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The map label for this gene is dapE [H]

Identifier: 148358402

GI number: 148358402

Start: 277208

End: 278617

Strand: Direct

Name: dapE [H]

Synonym: LPC_0267

Alternate gene names: 148358402

Gene position: 277208-278617 (Clockwise)

Preceding gene: 148358401

Following gene: 148358403

Centisome position: 7.75

GC content: 42.2

Gene sequence:

>1410_bases
ATGATTAGGAAAAAGATAACTCAAATTTCATTTTTTATGATTTTGGCATTGATTGTTGGGACTGTAGAAGCTAAGACTGC
TCGTCCCGCGGATGAACAACAACTTGCTCGCTCTATTTATAAACAATTTATCGAAGTGCAATCAGGATTTACTACCGGTT
CAACAACGCCGCTGGTTGAGGTGGCTGTAAAATACTTAAAGAAAGCCGGTTTTTCCAACGAGGACATTTTCGTTGGTGGA
GCCAGTCCACAAAAAGCCAATCTGGTTGTACGTTATCGCGGTACTGGGGAGATGAAACCCTTGTTATTACTTGCGCATAC
GGACGTTGTTGAAGCCAAAGCTTCCGATTGGAGCATGAATCCTTTCCAACTGACTGAAAAAGATGGGTATTTTTATGGCA
GAGGCACTTTGGATGATAAAGCGCAAGCGGCTATTTGGATAGCCAACTTAATCCAATATAAACAGGAAGGATTTAAACCC
AAACGCGATATCATTGTTGCCTTGACGGCTGATGAAGAAGGAAGCAGCCCATACAACGGGATTAGTTGGCTGATTAAAAA
TCACAAGGATTTAATCGAGGCAGATTTCGCTCTTAATGAGGGTGGATGGGGTGATTTGGCTAACGGGAAAAAAATATCAC
AAAATATCCAGGTGAGTGAAAAATACATTGTCAATTACAACCTTGAGGTCCGTAATAAAGGGGGGCATAGTTCGCTGCCA
ACCAAAGATAATGCCATTTATCGTCTTGCCGGGGCTTTAGAGCGACTGTCAAAATTTAATTTTCCTTTAAAAACCAATGA
TGTCACTGCGGCCTATTTTAAACAAATGGCGGCTATTGAGACAGGGCCTCTGAAAACAGAAATGATTGAAGCAAGCAAAG
GCTCGAAGCAAGCTATGCAACGTTTAGCTAATAGTTCACCGCAATGGAATGCTATTTTACGAACAACCTGTACCCCTACC
TTACTTGAAGGAGGGCATGCAATGAATGCTTTACCACAATTAGCGGCTGTTACCATAAATTGTCGTGTGCTCCCAGAGGA
TTCACCTGAAATGGTTGAGCAATCTTTGAAGACAGCTATTAACGATCCAGAGGTTACACTAAAGCGGATTGGCAAATTGT
CCAGAGGCCCAAGTTCTCCACTTAGCCCGGAAATACTAAAAACAATTACTCATCTAACTCAAACTTATTGGCCTGAAGTT
CCTGCCATTCCAATTATGGTTACTGGCGCAACGGATGGACGTTATCTGCGATCAGCTGGAATTCCTACCTATGGAGTGAT
GGGGCTATTTTTAGATCGCGATGATTTCCGAGCCCATGGTCGTGATGAGCGGATTAGTGTCGAATCATTTTATGAAGCTC
ATGCATTCCTTTATGATTTGGTGAAACAACTGTCAAGCAATGTAACTTAA

Upstream 100 bases:

>100_bases
AGATTCAAGCTCTGGCTCCAAAAGCGCATTGATTTTTACTCAGATTACTTTATAGTGAGTTTTTCTTTAAACGCTTAATT
CTTTGAATGGATTTCATTTT

Downstream 100 bases:

>100_bases
GCATGATTTTTCCAGTTGGGGCCTCACTAAATCAGGCAGGATATTGATTTGAGGTCCCTAGGGTCAGTTTTGCAGAATTT
CCCAATGTAAAAGCTTGTAA

Product: hypothetical protein

Products: NA

Alternate protein names: SDAP desuccinylase [H]

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MIRKKITQISFFMILALIVGTVEAKTARPADEQQLARSIYKQFIEVQSGFTTGSTTPLVEVAVKYLKKAGFSNEDIFVGG
ASPQKANLVVRYRGTGEMKPLLLLAHTDVVEAKASDWSMNPFQLTEKDGYFYGRGTLDDKAQAAIWIANLIQYKQEGFKP
KRDIIVALTADEEGSSPYNGISWLIKNHKDLIEADFALNEGGWGDLANGKKISQNIQVSEKYIVNYNLEVRNKGGHSSLP
TKDNAIYRLAGALERLSKFNFPLKTNDVTAAYFKQMAAIETGPLKTEMIEASKGSKQAMQRLANSSPQWNAILRTTCTPT
LLEGGHAMNALPQLAAVTINCRVLPEDSPEMVEQSLKTAINDPEVTLKRIGKLSRGPSSPLSPEILKTITHLTQTYWPEV
PAIPIMVTGATDGRYLRSAGIPTYGVMGLFLDRDDFRAHGRDERISVESFYEAHAFLYDLVKQLSSNVT

Sequences:

>Translated_469_residues
MIRKKITQISFFMILALIVGTVEAKTARPADEQQLARSIYKQFIEVQSGFTTGSTTPLVEVAVKYLKKAGFSNEDIFVGG
ASPQKANLVVRYRGTGEMKPLLLLAHTDVVEAKASDWSMNPFQLTEKDGYFYGRGTLDDKAQAAIWIANLIQYKQEGFKP
KRDIIVALTADEEGSSPYNGISWLIKNHKDLIEADFALNEGGWGDLANGKKISQNIQVSEKYIVNYNLEVRNKGGHSSLP
TKDNAIYRLAGALERLSKFNFPLKTNDVTAAYFKQMAAIETGPLKTEMIEASKGSKQAMQRLANSSPQWNAILRTTCTPT
LLEGGHAMNALPQLAAVTINCRVLPEDSPEMVEQSLKTAINDPEVTLKRIGKLSRGPSSPLSPEILKTITHLTQTYWPEV
PAIPIMVTGATDGRYLRSAGIPTYGVMGLFLDRDDFRAHGRDERISVESFYEAHAFLYDLVKQLSSNVT
>Mature_469_residues
MIRKKITQISFFMILALIVGTVEAKTARPADEQQLARSIYKQFIEVQSGFTTGSTTPLVEVAVKYLKKAGFSNEDIFVGG
ASPQKANLVVRYRGTGEMKPLLLLAHTDVVEAKASDWSMNPFQLTEKDGYFYGRGTLDDKAQAAIWIANLIQYKQEGFKP
KRDIIVALTADEEGSSPYNGISWLIKNHKDLIEADFALNEGGWGDLANGKKISQNIQVSEKYIVNYNLEVRNKGGHSSLP
TKDNAIYRLAGALERLSKFNFPLKTNDVTAAYFKQMAAIETGPLKTEMIEASKGSKQAMQRLANSSPQWNAILRTTCTPT
LLEGGHAMNALPQLAAVTINCRVLPEDSPEMVEQSLKTAINDPEVTLKRIGKLSRGPSSPLSPEILKTITHLTQTYWPEV
PAIPIMVTGATDGRYLRSAGIPTYGVMGLFLDRDDFRAHGRDERISVESFYEAHAFLYDLVKQLSSNVT

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; fifth step. [C]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family [H]

Homologues:

Organism=Homo sapiens, GI269846968, Length=374, Percent_Identity=30.7486631016043, Blast_Score=160, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6322289, Length=496, Percent_Identity=23.7903225806452, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24649210, Length=443, Percent_Identity=21.8961625282167, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24649212, Length=223, Percent_Identity=22.8699551569507, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001261
- InterPro:   IPR010182
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.5.1.18 [H]

Molecular weight: Translated: 51888; Mature: 51888

Theoretical pI: Translated: 8.80; Mature: 8.80

Prosite motif: PS00758 ARGE_DAPE_CPG2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRKKITQISFFMILALIVGTVEAKTARPADEQQLARSIYKQFIEVQSGFTTGSTTPLVE
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
VAVKYLKKAGFSNEDIFVGGASPQKANLVVRYRGTGEMKPLLLLAHTDVVEAKASDWSMN
HHHHHHHHCCCCCCCEEEECCCCCCCCEEEEECCCCCCCCEEEEEECCHHHCCCCCCCCC
PFQLTEKDGYFYGRGTLDDKAQAAIWIANLIQYKQEGFKPKRDIIVALTADEEGSSPYNG
CEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHH
ISWLIKNHKDLIEADFALNEGGWGDLANGKKISQNIQVSEKYIVNYNLEVRNKGGHSSLP
HHHHHHCCHHHHHHHHEECCCCCCCCCCCCCCCCCCEECEEEEEEEEEEEECCCCCCCCC
TKDNAIYRLAGALERLSKFNFPLKTNDVTAAYFKQMAAIETGPLKTEMIEASKGSKQAMQ
CCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHH
RLANSSPQWNAILRTTCTPTLLEGGHAMNALPQLAAVTINCRVLPEDSPEMVEQSLKTAI
HHHCCCCCCCEEEEECCCHHHHCCCCHHHHHHHEEEEEEEEEECCCCCHHHHHHHHHHHC
NDPEVTLKRIGKLSRGPSSPLSPEILKTITHLTQTYWPEVPAIPIMVTGATDGRYLRSAG
CCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHCC
IPTYGVMGLFLDRDDFRAHGRDERISVESFYEAHAFLYDLVKQLSSNVT
CCCHHHEEEEECCHHHHCCCCCCEECHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIRKKITQISFFMILALIVGTVEAKTARPADEQQLARSIYKQFIEVQSGFTTGSTTPLVE
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
VAVKYLKKAGFSNEDIFVGGASPQKANLVVRYRGTGEMKPLLLLAHTDVVEAKASDWSMN
HHHHHHHHCCCCCCCEEEECCCCCCCCEEEEECCCCCCCCEEEEEECCHHHCCCCCCCCC
PFQLTEKDGYFYGRGTLDDKAQAAIWIANLIQYKQEGFKPKRDIIVALTADEEGSSPYNG
CEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHH
ISWLIKNHKDLIEADFALNEGGWGDLANGKKISQNIQVSEKYIVNYNLEVRNKGGHSSLP
HHHHHHCCHHHHHHHHEECCCCCCCCCCCCCCCCCCEECEEEEEEEEEEEECCCCCCCCC
TKDNAIYRLAGALERLSKFNFPLKTNDVTAAYFKQMAAIETGPLKTEMIEASKGSKQAMQ
CCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHH
RLANSSPQWNAILRTTCTPTLLEGGHAMNALPQLAAVTINCRVLPEDSPEMVEQSLKTAI
HHHCCCCCCCEEEEECCCHHHHCCCCHHHHHHHEEEEEEEEEECCCCCHHHHHHHHHHHC
NDPEVTLKRIGKLSRGPSSPLSPEILKTITHLTQTYWPEVPAIPIMVTGATDGRYLRSAG
CCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHCC
IPTYGVMGLFLDRDDFRAHGRDERISVESFYEAHAFLYDLVKQLSSNVT
CCCHHHEEEEECCHHHHCCCCCCEECHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]