BacMap

Definition	Acidiphilium cryptum JF-5 chromosome, complete genome.
Accession	NC_009484
Length	3,389,227

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The map label for this gene is ppi [H]

Identifier: 148260181

GI number: 148260181

Start: 1312752

End: 1313306

Strand: Reverse

Name: ppi [H]

Synonym: Acry_1177

Alternate gene names: 148260181

Gene position: 1313306-1312752 (Counterclockwise)

Preceding gene: 148260182

Following gene: 148260171

Centisome position: 38.75

GC content: 64.86

Gene sequence:

>555_bases
ATGATCATCAGACGCCGCACGCTTCTCGCCGCCGCCGCTTCCACCCCCCTTGCCGGAGTTTTCATGTCCGAATCCGCTTC
CGCCGCCAGCACGTCGAACACCATTCACATGACGCTGCCCTTCGGCGTCGTCACGATCGAGCTGCGCCCCGACCTCGCGC
CGAAAACCTGCGAGCAGATCCGCACGCTGACCGCGCGCGGCTTCTACAACGGCTGCGAATTCTTCCGCGTGATCGCCGGC
TTCATGGCGCAGACCGGCGACCCCACCAACACCGGCACCGGCGGCAGCAACCTGCCCAACGTGCCCGCCGAGTTCACCGA
CAAGGCAAAGTTCCTCACCGGTTCGGTGGGCATGGCCCGCACCAGCGACCCGAACAGCGGGAACAGCCAGTTCTTCATCT
GCTTCGCTCCCGCCGCCTGGCTTGACGGCCAGTACACCCTGTTCGGCCAGGTGACGGCGGGCATGGACTATGTGGACGAG
ATCAAGAAGGGCCAGGGCCAAAGCGGCCGGGTCACTGACCCGACCAAGATCATCAAGATGGAACTCGCCGCGTAA

Upstream 100 bases:

>100_bases
CGTCGCGTTTCGTCAAGGAGATCGCCCAGCTGGGCGGCGACATCTCGAGCTTCGTTCCGAAACTGACGTTGGAGAGGACC
CTTCGCCGGGTTGGCAGACC

Downstream 100 bases:

>100_bases
TACCGGCAATCCGTCTCAGCCTCTTGACGAACCCCGCCGGAATTGGTCTTTCCGGCGGGCACATTGGTGAGAGCCCGTAG
CTCAGTTGGTAGAGCACGAG

Product: cyclophilin type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 184; Mature: 184

Protein sequence:

>184_residues
MIIRRRTLLAAAASTPLAGVFMSESASAASTSNTIHMTLPFGVVTIELRPDLAPKTCEQIRTLTARGFYNGCEFFRVIAG
FMAQTGDPTNTGTGGSNLPNVPAEFTDKAKFLTGSVGMARTSDPNSGNSQFFICFAPAAWLDGQYTLFGQVTAGMDYVDE
IKKGQGQSGRVTDPTKIIKMELAA

Sequences:

>Translated_184_residues
MIIRRRTLLAAAASTPLAGVFMSESASAASTSNTIHMTLPFGVVTIELRPDLAPKTCEQIRTLTARGFYNGCEFFRVIAG
FMAQTGDPTNTGTGGSNLPNVPAEFTDKAKFLTGSVGMARTSDPNSGNSQFFICFAPAAWLDGQYTLFGQVTAGMDYVDE
IKKGQGQSGRVTDPTKIIKMELAA
>Mature_184_residues
MIIRRRTLLAAAASTPLAGVFMSESASAASTSNTIHMTLPFGVVTIELRPDLAPKTCEQIRTLTARGFYNGCEFFRVIAG
FMAQTGDPTNTGTGGSNLPNVPAEFTDKAKFLTGSVGMARTSDPNSGNSQFFICFAPAAWLDGQYTLFGQVTAGMDYVDE
IKKGQGQSGRVTDPTKIIKMELAA

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=149, Percent_Identity=36.9127516778523, Blast_Score=107, Evalue=9e-24,
Organism=Homo sapiens, GI19557636, Length=135, Percent_Identity=42.2222222222222, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI5031987, Length=144, Percent_Identity=41.6666666666667, Blast_Score=97, Evalue=8e-21,
Organism=Homo sapiens, GI24308049, Length=144, Percent_Identity=38.8888888888889, Blast_Score=95, Evalue=4e-20,
Organism=Homo sapiens, GI10863927, Length=146, Percent_Identity=39.041095890411, Blast_Score=91, Evalue=6e-19,
Organism=Homo sapiens, GI310110104, Length=139, Percent_Identity=38.1294964028777, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI310129267, Length=141, Percent_Identity=36.8794326241135, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI310120620, Length=141, Percent_Identity=36.8794326241135, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI45439316, Length=162, Percent_Identity=35.8024691358025, Blast_Score=83, Evalue=1e-16,
Organism=Homo sapiens, GI5174637, Length=158, Percent_Identity=34.8101265822785, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI310127646, Length=146, Percent_Identity=36.986301369863, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI310114371, Length=146, Percent_Identity=36.986301369863, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI310119221, Length=146, Percent_Identity=36.986301369863, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI303305009, Length=150, Percent_Identity=36, Blast_Score=81, Evalue=5e-16,
Organism=Homo sapiens, GI256017253, Length=126, Percent_Identity=39.6825396825397, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI221139811, Length=126, Percent_Identity=39.6825396825397, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI256017251, Length=126, Percent_Identity=39.6825396825397, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI169163387, Length=146, Percent_Identity=36.3013698630137, Blast_Score=78, Evalue=4e-15,
Organism=Homo sapiens, GI169164185, Length=146, Percent_Identity=36.3013698630137, Blast_Score=78, Evalue=4e-15,
Organism=Homo sapiens, GI169163623, Length=146, Percent_Identity=36.3013698630137, Blast_Score=78, Evalue=4e-15,
Organism=Homo sapiens, GI64276486, Length=119, Percent_Identity=37.8151260504202, Blast_Score=77, Evalue=6e-15,
Organism=Homo sapiens, GI178057341, Length=129, Percent_Identity=37.984496124031, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI209417936, Length=129, Percent_Identity=37.984496124031, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI30102944, Length=129, Percent_Identity=37.984496124031, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI219842199, Length=129, Percent_Identity=37.984496124031, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI169214050, Length=150, Percent_Identity=36, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI239751853, Length=150, Percent_Identity=36, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI113428306, Length=150, Percent_Identity=36, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI310132444, Length=146, Percent_Identity=32.8767123287671, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI310113152, Length=146, Percent_Identity=32.8767123287671, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI4505991, Length=127, Percent_Identity=37.7952755905512, Blast_Score=71, Evalue=5e-13,
Organism=Homo sapiens, GI22547212, Length=120, Percent_Identity=43.3333333333333, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI7657473, Length=120, Percent_Identity=43.3333333333333, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI22547215, Length=118, Percent_Identity=44.0677966101695, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI42560244, Length=142, Percent_Identity=35.9154929577465, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI310114540, Length=128, Percent_Identity=37.5, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI310127745, Length=128, Percent_Identity=37.5, Blast_Score=68, Evalue=4e-12,
Organism=Homo sapiens, GI310119290, Length=128, Percent_Identity=37.5, Blast_Score=68, Evalue=4e-12,
Organism=Homo sapiens, GI4758950, Length=127, Percent_Identity=37.007874015748, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI20911035, Length=134, Percent_Identity=33.5820895522388, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1789763, Length=164, Percent_Identity=35.9756097560976, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1786736, Length=144, Percent_Identity=34.0277777777778, Blast_Score=66, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17506311, Length=153, Percent_Identity=43.1372549019608, Blast_Score=110, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI71980594, Length=134, Percent_Identity=47.0149253731343, Blast_Score=107, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI71980590, Length=134, Percent_Identity=47.0149253731343, Blast_Score=106, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17539496, Length=120, Percent_Identity=40, Blast_Score=98, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17532641, Length=141, Percent_Identity=36.1702127659575, Blast_Score=94, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17539498, Length=146, Percent_Identity=39.041095890411, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17565860, Length=145, Percent_Identity=40, Blast_Score=83, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17566266, Length=143, Percent_Identity=35.6643356643357, Blast_Score=80, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17559074, Length=142, Percent_Identity=33.8028169014084, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17552782, Length=151, Percent_Identity=33.7748344370861, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17552780, Length=139, Percent_Identity=37.410071942446, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71997782, Length=116, Percent_Identity=38.7931034482759, Blast_Score=70, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17506307, Length=132, Percent_Identity=35.6060606060606, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320359, Length=129, Percent_Identity=41.0852713178295, Blast_Score=82, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6323562, Length=177, Percent_Identity=33.8983050847458, Blast_Score=79, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6321848, Length=137, Percent_Identity=38.6861313868613, Blast_Score=65, Evalue=5e-12,
Organism=Drosophila melanogaster, GI17986117, Length=148, Percent_Identity=40.5405405405405, Blast_Score=106, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24652460, Length=135, Percent_Identity=44.4444444444444, Blast_Score=100, Evalue=5e-22,
Organism=Drosophila melanogaster, GI45549139, Length=145, Percent_Identity=41.3793103448276, Blast_Score=97, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24664125, Length=143, Percent_Identity=37.7622377622378, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI21357783, Length=143, Percent_Identity=37.7622377622378, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI21357249, Length=144, Percent_Identity=34.0277777777778, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI17647301, Length=136, Percent_Identity=38.9705882352941, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI19922376, Length=133, Percent_Identity=34.5864661654135, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI19922912, Length=181, Percent_Identity=36.4640883977901, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI17136360, Length=167, Percent_Identity=32.3353293413174, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24661775, Length=186, Percent_Identity=30.6451612903226, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21355237, Length=186, Percent_Identity=30.6451612903226, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24661771, Length=186, Percent_Identity=30.6451612903226, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI20130249, Length=131, Percent_Identity=34.3511450381679, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 19588; Mature: 19588

Theoretical pI: Translated: 8.04; Mature: 8.04

Prosite motif: PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIRRRTLLAAAASTPLAGVFMSESASAASTSNTIHMTLPFGVVTIELRPDLAPKTCEQI
CEECCHHHHHHHCCCCEEEEEECCCCCCCCCCCEEEEEECCEEEEEEECCCCCHHHHHHH
RTLTARGFYNGCEFFRVIAGFMAQTGDPTNTGTGGSNLPNVPAEFTDKAKFLTGSVGMAR
HHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHCCCCCEEECCCCCCC
TSDPNSGNSQFFICFAPAAWLDGQYTLFGQVTAGMDYVDEIKKGQGQSGRVTDPTKIIKM
CCCCCCCCCEEEEEECCCHHCCCCEEEEEEECCCCHHHHHHHHCCCCCCCCCCCCEEEEE
ELAA
EECC
>Mature Secondary Structure
MIIRRRTLLAAAASTPLAGVFMSESASAASTSNTIHMTLPFGVVTIELRPDLAPKTCEQI
CEECCHHHHHHHCCCCEEEEEECCCCCCCCCCCEEEEEECCEEEEEEECCCCCHHHHHHH
RTLTARGFYNGCEFFRVIAGFMAQTGDPTNTGTGGSNLPNVPAEFTDKAKFLTGSVGMAR
HHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHCCCCCEEECCCCCCC
TSDPNSGNSQFFICFAPAAWLDGQYTLFGQVTAGMDYVDEIKKGQGQSGRVTDPTKIIKM
CCCCCCCCCEEEEEECCCHHCCCCEEEEEEECCCCHHHHHHHHCCCCCCCCCCCCEEEEE
ELAA
EECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA