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The map label for this gene is pth [H]

Identifier: 148284982

GI number: 148284982

Start: 1743559

End: 1744119

Strand: Direct

Name: pth [H]

Synonym: OTBS_1803

Alternate gene names: 148284982

Gene position: 1743559-1744119 (Clockwise)

Preceding gene: 148284981

Following gene: 148284983

Centisome position: 81.97

GC content: 31.02

Gene sequence:

>561_bases
GTGTTGGTAGTAGGTCTTGGTAATCCTGGCAAAGAATACGCAAACTCAAGGCATAACGCTGGCTATATTGTTCTAGAACA
AATTGCATTTTATAATAATTTAAGCTTTAGTAAAAGCACTAAATATAAATCTGACATTGCCAAAATATTGCTTTTAGGGC
AAAAAATTATTTTTATAAAACCATTAACCTATATGAATCTTTCTGGTACAGCAGTTTGCTTAATAAAGGATTTTTATAAG
TTGCAGAATTACGACATAATTGTTATTCATGATGATATTGACCTACCTTTAGGTATTGTAAAGTTAAAGGTAGGTGGTGG
TAGTGGAGGGCATAACGGGCTAAAATCTATTAGTAGTGCAATTGGTGACAGTTATTTAAGAATTAAGATCGGTATTGGCA
GACCTATCTCTGAGCATTTATCAGTTGCAAGTTATGTTTTATCTGATTTTTTAGTTGAGGAATTAACAGTGTTATATTCT
ATAGCAAGAAAAATTGCTGAAAATGTTGAGCTAGCAGTTCAAAAACAATTCAGTGAATTTATGTTTAAGATAAAAAATTG
A

Upstream 100 bases:

>100_bases
AGAGTACTACAGACTATGTCATTGCATCTGTTATTGGTAAATCTAGTAAGCAGGATAAAGAGGAAGAAGGAACAGCAGAA
GATGGCGCTGATAGTAAGTA

Downstream 100 bases:

>100_bases
TTGATAAAAATGGAACTTAGATATGGAATAGTTGGATTGCCTAACGTAGGAAAATCAACCTTATTTAATGCTTTAACTGC
TACTCAAGCTGCTAATGTTG

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 186; Mature: 186

Protein sequence:

>186_residues
MLVVGLGNPGKEYANSRHNAGYIVLEQIAFYNNLSFSKSTKYKSDIAKILLLGQKIIFIKPLTYMNLSGTAVCLIKDFYK
LQNYDIIVIHDDIDLPLGIVKLKVGGGSGGHNGLKSISSAIGDSYLRIKIGIGRPISEHLSVASYVLSDFLVEELTVLYS
IARKIAENVELAVQKQFSEFMFKIKN

Sequences:

>Translated_186_residues
MLVVGLGNPGKEYANSRHNAGYIVLEQIAFYNNLSFSKSTKYKSDIAKILLLGQKIIFIKPLTYMNLSGTAVCLIKDFYK
LQNYDIIVIHDDIDLPLGIVKLKVGGGSGGHNGLKSISSAIGDSYLRIKIGIGRPISEHLSVASYVLSDFLVEELTVLYS
IARKIAENVELAVQKQFSEFMFKIKN
>Mature_186_residues
MLVVGLGNPGKEYANSRHNAGYIVLEQIAFYNNLSFSKSTKYKSDIAKILLLGQKIIFIKPLTYMNLSGTAVCLIKDFYK
LQNYDIIVIHDDIDLPLGIVKLKVGGGSGGHNGLKSISSAIGDSYLRIKIGIGRPISEHLSVASYVLSDFLVEELTVLYS
IARKIAENVELAVQKQFSEFMFKIKN

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=160, Percent_Identity=32.5, Blast_Score=96, Evalue=1e-20,
Organism=Escherichia coli, GI1787455, Length=187, Percent_Identity=36.3636363636364, Blast_Score=101, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6321983, Length=175, Percent_Identity=30.8571428571429, Blast_Score=72, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 20576; Mature: 20576

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVVGLGNPGKEYANSRHNAGYIVLEQIAFYNNLSFSKSTKYKSDIAKILLLGQKIIFIK
CEEEECCCCCHHHCCCCCCCCEEEEEHHHHHCCCCCCCCCHHHHHHHHHHHHCCEEEEEE
PLTYMNLSGTAVCLIKDFYKLQNYDIIVIHDDIDLPLGIVKLKVGGGSGGHNGLKSISSA
CEEEECCCCCEEHEEHHHHHHCCCCEEEEECCCCCCEEEEEEEECCCCCCCHHHHHHHHH
IGDSYLRIKIGIGRPISEHLSVASYVLSDFLVEELTVLYSIARKIAENVELAVQKQFSEF
HCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MFKIKN
HHEECC
>Mature Secondary Structure
MLVVGLGNPGKEYANSRHNAGYIVLEQIAFYNNLSFSKSTKYKSDIAKILLLGQKIIFIK
CEEEECCCCCHHHCCCCCCCCEEEEEHHHHHCCCCCCCCCHHHHHHHHHHHHCCEEEEEE
PLTYMNLSGTAVCLIKDFYKLQNYDIIVIHDDIDLPLGIVKLKVGGGSGGHNGLKSISSA
CEEEECCCCCEEHEEHHHHHHCCCCEEEEECCCCCCEEEEEEEECCCCCCCHHHHHHHHH
IGDSYLRIKIGIGRPISEHLSVASYVLSDFLVEELTVLYSIARKIAENVELAVQKQFSEF
HCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MFKIKN
HHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA