Click here to switch to the map view.

The map label for this gene is ubiB [H]

Identifier: 148260481

GI number: 148260481

Start: 1643411

End: 1644769

Strand: Reverse

Name: ubiB [H]

Synonym: Acry_1481

Alternate gene names: 148260481

Gene position: 1644769-1643411 (Counterclockwise)

Preceding gene: 148260482

Following gene: 148260480

Centisome position: 48.53

GC content: 63.72

Gene sequence:

>1359_bases
ATGGGCAACGAAGCGGATACCGGCGGCACGCTGTTCGGCGAAATCAGGCGCTTTGCCCGCACCTCGGGCGCGGTTTCCGG
CATTGCGGCGCGGGTGGCGGGCGAGCGGGTTTTCGGTATCCGCACCGACCGCGGCCGCCATGCCGAAGACCTGAAGACCA
TTCTCGGTGGCCTCAAGGGGCCGATGATGAAGATCGCCCAGATCCTCAGCACCGTGCCCGACGCCCTGCCCGAGGAATAT
GCCCGGGAACTGGCGCAGTTGCAGTCGAACGCGCCACCGATGGGCTGGGCCTTCGTCCGCCGCCGGATGGCTGCCGAACT
CGGCCCTGACTGGGAAGGGAAATTCCGCACCTTCGGGCGTGAGGCCGCGGCTGCCGCCAGTCTGGGCCAGGTTCACAAGG
CCGAACTGCCGGATGGCCGCATCGTCGCCTGCAAGCTGCAATATCCCGACATGCCGAGCACCGTGGAATCCGACCTCCGG
CAACTCAAGCTCGCGATGGCCGTCTACAAGCGGATGGATAACGCGATCCACCAGGACGACATCTATGTCGAGCTCGCAAC
GCGGCTGCGCGAGGAACTCGATTATACGCGCGAGGCAGCGCAGGCCCGGCTCTATGCGATCATGCTCGAAGGGCAGCCCG
ATATCGTCATCCCCGAGCCGATCCCCGAATATTCCTCCCGTCGCCTGCTGACCATGACCTGGCTGGACGGCATCGGGATG
CAGGCCTTTCTGGATACCGACCCCGATCAGGAAAGTCGCAATCGGGTGGCCCGCGCCCTGTTCCGGGCCTGGTATGTGCC
GTTCTACCGATACGGCGTCATCCATGGCGATCCGCATCTCGGCAATTATCAGGTGAACAAGGCTGGTGGCATCAATCTGC
TCGATTTCGGCGCCATTCGCGTGTTCGGCTCGCGCTTCGTCGCCGGTGTGATCGACCTTTTCCGCGCGATCCGTGACAAT
GACGATGCGCTCGCCCATCACGCCTATTCCTCATGGGGTTTTACCGATATCACCAAGGAAAAGCTCGACGTGCTGAACGA
ATGGGCCCGGTTCCTGTACGAGCCGCTGATGCAGGACCGGGTGCGGCCCATACAGGAGACCAACGACGTAACCTTCGGTC
GCAGTGTTGCGGAGAAGGTTCATGAAGGGCTGAAGCGCACCGGCGGTGTTCGTCCGCCGCGCGAGTTCGTGCTGATGGAC
CGCTCCGCCATCGGGCTTGGCAGCGTGTTTCTCCGGTTGCGCGCGGAACTCAACTGGCACCAGCTTTTCCAGGAGACGGT
CGCGGAATTCGATGCCGCCTCGCTCGATGCTCGTCAGGATGCCGCCTTGGCCAGTGCCGGCGTGCCGAAGCCGCTCTGA

Upstream 100 bases:

>100_bases
TTTGGCCTCGATGCGTCCGATCCGGCGTTCTGGCGCAGGGGGCTCGATGTGATTGCCGGCTTTATCGACGAACTGGAAAA
CTGAGGAAAATCGGGGATAC

Downstream 100 bases:

>100_bases
CCATGGCGATTCTTCAGCGCGGGCTGCGCGGCGGGTTGCTGGCACGGGCCTACAGGAAAATCCTGCATTCGTGGTATCTC
AATGATCTGGCGTTCGATAT

Product: hypothetical protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MGNEADTGGTLFGEIRRFARTSGAVSGIAARVAGERVFGIRTDRGRHAEDLKTILGGLKGPMMKIAQILSTVPDALPEEY
ARELAQLQSNAPPMGWAFVRRRMAAELGPDWEGKFRTFGREAAAAASLGQVHKAELPDGRIVACKLQYPDMPSTVESDLR
QLKLAMAVYKRMDNAIHQDDIYVELATRLREELDYTREAAQARLYAIMLEGQPDIVIPEPIPEYSSRRLLTMTWLDGIGM
QAFLDTDPDQESRNRVARALFRAWYVPFYRYGVIHGDPHLGNYQVNKAGGINLLDFGAIRVFGSRFVAGVIDLFRAIRDN
DDALAHHAYSSWGFTDITKEKLDVLNEWARFLYEPLMQDRVRPIQETNDVTFGRSVAEKVHEGLKRTGGVRPPREFVLMD
RSAIGLGSVFLRLRAELNWHQLFQETVAEFDAASLDARQDAALASAGVPKPL

Sequences:

>Translated_452_residues
MGNEADTGGTLFGEIRRFARTSGAVSGIAARVAGERVFGIRTDRGRHAEDLKTILGGLKGPMMKIAQILSTVPDALPEEY
ARELAQLQSNAPPMGWAFVRRRMAAELGPDWEGKFRTFGREAAAAASLGQVHKAELPDGRIVACKLQYPDMPSTVESDLR
QLKLAMAVYKRMDNAIHQDDIYVELATRLREELDYTREAAQARLYAIMLEGQPDIVIPEPIPEYSSRRLLTMTWLDGIGM
QAFLDTDPDQESRNRVARALFRAWYVPFYRYGVIHGDPHLGNYQVNKAGGINLLDFGAIRVFGSRFVAGVIDLFRAIRDN
DDALAHHAYSSWGFTDITKEKLDVLNEWARFLYEPLMQDRVRPIQETNDVTFGRSVAEKVHEGLKRTGGVRPPREFVLMD
RSAIGLGSVFLRLRAELNWHQLFQETVAEFDAASLDARQDAALASAGVPKPL
>Mature_451_residues
GNEADTGGTLFGEIRRFARTSGAVSGIAARVAGERVFGIRTDRGRHAEDLKTILGGLKGPMMKIAQILSTVPDALPEEYA
RELAQLQSNAPPMGWAFVRRRMAAELGPDWEGKFRTFGREAAAAASLGQVHKAELPDGRIVACKLQYPDMPSTVESDLRQ
LKLAMAVYKRMDNAIHQDDIYVELATRLREELDYTREAAQARLYAIMLEGQPDIVIPEPIPEYSSRRLLTMTWLDGIGMQ
AFLDTDPDQESRNRVARALFRAWYVPFYRYGVIHGDPHLGNYQVNKAGGINLLDFGAIRVFGSRFVAGVIDLFRAIRDND
DALAHHAYSSWGFTDITKEKLDVLNEWARFLYEPLMQDRVRPIQETNDVTFGRSVAEKVHEGLKRTGGVRPPREFVLMDR
SAIGLGSVFLRLRAELNWHQLFQETVAEFDAASLDARQDAALASAGVPKPL

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI34147522, Length=390, Percent_Identity=26.6666666666667, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI27363457, Length=418, Percent_Identity=25.1196172248804, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI217416386, Length=363, Percent_Identity=26.1707988980716, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI40254938, Length=277, Percent_Identity=27.7978339350181, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI41393593, Length=281, Percent_Identity=29.5373665480427, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI217035081, Length=208, Percent_Identity=27.4038461538462, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI2367309, Length=383, Percent_Identity=25.065274151436, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI32565180, Length=451, Percent_Identity=27.7161862527716, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17559152, Length=264, Percent_Identity=26.5151515151515, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6321319, Length=378, Percent_Identity=27.7777777777778, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6323282, Length=307, Percent_Identity=26.0586319218241, Blast_Score=76, Evalue=9e-15,
Organism=Drosophila melanogaster, GI18859849, Length=264, Percent_Identity=28.030303030303, Blast_Score=109, Evalue=5e-24,
Organism=Drosophila melanogaster, GI22024280, Length=338, Percent_Identity=28.1065088757396, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24662575, Length=250, Percent_Identity=30.4, Blast_Score=102, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 50562; Mature: 50431

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNEADTGGTLFGEIRRFARTSGAVSGIAARVAGERVFGIRTDRGRHAEDLKTILGGLKG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHCCC
PMMKIAQILSTVPDALPEEYARELAQLQSNAPPMGWAFVRRRMAAELGPDWEGKFRTFGR
HHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHH
EAAAAASLGQVHKAELPDGRIVACKLQYPDMPSTVESDLRQLKLAMAVYKRMDNAIHQDD
HHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCH
IYVELATRLREELDYTREAAQARLYAIMLEGQPDIVIPEPIPEYSSRRLLTMTWLDGIGM
HHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCEECCCCCCCCCCCEEEEEEHHCCCCC
QAFLDTDPDQESRNRVARALFRAWYVPFYRYGVIHGDPHLGNYQVNKAGGINLLDFGAIR
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEECCCCCCCEEHHHHHH
VFGSRFVAGVIDLFRAIRDNDDALAHHAYSSWGFTDITKEKLDVLNEWARFLYEPLMQDR
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VRPIQETNDVTFGRSVAEKVHEGLKRTGGVRPPREFVLMDRSAIGLGSVFLRLRAELNWH
CCCHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHEEECCCHHHHHHHHHHHHHCCCHH
QLFQETVAEFDAASLDARQDAALASAGVPKPL
HHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure 
GNEADTGGTLFGEIRRFARTSGAVSGIAARVAGERVFGIRTDRGRHAEDLKTILGGLKG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHCCC
PMMKIAQILSTVPDALPEEYARELAQLQSNAPPMGWAFVRRRMAAELGPDWEGKFRTFGR
HHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHH
EAAAAASLGQVHKAELPDGRIVACKLQYPDMPSTVESDLRQLKLAMAVYKRMDNAIHQDD
HHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCH
IYVELATRLREELDYTREAAQARLYAIMLEGQPDIVIPEPIPEYSSRRLLTMTWLDGIGM
HHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCEECCCCCCCCCCCEEEEEEHHCCCCC
QAFLDTDPDQESRNRVARALFRAWYVPFYRYGVIHGDPHLGNYQVNKAGGINLLDFGAIR
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEECCCCCCCEEHHHHHH
VFGSRFVAGVIDLFRAIRDNDDALAHHAYSSWGFTDITKEKLDVLNEWARFLYEPLMQDR
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VRPIQETNDVTFGRSVAEKVHEGLKRTGGVRPPREFVLMDRSAIGLGSVFLRLRAELNWH
CCCHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHEEECCCHHHHHHHHHHHHHCCCHH
QLFQETVAEFDAASLDARQDAALASAGVPKPL
HHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]