BacMap

Definition	Legionella pneumophila str. Corby chromosome, complete genome.
Accession	NC_009494
Length	3,576,470

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The map label for this gene is cadA [H]

Identifier: 148359913

GI number: 148359913

Start: 2788229

End: 2788714

Strand: Reverse

Name: cadA [H]

Synonym: LPC_1842

Alternate gene names: 148359913

Gene position: 2788714-2788229 (Counterclockwise)

Preceding gene: 148359914

Following gene: 148359907

Centisome position: 77.97

GC content: 39.3

Gene sequence:

>486_bases
ATGGGTATTGAACGTGTGGTTATGCTCACAGGAGATAATTTGATAACTGCCTCCTCAATTGGCGAACAAGCGGGTGTTGA
TGAGGTATTTTCTGATTTATCACCAGAAGATAAGACACGAAAAATTGAAGAGCTAGAAATCCGTTATGGTAAGGTAATGA
TGGTTGGTGATGGAGTAAATGATGCACCAGCACTCGCAGCAGCCCATGTAGGAGTTGCTATGGGTGCTGTCGGAACCGAT
GTCGCATTAGAAACTGCGGATGTAGCCTTAATGGGGGATAATTTATTAAAATTACCTTATCTTATCGAATTTAGTCGTCG
AACTTGGAATATAATTTTACAAAATTTGGGACTTTCTATTATTGTAATTGGCTCTCTTGTTGTCGGGGCAGTAACAGGTT
ATTTTACGTTGCCGATAGCAGTTTTAGCTCATGAAATCAGTGAGCTTATTGTTATTGCAAGTGGTCTTCGTATGTTAAAA
TCTTAA

Upstream 100 bases:

>100_bases
GTCGTATTATTAGGAACTGATAAGGAAATCCTCGGTTTAATTGCAATTGCGGATCCTTCTAAGACCAACAGCAAGGCAGA
TGGTGTCAAACTTAAAATCG

Downstream 100 bases:

>100_bases
CCGTAGATGAGTAATTATAATGCGTTTAATACCCTCTCCAGTCGTTTCCTGACTTCACTAGCGATCTGATTAATTTCAGG
ATTGCTGACCAATTCTAATA

Product: hypothetical protein

Products: NA

Alternate protein names: Cadmium efflux ATPase [H]

Number of amino acids: Translated: 161; Mature: 160

Protein sequence:

>161_residues
MGIERVVMLTGDNLITASSIGEQAGVDEVFSDLSPEDKTRKIEELEIRYGKVMMVGDGVNDAPALAAAHVGVAMGAVGTD
VALETADVALMGDNLLKLPYLIEFSRRTWNIILQNLGLSIIVIGSLVVGAVTGYFTLPIAVLAHEISELIVIASGLRMLK
S

Sequences:

>Translated_161_residues
MGIERVVMLTGDNLITASSIGEQAGVDEVFSDLSPEDKTRKIEELEIRYGKVMMVGDGVNDAPALAAAHVGVAMGAVGTD
VALETADVALMGDNLLKLPYLIEFSRRTWNIILQNLGLSIIVIGSLVVGAVTGYFTLPIAVLAHEISELIVIASGLRMLK
S
>Mature_160_residues
GIERVVMLTGDNLITASSIGEQAGVDEVFSDLSPEDKTRKIEELEIRYGKVMMVGDGVNDAPALAAAHVGVAMGAVGTDV
ALETADVALMGDNLLKLPYLIEFSRRTWNIILQNLGLSIIVIGSLVVGAVTGYFTLPIAVLAHEISELIVIASGLRMLKS

Specific function: This electroneutral antiporter ejects one cadmium ion while accumulating two protons by an energy-dependent efflux mechanism [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743073, Length=121, Percent_Identity=49.5867768595041, Blast_Score=106, Evalue=8e-24,
Organism=Homo sapiens, GI55743071, Length=121, Percent_Identity=49.5867768595041, Blast_Score=106, Evalue=9e-24,
Organism=Homo sapiens, GI115529486, Length=121, Percent_Identity=47.1074380165289, Blast_Score=101, Evalue=2e-22,
Organism=Homo sapiens, GI28373113, Length=184, Percent_Identity=32.0652173913043, Blast_Score=67, Evalue=6e-12,
Organism=Homo sapiens, GI28373103, Length=184, Percent_Identity=32.0652173913043, Blast_Score=67, Evalue=6e-12,
Organism=Homo sapiens, GI28373109, Length=184, Percent_Identity=32.0652173913043, Blast_Score=67, Evalue=7e-12,
Organism=Homo sapiens, GI28373115, Length=184, Percent_Identity=32.0652173913043, Blast_Score=67, Evalue=7e-12,
Organism=Homo sapiens, GI28373111, Length=184, Percent_Identity=32.0652173913043, Blast_Score=67, Evalue=7e-12,
Organism=Homo sapiens, GI28373105, Length=184, Percent_Identity=32.0652173913043, Blast_Score=67, Evalue=7e-12,
Organism=Homo sapiens, GI28373107, Length=184, Percent_Identity=32.0652173913043, Blast_Score=67, Evalue=7e-12,
Organism=Homo sapiens, GI48762685, Length=84, Percent_Identity=45.2380952380952, Blast_Score=65, Evalue=2e-11,
Organism=Homo sapiens, GI48762687, Length=84, Percent_Identity=45.2380952380952, Blast_Score=65, Evalue=2e-11,
Organism=Homo sapiens, GI48762689, Length=84, Percent_Identity=45.2380952380952, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI48762691, Length=84, Percent_Identity=45.2380952380952, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI22748667, Length=120, Percent_Identity=35.8333333333333, Blast_Score=64, Evalue=8e-11,
Organism=Escherichia coli, GI1789879, Length=154, Percent_Identity=43.5064935064935, Blast_Score=106, Evalue=8e-25,
Organism=Escherichia coli, GI1786691, Length=163, Percent_Identity=41.1042944785276, Blast_Score=103, Evalue=4e-24,
Organism=Escherichia coli, GI1786914, Length=107, Percent_Identity=41.1214953271028, Blast_Score=67, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17556548, Length=121, Percent_Identity=47.9338842975207, Blast_Score=89, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17531459, Length=148, Percent_Identity=33.1081081081081, Blast_Score=70, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17557486, Length=107, Percent_Identity=36.4485981308411, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17557770, Length=125, Percent_Identity=34.4, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI32566766, Length=107, Percent_Identity=36.4485981308411, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI193203356, Length=156, Percent_Identity=29.4871794871795, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI193203354, Length=156, Percent_Identity=29.4871794871795, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71997262, Length=165, Percent_Identity=32.1212121212121, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71997275, Length=168, Percent_Identity=31.547619047619, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71997269, Length=134, Percent_Identity=35.0746268656716, Blast_Score=64, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI193210130, Length=141, Percent_Identity=32.6241134751773, Blast_Score=63, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17559224, Length=92, Percent_Identity=40.2173913043478, Blast_Score=63, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI71988506, Length=141, Percent_Identity=32.6241134751773, Blast_Score=63, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17554158, Length=141, Percent_Identity=32.6241134751773, Blast_Score=63, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6321271, Length=172, Percent_Identity=31.3953488372093, Blast_Score=73, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320245, Length=136, Percent_Identity=35.2941176470588, Blast_Score=71, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6320243, Length=136, Percent_Identity=35.2941176470588, Blast_Score=71, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6320244, Length=136, Percent_Identity=35.2941176470588, Blast_Score=71, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6320475, Length=119, Percent_Identity=36.9747899159664, Blast_Score=71, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6321432, Length=133, Percent_Identity=33.0827067669173, Blast_Score=66, Evalue=3e-12,
Organism=Drosophila melanogaster, GI221329854, Length=116, Percent_Identity=45.6896551724138, Blast_Score=93, Evalue=8e-20,
Organism=Drosophila melanogaster, GI17136664, Length=184, Percent_Identity=30.9782608695652, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24762455, Length=184, Percent_Identity=30.9782608695652, Blast_Score=66, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24762453, Length=184, Percent_Identity=30.9782608695652, Blast_Score=66, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24762447, Length=184, Percent_Identity=30.9782608695652, Blast_Score=66, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24762457, Length=184, Percent_Identity=30.9782608695652, Blast_Score=66, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24762449, Length=184, Percent_Identity=30.9782608695652, Blast_Score=66, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24762445, Length=184, Percent_Identity=30.9782608695652, Blast_Score=66, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24762451, Length=184, Percent_Identity=30.9782608695652, Blast_Score=66, Evalue=8e-12,
Organism=Drosophila melanogaster, GI281366676, Length=92, Percent_Identity=43.4782608695652, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: =3.6.3.3 [H]

Molecular weight: Translated: 17052; Mature: 16921

Theoretical pI: Translated: 4.30; Mature: 4.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIERVVMLTGDNLITASSIGEQAGVDEVFSDLSPEDKTRKIEELEIRYGKVMMVGDGVN
CCCCEEEEEECCCEEEHHHCCCCCCHHHHHHCCCCCCHHHHHHHHHEEECEEEEEECCCC
DAPALAAAHVGVAMGAVGTDVALETADVALMGDNLLKLPYLIEFSRRTWNIILQNLGLSI
CCHHHHHHHHHHHHCCCCCCCEEECCCEEEECCCCCCCCHHEEECHHHHHHHHHHCCCHH
IVIGSLVVGAVTGYFTLPIAVLAHEISELIVIASGLRMLKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GIERVVMLTGDNLITASSIGEQAGVDEVFSDLSPEDKTRKIEELEIRYGKVMMVGDGVN
CCCEEEEEECCCEEEHHHCCCCCCHHHHHHCCCCCCHHHHHHHHHEEECEEEEEECCCC
DAPALAAAHVGVAMGAVGTDVALETADVALMGDNLLKLPYLIEFSRRTWNIILQNLGLSI
CCHHHHHHHHHHHHCCCCCCCEEECCCEEEECCCCCCCCHHEEECHHHHHHHHHHCCCHH
IVIGSLVVGAVTGYFTLPIAVLAHEISELIVIASGLRMLKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8188605; 8188606 [H]