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The map label for this gene is trxA3 [H]

Identifier: 148358943

GI number: 148358943

Start: 1623352

End: 1623714

Strand: Direct

Name: trxA3 [H]

Synonym: LPC_0828

Alternate gene names: 148358943

Gene position: 1623352-1623714 (Clockwise)

Preceding gene: 148358942

Following gene: 148358945

Centisome position: 45.39

GC content: 37.47

Gene sequence:

>363_bases
ATGCCGACCCAGACTATTAACAGCGCTGAATTTGAATCATTAATTAATGACAATGAGATAGTTTTTATTGATTTCTGGGC
TGAGTGGTGTGCTCCCTGTAAGCAATTTTCAAAAGTATATGAGCAAGTTTCCGATCAATTTCCAGCTATTAAATTTGTTA
AAGTTAACATTGAAGAGCAACAAGAGTTAGCAGATTTTTTCGAGATCCGATCCATCCCTCATCTTATGGTTTTCAAAGAC
AGTATTGTTATTTATTCTGATGCTGGAAGCATACCCGAGTCCACTTTAAAAGAATTGGCGCAACAAGCACTTGATGCTGA
TGTTAGTGAAATACGAGCTCAGCTTGAGCAGAAGGATAAGTAG

Upstream 100 bases:

>100_bases
GCTCTAAAGAAGCTCCAAAATTTCACACTATTAGTGGTACAGGTACAGTAGAGCAAATATTTGACAACATCGTAACGATA
CTCGAAACTTAGGAGTTAAC

Downstream 100 bases:

>100_bases
ATATACTAGCCAGATAATCCGCAAGTTCTTTTTTACTGGCATTATCCATAGTAAGGCCGAGCTTAGTGCGGCGGTTAAGT
ATGTCATCACAATAATTTGC

Product: thioredoxin

Products: NA

Alternate protein names: Trx-2; Protein-disulfide reductase [H]

Number of amino acids: Translated: 120; Mature: 119

Protein sequence:

>120_residues
MPTQTINSAEFESLINDNEIVFIDFWAEWCAPCKQFSKVYEQVSDQFPAIKFVKVNIEEQQELADFFEIRSIPHLMVFKD
SIVIYSDAGSIPESTLKELAQQALDADVSEIRAQLEQKDK

Sequences:

>Translated_120_residues
MPTQTINSAEFESLINDNEIVFIDFWAEWCAPCKQFSKVYEQVSDQFPAIKFVKVNIEEQQELADFFEIRSIPHLMVFKD
SIVIYSDAGSIPESTLKELAQQALDADVSEIRAQLEQKDK
>Mature_119_residues
PTQTINSAEFESLINDNEIVFIDFWAEWCAPCKQFSKVYEQVSDQFPAIKFVKVNIEEQQELADFFEIRSIPHLMVFKDS
IVIYSDAGSIPESTLKELAQQALDADVSEIRAQLEQKDK

Specific function: Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1788936, Length=95, Percent_Identity=37.8947368421053, Blast_Score=83, Evalue=5e-18,
Organism=Escherichia coli, GI87082331, Length=90, Percent_Identity=33.3333333333333, Blast_Score=72, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323072, Length=103, Percent_Identity=32.0388349514563, Blast_Score=74, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6319925, Length=100, Percent_Identity=32, Blast_Score=68, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6321648, Length=103, Percent_Identity=28.1553398058252, Blast_Score=62, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 13808; Mature: 13676

Theoretical pI: Translated: 4.04; Mature: 4.04

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTQTINSAEFESLINDNEIVFIDFWAEWCAPCKQFSKVYEQVSDQFPAIKFVKVNIEEQ
CCCCCCCHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHH
QELADFFEIRSIPHLMVFKDSIVIYSDAGSIPESTLKELAQQALDADVSEIRAQLEQKDK
HHHHHHHHHHCCCCEEEEECCEEEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
PTQTINSAEFESLINDNEIVFIDFWAEWCAPCKQFSKVYEQVSDQFPAIKFVKVNIEEQ
CCCCCCHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHH
QELADFFEIRSIPHLMVFKDSIVIYSDAGSIPESTLKELAQQALDADVSEIRAQLEQKDK
HHHHHHHHHHCCCCEEEEECCEEEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]