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The map label for this gene is hom [H]

Identifier: 148260301

GI number: 148260301

Start: 1451206

End: 1452495

Strand: Reverse

Name: hom [H]

Synonym: Acry_1298

Alternate gene names: 148260301

Gene position: 1452495-1451206 (Counterclockwise)

Preceding gene: 148260302

Following gene: 148260300

Centisome position: 42.86

GC content: 71.78

Gene sequence:

>1290_bases
ATGAATGGTGAACTGTCGGTCGGGATCGCCGGGCTGGGGACGGTCGGCGCCGGGGTCGTGCGGCTGTTGCAGGAGAATGC
GGCGATCATCGCCGCGCGGGCCGGTCGGCCGGTGCGCGTGGTGGCGGTGTCCGCGCGGGACCGGACGCGGGATCGCGGGG
TGTCGCTCGAGGGTATCCGCTGGGTCGAGGACCCGCTGGTGCTCGCCACCGATCCGGCCGTGGATGTCGTCGTCGAGCTG
ATCGGCGGTGCTTCAGGTGCCGCGCGGGACCTGGTCGAGGCGGCCCTGGCCGCGGGCAAGCCGGTGGTGACGGCGAACAA
GGCGCTGATCGCGCAGGCGGGCGGCGACCTCGCGGGGTTGATCCGCGGCGGGCCGGGCATCCGCTTCGAGGCGGCGGTGG
CGGGCGGCATTCCCGTCATCAAGGCGCTGCGCGAGGGGCTCGGCGCCAACCGGATCGCCAGCGTGTCCGGCATCTTCAAC
GGCACCTGCAACTACATGCTCACGCGGATGCGCGACGAGAAGATGGAGTTCGCCGACGTGCTCGCCGAGGCCCAGGCGCT
CGGCTATGCCGAGGCCGACCCCTCGGCCGATATCGACGGGGTGGATACCGCCCACAAGCTGGCGATCCTCGCGGCCATCG
CCTTCGGCCGCCAGGTGGATTTCGGGGCGGTGCATGTCGAGGGCATCCGCCGGATCAGCGCGGTGGATATCGCCTTCGCC
GACGAGCTCGGCTACCGGATCAAGCTGCTCGGCATCGCCCGCGCGAGCGAGGCCGGAATCGAGACCCGCGTGCATCCGGC
GATGGTGCCGGAGAACTCGGCGCTGGCGAAGGTGGATGGCGTGAACAACGCGGTCGTGATCAGCGGCGAGCCGGTGGGCG
ATATCGTGATCCAGGGGCGCGGCGCCGGGGCGGGGCCGACCGCCTCGGCCGTGGTGGCCGACCTGATCGACCTTGCCCGC
GGCCGGCAGACGCCCATGCTCGGCATGGCGCCCGATGCGCTGCGCAGCGAGGCCTCGGTGCCGATGGCGGCGCATCGCGG
GGCCTATTGCCTGCGGCTGATGGTGCTGGATCAGCCCGGCGTGATCGCCGATGTCACCGCGGTGCTGCGCGATCACGGCA
TCTCGCTGGAAACGATGCTCCAGCGCGGCCGCAGCCCGGGCGATGTGGTGCCGGTGGTGATCATCACCCATGAGACTGAC
GAGGCCGCGATGGCGGCGGCGCTGGTGCAGATCGCCGCACTGCCGGCGGTGCAGGAGCCGCCGGCGCTCATCCGCATCGA
ACAGGCCTGA

Upstream 100 bases:

>100_bases
CGCTCGTCGAAAATACCCATCGGCTCCGGCAGGCGGTGCGGAACATCCGCGCCTTCATGGCACCGGGCAATGCGCCCAAC
CAGCAGGAGAGCGTCTCGGC

Downstream 100 bases:

>100_bases
TCGACGCTCGACCCGCAGGAGACCGCGAAGATGGACAACGCCAAGACCCCGGCCCAGTCGGACCGTAACCTCGCCCTCGA
ACTCGTGCGCGTCACGGAAG

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MNGELSVGIAGLGTVGAGVVRLLQENAAIIAARAGRPVRVVAVSARDRTRDRGVSLEGIRWVEDPLVLATDPAVDVVVEL
IGGASGAARDLVEAALAAGKPVVTANKALIAQAGGDLAGLIRGGPGIRFEAAVAGGIPVIKALREGLGANRIASVSGIFN
GTCNYMLTRMRDEKMEFADVLAEAQALGYAEADPSADIDGVDTAHKLAILAAIAFGRQVDFGAVHVEGIRRISAVDIAFA
DELGYRIKLLGIARASEAGIETRVHPAMVPENSALAKVDGVNNAVVISGEPVGDIVIQGRGAGAGPTASAVVADLIDLAR
GRQTPMLGMAPDALRSEASVPMAAHRGAYCLRLMVLDQPGVIADVTAVLRDHGISLETMLQRGRSPGDVVPVVIITHETD
EAAMAAALVQIAALPAVQEPPALIRIEQA

Sequences:

>Translated_429_residues
MNGELSVGIAGLGTVGAGVVRLLQENAAIIAARAGRPVRVVAVSARDRTRDRGVSLEGIRWVEDPLVLATDPAVDVVVEL
IGGASGAARDLVEAALAAGKPVVTANKALIAQAGGDLAGLIRGGPGIRFEAAVAGGIPVIKALREGLGANRIASVSGIFN
GTCNYMLTRMRDEKMEFADVLAEAQALGYAEADPSADIDGVDTAHKLAILAAIAFGRQVDFGAVHVEGIRRISAVDIAFA
DELGYRIKLLGIARASEAGIETRVHPAMVPENSALAKVDGVNNAVVISGEPVGDIVIQGRGAGAGPTASAVVADLIDLAR
GRQTPMLGMAPDALRSEASVPMAAHRGAYCLRLMVLDQPGVIADVTAVLRDHGISLETMLQRGRSPGDVVPVVIITHETD
EAAMAAALVQIAALPAVQEPPALIRIEQA
>Mature_429_residues
MNGELSVGIAGLGTVGAGVVRLLQENAAIIAARAGRPVRVVAVSARDRTRDRGVSLEGIRWVEDPLVLATDPAVDVVVEL
IGGASGAARDLVEAALAAGKPVVTANKALIAQAGGDLAGLIRGGPGIRFEAAVAGGIPVIKALREGLGANRIASVSGIFN
GTCNYMLTRMRDEKMEFADVLAEAQALGYAEADPSADIDGVDTAHKLAILAAIAFGRQVDFGAVHVEGIRRISAVDIAFA
DELGYRIKLLGIARASEAGIETRVHPAMVPENSALAKVDGVNNAVVISGEPVGDIVIQGRGAGAGPTASAVVADLIDLAR
GRQTPMLGMAPDALRSEASVPMAAHRGAYCLRLMVLDQPGVIADVTAVLRDHGISLETMLQRGRSPGDVVPVVIITHETD
EAAMAAALVQIAALPAVQEPPALIRIEQA

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=263, Percent_Identity=30.0380228136882, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1790376, Length=349, Percent_Identity=25.7879656160458, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322599, Length=156, Percent_Identity=29.4871794871795, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 44036; Mature: 44036

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGELSVGIAGLGTVGAGVVRLLQENAAIIAARAGRPVRVVAVSARDRTRDRGVSLEGIR
CCCCEEEEEECCCHHHHHHHHHHHCCCEEEEECCCCCEEEEEECCCCCHHHCCCCCCCCE
WVEDPLVLATDPAVDVVVELIGGASGAARDLVEAALAAGKPVVTANKALIAQAGGDLAGL
EECCCEEEEECCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEECCEEEEECCCCEEEE
IRGGPGIRFEAAVAGGIPVIKALREGLGANRIASVSGIFNGTCNYMLTRMRDEKMEFADV
EECCCCCEEEEEECCCCHHHHHHHHCCCCCCEEHHHHCCCCHHHHHHHHHHHHHHHHHHH
LAEAQALGYAEADPSADIDGVDTAHKLAILAAIAFGRQVDFGAVHVEGIRRISAVDIAFA
HHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHEEEEEH
DELGYRIKLLGIARASEAGIETRVHPAMVPENSALAKVDGVNNAVVISGEPVGDIVIQGR
HCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEECCCCCCEEEEECC
GAGAGPTASAVVADLIDLARGRQTPMLGMAPDALRSEASVPMAAHRGAYCLRLMVLDQPG
CCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCHHHCCCCEEEEEEEECCCC
VIADVTAVLRDHGISLETMLQRGRSPGDVVPVVIITHETDEAAMAAALVQIAALPAVQEP
HHHHHHHHHHHCCCCHHHHHHCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHCCCCCCC
PALIRIEQA
CCEEEEECC
>Mature Secondary Structure
MNGELSVGIAGLGTVGAGVVRLLQENAAIIAARAGRPVRVVAVSARDRTRDRGVSLEGIR
CCCCEEEEEECCCHHHHHHHHHHHCCCEEEEECCCCCEEEEEECCCCCHHHCCCCCCCCE
WVEDPLVLATDPAVDVVVELIGGASGAARDLVEAALAAGKPVVTANKALIAQAGGDLAGL
EECCCEEEEECCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEECCEEEEECCCCEEEE
IRGGPGIRFEAAVAGGIPVIKALREGLGANRIASVSGIFNGTCNYMLTRMRDEKMEFADV
EECCCCCEEEEEECCCCHHHHHHHHCCCCCCEEHHHHCCCCHHHHHHHHHHHHHHHHHHH
LAEAQALGYAEADPSADIDGVDTAHKLAILAAIAFGRQVDFGAVHVEGIRRISAVDIAFA
HHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHEEEEEH
DELGYRIKLLGIARASEAGIETRVHPAMVPENSALAKVDGVNNAVVISGEPVGDIVIQGR
HCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEECCCCCCEEEEECC
GAGAGPTASAVVADLIDLARGRQTPMLGMAPDALRSEASVPMAAHRGAYCLRLMVLDQPG
CCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCHHHCCCCEEEEEEEECCCC
VIADVTAVLRDHGISLETMLQRGRSPGDVVPVVIITHETDEAAMAAALVQIAALPAVQEP
HHHHHHHHHHHCCCCHHHHHHCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHCCCCCCC
PALIRIEQA
CCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]