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The map label for this gene is guaB [H]

Identifier: 148260198

GI number: 148260198

Start: 1329366

End: 1330865

Strand: Reverse

Name: guaB [H]

Synonym: Acry_1194

Alternate gene names: 148260198

Gene position: 1330865-1329366 (Counterclockwise)

Preceding gene: 148260200

Following gene: 148260197

Centisome position: 39.27

GC content: 68.67

Gene sequence:

>1500_bases
ATGGCTCCCAGCAATGAGACTTTTCTCCCGCGAGGCTCCGACCGCATCACGGAGGCTTATGCCTTCGACGATGTGCTCCT
CGTTCCCGGCTATTCCTCGGTGCTCCCCGCCGCGGTCAACACCCGCACGCGGCTGACCCGCTCCATCTCGCTCAACATTC
CCGTCATCTCCGCCGCGATGGACACCGTGACGGAGGCGCCGATGGCGATCGCCATGGCGCAGCAGGGCGGCATCGGCGTG
GTGCACAAGAACCTCTCGATCGAGGATCAGGCGGACCAGGTGCGCCAGGTCAAGAAATTCGAGAGCGGCATGGTGGTCAA
CCCGCTCACCATCCACCCCGAGCAGACCCTGGCCGAGGCGCAGGCGCTGATGGCCCAGCATCGGATTTCCGGCGTTCCCG
TGGTCGAGCGCGACACCAACCGCCTTGTCGGCATCCTTACCCATCGTGACGTCCGCTTCGCGACCGACCCGGCCGCCCGC
GTGTATGAGCTGATGACGCGGGAAAACCTCGTCACCGCGCCGGCCAATGTCGCGCCCGAGGTCGCGCGGTCGCTGCTCCA
CAAGCACCGGATCGAGAAGCTGCTGGTGGTGGACGAAGACTATCGCTGCGTCGGCCTGATCACCGTGAAGGACATGGACA
AGGCCGAGGCGCATCCCCTCGCCAACAAGGACGAACTCGGGCGCCTGCGCGTTGCCGCGGCGACCGGCGTCGGCGAGGAC
GGGGCGCGCCGCGCCGAGGCGCTGATCGCCGCGGGGGTGGATGTCGTGGTGGTGGATACCGCGCATGGCCATTCAGAGGG
CGTGCTGCGCGCCGTCGCGCGCATCAAGGAGCGTTCGAACGCGGTGCAGATCGTTGCCGGCAACGTCGCGACGCCCGAGG
CCGCCGCGGCGCTGATCAAGGCGGGTGCTGACGCGGTGAAGATCGGCATCGGCCCGGGCAGCATCTGCACCACCCGCGTG
GTTGCCGGCGTCGGCGTGCCGCAGTTCTCGGCCGTGATGGAGACCGCCGCCGCCTGTCACGAAGCCGACGTGCCGGCGAT
CGCCGATGGCGGGATCCGCACCTCGGGCGACGTGGTCAAGGCGCTCGCCGCCGGGGCGGACTGCGTGATGATCGGCTCGC
TCCTCGCCGGCACCGACGAGGCGCCCGGCGAGGTGTTTCTCTACCAGGGCCGGTCCTACAAGTCCTATCGCGGCATGGGC
AGCCTGGGTGCGATGGCCCGCGGCTCGGCCGACCGCTATTTCCAGCAGGACATCAAGGACTCGCTGAAACTTGTGCCTGA
GGGGATCGAGGGGCGCGTTGGCTACAAGGGCCCGATGGCCGGGGTGGTGCACCAGCTGGTCGGCGGGCTGCGCGCCGGCA
TGGGCTATACCGGTTGCGCCACCATCGCCGACCTGCAGACAAGGGCGCAATTTCGCCGCATCACCGGCGCCGGCCTCCGC
GAGAGCCACGTTCATGACGTGGCGATCACCCGCGAGGCGCCGAATTACCGGCAGGACTGA

Upstream 100 bases:

>100_bases
TCCGGCGCTGCGCGGGCTGCCCTGCGCCGCCGGCCTTGCCGGATTGCCGGGAGCCGGATAGTAGGGATCGCCAAGGTCCG
CAAACCGGCAAGGACGCACC

Downstream 100 bases:

>100_bases
GCCTTGACCCCCGCGGGCCGGCTGCAGGCGGCGATCGAGCTGCTCGGCACGATCGAGGCCGATCGCCGGCCGGCCGATGC
CATCGCCAACGACTTCCTTC

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 499; Mature: 498

Protein sequence:

>499_residues
MAPSNETFLPRGSDRITEAYAFDDVLLVPGYSSVLPAAVNTRTRLTRSISLNIPVISAAMDTVTEAPMAIAMAQQGGIGV
VHKNLSIEDQADQVRQVKKFESGMVVNPLTIHPEQTLAEAQALMAQHRISGVPVVERDTNRLVGILTHRDVRFATDPAAR
VYELMTRENLVTAPANVAPEVARSLLHKHRIEKLLVVDEDYRCVGLITVKDMDKAEAHPLANKDELGRLRVAAATGVGED
GARRAEALIAAGVDVVVVDTAHGHSEGVLRAVARIKERSNAVQIVAGNVATPEAAAALIKAGADAVKIGIGPGSICTTRV
VAGVGVPQFSAVMETAAACHEADVPAIADGGIRTSGDVVKALAAGADCVMIGSLLAGTDEAPGEVFLYQGRSYKSYRGMG
SLGAMARGSADRYFQQDIKDSLKLVPEGIEGRVGYKGPMAGVVHQLVGGLRAGMGYTGCATIADLQTRAQFRRITGAGLR
ESHVHDVAITREAPNYRQD

Sequences:

>Translated_499_residues
MAPSNETFLPRGSDRITEAYAFDDVLLVPGYSSVLPAAVNTRTRLTRSISLNIPVISAAMDTVTEAPMAIAMAQQGGIGV
VHKNLSIEDQADQVRQVKKFESGMVVNPLTIHPEQTLAEAQALMAQHRISGVPVVERDTNRLVGILTHRDVRFATDPAAR
VYELMTRENLVTAPANVAPEVARSLLHKHRIEKLLVVDEDYRCVGLITVKDMDKAEAHPLANKDELGRLRVAAATGVGED
GARRAEALIAAGVDVVVVDTAHGHSEGVLRAVARIKERSNAVQIVAGNVATPEAAAALIKAGADAVKIGIGPGSICTTRV
VAGVGVPQFSAVMETAAACHEADVPAIADGGIRTSGDVVKALAAGADCVMIGSLLAGTDEAPGEVFLYQGRSYKSYRGMG
SLGAMARGSADRYFQQDIKDSLKLVPEGIEGRVGYKGPMAGVVHQLVGGLRAGMGYTGCATIADLQTRAQFRRITGAGLR
ESHVHDVAITREAPNYRQD
>Mature_498_residues
APSNETFLPRGSDRITEAYAFDDVLLVPGYSSVLPAAVNTRTRLTRSISLNIPVISAAMDTVTEAPMAIAMAQQGGIGVV
HKNLSIEDQADQVRQVKKFESGMVVNPLTIHPEQTLAEAQALMAQHRISGVPVVERDTNRLVGILTHRDVRFATDPAARV
YELMTRENLVTAPANVAPEVARSLLHKHRIEKLLVVDEDYRCVGLITVKDMDKAEAHPLANKDELGRLRVAAATGVGEDG
ARRAEALIAAGVDVVVVDTAHGHSEGVLRAVARIKERSNAVQIVAGNVATPEAAAALIKAGADAVKIGIGPGSICTTRVV
AGVGVPQFSAVMETAAACHEADVPAIADGGIRTSGDVVKALAAGADCVMIGSLLAGTDEAPGEVFLYQGRSYKSYRGMGS
LGAMARGSADRYFQQDIKDSLKLVPEGIEGRVGYKGPMAGVVHQLVGGLRAGMGYTGCATIADLQTRAQFRRITGAGLRE
SHVHDVAITREAPNYRQD

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=480, Percent_Identity=40.4166666666667, Blast_Score=327, Evalue=2e-89,
Organism=Homo sapiens, GI156616279, Length=480, Percent_Identity=40.4166666666667, Blast_Score=325, Evalue=7e-89,
Organism=Homo sapiens, GI34328928, Length=480, Percent_Identity=40.4166666666667, Blast_Score=325, Evalue=7e-89,
Organism=Homo sapiens, GI34328930, Length=480, Percent_Identity=40.4166666666667, Blast_Score=325, Evalue=8e-89,
Organism=Homo sapiens, GI217035152, Length=484, Percent_Identity=40.702479338843, Blast_Score=323, Evalue=2e-88,
Organism=Homo sapiens, GI66933016, Length=484, Percent_Identity=39.4628099173554, Blast_Score=323, Evalue=3e-88,
Organism=Homo sapiens, GI217035148, Length=480, Percent_Identity=39.5833333333333, Blast_Score=311, Evalue=7e-85,
Organism=Homo sapiens, GI217035150, Length=480, Percent_Identity=37.7083333333333, Blast_Score=286, Evalue=3e-77,
Organism=Homo sapiens, GI50541954, Length=258, Percent_Identity=39.5348837209302, Blast_Score=162, Evalue=8e-40,
Organism=Homo sapiens, GI50541952, Length=258, Percent_Identity=39.5348837209302, Blast_Score=162, Evalue=8e-40,
Organism=Homo sapiens, GI50541948, Length=258, Percent_Identity=39.5348837209302, Blast_Score=162, Evalue=8e-40,
Organism=Homo sapiens, GI50541956, Length=258, Percent_Identity=39.5348837209302, Blast_Score=162, Evalue=9e-40,
Organism=Homo sapiens, GI156104880, Length=250, Percent_Identity=38.4, Blast_Score=160, Evalue=2e-39,
Organism=Escherichia coli, GI1788855, Length=481, Percent_Identity=58.8357588357588, Blast_Score=526, Evalue=1e-151,
Organism=Escherichia coli, GI1786293, Length=224, Percent_Identity=39.7321428571429, Blast_Score=154, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI71994385, Length=498, Percent_Identity=34.7389558232932, Blast_Score=264, Evalue=8e-71,
Organism=Caenorhabditis elegans, GI71994389, Length=419, Percent_Identity=36.5155131264916, Blast_Score=254, Evalue=9e-68,
Organism=Caenorhabditis elegans, GI17560440, Length=269, Percent_Identity=36.8029739776952, Blast_Score=168, Evalue=5e-42,
Organism=Saccharomyces cerevisiae, GI6322012, Length=487, Percent_Identity=37.9876796714579, Blast_Score=327, Evalue=2e-90,
Organism=Saccharomyces cerevisiae, GI6323585, Length=480, Percent_Identity=38.75, Blast_Score=324, Evalue=3e-89,
Organism=Saccharomyces cerevisiae, GI6323464, Length=480, Percent_Identity=38.9583333333333, Blast_Score=312, Evalue=8e-86,
Organism=Saccharomyces cerevisiae, GI6319352, Length=342, Percent_Identity=39.1812865497076, Blast_Score=249, Evalue=1e-66,
Organism=Saccharomyces cerevisiae, GI6319353, Length=119, Percent_Identity=38.655462184874, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24641071, Length=482, Percent_Identity=38.5892116182573, Blast_Score=304, Evalue=1e-82,
Organism=Drosophila melanogaster, GI24641073, Length=482, Percent_Identity=38.5892116182573, Blast_Score=304, Evalue=1e-82,
Organism=Drosophila melanogaster, GI28571163, Length=439, Percent_Identity=38.496583143508, Blast_Score=274, Evalue=1e-73,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52710; Mature: 52579

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPSNETFLPRGSDRITEAYAFDDVLLVPGYSSVLPAAVNTRTRLTRSISLNIPVISAAM
CCCCCCCCCCCCCCHHHHHHCCCCEEEECCCHHHCCHHHCHHHHEEEEEEECCCCHHHHH
DTVTEAPMAIAMAQQGGIGVVHKNLSIEDQADQVRQVKKFESGMVVNPLTIHPEQTLAEA
HHHHHCCCEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEECCEEECCHHHHHHH
QALMAQHRISGVPVVERDTNRLVGILTHRDVRFATDPAARVYELMTRENLVTAPANVAPE
HHHHHHHHCCCCCEEECCCCCEEEEEEECCEEECCCHHHHHHHHHHHCCCEECCCCCCHH
VARSLLHKHRIEKLLVVDEDYRCVGLITVKDMDKAEAHPLANKDELGRLRVAAATGVGED
HHHHHHHHHHHHEEEEECCCCEEEEEEEECCCCCHHCCCCCCCCCCCEEEEEEECCCCCC
GARRAEALIAAGVDVVVVDTAHGHSEGVLRAVARIKERSNAVQIVAGNVATPEAAAALIK
HHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHH
AGADAVKIGIGPGSICTTRVVAGVGVPQFSAVMETAAACHEADVPAIADGGIRTSGDVVK
CCCCEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
ALAAGADCVMIGSLLAGTDEAPGEVFLYQGRSYKSYRGMGSLGAMARGSADRYFQQDIKD
HHHCCCCCEEHHHHHCCCCCCCCCEEEEECCCCCHHCCCCCHHHHHCCCHHHHHHHHHHH
SLKLVPEGIEGRVGYKGPMAGVVHQLVGGLRAGMGYTGCATIADLQTRAQFRRITGAGLR
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCC
ESHVHDVAITREAPNYRQD
CCCCCEEEEECCCCCCCCC
>Mature Secondary Structure 
APSNETFLPRGSDRITEAYAFDDVLLVPGYSSVLPAAVNTRTRLTRSISLNIPVISAAM
CCCCCCCCCCCCCHHHHHHCCCCEEEECCCHHHCCHHHCHHHHEEEEEEECCCCHHHHH
DTVTEAPMAIAMAQQGGIGVVHKNLSIEDQADQVRQVKKFESGMVVNPLTIHPEQTLAEA
HHHHHCCCEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEECCEEECCHHHHHHH
QALMAQHRISGVPVVERDTNRLVGILTHRDVRFATDPAARVYELMTRENLVTAPANVAPE
HHHHHHHHCCCCCEEECCCCCEEEEEEECCEEECCCHHHHHHHHHHHCCCEECCCCCCHH
VARSLLHKHRIEKLLVVDEDYRCVGLITVKDMDKAEAHPLANKDELGRLRVAAATGVGED
HHHHHHHHHHHHEEEEECCCCEEEEEEEECCCCCHHCCCCCCCCCCCEEEEEEECCCCCC
GARRAEALIAAGVDVVVVDTAHGHSEGVLRAVARIKERSNAVQIVAGNVATPEAAAALIK
HHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHH
AGADAVKIGIGPGSICTTRVVAGVGVPQFSAVMETAAACHEADVPAIADGGIRTSGDVVK
CCCCEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
ALAAGADCVMIGSLLAGTDEAPGEVFLYQGRSYKSYRGMGSLGAMARGSADRYFQQDIKD
HHHCCCCCEEHHHHHCCCCCCCCCEEEEECCCCCHHCCCCCHHHHHCCCHHHHHHHHHHH
SLKLVPEGIEGRVGYKGPMAGVVHQLVGGLRAGMGYTGCATIADLQTRAQFRRITGAGLR
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCC
ESHVHDVAITREAPNYRQD
CCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA