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The map label for this gene is lprN [H]

Identifier: 148360025

GI number: 148360025

Start: 3019748

End: 3021301

Strand: Reverse

Name: lprN [H]

Synonym: LPC_1956

Alternate gene names: 148360025

Gene position: 3021301-3019748 (Counterclockwise)

Preceding gene: 148360024

Following gene: 148360026

Centisome position: 84.48

GC content: 41.57

Gene sequence:

>1554_bases
ATGTTGAAAATCCTTGCTCTCTTAAGTTGTTTGATTCTAAGCTCCTGTCTGGTCGGGCCAAATTTTAAAGAGCCTAAAAA
AGATGCCGCCAATTATTGGCTTACTTCAAGCCCTGCAATAAAACAATCCGCTTTTCAAAATGCGAATTGGTGGAAAGTCT
TTAATGATCCCACTTTAACAGTCTTAATCGATAACGGTTATCATAATAATCTTTCCTTGCAAATGGCAGGAGTACGAGTT
TTGCAAGCAAGAGCTCAACTTGCTCAATCGGTTGGGGAGCTTTATCCCCAGCAACAAGCTATGGTGGGAGATTATAATTA
CAACCGAATTGGGGGTAATCAATTAGAAGGGCTTCTGCCTCCCGATTTTTTAACGGCCAGCCTTGGATTTTCCGCAAGCT
GGGAACTTGATTTTTGGGGAAAATACCGAAGGGCGATTCAATCTAATGATGCCTTGTTCCTTGCCTCTCTTGCCGCTTAT
GATTCTGCATTGGTTACTCTCACGTCAGATATTGCCAGTACTTTTATTAAAATCCGTACCAGCGAAGAATTAATCAAAGT
AACAAAAGCCAATATCCAGGTGCAGGCGATGAGTCTTAAAATCGCAAAGGATCGTTATTCTGGTGGTCAAACCAGTTTAC
TGGATGTGGAACAAGCGGCAACAGAACTTGCGGAAACCCAAGCAAAACTGCCTCAATACGTGAGTGATCTCCAACATCAA
AAAGATATTTTGGCTGTATTACTTGGTACTACTCCCGATAAAGTGGATGACTTGCTTAAAAAAAATAAAGGAATACCAAA
AGCTTCAGCGGTAGTGGAAGTTGGAATTCCTAAAGAAGTGATAGCACGAAGGCCTGATGTCTACCAAGCCAGAATGGAGG
CTATAGCCCAATCAGCTGCAATTGGCGCTGTGAAGGCTAATCTATATCCTTCACTTTCATTGGTGGGTACTTTTGTCTTT
GCTTCAAATAATATTGGCAGTTCTACTATAAGCGATATATTTGACTGGTCGAATCGCAATATAGTCGCAGGTCCGTCACT
GACATGGTCTTTATTAAATTATGGTCAAATCACGAATGCAGTACGGGCTCAAGATGCTGCTTTCCAACAAGCCTTGCTCA
ATTATCTTAATTTGGTGCTCAAAGTGCAGCAGGAAGTTCAAGACAATATTACGCGCTATGTTGAGGGGCAAAAAACAGTC
TCTTCACTTAAAACAGCCAATGCCTCTGCTATAGAATCAACAAGGCTTGCTTTAGTGCGATATAAGGAAGGAGAAGCAAA
TTATACCACTGTGCTGAATGCAGAACAGCAACAATTGCGAGTACAAACCTCGCTGGTCAATGCCACAGGAGAATTGGCTT
TGTCTCTGGTTGGCTTATACCGCTCACTTGGAGGCGGTTGGCAAATACGAGGCAAGAATGATATTGTTTCAAATCAAATA
AAAAGTGAAATGGCTGCCCGTACTAATTGGGGTAGTTTATTGAAGCAGGAAAATCATTTGCCTCCGGATTCTAATGGACA
ACGAATGAAACAATTATATTTACCAACCTGGTGA

Upstream 100 bases:

>100_bases
GTATTCATAGATAATATCTAATGATTGATGAACCAATAGTTCAAATCCATCTTCAATCTACATAAGCTGCTTTTGAACAG
ATAGGGAAATACTGGTATAC

Downstream 100 bases:

>100_bases
TGAGAATGAACTCTCAAAATAAACAAAATTTAGTTAAAACCGTGGCAATTGTATTTTTTGGTATTGTCTTTGTTTATTTA
GTATATGACCATTTTACAAG

Product: outer membrane efflux protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 517; Mature: 517

Protein sequence:

>517_residues
MLKILALLSCLILSSCLVGPNFKEPKKDAANYWLTSSPAIKQSAFQNANWWKVFNDPTLTVLIDNGYHNNLSLQMAGVRV
LQARAQLAQSVGELYPQQQAMVGDYNYNRIGGNQLEGLLPPDFLTASLGFSASWELDFWGKYRRAIQSNDALFLASLAAY
DSALVTLTSDIASTFIKIRTSEELIKVTKANIQVQAMSLKIAKDRYSGGQTSLLDVEQAATELAETQAKLPQYVSDLQHQ
KDILAVLLGTTPDKVDDLLKKNKGIPKASAVVEVGIPKEVIARRPDVYQARMEAIAQSAAIGAVKANLYPSLSLVGTFVF
ASNNIGSSTISDIFDWSNRNIVAGPSLTWSLLNYGQITNAVRAQDAAFQQALLNYLNLVLKVQQEVQDNITRYVEGQKTV
SSLKTANASAIESTRLALVRYKEGEANYTTVLNAEQQQLRVQTSLVNATGELALSLVGLYRSLGGGWQIRGKNDIVSNQI
KSEMAARTNWGSLLKQENHLPPDSNGQRMKQLYLPTW

Sequences:

>Translated_517_residues
MLKILALLSCLILSSCLVGPNFKEPKKDAANYWLTSSPAIKQSAFQNANWWKVFNDPTLTVLIDNGYHNNLSLQMAGVRV
LQARAQLAQSVGELYPQQQAMVGDYNYNRIGGNQLEGLLPPDFLTASLGFSASWELDFWGKYRRAIQSNDALFLASLAAY
DSALVTLTSDIASTFIKIRTSEELIKVTKANIQVQAMSLKIAKDRYSGGQTSLLDVEQAATELAETQAKLPQYVSDLQHQ
KDILAVLLGTTPDKVDDLLKKNKGIPKASAVVEVGIPKEVIARRPDVYQARMEAIAQSAAIGAVKANLYPSLSLVGTFVF
ASNNIGSSTISDIFDWSNRNIVAGPSLTWSLLNYGQITNAVRAQDAAFQQALLNYLNLVLKVQQEVQDNITRYVEGQKTV
SSLKTANASAIESTRLALVRYKEGEANYTTVLNAEQQQLRVQTSLVNATGELALSLVGLYRSLGGGWQIRGKNDIVSNQI
KSEMAARTNWGSLLKQENHLPPDSNGQRMKQLYLPTW
>Mature_517_residues
MLKILALLSCLILSSCLVGPNFKEPKKDAANYWLTSSPAIKQSAFQNANWWKVFNDPTLTVLIDNGYHNNLSLQMAGVRV
LQARAQLAQSVGELYPQQQAMVGDYNYNRIGGNQLEGLLPPDFLTASLGFSASWELDFWGKYRRAIQSNDALFLASLAAY
DSALVTLTSDIASTFIKIRTSEELIKVTKANIQVQAMSLKIAKDRYSGGQTSLLDVEQAATELAETQAKLPQYVSDLQHQ
KDILAVLLGTTPDKVDDLLKKNKGIPKASAVVEVGIPKEVIARRPDVYQARMEAIAQSAAIGAVKANLYPSLSLVGTFVF
ASNNIGSSTISDIFDWSNRNIVAGPSLTWSLLNYGQITNAVRAQDAAFQQALLNYLNLVLKVQQEVQDNITRYVEGQKTV
SSLKTANASAIESTRLALVRYKEGEANYTTVLNAEQQQLRVQTSLVNATGELALSLVGLYRSLGGGWQIRGKNDIVSNQI
KSEMAARTNWGSLLKQENHLPPDSNGQRMKQLYLPTW

Specific function: In Pathogenic Strains It Allows The Bacteria To Invade Brain Microvascular Endothelial Cells (Bmec) Thus Allowing It To Cross The Blood-Brain Barrier And Cause Neonatal Meningitis. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI1786785, Length=478, Percent_Identity=23.4309623430962, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI2367348, Length=493, Percent_Identity=23.5294117647059, Blast_Score=101, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010131 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 56794; Mature: 56794

Theoretical pI: Translated: 9.17; Mature: 9.17

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKILALLSCLILSSCLVGPNFKEPKKDAANYWLTSSPAIKQSAFQNANWWKVFNDPTLT
CHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCEEECCCCHHHHHHHCCCCCEEEECCCEEE
VLIDNGYHNNLSLQMAGVRVLQARAQLAQSVGELYPQQQAMVGDYNYNRIGGNQLEGLLP
EEEECCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCHHHEECCCCCCCCCCCCCCCCCC
PDFLTASLGFSASWELDFWGKYRRAIQSNDALFLASLAAYDSALVTLTSDIASTFIKIRT
HHHHHHHCCCCEEECCHHHHHHHHHHCCCCCEEEHHHHHHCHHHHHHHHHHHHHHEEEEC
SEELIKVTKANIQVQAMSLKIAKDRYSGGQTSLLDVEQAATELAETQAKLPQYVSDLQHQ
HHHHHHHHHCCEEEEEEEEEEEHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KDILAVLLGTTPDKVDDLLKKNKGIPKASAVVEVGIPKEVIARRPDVYQARMEAIAQSAA
HHHHHHHCCCCHHHHHHHHHHCCCCCCHHCEEEECCCHHHHHCCCHHHHHHHHHHHHHHH
IGAVKANLYPSLSLVGTFVFASNNIGSSTISDIFDWSNRNIVAGPSLTWSLLNYGQITNA
HHHHHHCCCCCHHHHEEEEEECCCCCCHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHH
VRAQDAAFQQALLNYLNLVLKVQQEVQDNITRYVEGQKTVSSLKTANASAIESTRLALVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHEEEEEE
YKEGEANYTTVLNAEQQQLRVQTSLVNATGELALSLVGLYRSLGGGWQIRGKNDIVSNQI
EECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHH
KSEMAARTNWGSLLKQENHLPPDSNGQRMKQLYLPTW
HHHHHHCCCHHHHHHHCCCCCCCCCCHHHHHHCCCCC
>Mature Secondary Structure
MLKILALLSCLILSSCLVGPNFKEPKKDAANYWLTSSPAIKQSAFQNANWWKVFNDPTLT
CHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCEEECCCCHHHHHHHCCCCCEEEECCCEEE
VLIDNGYHNNLSLQMAGVRVLQARAQLAQSVGELYPQQQAMVGDYNYNRIGGNQLEGLLP
EEEECCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCHHHEECCCCCCCCCCCCCCCCCC
PDFLTASLGFSASWELDFWGKYRRAIQSNDALFLASLAAYDSALVTLTSDIASTFIKIRT
HHHHHHHCCCCEEECCHHHHHHHHHHCCCCCEEEHHHHHHCHHHHHHHHHHHHHHEEEEC
SEELIKVTKANIQVQAMSLKIAKDRYSGGQTSLLDVEQAATELAETQAKLPQYVSDLQHQ
HHHHHHHHHCCEEEEEEEEEEEHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KDILAVLLGTTPDKVDDLLKKNKGIPKASAVVEVGIPKEVIARRPDVYQARMEAIAQSAA
HHHHHHHCCCCHHHHHHHHHHCCCCCCHHCEEEECCCHHHHHCCCHHHHHHHHHHHHHHH
IGAVKANLYPSLSLVGTFVFASNNIGSSTISDIFDWSNRNIVAGPSLTWSLLNYGQITNA
HHHHHHCCCCCHHHHEEEEEECCCCCCHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHH
VRAQDAAFQQALLNYLNLVLKVQQEVQDNITRYVEGQKTVSSLKTANASAIESTRLALVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHEEEEEE
YKEGEANYTTVLNAEQQQLRVQTSLVNATGELALSLVGLYRSLGGGWQIRGKNDIVSNQI
EECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHH
KSEMAARTNWGSLLKQENHLPPDSNGQRMKQLYLPTW
HHHHHHCCCHHHHHHHCCCCCCCCCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2338917; 2622339 [H]