| Definition | Legionella pneumophila str. Corby chromosome, complete genome. |
|---|---|
| Accession | NC_009494 |
| Length | 3,576,470 |
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The map label for this gene is mvaA [H]
Identifier: 148359626
GI number: 148359626
Start: 2410582
End: 2411880
Strand: Direct
Name: mvaA [H]
Synonym: LPC_1538
Alternate gene names: 148359626
Gene position: 2410582-2411880 (Clockwise)
Preceding gene: 148359625
Following gene: 148359627
Centisome position: 67.4
GC content: 40.49
Gene sequence:
>1299_bases ATGTCCATAGCTGCTAATGCCGGTGAATTATTTCGCGGATTCTCAAAGTTATCACGTGAAGAGCGCTTTCAAAGGTTATG CGCTTTAGGTGCCTTGACTCATGAAGACATAACATTTCTTAAACAAGGCGGTATTAAAGATTTAAATCTGGCCGACAAAT TGATTGAAAATGTGATTGGATATTTTCAGCTTCCATTGGGTGTGGCTACTAATTTTAATATTGATGGACGTGATTATGTA ATACCTTTGGCAGTAGAAGAAACCTCTATTATTGCCGCTCTTTCCAAATCAGCGAAATGGATTAGGCAGCATGGTGAAAT CAATACCTGGGTTCACGGAGAATGTATTCTTGGGCAAATTCAACTGGCAAAAGTAAAGGACTTTCACAGATTCTCTGACC TCTTTAATAAAAATCGTCAATATTTTATAGAAATAGCGAATAAAGACGTTGCCGCCAATATGGTCAAACGAGGCGGCGGT GTTACCGATTTGCAAGTACGTCATTTAAAGAGAGAAGATGGACAAGATATGGCAGTAATTCATTTGACGATGAACAGCTG CGATGCTATGGGTGCCAATATCATCAATCAAGTACTTGAATATTTAAAACAACCCATAGAACAAATAACTGGTGAAGAAG TCACCATGTGTATTTTATCCAATTTAAACGATCAAAAATTAACGACCGCTCAAGTCATCATTCGTAATATTGACCCCATC CTCGGTCAAAAATTGCAAGAGGCCTCACTCTTTGCAGAAATAGATCCCTATCGCGCTGCTACCCATAATAAAGGGGTTAT GAATGGAATTGATCCGGTTTTAATTGCTACAGGGAATGATTGGCGAGCTGTGGAAGCTGGAATACACTCCTATGCGGCAC GTTCGGGACAATACAAAGCGATTACTCGCTGGCGGTATCAAAATGAAATACTCACAGGAGAGTTAACTGCTCCTATCATA GTAGGTACTGTTGGAGGCGTAACATCTTTACACCCCACGGCTAAAATGTGCTTACGAATGATGGATATCACTTCTGCCAA TCAACTCTCCCAGGTGATCGCAGCAGTTGGACTAGTACAAAATCTTGGCGCACTCAAAGCTTTATGCACTGACGGGATCA TTCAAGGCCATATGAAATTGCATATTGATAATTTGCTATTAGTTGCAGGGGCTAATGAAAATGAAATGCCCGTGCTCAAA GAAAAATTGCAAGAATGGCTTAACCTGAACAAACGAGTCAGCTTGAATAACGCTTATGACCTATTAGCTGAAATCCGACA AGCTCCTGTTGCAGTATGA
Upstream 100 bases:
>100_bases CCGGGCAAGTACTGACCCAAATGAATACAATTGAATATGAATTGAAAACTGCTATGTTTTGTACTGGCAGCCGAGTTCTT GATGATTTAAAGGAGAAGGC
Downstream 100 bases:
>100_bases AATGGCAAATTCCCGCTAAAACATTTTTATTAGGAGAATACGCTGCCATTGCGGGAGAACCAGCTATCCTATTAACGACA AGCCCTTGCTTTACTCTTAC
Product: hydroxymethylglutaryl CoA reductase
Products: NA
Alternate protein names: HMG-CoA reductase [H]
Number of amino acids: Translated: 432; Mature: 431
Protein sequence:
>432_residues MSIAANAGELFRGFSKLSREERFQRLCALGALTHEDITFLKQGGIKDLNLADKLIENVIGYFQLPLGVATNFNIDGRDYV IPLAVEETSIIAALSKSAKWIRQHGEINTWVHGECILGQIQLAKVKDFHRFSDLFNKNRQYFIEIANKDVAANMVKRGGG VTDLQVRHLKREDGQDMAVIHLTMNSCDAMGANIINQVLEYLKQPIEQITGEEVTMCILSNLNDQKLTTAQVIIRNIDPI LGQKLQEASLFAEIDPYRAATHNKGVMNGIDPVLIATGNDWRAVEAGIHSYAARSGQYKAITRWRYQNEILTGELTAPII VGTVGGVTSLHPTAKMCLRMMDITSANQLSQVIAAVGLVQNLGALKALCTDGIIQGHMKLHIDNLLLVAGANENEMPVLK EKLQEWLNLNKRVSLNNAYDLLAEIRQAPVAV
Sequences:
>Translated_432_residues MSIAANAGELFRGFSKLSREERFQRLCALGALTHEDITFLKQGGIKDLNLADKLIENVIGYFQLPLGVATNFNIDGRDYV IPLAVEETSIIAALSKSAKWIRQHGEINTWVHGECILGQIQLAKVKDFHRFSDLFNKNRQYFIEIANKDVAANMVKRGGG VTDLQVRHLKREDGQDMAVIHLTMNSCDAMGANIINQVLEYLKQPIEQITGEEVTMCILSNLNDQKLTTAQVIIRNIDPI LGQKLQEASLFAEIDPYRAATHNKGVMNGIDPVLIATGNDWRAVEAGIHSYAARSGQYKAITRWRYQNEILTGELTAPII VGTVGGVTSLHPTAKMCLRMMDITSANQLSQVIAAVGLVQNLGALKALCTDGIIQGHMKLHIDNLLLVAGANENEMPVLK EKLQEWLNLNKRVSLNNAYDLLAEIRQAPVAV >Mature_431_residues SIAANAGELFRGFSKLSREERFQRLCALGALTHEDITFLKQGGIKDLNLADKLIENVIGYFQLPLGVATNFNIDGRDYVI PLAVEETSIIAALSKSAKWIRQHGEINTWVHGECILGQIQLAKVKDFHRFSDLFNKNRQYFIEIANKDVAANMVKRGGGV TDLQVRHLKREDGQDMAVIHLTMNSCDAMGANIINQVLEYLKQPIEQITGEEVTMCILSNLNDQKLTTAQVIIRNIDPIL GQKLQEASLFAEIDPYRAATHNKGVMNGIDPVLIATGNDWRAVEAGIHSYAARSGQYKAITRWRYQNEILTGELTAPIIV GTVGGVTSLHPTAKMCLRMMDITSANQLSQVIAAVGLVQNLGALKALCTDGIIQGHMKLHIDNLLLVAGANENEMPVLKE KLQEWLNLNKRVSLNNAYDLLAEIRQAPVAV
Specific function: P.mevalonii can use mevalonate as sole carbon source. With this enzyme mevalonate is deacetylated to HMG-CoA [H]
COG id: COG1257
COG function: function code I; Hydroxymethylglutaryl-CoA reductase
Gene ontology:
Cell location: Cytoplasmic
Metaboloic importance: NA
Operon status: Not Known
Operon components: None
Similarity: Belongs to the HMG-CoA reductase family [H]
Homologues:
None
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002202 - InterPro: IPR004553 - InterPro: IPR023074 - InterPro: IPR023076 - InterPro: IPR009023 - InterPro: IPR009029 [H]
Pfam domain/function: PF00368 HMG-CoA_red [H]
EC number: =1.1.1.88 [H]
Molecular weight: Translated: 47759; Mature: 47628
Theoretical pI: Translated: 6.90; Mature: 6.90
Prosite motif: PS00066 HMG_COA_REDUCTASE_1 ; PS01192 HMG_COA_REDUCTASE_3 ; PS50065 HMG_COA_REDUCTASE_4
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.4 %Cys (Translated Protein) 2.8 %Met (Translated Protein) 4.2 %Cys+Met (Translated Protein) 1.4 %Cys (Mature Protein) 2.6 %Met (Mature Protein) 3.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSIAANAGELFRGFSKLSREERFQRLCALGALTHEDITFLKQGGIKDLNLADKLIENVIG CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHH YFQLPLGVATNFNIDGRDYVIPLAVEETSIIAALSKSAKWIRQHGEINTWVHGECILGQI HHCCCCCCEECCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCCCEEECCEEEECCE QLAKVKDFHRFSDLFNKNRQYFIEIANKDVAANMVKRGGGVTDLQVRHLKREDGQDMAVI EHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCCCHHHHHHHHCCCCCCEEEE HLTMNSCDAMGANIINQVLEYLKQPIEQITGEEVTMCILSNLNDQKLTTAQVIIRNIDPI EEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHCCCCCCHHHHHHHHHHHCCHH LGQKLQEASLFAEIDPYRAATHNKGVMNGIDPVLIATGNDWRAVEAGIHSYAARSGQYKA HHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCEEH ITRWRYQNEILTGELTAPIIVGTVGGVTSLHPTAKMCLRMMDITSANQLSQVIAAVGLVQ HHHHHHHCCEEECCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH NLGALKALCTDGIIQGHMKLHIDNLLLVAGANENEMPVLKEKLQEWLNLNKRVSLNNAYD HHHHHHHHHHHHHHHCCCEEEEEEEEEEECCCCCCCHHHHHHHHHHHCCCCEEECCHHHH LLAEIRQAPVAV HHHHHHHCCCCC >Mature Secondary Structure SIAANAGELFRGFSKLSREERFQRLCALGALTHEDITFLKQGGIKDLNLADKLIENVIG CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHH YFQLPLGVATNFNIDGRDYVIPLAVEETSIIAALSKSAKWIRQHGEINTWVHGECILGQI HHCCCCCCEECCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCCCEEECCEEEECCE QLAKVKDFHRFSDLFNKNRQYFIEIANKDVAANMVKRGGGVTDLQVRHLKREDGQDMAVI EHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCCCHHHHHHHHCCCCCCEEEE HLTMNSCDAMGANIINQVLEYLKQPIEQITGEEVTMCILSNLNDQKLTTAQVIIRNIDPI EEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHCCCCCCHHHHHHHHHHHCCHH LGQKLQEASLFAEIDPYRAATHNKGVMNGIDPVLIATGNDWRAVEAGIHSYAARSGQYKA HHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCEEH ITRWRYQNEILTGELTAPIIVGTVGGVTSLHPTAKMCLRMMDITSANQLSQVIAAVGLVQ HHHHHHHCCEEECCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH NLGALKALCTDGIIQGHMKLHIDNLLLVAGANENEMPVLKEKLQEWLNLNKRVSLNNAYD HHHHHHHHHHHHHHHCCCEEEEEEEEEEECCCCCCCHHHHHHHHHHHCCCCEEECCHHHH LLAEIRQAPVAV HHHHHHHCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 2656635; 2477360; 2123872; 1634543; 10377386 [H]