier: 148360026

GI number: 148360026

Start: 3018588

End: 3019742

Strand: Reverse

Name: lmxE [H]

Synonym: LPC_1957

Alternate gene names: 148360026

Gene position: 3019742-3018588 (Counterclockwise)

Preceding gene: 148360025

Following gene: 148360027

Centisome position: 84.43

GC content: 41.39

Gene sequence:

>1155_bases
ATGAACTCTCAAAATAAACAAAATTTAGTTAAAACCGTGGCAATTGTATTTTTTGGTATTGTCTTTGTTTATTTAGTATA
TGACCATTTTACAAGAACCCAGGTAGCAACCCCAGCACCACCATTTGTGATAGTTCAAAAGCCCAAGTTAGTGAAAATGG
GGCAGTACGTTACACAGACAGGCAATACAGTAGCATTTCAATCGGTAGATTTGGTGGCACGTATTGAAGGCTATTTAGAC
GCCATAAAATTTACTGACGGTGCTTTTGTCAAAAAGAATCAGGAATTATTTATTATTGAACCCGAGCCTTATCTTGAGCA
ATTGCGTGCGGCCGAAGCCAAGGTAGCGGCTCAAAAAGCGAATTATGCTTACGCCAAATCAGAATATGCCAGACAGCAAC
GCATGTATAAACAAAATGCCACGTCTCTTAACAGTGTTGAAAAATGGAAAGCAAAAGTTGAAGAAGCACAGGCGGAAGTG
GATAAATCGGAAGCTGATGCCAAGAACGCCGCAATTACATATGGCTATACCCACCTTTCAGCTCCTTTCGATGGACGGAT
GGGAAGACATTTAGTCGATGTGGGGAATTTGGTTGGGCATGGTGCTGCGACGGATTTGGCTACCATAGAACAAATAGACC
CTATTTACGTTTATTTTAATTTAAATGAACTGGATTTAATCAAAATTAGAAATGCAGCTCGCAAGAGAGGATATAAGCCA
ATGGAGCTGGTCAAAATCCCTGTTGAAGTAGCTTTGCAAGATGAAAAAGGATTTCCTCATAAAGGAACATTGGATTTTGT
AAATACCGGTTTAAACGCTTCAACTGGAACTATGGAGTTTCGTGCCTTGTTACCTAATAAGGGATATCCCCTAGTGCCTG
GTTTATTTGTGCAAGTCCGGGTACCGATATCTGAACCCTCTCCAAAATTAACAATACCTGACACCTCTGTGCAATATGAT
CAAATTGGGCCCTATGTGCTTGTGGTTGATAAAGATAATTATGTGCTTACCAGGCGTGTGACACTTGGCGGGCTAGAAAA
TGGGGTAAGGGCTATTACCAAAGGCCTCGATGCTCAGGACAGAGTGATTGTTTCCGGGTTGCAAAATGCAACTCCCAATC
ATCAGGTTACGCCTAAAACAGAGCAACCTGAGTAA

Upstream 100 bases:

>100_bases
GTACTAATTGGGGTAGTTTATTGAAGCAGGAAAATCATTTGCCTCCGGATTCTAATGGACAACGAATGAAACAATTATAT
TTACCAACCTGGTGATGAGA

Downstream 100 bases:

>100_bases
AAAAACTGTAAGAATTTAAGATACGCTATTCAGGGAGCGAAACAACTGAAATGATTTCCAAATTTTTTATTGAAAGACCC
GTTCTGGCCAATGTCATCGC

Product: RND multidrug efflux membrane fusion protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MNSQNKQNLVKTVAIVFFGIVFVYLVYDHFTRTQVATPAPPFVIVQKPKLVKMGQYVTQTGNTVAFQSVDLVARIEGYLD
AIKFTDGAFVKKNQELFIIEPEPYLEQLRAAEAKVAAQKANYAYAKSEYARQQRMYKQNATSLNSVEKWKAKVEEAQAEV
DKSEADAKNAAITYGYTHLSAPFDGRMGRHLVDVGNLVGHGAATDLATIEQIDPIYVYFNLNELDLIKIRNAARKRGYKP
MELVKIPVEVALQDEKGFPHKGTLDFVNTGLNASTGTMEFRALLPNKGYPLVPGLFVQVRVPISEPSPKLTIPDTSVQYD
QIGPYVLVVDKDNYVLTRRVTLGGLENGVRAITKGLDAQDRVIVSGLQNATPNHQVTPKTEQPE

Sequences:

>Translated_384_residues
MNSQNKQNLVKTVAIVFFGIVFVYLVYDHFTRTQVATPAPPFVIVQKPKLVKMGQYVTQTGNTVAFQSVDLVARIEGYLD
AIKFTDGAFVKKNQELFIIEPEPYLEQLRAAEAKVAAQKANYAYAKSEYARQQRMYKQNATSLNSVEKWKAKVEEAQAEV
DKSEADAKNAAITYGYTHLSAPFDGRMGRHLVDVGNLVGHGAATDLATIEQIDPIYVYFNLNELDLIKIRNAARKRGYKP
MELVKIPVEVALQDEKGFPHKGTLDFVNTGLNASTGTMEFRALLPNKGYPLVPGLFVQVRVPISEPSPKLTIPDTSVQYD
QIGPYVLVVDKDNYVLTRRVTLGGLENGVRAITKGLDAQDRVIVSGLQNATPNHQVTPKTEQPE
>Mature_384_residues
MNSQNKQNLVKTVAIVFFGIVFVYLVYDHFTRTQVATPAPPFVIVQKPKLVKMGQYVTQTGNTVAFQSVDLVARIEGYLD
AIKFTDGAFVKKNQELFIIEPEPYLEQLRAAEAKVAAQKANYAYAKSEYARQQRMYKQNATSLNSVEKWKAKVEEAQAEV
DKSEADAKNAAITYGYTHLSAPFDGRMGRHLVDVGNLVGHGAATDLATIEQIDPIYVYFNLNELDLIKIRNAARKRGYKP
MELVKIPVEVALQDEKGFPHKGTLDFVNTGLNASTGTMEFRALLPNKGYPLVPGLFVQVRVPISEPSPKLTIPDTSVQYD
QIGPYVLVVDKDNYVLTRRVTLGGLENGVRAITKGLDAQDRVIVSGLQNATPNHQVTPKTEQPE

Specific function: May contribute to resistance to some drugs, such as deoxycholate, sodium dodecyl sulfate and nalidixic acid, in the absence of BepD and BepE [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789665, Length=338, Percent_Identity=29.8816568047337, Blast_Score=143, Evalue=1e-35,
Organism=Escherichia coli, GI87082036, Length=338, Percent_Identity=29.2899408284024, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1789929, Length=313, Percent_Identity=28.4345047923323, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1786668, Length=317, Percent_Identity=29.9684542586751, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI87081796, Length=380, Percent_Identity=23.9473684210526, Blast_Score=72, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 42663; Mature: 42663

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSQNKQNLVKTVAIVFFGIVFVYLVYDHFTRTQVATPAPPFVIVQKPKLVKMGQYVTQT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHCC
GNTVAFQSVDLVARIEGYLDAIKFTDGAFVKKNQELFIIEPEPYLEQLRAAEAKVAAQKA
CCEEEEEHHHHHHHHHHHHHHHEECCCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHC
NYAYAKSEYARQQRMYKQNATSLNSVEKWKAKVEEAQAEVDKSEADAKNAAITYGYTHLS
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCHHHCCCCCCEEEEEEEEEC
APFDGRMGRHLVDVGNLVGHGAATDLATIEQIDPIYVYFNLNELDLIKIRNAARKRGYKP
CCCCCCCCHHHHHHHHHHCCCCCCCHHHHHCCCEEEEEEECCCEEEEHHHHHHHHCCCCC
MELVKIPVEVALQDEKGFPHKGTLDFVNTGLNASTGTMEFRALLPNKGYPLVPGLFVQVR
HHEEEECEEEEEECCCCCCCCCCHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCEEEEEE
VPISEPSPKLTIPDTSVQYDQIGPYVLVVDKDNYVLTRRVTLGGLENGVRAITKGLDAQD
EECCCCCCEEECCCCCCCHHCCCCEEEEEECCCEEEEEEEEECCHHHHHHHHHHCCCCCC
RVIVSGLQNATPNHQVTPKTEQPE
HHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNSQNKQNLVKTVAIVFFGIVFVYLVYDHFTRTQVATPAPPFVIVQKPKLVKMGQYVTQT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHCC
GNTVAFQSVDLVARIEGYLDAIKFTDGAFVKKNQELFIIEPEPYLEQLRAAEAKVAAQKA
CCEEEEEHHHHHHHHHHHHHHHEECCCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHC
NYAYAKSEYARQQRMYKQNATSLNSVEKWKAKVEEAQAEVDKSEADAKNAAITYGYTHLS
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCHHHCCCCCCEEEEEEEEEC
APFDGRMGRHLVDVGNLVGHGAATDLATIEQIDPIYVYFNLNELDLIKIRNAARKRGYKP
CCCCCCCCHHHHHHHHHHCCCCCCCHHHHHCCCEEEEEEECCCEEEEHHHHHHHHCCCCC
MELVKIPVEVALQDEKGFPHKGTLDFVNTGLNASTGTMEFRALLPNKGYPLVPGLFVQVR
HHEEEECEEEEEECCCCCCCCCCHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCEEEEEE
VPISEPSPKLTIPDTSVQYDQIGPYVLVVDKDNYVLTRRVTLGGLENGVRAITKGLDAQD
EECCCCCCEEECCCCCCCHHCCCCEEEEEECCCEEEEEEEEECCHHHHHHHHHHCCCCCC
RVIVSGLQNATPNHQVTPKTEQPE
HHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12271122 [H]