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The map label for this gene is macA [H]

Identifier: 148358371

GI number: 148358371

Start: 249436

End: 250635

Strand: Direct

Name: macA [H]

Synonym: LPC_0235

Alternate gene names: 148358371

Gene position: 249436-250635 (Clockwise)

Preceding gene: 148358370

Following gene: 148358378

Centisome position: 6.97

GC content: 40.33

Gene sequence:

>1200_bases
ATGAAGATAATGAACCTGAATTTGAAAAAACTAATAGGGTATTTTCTGGCAATAGTGATATTTTTCAGTGTTGTTCTCTG
GTTCCTTTCTCATCAAGGTATTTCAGTTGAAAGGGCAAAAGTGAAATATGATCACTTCATTCAGTATATTGAAGACGATG
CGAAAACGCGTGCTATAAAAATATACAGTATTGTGTCTCCAGTGTCAGGAGAATTGTTACGCATTAATTTGACGGAAGGT
GATAAAGTAAAAAAAGATGACGTAATTGCCACTATTAAGTCTAAAATACCTGCTTTGCTGGACATTCGAGCAAAGCAAGA
ATTAGAGCATGAGTTGGGCACTGCTGAGGCCTTGTATGAACAGGCAAAGGCAGAGTCAATTCGCGCTGAAGCAGCACTGG
AGACGGCCCAGTCAGATTTCAAAAGAAAAGAGCCACTGGCAAAAAAAGGGTTCGTTTCGGAAACAGAATTGGAGCATGCT
CAATTGGAATATCAATTAAGACAGAAAGAACATAATGCCGCATTGCGTAAGTTACATGCTGCAGAGCATTACATTTTAAA
AGTTAAAGCATCCCTTTCGGCATCAGAGGGCAGTGAAGCGAGTCAGCAAGACAAGATTGAGATTCGTTCACCTGTAACGG
GCTCGATTTTGAGAGTGATTGAAAAAAGTTCAACTACCGTTGAGCCTGGCACAAAAATTATGGATATTGCCGATGTGGTC
GGTCTTGAAGTTGTGGCTGACATATTAAGCGATGATGCCGCAAAAATTCCTCCGTATGCAAGAGTCATCATAAAACGATG
GGGAGGGCCTTATCCTTTGGAAGGGCGCGTTCGAATTGTTGAGCCAAGCGGTTATACTAAAATATCAGCGCTTGGAGTTG
AGGAACAACGAGTCAATGTCATCATTGATATCACGACCCCATATGAATTATGGAAAAATCTTGGTGATGGATATCGGGTG
GATGTTGAAATTATTCTTTTTGAATCGAACCATGCTCTTGTAGTGCCTATGAGTGCTTTATTTCGAGACGGGGAAGATTG
GGCTGTTTTTGTCGTGAAAGGGCACAGAGCTTATAAGAAGAAGTTAACTATAAAATATCATAACCCAGATTACGCGGTAA
TAGAGCGTGGTTTAGAGTTAGGCGATGAAGTCATTCTTTATCCCAGCTCTTTAATTCATGATGGGGTCTTAATTAAATAA

Upstream 100 bases:

>100_bases
CGATTATGGTGATATTTTTTTCTAGTTTAATTAGTTTTTATATTATTCAGCGTAAAGCAAGCCATCTGAATTTAACAGCG
GTATTAAAGGTAGCAGACTG

Downstream 100 bases:

>100_bases
TGAGGTCATTTTCAAAGAATTGAATGTCTCCGGGTTTAATTTCCTCGTAATTTAGCAGCGTCAAAATGTGATTATTCTCT
GATAAAAAACAACCCTTTTT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MKIMNLNLKKLIGYFLAIVIFFSVVLWFLSHQGISVERAKVKYDHFIQYIEDDAKTRAIKIYSIVSPVSGELLRINLTEG
DKVKKDDVIATIKSKIPALLDIRAKQELEHELGTAEALYEQAKAESIRAEAALETAQSDFKRKEPLAKKGFVSETELEHA
QLEYQLRQKEHNAALRKLHAAEHYILKVKASLSASEGSEASQQDKIEIRSPVTGSILRVIEKSSTTVEPGTKIMDIADVV
GLEVVADILSDDAAKIPPYARVIIKRWGGPYPLEGRVRIVEPSGYTKISALGVEEQRVNVIIDITTPYELWKNLGDGYRV
DVEIILFESNHALVVPMSALFRDGEDWAVFVVKGHRAYKKKLTIKYHNPDYAVIERGLELGDEVILYPSSLIHDGVLIK

Sequences:

>Translated_399_residues
MKIMNLNLKKLIGYFLAIVIFFSVVLWFLSHQGISVERAKVKYDHFIQYIEDDAKTRAIKIYSIVSPVSGELLRINLTEG
DKVKKDDVIATIKSKIPALLDIRAKQELEHELGTAEALYEQAKAESIRAEAALETAQSDFKRKEPLAKKGFVSETELEHA
QLEYQLRQKEHNAALRKLHAAEHYILKVKASLSASEGSEASQQDKIEIRSPVTGSILRVIEKSSTTVEPGTKIMDIADVV
GLEVVADILSDDAAKIPPYARVIIKRWGGPYPLEGRVRIVEPSGYTKISALGVEEQRVNVIIDITTPYELWKNLGDGYRV
DVEIILFESNHALVVPMSALFRDGEDWAVFVVKGHRAYKKKLTIKYHNPDYAVIERGLELGDEVILYPSSLIHDGVLIK
>Mature_399_residues
MKIMNLNLKKLIGYFLAIVIFFSVVLWFLSHQGISVERAKVKYDHFIQYIEDDAKTRAIKIYSIVSPVSGELLRINLTEG
DKVKKDDVIATIKSKIPALLDIRAKQELEHELGTAEALYEQAKAESIRAEAALETAQSDFKRKEPLAKKGFVSETELEHA
QLEYQLRQKEHNAALRKLHAAEHYILKVKASLSASEGSEASQQDKIEIRSPVTGSILRVIEKSSTTVEPGTKIMDIADVV
GLEVVADILSDDAAKIPPYARVIIKRWGGPYPLEGRVRIVEPSGYTKISALGVEEQRVNVIIDITTPYELWKNLGDGYRV
DVEIILFESNHALVVPMSALFRDGEDWAVFVVKGHRAYKKKLTIKYHNPDYAVIERGLELGDEVILYPSSLIHDGVLIK

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=386, Percent_Identity=23.5751295336788, Blast_Score=79, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 44814; Mature: 44814

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIMNLNLKKLIGYFLAIVIFFSVVLWFLSHQGISVERAKVKYDHFIQYIEDDAKTRAIK
CEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHCCCHHEEEE
IYSIVSPVSGELLRINLTEGDKVKKDDVIATIKSKIPALLDIRAKQELEHELGTAEALYE
EEEEECCCCCCEEEEECCCCCCCCCCHHHHHHHHCCCHHEEHHHHHHHHHHHCHHHHHHH
QAKAESIRAEAALETAQSDFKRKEPLAKKGFVSETELEHAQLEYQLRQKEHNAALRKLHA
HHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEHYILKVKASLSASEGSEASQQDKIEIRSPVTGSILRVIEKSSTTVEPGTKIMDIADVV
CCEEEEEEEECCCCCCCCCCCCCCCEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHH
GLEVVADILSDDAAKIPPYARVIIKRWGGPYPLEGRVRIVEPSGYTKISALGVEEQRVNV
HHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCEEEEEECCCCCEEEE
IIDITTPYELWKNLGDGYRVDVEIILFESNHALVVPMSALFRDGEDWAVFVVKGHRAYKK
EEEECCHHHHHHHCCCCEEEEEEEEEEECCCEEEEEHHHHHCCCCCEEEEEEECCCCEEE
KLTIKYHNPDYAVIERGLELGDEVILYPSSLIHDGVLIK
EEEEEEECCCHHHHHHHHHCCCEEEEECHHHHCCCCEEC
>Mature Secondary Structure
MKIMNLNLKKLIGYFLAIVIFFSVVLWFLSHQGISVERAKVKYDHFIQYIEDDAKTRAIK
CEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHCCCHHEEEE
IYSIVSPVSGELLRINLTEGDKVKKDDVIATIKSKIPALLDIRAKQELEHELGTAEALYE
EEEEECCCCCCEEEEECCCCCCCCCCHHHHHHHHCCCHHEEHHHHHHHHHHHCHHHHHHH
QAKAESIRAEAALETAQSDFKRKEPLAKKGFVSETELEHAQLEYQLRQKEHNAALRKLHA
HHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEHYILKVKASLSASEGSEASQQDKIEIRSPVTGSILRVIEKSSTTVEPGTKIMDIADVV
CCEEEEEEEECCCCCCCCCCCCCCCEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHH
GLEVVADILSDDAAKIPPYARVIIKRWGGPYPLEGRVRIVEPSGYTKISALGVEEQRVNV
HHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCEEEEEECCCCCEEEE
IIDITTPYELWKNLGDGYRVDVEIILFESNHALVVPMSALFRDGEDWAVFVVKGHRAYKK
EEEECCHHHHHHHCCCCEEEEEEEEEEECCCEEEEEHHHHHCCCCCEEEEEEECCCCEEE
KLTIKYHNPDYAVIERGLELGDEVILYPSSLIHDGVLIK
EEEEEEECCCHHHHHHHHHCCCEEEEECHHHHCCCCEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]