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The map label for this gene is nuoL [H]

Identifier: 148260114

GI number: 148260114

Start: 1236699

End: 1238555

Strand: Reverse

Name: nuoL [H]

Synonym: Acry_1110

Alternate gene names: 148260114

Gene position: 1238555-1236699 (Counterclockwise)

Preceding gene: 148260115

Following gene: 148260113

Centisome position: 36.54

GC content: 70.22

Gene sequence:

>1857_bases
ATGCAGCATTTCCTCTGGCTCGTCCCCGCGCTGCCGCTCCTCGGCTCGATCGTCCTGATGCTCGGCACCGGGCGCCTGTC
GCACCGCGCCGAGGCGCTGATCGGCGTGCTCTCGGTCGGCCTCGCCGCCGTCGTCGCCTTCGCCATCGCCGGCGCCTTCC
TGCTCGATCCGCCGGCCGGCGCCGCCTACCAGCAGTCCCTGTGGCGCTGGTTCGCGGTCGGGCATTTCTCCTTCGGCATC
GCCCTGCGGGTCGATCCGCTCTCGCTGCTGATGATGCTCGTCACCAGCGGCGTCGGCTTCCTCATCCATCTCTTCTCGAC
CGAGTTCATGGAGGGCGAGGAGGGCTACGGCCGGTTCTTCGCCTATCTCAACCTCTTCGTCGCCGCCATGCTGCTGCTGG
TGATGGCCGACAATTTCCTCGTCCTCTACGCCGGCTGGGAAGGGGTCGGGCTCTGCTCCTACCTGCTGATCGGCTTCTGG
TGGCGCGACCCCGCCAACGGCCTCGCCGCGCGCAAGGCCTTCATCGTCACCCGCGTCGGCGACACCGCCTTCCTGATCGG
CCTGCTGCTGATCGCGAGCCGCCTCGGCACGCTGAACATCGCCGGGGCGATGGACGCCGCGTCCCGCACCTGGCATCCCG
GCTCGCCGGCCGCGACGCTGATCGCCTTCCTCCTGCTCGGCGGCGCCGTCGGCAAGTCCGCGCAGTTGCCGCTGCAGACC
TGGCTGCCCGACGCGATGGCCGGCCCCACCCCGGTCAGCGCGCTCATCCACGCCGCGACGATGGTCACCGCCGGCGTCTA
CCTCATCGCCCGCACCCATGTGCTGTTCCTGCTCGCGCCGGCGGCGGAAATCACCGTCGGCATCGTCGGCGCGGCGACCC
TGCTGCTCGCCGGCTTCAGCGCCCTCGCGCAGAACGACATCAAGCGCATCCTCGCCTATTCGACGATGAGCCAGATCGGC
TACATGTTCCTCGCCCTGGGCGTCGGCGCCTGGCGCGCGGCGATGTTCCACTTCATGACGCACGCCTTCTTCAAGGCGCT
GCTGTTCCTCTCGGCCGGCGCCGTCACCATGCGCCTGCATCACGAGCAGGACATCTACCGGATGGGCGGCCTCGCCCGCC
GCCTGCCCGCCGCCTTCTGGAGCTTCCTGATCGGCAGCGCCGCCCTTGCCGCCCTGCCGCTGATCACCTCGGGGTTCTAC
AGCAAGGAAGCGATCCTCTCGGGCGCCTGGGCCGACGGCAATGGCGGCCGCGTGCTCTGGCTCGCCGGCGTCATCGGCGC
CTTCGTCACCGGAATCTACATCTTCCGCGCCGTCTTCATCGCCTTTTTCGGCGAGGAGCACACCCATGTCAGCGGCTCCT
ACGGCTGGCGCGTCATCGTGCCGCTGGTGGTGCTCTCGGTGCTGTCGCTGGTCGGCGGCTTCATCGAACTGCCGCCGGCC
TTCGGCCACGTCACGCTGCTCTCCAGGCTCCTCGCCCCGGTGCTGCCCCCGACCAGGGAGGTGACCGACATGACCCCGCT
GCTGCTCGCCAGCGCCGCGTCCATCCTCGGCATCGCGCTGGCCGCCGTGCTCTACTGGCGCCCGTCGCGCCCGCCGGCCG
AAACGCCGCTCTGGCGCTTCTGGCACGCCGCCGCCGGGTTCGACGCGCTCTATGACCGCCTGCTGGTCCGCCCCGTGATC
TGGGCCGCCCGGGTCGACCGCGACGATTTCATCGACAGTTTCTACGACGGCATCGCCTGGGCCACGCAGGCGATCCACCG
GGCGATCCGGCGCACCCAGACCGGCCGGGTCCGCCTCTATGCCGCGAGCCTCGCCATCGGCTCGGTCGGCCTGATCGCGA
TCGCGGTGCTGCGATGA

Upstream 100 bases:

>100_bases
GCGGCGGAAGTCTCGGTCGGCCTGGCACTCATCCTGCTGATGCACCGGCGGATCCCCACGCTCGATGCCGATGCCGGCGA
CGGTCTGAGGGGGTAGAAAG

Downstream 100 bases:

>100_bases
TCCTGTTCTGGCTCCTCATCTTCCCGGCGGTCGGCGGCGTGCTGGCCTGGATCGCCGGCACCCGCAACCCGGATGCCCCG
CGCTGGGTGTCGATCGCGGT

Product: proton-translocating NADH-quinone oxidoreductase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L; NUO12 [H]

Number of amino acids: Translated: 618; Mature: 618

Protein sequence:

>618_residues
MQHFLWLVPALPLLGSIVLMLGTGRLSHRAEALIGVLSVGLAAVVAFAIAGAFLLDPPAGAAYQQSLWRWFAVGHFSFGI
ALRVDPLSLLMMLVTSGVGFLIHLFSTEFMEGEEGYGRFFAYLNLFVAAMLLLVMADNFLVLYAGWEGVGLCSYLLIGFW
WRDPANGLAARKAFIVTRVGDTAFLIGLLLIASRLGTLNIAGAMDAASRTWHPGSPAATLIAFLLLGGAVGKSAQLPLQT
WLPDAMAGPTPVSALIHAATMVTAGVYLIARTHVLFLLAPAAEITVGIVGAATLLLAGFSALAQNDIKRILAYSTMSQIG
YMFLALGVGAWRAAMFHFMTHAFFKALLFLSAGAVTMRLHHEQDIYRMGGLARRLPAAFWSFLIGSAALAALPLITSGFY
SKEAILSGAWADGNGGRVLWLAGVIGAFVTGIYIFRAVFIAFFGEEHTHVSGSYGWRVIVPLVVLSVLSLVGGFIELPPA
FGHVTLLSRLLAPVLPPTREVTDMTPLLLASAASILGIALAAVLYWRPSRPPAETPLWRFWHAAAGFDALYDRLLVRPVI
WAARVDRDDFIDSFYDGIAWATQAIHRAIRRTQTGRVRLYAASLAIGSVGLIAIAVLR

Sequences:

>Translated_618_residues
MQHFLWLVPALPLLGSIVLMLGTGRLSHRAEALIGVLSVGLAAVVAFAIAGAFLLDPPAGAAYQQSLWRWFAVGHFSFGI
ALRVDPLSLLMMLVTSGVGFLIHLFSTEFMEGEEGYGRFFAYLNLFVAAMLLLVMADNFLVLYAGWEGVGLCSYLLIGFW
WRDPANGLAARKAFIVTRVGDTAFLIGLLLIASRLGTLNIAGAMDAASRTWHPGSPAATLIAFLLLGGAVGKSAQLPLQT
WLPDAMAGPTPVSALIHAATMVTAGVYLIARTHVLFLLAPAAEITVGIVGAATLLLAGFSALAQNDIKRILAYSTMSQIG
YMFLALGVGAWRAAMFHFMTHAFFKALLFLSAGAVTMRLHHEQDIYRMGGLARRLPAAFWSFLIGSAALAALPLITSGFY
SKEAILSGAWADGNGGRVLWLAGVIGAFVTGIYIFRAVFIAFFGEEHTHVSGSYGWRVIVPLVVLSVLSLVGGFIELPPA
FGHVTLLSRLLAPVLPPTREVTDMTPLLLASAASILGIALAAVLYWRPSRPPAETPLWRFWHAAAGFDALYDRLLVRPVI
WAARVDRDDFIDSFYDGIAWATQAIHRAIRRTQTGRVRLYAASLAIGSVGLIAIAVLR
>Mature_618_residues
MQHFLWLVPALPLLGSIVLMLGTGRLSHRAEALIGVLSVGLAAVVAFAIAGAFLLDPPAGAAYQQSLWRWFAVGHFSFGI
ALRVDPLSLLMMLVTSGVGFLIHLFSTEFMEGEEGYGRFFAYLNLFVAAMLLLVMADNFLVLYAGWEGVGLCSYLLIGFW
WRDPANGLAARKAFIVTRVGDTAFLIGLLLIASRLGTLNIAGAMDAASRTWHPGSPAATLIAFLLLGGAVGKSAQLPLQT
WLPDAMAGPTPVSALIHAATMVTAGVYLIARTHVLFLLAPAAEITVGIVGAATLLLAGFSALAQNDIKRILAYSTMSQIG
YMFLALGVGAWRAAMFHFMTHAFFKALLFLSAGAVTMRLHHEQDIYRMGGLARRLPAAFWSFLIGSAALAALPLITSGFY
SKEAILSGAWADGNGGRVLWLAGVIGAFVTGIYIFRAVFIAFFGEEHTHVSGSYGWRVIVPLVVLSVLSLVGGFIELPPA
FGHVTLLSRLLAPVLPPTREVTDMTPLLLASAASILGIALAAVLYWRPSRPPAETPLWRFWHAAAGFDALYDRLLVRPVI
WAARVDRDDFIDSFYDGIAWATQAIHRAIRRTQTGRVRLYAASLAIGSVGLIAIAVLR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=487, Percent_Identity=34.0862422997947, Blast_Score=242, Evalue=1e-63,
Organism=Escherichia coli, GI1788614, Length=617, Percent_Identity=50.4051863857374, Blast_Score=548, Evalue=1e-157,
Organism=Escherichia coli, GI1788829, Length=343, Percent_Identity=34.402332361516, Blast_Score=150, Evalue=3e-37,
Organism=Escherichia coli, GI1788827, Length=355, Percent_Identity=34.3661971830986, Blast_Score=133, Evalue=4e-32,
Organism=Escherichia coli, GI1788831, Length=343, Percent_Identity=29.7376093294461, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI1788613, Length=394, Percent_Identity=27.4111675126904, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI2367154, Length=352, Percent_Identity=26.4204545454545, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI145693160, Length=272, Percent_Identity=26.8382352941176, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 66403; Mature: 66403

Theoretical pI: Translated: 9.83; Mature: 9.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHFLWLVPALPLLGSIVLMLGTGRLSHRAEALIGVLSVGLAAVVAFAIAGAFLLDPPAG
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
AAYQQSLWRWFAVGHFSFGIALRVDPLSLLMMLVTSGVGFLIHLFSTEFMEGEEGYGRFF
HHHHHHHHHHHHHHHHHEEEEEEECHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHH
AYLNLFVAAMLLLVMADNFLVLYAGWEGVGLCSYLLIGFWWRDPANGLAARKAFIVTRVG
HHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCHHHHHHEEEEECC
DTAFLIGLLLIASRLGTLNIAGAMDAASRTWHPGSPAATLIAFLLLGGAVGKSAQLPLQT
HHHHHHHHHHHHHHCCCEEECCCHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHH
WLPDAMAGPTPVSALIHAATMVTAGVYLIARTHVLFLLAPAAEITVGIVGAATLLLAGFS
CCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
ALAQNDIKRILAYSTMSQIGYMFLALGVGAWRAAMFHFMTHAFFKALLFLSAGAVTMRLH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEEC
HEQDIYRMGGLARRLPAAFWSFLIGSAALAALPLITSGFYSKEAILSGAWADGNGGRVLW
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCEEEH
LAGVIGAFVTGIYIFRAVFIAFFGEEHTHVSGSYGWRVIVPLVVLSVLSLVGGFIELPPA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCHHHHHHHHHHHHHHHHCCHHCCCCC
FGHVTLLSRLLAPVLPPTREVTDMTPLLLASAASILGIALAAVLYWRPSRPPAETPLWRF
CHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
WHAAAGFDALYDRLLVRPVIWAARVDRDDFIDSFYDGIAWATQAIHRAIRRTQTGRVRLY
HHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
AASLAIGSVGLIAIAVLR
EEHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQHFLWLVPALPLLGSIVLMLGTGRLSHRAEALIGVLSVGLAAVVAFAIAGAFLLDPPAG
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
AAYQQSLWRWFAVGHFSFGIALRVDPLSLLMMLVTSGVGFLIHLFSTEFMEGEEGYGRFF
HHHHHHHHHHHHHHHHHEEEEEEECHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHH
AYLNLFVAAMLLLVMADNFLVLYAGWEGVGLCSYLLIGFWWRDPANGLAARKAFIVTRVG
HHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCHHHHHHEEEEECC
DTAFLIGLLLIASRLGTLNIAGAMDAASRTWHPGSPAATLIAFLLLGGAVGKSAQLPLQT
HHHHHHHHHHHHHHCCCEEECCCHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHH
WLPDAMAGPTPVSALIHAATMVTAGVYLIARTHVLFLLAPAAEITVGIVGAATLLLAGFS
CCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
ALAQNDIKRILAYSTMSQIGYMFLALGVGAWRAAMFHFMTHAFFKALLFLSAGAVTMRLH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEEC
HEQDIYRMGGLARRLPAAFWSFLIGSAALAALPLITSGFYSKEAILSGAWADGNGGRVLW
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCEEEH
LAGVIGAFVTGIYIFRAVFIAFFGEEHTHVSGSYGWRVIVPLVVLSVLSLVGGFIELPPA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCHHHHHHHHHHHHHHHHCCHHCCCCC
FGHVTLLSRLLAPVLPPTREVTDMTPLLLASAASILGIALAAVLYWRPSRPPAETPLWRF
CHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
WHAAAGFDALYDRLLVRPVIWAARVDRDDFIDSFYDGIAWATQAIHRAIRRTQTGRVRLY
HHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
AASLAIGSVGLIAIAVLR
EEHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7690854; 9205837; 9278503 [H]