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The map label for this gene is nuoC

Identifier: 148260122

GI number: 148260122

Start: 1245392

End: 1247170

Strand: Reverse

Name: nuoC

Synonym: Acry_1118

Alternate gene names: 148260122

Gene position: 1247170-1245392 (Counterclockwise)

Preceding gene: 148260123

Following gene: 148260121

Centisome position: 36.8

GC content: 65.26

Gene sequence:

>1779_bases
ATGCTGACGGAATTCAACAGCATCCCCGCCACAGAGGCCGAACAGGGTATCGTGTCCGACCTGGTCCGCACGCTCGGGCC
GATCTCCTTCACCCTGCAGCAGACCGCCGACCGGATCCCGACCATCTGGATCGATCGCGACATCGTGCACGCCGTGCTCC
GGCACCTGCGCGACGGCGCCACAAGGCGCTTCCAGATGCTCTACGACCTCACCGCGATCGACGAGCGCCAGCGCGTCCAC
CGCGATGGCCTGCCGAAATCCGATTTCACCCTCGTCTATCACCTCGTCTCCTTCGAGCGGAACGACGATGTCCGCGTCAA
GGTCCCGCTCGCCGAGGGCGCGCTCGAGGTGCAGAGCATCGCGGATATCTGGCCCAACGCCAACTGGTACGAACGCGAGG
TCTGGGACATGTTCGGCATCGGCTTCGCCGGCCACCCGACCCTGTTCCGCATCCTCACGCCGCCGACCTGGACCGGCCAT
CCGCTGCGCAAGGACTACATCGCCCGCGCCACCGAAATGGGCCCCTACATCCTCACCGAGGAGAAGGAACGCGCCGAACA
GGAGGCGCTGCGCTTCAACCCCGAGGCCTGGGGCATGAAGCGGCACAGCGAGAACTCCGACTTCATGTTCCTCAATCTCG
GCCCCAACCACCCGAGCGTCCACGGCGTGTTCCGCATCATCCTCCAGCTCGAGGGCGAGGAAATCGTCGACGCCGTGCCC
GAGATCGGCTTTCATCACCGCGGCGCCGAGAAGATGGCCGAGCGCCAGTCCTGGCACACCTACATCCCCTATACCGACCG
CATCGACTATCTCGGCGGCGTGATGAACAACTTCCCCTACGTGATGGCGGTCGAGCGCCTCGCGGGGATCGAGGTGCCGT
CACGCGCGCAGATGATCCGCATCATGCTCGCCGAGCTGTTCCGCATCGCCAGCCATCTCGTGTTCTACGGCACCATGTCG
CAGGATGTCGGCCAGCTTTCGCCGGTCTTCTACATGTTCTCCGACCGCGAGCGGGTGTTCCAGATCATCGAGGCGATCTG
CGGCTTCCGCATGCACCCCGCCTGGTTCCGCATCGGCGGCGTGGCGGCGGACCTGCCCCAGGGCTGGGACCGGATGATCC
GCGACTATCTCGGCTACCAGTCGAAGCGGCTCGACGAGTACGACAAGCTCGTCATGCGCAACCGCCTCTTCAAGGCCCGC
ACGATCGGCGTCGGCGCCTACACGCTGGAGGAAGCGCTGGACTGGGGCGTGACCGGCCCCGGCCTGCGCGCCTGCGGCCT
CGGCTGGGACTATCGCCGCCAGCGCCCCTATTCCGGATACGACCAGCTCGAGTTCGACATTCCGATCTGCCACAACGGCG
ACTGTTACGACCGCGTGGTGGTCCATATCGAGGAAATCCGCCAGAGCCTGCGCATCATCCGCCAGTGCCTCGATAACATG
CCGCCCGGCCCCTACAAGTCCGACCACCGGCTGACGACGCCGCCGCTCAAGGAGCGGACGATGCAGGACATCGAAACCCT
CATCACCCATTTCCTCAATGTCAGCTGGGGCCCCGTGCTTCCGCCCGGCGAGGCGATGGTCAGCATCGAGGCGACCAAGG
GCATCAACGGCTATTACCTCGTCGCCGACGGCGACACCGTCTCCTACCGCACCCGCATCCGCACCCCGTCCTTTCCCCAT
CTGCAGATGATCCCGCTGATCAGCCGCGGCGCCTATGTCGCCGACCTGATCGCGATCATCGGCAGCATCGATTTCGTGAT
GGCCGATGTCGACCGCTGA

Upstream 100 bases:

>100_bases
GCCGAGAAGATCGAGCGGCCCAGCTTCCGCGATCTCAAACACCAGGAGAGGCAAGCGGCCGGCAGCCTCCCCACGCCGGA
CAGCGTTTAGGGAGGGCGGG

Downstream 100 bases:

>100_bases
ACCCGATCCGGCCGCCGCGCCGCTCGATGCCGCCCTGCGCGAGACGATCGCGACCTTTCTGCGCGAGTCCGAAACCCCGC
GCGCCGCCGGCATCGATGCG

Product: bifunctional NADH:ubiquinone oxidoreductase subunit C/D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit C/D; NDH-1 subunit C/D

Number of amino acids: Translated: 592; Mature: 592

Protein sequence:

>592_residues
MLTEFNSIPATEAEQGIVSDLVRTLGPISFTLQQTADRIPTIWIDRDIVHAVLRHLRDGATRRFQMLYDLTAIDERQRVH
RDGLPKSDFTLVYHLVSFERNDDVRVKVPLAEGALEVQSIADIWPNANWYEREVWDMFGIGFAGHPTLFRILTPPTWTGH
PLRKDYIARATEMGPYILTEEKERAEQEALRFNPEAWGMKRHSENSDFMFLNLGPNHPSVHGVFRIILQLEGEEIVDAVP
EIGFHHRGAEKMAERQSWHTYIPYTDRIDYLGGVMNNFPYVMAVERLAGIEVPSRAQMIRIMLAELFRIASHLVFYGTMS
QDVGQLSPVFYMFSDRERVFQIIEAICGFRMHPAWFRIGGVAADLPQGWDRMIRDYLGYQSKRLDEYDKLVMRNRLFKAR
TIGVGAYTLEEALDWGVTGPGLRACGLGWDYRRQRPYSGYDQLEFDIPICHNGDCYDRVVVHIEEIRQSLRIIRQCLDNM
PPGPYKSDHRLTTPPLKERTMQDIETLITHFLNVSWGPVLPPGEAMVSIEATKGINGYYLVADGDTVSYRTRIRTPSFPH
LQMIPLISRGAYVADLIAIIGSIDFVMADVDR

Sequences:

>Translated_592_residues
MLTEFNSIPATEAEQGIVSDLVRTLGPISFTLQQTADRIPTIWIDRDIVHAVLRHLRDGATRRFQMLYDLTAIDERQRVH
RDGLPKSDFTLVYHLVSFERNDDVRVKVPLAEGALEVQSIADIWPNANWYEREVWDMFGIGFAGHPTLFRILTPPTWTGH
PLRKDYIARATEMGPYILTEEKERAEQEALRFNPEAWGMKRHSENSDFMFLNLGPNHPSVHGVFRIILQLEGEEIVDAVP
EIGFHHRGAEKMAERQSWHTYIPYTDRIDYLGGVMNNFPYVMAVERLAGIEVPSRAQMIRIMLAELFRIASHLVFYGTMS
QDVGQLSPVFYMFSDRERVFQIIEAICGFRMHPAWFRIGGVAADLPQGWDRMIRDYLGYQSKRLDEYDKLVMRNRLFKAR
TIGVGAYTLEEALDWGVTGPGLRACGLGWDYRRQRPYSGYDQLEFDIPICHNGDCYDRVVVHIEEIRQSLRIIRQCLDNM
PPGPYKSDHRLTTPPLKERTMQDIETLITHFLNVSWGPVLPPGEAMVSIEATKGINGYYLVADGDTVSYRTRIRTPSFPH
LQMIPLISRGAYVADLIAIIGSIDFVMADVDR
>Mature_592_residues
MLTEFNSIPATEAEQGIVSDLVRTLGPISFTLQQTADRIPTIWIDRDIVHAVLRHLRDGATRRFQMLYDLTAIDERQRVH
RDGLPKSDFTLVYHLVSFERNDDVRVKVPLAEGALEVQSIADIWPNANWYEREVWDMFGIGFAGHPTLFRILTPPTWTGH
PLRKDYIARATEMGPYILTEEKERAEQEALRFNPEAWGMKRHSENSDFMFLNLGPNHPSVHGVFRIILQLEGEEIVDAVP
EIGFHHRGAEKMAERQSWHTYIPYTDRIDYLGGVMNNFPYVMAVERLAGIEVPSRAQMIRIMLAELFRIASHLVFYGTMS
QDVGQLSPVFYMFSDRERVFQIIEAICGFRMHPAWFRIGGVAADLPQGWDRMIRDYLGYQSKRLDEYDKLVMRNRLFKAR
TIGVGAYTLEEALDWGVTGPGLRACGLGWDYRRQRPYSGYDQLEFDIPICHNGDCYDRVVVHIEEIRQSLRIIRQCLDNM
PPGPYKSDHRLTTPPLKERTMQDIETLITHFLNVSWGPVLPPGEAMVSIEATKGINGYYLVADGDTVSYRTRIRTPSFPH
LQMIPLISRGAYVADLIAIIGSIDFVMADVDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the complex I 49 kDa subunit family

Homologues:

Organism=Homo sapiens, GI4758786, Length=382, Percent_Identity=43.979057591623, Blast_Score=336, Evalue=5e-92,
Organism=Homo sapiens, GI260898743, Length=372, Percent_Identity=43.8172043010753, Blast_Score=327, Evalue=3e-89,
Organism=Homo sapiens, GI4758788, Length=125, Percent_Identity=43.2, Blast_Score=97, Evalue=6e-20,
Organism=Escherichia coli, GI145693162, Length=577, Percent_Identity=60.6585788561525, Blast_Score=760, Evalue=0.0,
Organism=Escherichia coli, GI1789076, Length=510, Percent_Identity=28.8235294117647, Blast_Score=165, Evalue=8e-42,
Organism=Escherichia coli, GI1788832, Length=508, Percent_Identity=26.9685039370079, Blast_Score=140, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17555284, Length=393, Percent_Identity=43.5114503816794, Blast_Score=356, Evalue=2e-98,
Organism=Caenorhabditis elegans, GI17568379, Length=393, Percent_Identity=43.5114503816794, Blast_Score=354, Evalue=6e-98,
Organism=Caenorhabditis elegans, GI71990788, Length=118, Percent_Identity=37.2881355932203, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI32563621, Length=118, Percent_Identity=37.2881355932203, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221459469, Length=383, Percent_Identity=40.9921671018277, Blast_Score=355, Evalue=5e-98,
Organism=Drosophila melanogaster, GI24638644, Length=384, Percent_Identity=42.96875, Blast_Score=349, Evalue=2e-96,
Organism=Drosophila melanogaster, GI24656494, Length=135, Percent_Identity=37.037037037037, Blast_Score=84, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOCD_ACICJ (A5FXJ8)

Other databases:

- EMBL:   CP000697
- RefSeq:   YP_001234249.1
- ProteinModelPortal:   A5FXJ8
- STRING:   A5FXJ8
- GeneID:   5162138
- GenomeReviews:   CP000697_GR
- KEGG:   acr:Acry_1118
- eggNOG:   COG0649
- HOGENOM:   HBG459705
- OMA:   PHLQQIP
- ProtClustDB:   PRK11742
- BioCyc:   ACRY349163:ACRY_1118-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_01359
- InterPro:   IPR010219
- InterPro:   IPR010218
- InterPro:   IPR023062
- InterPro:   IPR001135
- InterPro:   IPR001268
- InterPro:   IPR014029
- InterPro:   IPR022885
- ProDom:   PD001581
- TIGRFAMs:   TIGR01961
- TIGRFAMs:   TIGR01962

Pfam domain/function: PF00329 Complex1_30kDa; PF00346 Complex1_49kDa

EC number: =1.6.99.5

Molecular weight: Translated: 68009; Mature: 68009

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS00542 COMPLEX1_30K; PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTEFNSIPATEAEQGIVSDLVRTLGPISFTLQQTADRIPTIWIDRDIVHAVLRHLRDGA
CCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEECHHHHHHHHHHHHHCH
TRRFQMLYDLTAIDERQRVHRDGLPKSDFTLVYHLVSFERNDDVRVKVPLAEGALEVQSI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHH
ADIWPNANWYEREVWDMFGIGFAGHPTLFRILTPPTWTGHPLRKDYIARATEMGPYILTE
HHHCCCCCCHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCEEECC
EKERAEQEALRFNPEAWGMKRHSENSDFMFLNLGPNHPSVHGVFRIILQLEGEEIVDAVP
CHHHHHHHHHHCCCHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHH
EIGFHHRGAEKMAERQSWHTYIPYTDRIDYLGGVMNNFPYVMAVERLAGIEVPSRAQMIR
HCCCCCCCHHHHHHHCCCCEECCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHH
IMLAELFRIASHLVFYGTMSQDVGQLSPVFYMFSDRERVFQIIEAICGFRMHPAWFRIGG
HHHHHHHHHHHHHHEEECCHHHHHHCCCEEEEECCHHHHHHHHHHHHCCCCCCHHHEECC
VAADLPQGWDRMIRDYLGYQSKRLDEYDKLVMRNRLFKARTIGVGAYTLEEALDWGVTGP
CCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHCCCCCC
GLRACGLGWDYRRQRPYSGYDQLEFDIPICHNGDCYDRVVVHIEEIRQSLRIIRQCLDNM
CCCCCCCCCHHHHCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
PPGPYKSDHRLTTPPLKERTMQDIETLITHFLNVSWGPVLPPGEAMVSIEATKGINGYYL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCEEEE
VADGDTVSYRTRIRTPSFPHLQMIPLISRGAYVADLIAIIGSIDFVMADVDR
EECCCEEEEEEEECCCCCCCEEECHHHHCCHHHHHHHHHHHCHHHHEECCCC
>Mature Secondary Structure
MLTEFNSIPATEAEQGIVSDLVRTLGPISFTLQQTADRIPTIWIDRDIVHAVLRHLRDGA
CCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEECHHHHHHHHHHHHHCH
TRRFQMLYDLTAIDERQRVHRDGLPKSDFTLVYHLVSFERNDDVRVKVPLAEGALEVQSI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHH
ADIWPNANWYEREVWDMFGIGFAGHPTLFRILTPPTWTGHPLRKDYIARATEMGPYILTE
HHHCCCCCCHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCEEECC
EKERAEQEALRFNPEAWGMKRHSENSDFMFLNLGPNHPSVHGVFRIILQLEGEEIVDAVP
CHHHHHHHHHHCCCHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHH
EIGFHHRGAEKMAERQSWHTYIPYTDRIDYLGGVMNNFPYVMAVERLAGIEVPSRAQMIR
HCCCCCCCHHHHHHHCCCCEECCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHH
IMLAELFRIASHLVFYGTMSQDVGQLSPVFYMFSDRERVFQIIEAICGFRMHPAWFRIGG
HHHHHHHHHHHHHHEEECCHHHHHHCCCEEEEECCHHHHHHHHHHHHCCCCCCHHHEECC
VAADLPQGWDRMIRDYLGYQSKRLDEYDKLVMRNRLFKARTIGVGAYTLEEALDWGVTGP
CCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHCCCCCC
GLRACGLGWDYRRQRPYSGYDQLEFDIPICHNGDCYDRVVVHIEEIRQSLRIIRQCLDNM
CCCCCCCCCHHHHCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
PPGPYKSDHRLTTPPLKERTMQDIETLITHFLNVSWGPVLPPGEAMVSIEATKGINGYYL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCEEEE
VADGDTVSYRTRIRTPSFPHLQMIPLISRGAYVADLIAIIGSIDFVMADVDR
EECCCEEEEEEEECCCCCCCEEECHHHHCCHHHHHHHHHHHCHHHHEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA