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The map label for this gene is mutL [H]

Identifier: 148285056

GI number: 148285056

Start: 1893012

End: 1895054

Strand: Direct

Name: mutL [H]

Synonym: OTBS_1956

Alternate gene names: 148285056

Gene position: 1893012-1895054 (Clockwise)

Preceding gene: 148285055

Following gene: 148285057

Centisome position: 89.0

GC content: 30.84

Gene sequence:

>2043_bases
ATGGGTGTAATAAAATATTTGTCTGATACTACTATAAACCGTATAGCTGCTGGAGAGGTAGTAGAGCGTCCTGCTTCTGT
TGTTAAAGAACTAGTTGAGAACTCAATTGACTCAGGAGCAATGAAAGTTGATATTACACTAGAAAAGTCTGGTAAGAATT
TAATTATAGTTTCAGATAATGGCTGTGGTATGTCTGCTGAAGACTTAGAAACTGCAATTGAACGTCATACTACTTCGAAG
TTAAATGAAAATGATATTATGAATATTAATACTTTTGGATTTCGAGGTGAAGCTTTGCCTTCAATTGCTTCTGTCAGTAG
AATGCGCATTGTAACTAAATCTAAACTTCATGATCAAGCTCATGAAATTAATGTTCATGGTGGAGTTAAAACTAAAATAA
ATTCGTTACCTCAATTGCAGCTAACAGGAACTAAAATAGAAGTAAGAGACCTTTTTTTTGCTACTCCAGCGAGATTAAAA
TTTTTACGTTCAGATCGTACTGAATATATAGTGTGTTATGATGTAGTAAAAAGATTGGCAATTTCTTATCCTCATATTGC
ATTTTCATTAGTACATGATGATAAAACTATTTTAAAACTTAAAGCAAATGCTCAATTATCTTTTGATGATGCTAGAAAAT
CTAGAATATCTGAAATATTATCAAAAAATTTTATTGATAATGCAATATCAATAGGCATAGAAAGAGATGAATTATCTATT
ACTGGCTTTGTTAGCGTTCCAACATATAATAAGGCTTCAGCTGAAGATCAATTATTATTTGTTAATAATCGTCCAGTAAA
AGATAAACTGTTAATGACAGCAATCAGATTAGCATATCAAGGAGTATTAGCTCGTGAAAGATATCCAATAGTTGTAATTT
TTATTAGCGTTGCTCCTCATTTTATTGATGTTAATGTTCATCCTACTAAAAGTGAAGTAAGGTTTCATGACTCTAGTTTA
GTTAGAGGTATTATAATTAGTGCTATTAAACAAGCATTATTGAATACATCTCAGTTAGTTTCGTCGGTAGCTGCAAGTGA
TGCGAATAAATATATGAAACCTCAATACGATACTGGTATATCTGAAAAACTAGAATTAAGTAAGGATATTAAAAATATTC
AGCAGTTTCCATTACAAGAACTAGTAAATAATTTTAGCAAGGATTTTAATGTAAATTTGAAATCTAAATTTCAAGATGTT
CAAGCAAACAATTTTGTCAGTGATAACGAGCAGCAGAAAATAGAATCAACAATCGAGAATATAAAATTTTTTTCTGCATT
TAATCAATTAGGGAGTAATACAGAATCAAATCAGCATATTAGTATTTTGGATGATGATAAGACTACAGATGATATAACTG
CTCCTAACATAGCTACTAATGAGAAAGTGGATGCTAATAAGCAAGAAAGTGTACAGAAATTAAATGATAGTTTCTGTAAT
AATTTTGGAGATAGTTATCAACTGCCTTTAGGATTAGCTTGTGCTCAATTTCATGGTAATTATATTCTTGCTCAAACTAT
AGATAGCTTAATAATTGTAGATCAGCATGCAGCTCATGAAAGGATAACTTATGAGAATTTACGTTCTCAATTTCAGGCAG
GGCAAATTATCAGGCAGCGATTGTTGATGCCGCAAGTTGTTATTTTGCCTGATATTGTTAGAGTAGAAAAATTATGTGAT
AAAATGCAAGAAATTTTAGCATTAGGTATGGGATTTGAACGTTGTGGTGATGTACAAGTAAAAGTTTTAGAAATGCCTGC
AATATTACAATCTGTTGATATTGAAGCTGTTGTGAATGATGTTGCTGATTATTTACTTACTACTGATGATCATATATTAT
TAGCTGATATGGTGGAAAAAATATTACAATCTTATTCATGTTATCATTCTATAAGATCAGGTAGAATATTAACTATTGCA
GAGATGAATAGTTTATTACGTCAAATTGAAACAACGCCATTTTCTGGACAATGTAATCATGGTCGCCCAACTTATGTTAG
ATTTGAGCTAAAAGATATAGAGAAGCTATTTGGCAGGAGATGA

Upstream 100 bases:

>100_bases
ATAGTTATTATGATTACAGTAATTTATTTGCTTGATTATTGTAGCAAAAATCAGCAAAATCTAAGTTTCTAATTTAAATG
TATGGTAGTGGTAAAGTTGT

Downstream 100 bases:

>100_bases
TTTTTTCAGTCTACTACTTTATTTTCCTTATATCAAACGCAGGCTAAAAAGCAGTACATATAATCTGTTCTTTTCTTGCT
AATCCTAAGTTAAATGAGTA

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 680; Mature: 679

Protein sequence:

>680_residues
MGVIKYLSDTTINRIAAGEVVERPASVVKELVENSIDSGAMKVDITLEKSGKNLIIVSDNGCGMSAEDLETAIERHTTSK
LNENDIMNINTFGFRGEALPSIASVSRMRIVTKSKLHDQAHEINVHGGVKTKINSLPQLQLTGTKIEVRDLFFATPARLK
FLRSDRTEYIVCYDVVKRLAISYPHIAFSLVHDDKTILKLKANAQLSFDDARKSRISEILSKNFIDNAISIGIERDELSI
TGFVSVPTYNKASAEDQLLFVNNRPVKDKLLMTAIRLAYQGVLARERYPIVVIFISVAPHFIDVNVHPTKSEVRFHDSSL
VRGIIISAIKQALLNTSQLVSSVAASDANKYMKPQYDTGISEKLELSKDIKNIQQFPLQELVNNFSKDFNVNLKSKFQDV
QANNFVSDNEQQKIESTIENIKFFSAFNQLGSNTESNQHISILDDDKTTDDITAPNIATNEKVDANKQESVQKLNDSFCN
NFGDSYQLPLGLACAQFHGNYILAQTIDSLIIVDQHAAHERITYENLRSQFQAGQIIRQRLLMPQVVILPDIVRVEKLCD
KMQEILALGMGFERCGDVQVKVLEMPAILQSVDIEAVVNDVADYLLTTDDHILLADMVEKILQSYSCYHSIRSGRILTIA
EMNSLLRQIETTPFSGQCNHGRPTYVRFELKDIEKLFGRR

Sequences:

>Translated_680_residues
MGVIKYLSDTTINRIAAGEVVERPASVVKELVENSIDSGAMKVDITLEKSGKNLIIVSDNGCGMSAEDLETAIERHTTSK
LNENDIMNINTFGFRGEALPSIASVSRMRIVTKSKLHDQAHEINVHGGVKTKINSLPQLQLTGTKIEVRDLFFATPARLK
FLRSDRTEYIVCYDVVKRLAISYPHIAFSLVHDDKTILKLKANAQLSFDDARKSRISEILSKNFIDNAISIGIERDELSI
TGFVSVPTYNKASAEDQLLFVNNRPVKDKLLMTAIRLAYQGVLARERYPIVVIFISVAPHFIDVNVHPTKSEVRFHDSSL
VRGIIISAIKQALLNTSQLVSSVAASDANKYMKPQYDTGISEKLELSKDIKNIQQFPLQELVNNFSKDFNVNLKSKFQDV
QANNFVSDNEQQKIESTIENIKFFSAFNQLGSNTESNQHISILDDDKTTDDITAPNIATNEKVDANKQESVQKLNDSFCN
NFGDSYQLPLGLACAQFHGNYILAQTIDSLIIVDQHAAHERITYENLRSQFQAGQIIRQRLLMPQVVILPDIVRVEKLCD
KMQEILALGMGFERCGDVQVKVLEMPAILQSVDIEAVVNDVADYLLTTDDHILLADMVEKILQSYSCYHSIRSGRILTIA
EMNSLLRQIETTPFSGQCNHGRPTYVRFELKDIEKLFGRR
>Mature_679_residues
GVIKYLSDTTINRIAAGEVVERPASVVKELVENSIDSGAMKVDITLEKSGKNLIIVSDNGCGMSAEDLETAIERHTTSKL
NENDIMNINTFGFRGEALPSIASVSRMRIVTKSKLHDQAHEINVHGGVKTKINSLPQLQLTGTKIEVRDLFFATPARLKF
LRSDRTEYIVCYDVVKRLAISYPHIAFSLVHDDKTILKLKANAQLSFDDARKSRISEILSKNFIDNAISIGIERDELSIT
GFVSVPTYNKASAEDQLLFVNNRPVKDKLLMTAIRLAYQGVLARERYPIVVIFISVAPHFIDVNVHPTKSEVRFHDSSLV
RGIIISAIKQALLNTSQLVSSVAASDANKYMKPQYDTGISEKLELSKDIKNIQQFPLQELVNNFSKDFNVNLKSKFQDVQ
ANNFVSDNEQQKIESTIENIKFFSAFNQLGSNTESNQHISILDDDKTTDDITAPNIATNEKVDANKQESVQKLNDSFCNN
FGDSYQLPLGLACAQFHGNYILAQTIDSLIIVDQHAAHERITYENLRSQFQAGQIIRQRLLMPQVVILPDIVRVEKLCDK
MQEILALGMGFERCGDVQVKVLEMPAILQSVDIEAVVNDVADYLLTTDDHILLADMVEKILQSYSCYHSIRSGRILTIAE
MNSLLRQIETTPFSGQCNHGRPTYVRFELKDIEKLFGRR

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=327, Percent_Identity=35.474006116208, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI310128478, Length=354, Percent_Identity=29.3785310734463, Blast_Score=129, Evalue=1e-29,
Organism=Homo sapiens, GI4505913, Length=354, Percent_Identity=29.3785310734463, Blast_Score=129, Evalue=1e-29,
Organism=Homo sapiens, GI4505911, Length=335, Percent_Identity=28.6567164179104, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI189458898, Length=335, Percent_Identity=28.6567164179104, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI189458896, Length=321, Percent_Identity=28.9719626168224, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI310128480, Length=310, Percent_Identity=27.741935483871, Blast_Score=94, Evalue=5e-19,
Organism=Homo sapiens, GI263191589, Length=231, Percent_Identity=30.7359307359307, Blast_Score=93, Evalue=8e-19,
Organism=Homo sapiens, GI91992162, Length=431, Percent_Identity=25.5220417633411, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI91992160, Length=431, Percent_Identity=25.5220417633411, Blast_Score=82, Evalue=2e-15,
Organism=Escherichia coli, GI1790612, Length=328, Percent_Identity=39.3292682926829, Blast_Score=245, Evalue=6e-66,
Organism=Caenorhabditis elegans, GI71991825, Length=328, Percent_Identity=32.6219512195122, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17562796, Length=374, Percent_Identity=29.144385026738, Blast_Score=130, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6323819, Length=446, Percent_Identity=32.9596412556054, Blast_Score=180, Evalue=6e-46,
Organism=Saccharomyces cerevisiae, GI6324247, Length=362, Percent_Identity=25.6906077348066, Blast_Score=109, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6325093, Length=215, Percent_Identity=27.4418604651163, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17136968, Length=333, Percent_Identity=34.2342342342342, Blast_Score=174, Evalue=3e-43,
Organism=Drosophila melanogaster, GI17136970, Length=354, Percent_Identity=27.9661016949153, Blast_Score=109, Evalue=8e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 76319; Mature: 76188

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVIKYLSDTTINRIAAGEVVERPASVVKELVENSIDSGAMKVDITLEKSGKNLIIVSDN
CCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCEEEEEECC
GCGMSAEDLETAIERHTTSKLNENDIMNINTFGFRGEALPSIASVSRMRIVTKSKLHDQA
CCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
HEINVHGGVKTKINSLPQLQLTGTKIEVRDLFFATPARLKFLRSDRTEYIVCYDVVKRLA
HEEEECCCCHHHHCCCCCEEEECCEEEEHHHHHCCHHHHHHHHCCCCCEEEHHHHHHHHH
ISYPHIAFSLVHDDKTILKLKANAQLSFDDARKSRISEILSKNFIDNAISIGIERDELSI
HCCCCEEEEEEECCCEEEEEECCCEECHHHHHHHHHHHHHHHHHHHHHHHCCEEECCEEE
TGFVSVPTYNKASAEDQLLFVNNRPVKDKLLMTAIRLAYQGVLARERYPIVVIFISVAPH
EEEEECCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCE
FIDVNVHPTKSEVRFHDSSLVRGIIISAIKQALLNTSQLVSSVAASDANKYMKPQYDTGI
EEEEEECCCHHHHEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
SEKLELSKDIKNIQQFPLQELVNNFSKDFNVNLKSKFQDVQANNFVSDNEQQKIESTIEN
HHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHH
IKFFSAFNQLGSNTESNQHISILDDDKTTDDITAPNIATNEKVDANKQESVQKLNDSFCN
HHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
NFGDSYQLPLGLACAQFHGNYILAQTIDSLIIVDQHAAHERITYENLRSQFQAGQIIRQR
CCCCCCCCCHHHHHHHHCCCEEEEHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHH
LLMPQVVILPDIVRVEKLCDKMQEILALGMGFERCGDVQVKVLEMPAILQSVDIEAVVND
HHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCEEEEEEHHHHHHHHHHHHHHHH
VADYLLTTDDHILLADMVEKILQSYSCYHSIRSGRILTIAEMNSLLRQIETTPFSGQCNH
HHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHCCCCCCCCCCC
GRPTYVRFELKDIEKLFGRR
CCCCEEEEEHHHHHHHHCCC
>Mature Secondary Structure 
GVIKYLSDTTINRIAAGEVVERPASVVKELVENSIDSGAMKVDITLEKSGKNLIIVSDN
CCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCEEEEEECC
GCGMSAEDLETAIERHTTSKLNENDIMNINTFGFRGEALPSIASVSRMRIVTKSKLHDQA
CCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
HEINVHGGVKTKINSLPQLQLTGTKIEVRDLFFATPARLKFLRSDRTEYIVCYDVVKRLA
HEEEECCCCHHHHCCCCCEEEECCEEEEHHHHHCCHHHHHHHHCCCCCEEEHHHHHHHHH
ISYPHIAFSLVHDDKTILKLKANAQLSFDDARKSRISEILSKNFIDNAISIGIERDELSI
HCCCCEEEEEEECCCEEEEEECCCEECHHHHHHHHHHHHHHHHHHHHHHHCCEEECCEEE
TGFVSVPTYNKASAEDQLLFVNNRPVKDKLLMTAIRLAYQGVLARERYPIVVIFISVAPH
EEEEECCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCE
FIDVNVHPTKSEVRFHDSSLVRGIIISAIKQALLNTSQLVSSVAASDANKYMKPQYDTGI
EEEEEECCCHHHHEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
SEKLELSKDIKNIQQFPLQELVNNFSKDFNVNLKSKFQDVQANNFVSDNEQQKIESTIEN
HHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHH
IKFFSAFNQLGSNTESNQHISILDDDKTTDDITAPNIATNEKVDANKQESVQKLNDSFCN
HHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
NFGDSYQLPLGLACAQFHGNYILAQTIDSLIIVDQHAAHERITYENLRSQFQAGQIIRQR
CCCCCCCCCHHHHHHHHCCCEEEEHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHH
LLMPQVVILPDIVRVEKLCDKMQEILALGMGFERCGDVQVKVLEMPAILQSVDIEAVVND
HHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCEEEEEEHHHHHHHHHHHHHHHH
VADYLLTTDDHILLADMVEKILQSYSCYHSIRSGRILTIAEMNSLLRQIETTPFSGQCNH
HHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHCCCCCCCCCCC
GRPTYVRFELKDIEKLFGRR
CCCCEEEEEHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA