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The map label for this gene is trxC [H]

Identifier: 148260392

GI number: 148260392

Start: 1543342

End: 1543788

Strand: Reverse

Name: trxC [H]

Synonym: Acry_1389

Alternate gene names: 148260392

Gene position: 1543788-1543342 (Counterclockwise)

Preceding gene: 148260393

Following gene: 148260391

Centisome position: 45.55

GC content: 72.48

Gene sequence:

>447_bases
ATGGCTGACGCAACCCATCTCGTCTGTCCGCATTGCGGCGCGGTGAACCGCATCCCGCCGGCGCGCCCGGCGCAGGCCGC
GCAATGCGGCGCCTGCCACCGCAAGCTGTTCGACGGCCATCCCGTCGAGGTCGACCAGGCCGGCTTCGAGCGCCACGCCG
AGCGGGACGGGATTCCCCTCCTGCTCGATGTCTGGGCGCCCTGGTGCGGACCGTGCCGGATGATGGCGCCGCAATTCGAG
CAGGCGGCCACCATCCTCGAACCGGAGGTCCGGCTGCTCAAGCTCAATGCCGACGAGGCGCCGGAGATCTCCGCCCGCCT
CGGCGTGCGCGGCATCCCGGCGCTGTTCCTGCTCAGGGGCGGTCGGGTCATCGGCCAGAGCGCCGGGGCCATGAGCGCTC
AGGCGATCGTCGATTTCGCGCGCCGCCACCTCGCGGCGGCGGCGTGA

Upstream 100 bases:

>100_bases
GCCGGCGAGAGCGAGCCCTTCTACGAGCGGTTCCTGATGAAGCAGCTCAACATCACGAAGATTCACCACAACGACCGCAA
GCCGGCGAAAGGCGCGGGCC

Downstream 100 bases:

>100_bases
TGTTCAGAGCATCATCCGATCAGATGGAGTTATCTGATCGGATAAAGATGCTCAGGTTATCAATATGATGGAGCACGACA
TCCGATCCAGCAGGATCGGA

Product: thioredoxin domain-containing protein

Products: NA

Alternate protein names: Trx-2; Protein-disulfide reductase [H]

Number of amino acids: Translated: 148; Mature: 147

Protein sequence:

>148_residues
MADATHLVCPHCGAVNRIPPARPAQAAQCGACHRKLFDGHPVEVDQAGFERHAERDGIPLLLDVWAPWCGPCRMMAPQFE
QAATILEPEVRLLKLNADEAPEISARLGVRGIPALFLLRGGRVIGQSAGAMSAQAIVDFARRHLAAAA

Sequences:

>Translated_148_residues
MADATHLVCPHCGAVNRIPPARPAQAAQCGACHRKLFDGHPVEVDQAGFERHAERDGIPLLLDVWAPWCGPCRMMAPQFE
QAATILEPEVRLLKLNADEAPEISARLGVRGIPALFLLRGGRVIGQSAGAMSAQAIVDFARRHLAAAA
>Mature_147_residues
ADATHLVCPHCGAVNRIPPARPAQAAQCGACHRKLFDGHPVEVDQAGFERHAERDGIPLLLDVWAPWCGPCRMMAPQFEQ
AATILEPEVRLLKLNADEAPEISARLGVRGIPALFLLRGGRVIGQSAGAMSAQAIVDFARRHLAAAA

Specific function: Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1788936, Length=126, Percent_Identity=40.4761904761905, Blast_Score=116, Evalue=5e-28,
Organism=Escherichia coli, GI87082331, Length=86, Percent_Identity=38.3720930232558, Blast_Score=78, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI212646193, Length=111, Percent_Identity=29.7297297297297, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 15845; Mature: 15713

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: PS00194 THIOREDOXIN ; PS00195 GLUTAREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
4.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADATHLVCPHCGAVNRIPPARPAQAAQCGACHRKLFDGHPVEVDQAGFERHAERDGIPL
CCCCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCE
LLDVWAPWCGPCRMMAPQFEQAATILEPEVRLLKLNADEAPEISARLGVRGIPALFLLRG
EEECCCCCCCCHHHCCCCHHHHHHHCCCCEEEEEECCCCCCCHHHHCCCCCCHHHHHHHC
GRVIGQSAGAMSAQAIVDFARRHLAAAA
CEEECCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ADATHLVCPHCGAVNRIPPARPAQAAQCGACHRKLFDGHPVEVDQAGFERHAERDGIPL
CCCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCE
LLDVWAPWCGPCRMMAPQFEQAATILEPEVRLLKLNADEAPEISARLGVRGIPALFLLRG
EEECCCCCCCCHHHCCCCHHHHHHHCCCCEEEEEECCCCCCCHHHHCCCCCCHHHHHHHC
GRVIGQSAGAMSAQAIVDFARRHLAAAA
CEEECCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]