Click here to switch to the map view.

The map label for this gene is glpK [H]

Identifier: 148358945

GI number: 148358945

Start: 1625256

End: 1626731

Strand: Direct

Name: glpK [H]

Synonym: LPC_0830

Alternate gene names: 148358945

Gene position: 1625256-1626731 (Clockwise)

Preceding gene: 148358943

Following gene: 148358947

Centisome position: 45.44

GC content: 40.18

Gene sequence:

>1476_bases
ATGAACTATATACTAGCTATTGACCAGGGAACAAGTAGTACTCGCGCTATGATCTACACCCTTCAAGGTGATTTAATTGC
AAATAGTCAGTATCCGCTTACTCAATATTACCCCAATTTGGGTTGGGTAGAACACGATCCTGAGGAAATATGGCAAAAAA
CTCTGAATGCGATGAGGGATGTCGTATCTCAAGTTCAAGGAAAAGCAATTTTATGCTGTGGCCTTACCAACCAACGGGAA
ACTACTCTGATTTGGAACAAAAAAACAGGGGAATGCCTCGCGCCAGCTATTGTGTGGCAAGATAGACGTACGGAAGAGTT
TTGTTATTCATTGTCTGAATACTCGTCAATGATACAAGAGAAAACCGGATTACTTCCTGATCCCTATTTTTCAGCGAGCA
AGTTAAACTGGTTACTAAAGAATAATGCTCAAGCTCAATCACTAATTAATCAGGGGGATTTGGCATTTGGGACAATAGAC
AGTTTTTTAATATGGCGCATGACTAAAGGTGCCAGTCATGCTACCGATATCACTAACGCATCCAGAACTATGCTGTTTAA
TATTCATGATGAAAAATGGGATAAGCAGTTGCTGGAGCTTTTTTCTATTTCAGAATCGGTATTACCAGAGGTTTACTCCA
GTGATAATCATTTTGGGGTGATAGATAAAGAATGGCTGGGAGTAGAAATACCAATTACCGGGGTTGCAGGTGATCAACAA
GCCGCTTTAATTGGGCAAAGTTGTTTTAATGGCGGAATGGTTAAAGCTACTTTTGGTACGGGGGGATTTTTATTGCTCAA
TACAGGTGATAAACCAGTTTTCTCAAAACATAAATTGTTGACTACTATTGCCTATAAAATTAAAGAAAAAACAGCTTATG
GTTTGGAGGGTAGTATTTATCATGCCGGAACAACTGTTAAATGGTTACGCGATGAAATGAAGTTGATATCTCATTCTGCT
GAAACTGAAGTATTGGCACAAAGTCTTGATAGCAATAACGGTGTATATCTTGTTTCATCTTTTACTGGTCTTGGAGCACC
TCATTGGTTATCAATAACAGGAACGGCTATTATTGGCGTATCCCGTTCAACGAATAGAGCGCATTTTGCCAGAGCCGCCC
TGGAAGGCGTTTGTTATCAAACACGTGATGTATTAACCTGTATGAGAGATGATAGTCAATTGGATTTGACTTTATTAAGA
GCGGATGGAGGGATGGCAGTAAACCAATGGTTTCTACAATTTATGGCTGATCAGTGTCAGTTGACAATTCAAAAACCCAA
GGACATTGAAACGACTGCCAAAGGGGCAGCAGTATTAGCCGCAATAGGTTCTGGTCTATTTGATTCAGTTTCTTCAGTAA
ATAAGGTATGGGAAGTTGAGAACGAGTTTCAGCCATCCAGGGAAAGAGAGGTAGTTGAAAAAGATTTTCGTGGCTGGTTG
GAGGCGTTGGCAATGGTTAAAGCAAGGCATGCATAG

Upstream 100 bases:

>100_bases
GCCTCCACCAATAATTGCAACATCAAAAACCTGATCCATGTTTTTATCTCCGAAAAAAGATTACACTCAATATATATAAA
TATAGAGGGATTTTATAATA

Downstream 100 bases:

>100_bases
GCTAGTCTTATATTTAAATTAGTGCGATTAAATTAGATCGCAGTAGCTCGTATTATAGTTTAATACAAGCTACTGATTAA
CACGTTGGATTTTTTTATTT

Product: glycerol kinase

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase; Glycerokinase; GK [H]

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MNYILAIDQGTSSTRAMIYTLQGDLIANSQYPLTQYYPNLGWVEHDPEEIWQKTLNAMRDVVSQVQGKAILCCGLTNQRE
TTLIWNKKTGECLAPAIVWQDRRTEEFCYSLSEYSSMIQEKTGLLPDPYFSASKLNWLLKNNAQAQSLINQGDLAFGTID
SFLIWRMTKGASHATDITNASRTMLFNIHDEKWDKQLLELFSISESVLPEVYSSDNHFGVIDKEWLGVEIPITGVAGDQQ
AALIGQSCFNGGMVKATFGTGGFLLLNTGDKPVFSKHKLLTTIAYKIKEKTAYGLEGSIYHAGTTVKWLRDEMKLISHSA
ETEVLAQSLDSNNGVYLVSSFTGLGAPHWLSITGTAIIGVSRSTNRAHFARAALEGVCYQTRDVLTCMRDDSQLDLTLLR
ADGGMAVNQWFLQFMADQCQLTIQKPKDIETTAKGAAVLAAIGSGLFDSVSSVNKVWEVENEFQPSREREVVEKDFRGWL
EALAMVKARHA

Sequences:

>Translated_491_residues
MNYILAIDQGTSSTRAMIYTLQGDLIANSQYPLTQYYPNLGWVEHDPEEIWQKTLNAMRDVVSQVQGKAILCCGLTNQRE
TTLIWNKKTGECLAPAIVWQDRRTEEFCYSLSEYSSMIQEKTGLLPDPYFSASKLNWLLKNNAQAQSLINQGDLAFGTID
SFLIWRMTKGASHATDITNASRTMLFNIHDEKWDKQLLELFSISESVLPEVYSSDNHFGVIDKEWLGVEIPITGVAGDQQ
AALIGQSCFNGGMVKATFGTGGFLLLNTGDKPVFSKHKLLTTIAYKIKEKTAYGLEGSIYHAGTTVKWLRDEMKLISHSA
ETEVLAQSLDSNNGVYLVSSFTGLGAPHWLSITGTAIIGVSRSTNRAHFARAALEGVCYQTRDVLTCMRDDSQLDLTLLR
ADGGMAVNQWFLQFMADQCQLTIQKPKDIETTAKGAAVLAAIGSGLFDSVSSVNKVWEVENEFQPSREREVVEKDFRGWL
EALAMVKARHA
>Mature_491_residues
MNYILAIDQGTSSTRAMIYTLQGDLIANSQYPLTQYYPNLGWVEHDPEEIWQKTLNAMRDVVSQVQGKAILCCGLTNQRE
TTLIWNKKTGECLAPAIVWQDRRTEEFCYSLSEYSSMIQEKTGLLPDPYFSASKLNWLLKNNAQAQSLINQGDLAFGTID
SFLIWRMTKGASHATDITNASRTMLFNIHDEKWDKQLLELFSISESVLPEVYSSDNHFGVIDKEWLGVEIPITGVAGDQQ
AALIGQSCFNGGMVKATFGTGGFLLLNTGDKPVFSKHKLLTTIAYKIKEKTAYGLEGSIYHAGTTVKWLRDEMKLISHSA
ETEVLAQSLDSNNGVYLVSSFTGLGAPHWLSITGTAIIGVSRSTNRAHFARAALEGVCYQTRDVLTCMRDDSQLDLTLLR
ADGGMAVNQWFLQFMADQCQLTIQKPKDIETTAKGAAVLAAIGSGLFDSVSSVNKVWEVENEFQPSREREVVEKDFRGWL
EALAMVKARHA

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI4504007, Length=442, Percent_Identity=44.3438914027149, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI189409120, Length=502, Percent_Identity=42.0318725099602, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI41393575, Length=442, Percent_Identity=44.5701357466063, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI42794763, Length=447, Percent_Identity=43.8478747203579, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI88196792, Length=501, Percent_Identity=31.5369261477046, Blast_Score=280, Evalue=3e-75,
Organism=Escherichia coli, GI1790361, Length=493, Percent_Identity=44.421906693712, Blast_Score=431, Evalue=1e-122,
Organism=Escherichia coli, GI1789987, Length=486, Percent_Identity=24.4855967078189, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI1789168, Length=493, Percent_Identity=23.9350912778905, Blast_Score=89, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17535599, Length=447, Percent_Identity=38.4787472035794, Blast_Score=324, Evalue=8e-89,
Organism=Caenorhabditis elegans, GI71986140, Length=511, Percent_Identity=22.8962818003914, Blast_Score=162, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI71986147, Length=287, Percent_Identity=26.4808362369338, Blast_Score=110, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6321755, Length=484, Percent_Identity=33.4710743801653, Blast_Score=259, Evalue=1e-69,
Organism=Drosophila melanogaster, GI17864214, Length=491, Percent_Identity=39.7148676171079, Blast_Score=328, Evalue=4e-90,
Organism=Drosophila melanogaster, GI24655555, Length=452, Percent_Identity=37.6106194690265, Blast_Score=318, Evalue=5e-87,
Organism=Drosophila melanogaster, GI24655560, Length=452, Percent_Identity=37.6106194690265, Blast_Score=318, Evalue=5e-87,
Organism=Drosophila melanogaster, GI24655570, Length=452, Percent_Identity=37.6106194690265, Blast_Score=318, Evalue=5e-87,
Organism=Drosophila melanogaster, GI24655574, Length=452, Percent_Identity=37.6106194690265, Blast_Score=318, Evalue=5e-87,
Organism=Drosophila melanogaster, GI24655565, Length=452, Percent_Identity=37.6106194690265, Blast_Score=318, Evalue=5e-87,
Organism=Drosophila melanogaster, GI24654573, Length=423, Percent_Identity=41.371158392435, Blast_Score=309, Evalue=3e-84,
Organism=Drosophila melanogaster, GI19922058, Length=527, Percent_Identity=29.0322580645161, Blast_Score=228, Evalue=1e-59,
Organism=Drosophila melanogaster, GI24652871, Length=494, Percent_Identity=29.1497975708502, Blast_Score=216, Evalue=3e-56,
Organism=Drosophila melanogaster, GI21357867, Length=528, Percent_Identity=27.2727272727273, Blast_Score=211, Evalue=7e-55,
Organism=Drosophila melanogaster, GI24656367, Length=508, Percent_Identity=27.3622047244095, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24656372, Length=371, Percent_Identity=28.5714285714286, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI45552909, Length=286, Percent_Identity=29.020979020979, Blast_Score=126, Evalue=3e-29,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 54576; Mature: 54576

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS00933 FGGY_KINASES_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYILAIDQGTSSTRAMIYTLQGDLIANSQYPLTQYYPNLGWVEHDPEEIWQKTLNAMRD
CCEEEEEECCCCCCEEEEEEEECCEEECCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHH
VVSQVQGKAILCCGLTNQRETTLIWNKKTGECLAPAIVWQDRRTEEFCYSLSEYSSMIQE
HHHHHCCCEEEEEECCCCCCEEEEEECCCCCHHCHHHEECCCCHHHHHHHHHHHHHHHHH
KTGLLPDPYFSASKLNWLLKNNAQAQSLINQGDLAFGTIDSFLIWRMTKGASHATDITNA
HHCCCCCCCCCHHHHHHHHCCCCHHHHHHCCCCEEEHHHHHHHHHHCCCCCCCCCCCCCC
SRTMLFNIHDEKWDKQLLELFSISESVLPEVYSSDNHFGVIDKEWLGVEIPITGVAGDQQ
CEEEEEEECCHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEECCCCCEEEEEEECCCCCCH
AALIGQSCFNGGMVKATFGTGGFLLLNTGDKPVFSKHKLLTTIAYKIKEKTAYGLEGSIY
HHHHHHHHCCCCEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEE
HAGTTVKWLRDEMKLISHSAETEVLAQSLDSNNGVYLVSSFTGLGAPHWLSITGTAIIGV
ECCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEEECEEEEEE
SRSTNRAHFARAALEGVCYQTRDVLTCMRDDSQLDLTLLRADGGMAVNQWFLQFMADQCQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHE
LTIQKPKDIETTAKGAAVLAAIGSGLFDSVSSVNKVWEVENEFQPSREREVVEKDFRGWL
EEECCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHCHHHCCCCHHHHHHHHHHHHHH
EALAMVKARHA
HHHHHHHHCCC
>Mature Secondary Structure
MNYILAIDQGTSSTRAMIYTLQGDLIANSQYPLTQYYPNLGWVEHDPEEIWQKTLNAMRD
CCEEEEEECCCCCCEEEEEEEECCEEECCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHH
VVSQVQGKAILCCGLTNQRETTLIWNKKTGECLAPAIVWQDRRTEEFCYSLSEYSSMIQE
HHHHHCCCEEEEEECCCCCCEEEEEECCCCCHHCHHHEECCCCHHHHHHHHHHHHHHHHH
KTGLLPDPYFSASKLNWLLKNNAQAQSLINQGDLAFGTIDSFLIWRMTKGASHATDITNA
HHCCCCCCCCCHHHHHHHHCCCCHHHHHHCCCCEEEHHHHHHHHHHCCCCCCCCCCCCCC
SRTMLFNIHDEKWDKQLLELFSISESVLPEVYSSDNHFGVIDKEWLGVEIPITGVAGDQQ
CEEEEEEECCHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEECCCCCEEEEEEECCCCCCH
AALIGQSCFNGGMVKATFGTGGFLLLNTGDKPVFSKHKLLTTIAYKIKEKTAYGLEGSIY
HHHHHHHHCCCCEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEE
HAGTTVKWLRDEMKLISHSAETEVLAQSLDSNNGVYLVSSFTGLGAPHWLSITGTAIIGV
ECCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEEECEEEEEE
SRSTNRAHFARAALEGVCYQTRDVLTCMRDDSQLDLTLLRADGGMAVNQWFLQFMADQCQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHE
LTIQKPKDIETTAKGAAVLAAIGSGLFDSVSSVNKVWEVENEFQPSREREVVEKDFRGWL
EEECCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHCHHHCCCCHHHHHHHHHHHHHH
EALAMVKARHA
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA