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The map label for this gene is tadA [H]

Identifier: 148260476

GI number: 148260476

Start: 1640186

End: 1640641

Strand: Reverse

Name: tadA [H]

Synonym: Acry_1476

Alternate gene names: 148260476

Gene position: 1640641-1640186 (Counterclockwise)

Preceding gene: 148260480

Following gene: 148260475

Centisome position: 48.41

GC content: 64.47

Gene sequence:

>456_bases
ATGCAGCAAGCCCTTGCGGAAGCCGAAGCCGCCGCGCGCCGTGGCGAGGTGCCGGTTGGCGCCGTTGTCGTCGATGCTGG
CGGGTCCGTGCTTGCCGCGGCCGGCAACGAGGTTGAGGCTCGCGGCGATCCGACCGCGCATGCCGAAATTCTCGCGTTGC
GCGCGGCGGCGCAGCGGAGGGGTGGGAAATTTCTGCAGGGCTGCCGGCTGTTTGTAACCCTTGAACCCTGTCCTCTCTGT
GCGGCAGCAATTTCCTTGTTCCGCATCGACCGTCTGGTGTTCGGCGCCTACGATCCGAAATCGGGCGGAGTCGAGCACGG
GCCTAGGGTTTTCTCTCATCCGACGTGCCACTATCGGCCCGAGGTGGTCGGCGGGGTGGATCAGACGGCGGCGGCAGAGC
TGCTTAGGCACTTTTTTTCTCAAAAACGCGACTCGGCAAATTCTGCCGGGCGTTAA

Upstream 100 bases:

>100_bases
GCTGCTCCGCATCCAGTGTCAGTCCGATCAGGGGCCGGTTTTTCATGGCGCGAGCTAGACCTCATCCGGCCGTCAAGGCA
AGAGAGCAAGCGTGACCCCG

Downstream 100 bases:

>100_bases
CCGAACAGTTACCCATATAGGCGATTCTTGTCCTGCGACAAAAGGTCGCAATCGCAGGATGGATTCATGCAGTTCTCCAC
ACGGCTGCGTTGGGACTCAA

Product: zinc-binding CMP/dCMP deaminase

Products: uracil; NH3

Alternate protein names: NA

Number of amino acids: Translated: 151; Mature: 151

Protein sequence:

>151_residues
MQQALAEAEAAARRGEVPVGAVVVDAGGSVLAAAGNEVEARGDPTAHAEILALRAAAQRRGGKFLQGCRLFVTLEPCPLC
AAAISLFRIDRLVFGAYDPKSGGVEHGPRVFSHPTCHYRPEVVGGVDQTAAAELLRHFFSQKRDSANSAGR

Sequences:

>Translated_151_residues
MQQALAEAEAAARRGEVPVGAVVVDAGGSVLAAAGNEVEARGDPTAHAEILALRAAAQRRGGKFLQGCRLFVTLEPCPLC
AAAISLFRIDRLVFGAYDPKSGGVEHGPRVFSHPTCHYRPEVVGGVDQTAAAELLRHFFSQKRDSANSAGR
>Mature_151_residues
MQQALAEAEAAARRGEVPVGAVVVDAGGSVLAAAGNEVEARGDPTAHAEILALRAAAQRRGGKFLQGCRLFVTLEPCPLC
AAAISLFRIDRLVFGAYDPKSGGVEHGPRVFSHPTCHYRPEVVGGVDQTAAAELLRHFFSQKRDSANSAGR

Specific function: Deaminates adenosine-34 to inosine in tRNA-Arg2 [H]

COG id: COG0590

COG function: function code FJ; Cytosine/adenosine deaminases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Homo sapiens, GI124107608, Length=154, Percent_Identity=31.1688311688312, Blast_Score=68, Evalue=3e-12,
Organism=Escherichia coli, GI145693172, Length=148, Percent_Identity=42.5675675675676, Blast_Score=99, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17541138, Length=148, Percent_Identity=32.4324324324324, Blast_Score=74, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17554608, Length=112, Percent_Identity=33.9285714285714, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17555996, Length=97, Percent_Identity=39.1752577319588, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21355527, Length=146, Percent_Identity=34.2465753424658, Blast_Score=70, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: 3.5.4.1

Molecular weight: Translated: 15862; Mature: 15862

Theoretical pI: Translated: 7.99; Mature: 7.99

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQALAEAEAAARRGEVPVGAVVVDAGGSVLAAAGNEVEARGDPTAHAEILALRAAAQRR
CCHHHHHHHHHHHCCCCCEEEEEEECCCCEEEECCCEEECCCCCCHHHHHHHHHHHHHHC
GGKFLQGCRLFVTLEPCPLCAAAISLFRIDRLVFGAYDPKSGGVEHGPRVFSHPTCHYRP
CCHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
EVVGGVDQTAAAELLRHFFSQKRDSANSAGR
HHCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MQQALAEAEAAARRGEVPVGAVVVDAGGSVLAAAGNEVEARGDPTAHAEILALRAAAQRR
CCHHHHHHHHHHHCCCCCEEEEEEECCCCEEEECCCEEECCCCCCHHHHHHHHHHHHHHC
GGKFLQGCRLFVTLEPCPLCAAAISLFRIDRLVFGAYDPKSGGVEHGPRVFSHPTCHYRP
CCHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
EVVGGVDQTAAAELLRHFFSQKRDSANSAGR
HHCCCCCHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: cytosine; H2O

Specific reaction: cytosine + H2O = uracil + NH3

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]