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The map label for this gene is nuoH

Identifier: 148285162

GI number: 148285162

Start: 2105251

End: 2106321

Strand: Direct

Name: nuoH

Synonym: OTBS_2160

Alternate gene names: 148285162

Gene position: 2105251-2106321 (Clockwise)

Preceding gene: 148285161

Following gene: 148285163

Centisome position: 98.98

GC content: 31.28

Gene sequence:

>1071_bases
ATGACTATCTGTACAGATATAATTGCCAATGGCTATGATTTAAAGACACTAATTTATAATAGTGGAGTTGTTTCAATAAA
AGTTATAGCGTTAATTATTTGCTTGTTACTTGCAACAGCATATTTAACATTTGCTGAGAGAAAAGTCATTGCTTATATGC
AATTACGTGTTGGGCCTAGTTTGGCTGGCCCATTTGGATTGTTACAGCCAATAGCTGATGCTATAAAATTAGTTTTTAAA
GAGCCTATTATACCAGCAAAAGCTGATAGGAAATTGTTTATTATAGCTCCAATTATTACTTTTGTATTATCTTTATTAGG
TTGGTCTGTAATTCCAATTGACCATGATATCGTTCTTTCTAGAATTCATATAGGAGGAATATTATTTATATTAGCAGTAA
CTTCATTAGGAGTTTATGGAATTATAATTGCTGGCTGGGCAAGTAATTCTAAGTATGCTTTTTTAGGTGCTGTAAGGTCT
GCAGCGCAAATGATTTCATATGAATTAGCAATGGCACTAAGTATAGTTGCAGTACTTATTGTGACTGGAGAAATGGATTT
GATTCAAATTGTTGAAGCACAAAAAACTAGGCCTATATGGTTAACAATAATGATGCTACCATTAGCAGTTATTTATTTTA
TATCAATATTAGCTAAAACTAATAGGCTGCCATTTGATCTTCCAGAGGCTGAATCTGAGCTAGTTGCAGGATATAATGTT
GAATATTCTTCTATGGCTTTTGCTATGTTTTTTCTTGGAGAATATGCTAACATGATATTGGGTAGTAGCTTAATGACTAT
CATGTTTTTAGGAGGATACTTGCCTCCATTTAATTTAGAGATATTAACTTTCATTCCAGGTTATATATGGTTTATATTAA
AAGTATCTATGGTATTATTCTGTTTTTTATGGATACGAGCAACATTGCCACGATATAGATATGATCAATTAATGTATTTG
GGATTGAAAGTATTTTTGCCGATTGTATTAGCTTGGATAATAGTAGTATCAACTATTTTAGTATATAGTAATAACTTACC
CATAGCACTAGAAACTGTGCTAAACAAATAA

Upstream 100 bases:

>100_bases
TATCACCAGTTATGGCAGAATGTACAAAAGTACAAAAAGGATAATATTAGAGTTAAAGTTAAATCTTGTACATTAAATAA
AAAATAATAATTATGACTAT

Downstream 100 bases:

>100_bases
TTGGATTTAATGTAGAGAATCGAAAATGAAAATAACTAATTTTACTAAATCTTTTCTTTTGTATGAAATTATTGTTGGAA
TGTTTTTAACTTTGAAATAT

Product: NADH dehydrogenase I chain H

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MTICTDIIANGYDLKTLIYNSGVVSIKVIALIICLLLATAYLTFAERKVIAYMQLRVGPSLAGPFGLLQPIADAIKLVFK
EPIIPAKADRKLFIIAPIITFVLSLLGWSVIPIDHDIVLSRIHIGGILFILAVTSLGVYGIIIAGWASNSKYAFLGAVRS
AAQMISYELAMALSIVAVLIVTGEMDLIQIVEAQKTRPIWLTIMMLPLAVIYFISILAKTNRLPFDLPEAESELVAGYNV
EYSSMAFAMFFLGEYANMILGSSLMTIMFLGGYLPPFNLEILTFIPGYIWFILKVSMVLFCFLWIRATLPRYRYDQLMYL
GLKVFLPIVLAWIIVVSTILVYSNNLPIALETVLNK

Sequences:

>Translated_356_residues
MTICTDIIANGYDLKTLIYNSGVVSIKVIALIICLLLATAYLTFAERKVIAYMQLRVGPSLAGPFGLLQPIADAIKLVFK
EPIIPAKADRKLFIIAPIITFVLSLLGWSVIPIDHDIVLSRIHIGGILFILAVTSLGVYGIIIAGWASNSKYAFLGAVRS
AAQMISYELAMALSIVAVLIVTGEMDLIQIVEAQKTRPIWLTIMMLPLAVIYFISILAKTNRLPFDLPEAESELVAGYNV
EYSSMAFAMFFLGEYANMILGSSLMTIMFLGGYLPPFNLEILTFIPGYIWFILKVSMVLFCFLWIRATLPRYRYDQLMYL
GLKVFLPIVLAWIIVVSTILVYSNNLPIALETVLNK
>Mature_355_residues
TICTDIIANGYDLKTLIYNSGVVSIKVIALIICLLLATAYLTFAERKVIAYMQLRVGPSLAGPFGLLQPIADAIKLVFKE
PIIPAKADRKLFIIAPIITFVLSLLGWSVIPIDHDIVLSRIHIGGILFILAVTSLGVYGIIIAGWASNSKYAFLGAVRSA
AQMISYELAMALSIVAVLIVTGEMDLIQIVEAQKTRPIWLTIMMLPLAVIYFISILAKTNRLPFDLPEAESELVAGYNVE
YSSMAFAMFFLGEYANMILGSSLMTIMFLGGYLPPFNLEILTFIPGYIWFILKVSMVLFCFLWIRATLPRYRYDQLMYLG
LKVFLPIVLAWIIVVSTILVYSNNLPIALETVLNK

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=294, Percent_Identity=45.578231292517, Blast_Score=254, Evalue=1e-67,
Organism=Escherichia coli, GI1788618, Length=318, Percent_Identity=38.3647798742138, Blast_Score=237, Evalue=8e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOH_ORITB (A5CFN5)

Other databases:

- EMBL:   AM494475
- RefSeq:   YP_001249252.1
- STRING:   A5CFN5
- GeneID:   5219202
- GenomeReviews:   AM494475_GR
- KEGG:   ots:OTBS_2160
- eggNOG:   COG1005
- HOGENOM:   HBG727670
- OMA:   FMVEYGS
- ProtClustDB:   CLSK2325915
- BioCyc:   OTSU357244:OTBS_2160-MONOMER
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: =1.6.99.5

Molecular weight: Translated: 39539; Mature: 39408

Theoretical pI: Translated: 8.38; Mature: 8.38

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x10043ed0)-; HASH(0xdd6fba0)-; HASH(0xf1cbd6c)-; HASH(0xf5ca730)-; HASH(0xfb7a24c)-; HASH(0xf6456d4)-; HASH(0x1003d564)-; HASH(0x100602a4)-; HASH(0x10072e9c)-;

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTICTDIIANGYDLKTLIYNSGVVSIKVIALIICLLLATAYLTFAERKVIAYMQLRVGPS
CCCHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LAGPFGLLQPIADAIKLVFKEPIIPAKADRKLFIIAPIITFVLSLLGWSVIPIDHDIVLS
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHCCEEECCCHHHHHH
RIHIGGILFILAVTSLGVYGIIIAGWASNSKYAFLGAVRSAAQMISYELAMALSIVAVLI
HHHHHHHHHHHHHHHCCHHEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTGEMDLIQIVEAQKTRPIWLTIMMLPLAVIYFISILAKTNRLPFDLPEAESELVAGYNV
HCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCC
EYSSMAFAMFFLGEYANMILGSSLMTIMFLGGYLPPFNLEILTFIPGYIWFILKVSMVLF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
CFLWIRATLPRYRYDQLMYLGLKVFLPIVLAWIIVVSTILVYSNNLPIALETVLNK
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHCH
>Mature Secondary Structure 
TICTDIIANGYDLKTLIYNSGVVSIKVIALIICLLLATAYLTFAERKVIAYMQLRVGPS
CCHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LAGPFGLLQPIADAIKLVFKEPIIPAKADRKLFIIAPIITFVLSLLGWSVIPIDHDIVLS
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHCCEEECCCHHHHHH
RIHIGGILFILAVTSLGVYGIIIAGWASNSKYAFLGAVRSAAQMISYELAMALSIVAVLI
HHHHHHHHHHHHHHHCCHHEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTGEMDLIQIVEAQKTRPIWLTIMMLPLAVIYFISILAKTNRLPFDLPEAESELVAGYNV
HCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCC
EYSSMAFAMFFLGEYANMILGSSLMTIMFLGGYLPPFNLEILTFIPGYIWFILKVSMVLF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
CFLWIRATLPRYRYDQLMYLGLKVFLPIVLAWIIVVSTILVYSNNLPIALETVLNK
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA