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The map label for this gene is rnhA

Identifier: 148358914

GI number: 148358914

Start: 1596392

End: 1596823

Strand: Direct

Name: rnhA

Synonym: LPC_0799

Alternate gene names: 148358914

Gene position: 1596392-1596823 (Clockwise)

Preceding gene: 148358913

Following gene: 148358915

Centisome position: 44.64

GC content: 40.74

Gene sequence:

>432_bases
ATGAAGGTAGAAATCTATACTGATGGTGCATGTAAGGGAAATCCAGGGCCTGGCGGCTGGGGCGTATTGCTCCGATATAA
TGGTAGAGAAAAAACTCTTCATGGAGGAGAGGCGCAAACTACCAATAATCGCATGGAATTAATGGCAGCAATTAAGGGCC
TGGAAGCATTAAAACGTCCTTGTGAGGTGGATTTGTATACCGACTCCCAATATTTGCAGCAAGGAATGAAGGAATGGATC
AAAACATGGAAAAGAAATGGTTGGCGTAACTCCAAGAAAGAGTTGGTTAAAAATGCGGAATTATGGAAATCATTAGATAA
TCTGGCTTCTATTCATAATATTCATTGGCATTGGGTTAAAGGGCACTCAGGTCATTTGGAAAATGATTTGGTTGATGCTT
TGGCAAATTTGGGTATTGAGGAGTTATCATAG

Upstream 100 bases:

>100_bases
ATTTTTTTATTGATGAGGACGTATTAAAAAATAGTGGTGTCACTGATTTTTCTTGCTATGCTATGAATCCTAAAGCTCAA
CTTTGTCCTGATTTATTTTT

Downstream 100 bases:

>100_bases
AGTTATGAGACAAGTTATATTAGATACCGAAACGACTGGTATTGGACCTGAACAGGGACATAGAGTAATTGAAATAGGTT
GTATTGAGCTTATCGATAGA

Product: ribonuclease H

Products: NA

Alternate protein names: RNase H

Number of amino acids: Translated: 143; Mature: 143

Protein sequence:

>143_residues
MKVEIYTDGACKGNPGPGGWGVLLRYNGREKTLHGGEAQTTNNRMELMAAIKGLEALKRPCEVDLYTDSQYLQQGMKEWI
KTWKRNGWRNSKKELVKNAELWKSLDNLASIHNIHWHWVKGHSGHLENDLVDALANLGIEELS

Sequences:

>Translated_143_residues
MKVEIYTDGACKGNPGPGGWGVLLRYNGREKTLHGGEAQTTNNRMELMAAIKGLEALKRPCEVDLYTDSQYLQQGMKEWI
KTWKRNGWRNSKKELVKNAELWKSLDNLASIHNIHWHWVKGHSGHLENDLVDALANLGIEELS
>Mature_143_residues
MKVEIYTDGACKGNPGPGGWGVLLRYNGREKTLHGGEAQTTNNRMELMAAIKGLEALKRPCEVDLYTDSQYLQQGMKEWI
KTWKRNGWRNSKKELVKNAELWKSLDNLASIHNIHWHWVKGHSGHLENDLVDALANLGIEELS

Specific function: Endonuclease that specifically degrades the RNA of RNA- DNA hybrids

COG id: COG0328

COG function: function code L; Ribonuclease HI

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase H domain

Homologues:

Organism=Homo sapiens, GI21359816, Length=154, Percent_Identity=35.0649350649351, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1786408, Length=134, Percent_Identity=60.4477611940298, Blast_Score=175, Evalue=9e-46,
Organism=Caenorhabditis elegans, GI115532542, Length=141, Percent_Identity=36.1702127659575, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI17137476, Length=146, Percent_Identity=33.5616438356164, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI45552509, Length=146, Percent_Identity=33.5616438356164, Blast_Score=74, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNH_LEGPA (Q5X5I2)

Other databases:

- EMBL:   CR628336
- RefSeq:   YP_123662.1
- HSSP:   P0A7Y4
- ProteinModelPortal:   Q5X5I2
- SMR:   Q5X5I2
- STRING:   Q5X5I2
- GeneID:   3119623
- GenomeReviews:   CR628336_GR
- KEGG:   lpp:lpp1338
- LegioList:   lpp1338
- eggNOG:   COG0328
- HOGENOM:   HBG742437
- OMA:   NGWRTAD
- ProtClustDB:   PRK00203
- BioCyc:   LPNE297246:LPP1338-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00042
- InterPro:   IPR022892
- InterPro:   IPR012337
- InterPro:   IPR002156

Pfam domain/function: PF00075 RnaseH; SSF53098 RNaseH_fold

EC number: =3.1.26.4

Molecular weight: Translated: 16253; Mature: 16253

Theoretical pI: Translated: 8.24; Mature: 8.24

Prosite motif: PS50879 RNASE_H

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVEIYTDGACKGNPGPGGWGVLLRYNGREKTLHGGEAQTTNNRMELMAAIKGLEALKRP
CEEEEEECCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
CEVDLYTDSQYLQQGMKEWIKTWKRNGWRNSKKELVKNAELWKSLDNLASIHNIHWHWVK
CCEEEEECHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEC
GHSGHLENDLVDALANLGIEELS
CCCCCCHHHHHHHHHHCCHHHCC
>Mature Secondary Structure
MKVEIYTDGACKGNPGPGGWGVLLRYNGREKTLHGGEAQTTNNRMELMAAIKGLEALKRP
CEEEEEECCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
CEVDLYTDSQYLQQGMKEWIKTWKRNGWRNSKKELVKNAELWKSLDNLASIHNIHWHWVK
CCEEEEECHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEC
GHSGHLENDLVDALANLGIEELS
CCCCCCHHHHHHHHHHCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA