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The map label for this gene is pdxH

Identifier: 148259840

GI number: 148259840

Start: 918794

End: 919432

Strand: Reverse

Name: pdxH

Synonym: Acry_0829

Alternate gene names: 148259840

Gene position: 919432-918794 (Counterclockwise)

Preceding gene: 148259842

Following gene: 148259839

Centisome position: 27.13

GC content: 66.2

Gene sequence:

>639_bases
GTGCGGCGGCTTGGACTATCAAATATTGCGACACGGAAGAGAGAGCAACCGATGATCGATATCAGTGCCGATCCGTTCCA
GCTTTTCGCCGCCTGGATGCAGGACGCCGAGGCGGCGGAACCGAACGATCCCAATGCGATGACGCTGGCGACGGCGACGC
CGGACGGCCGGCCTTCGGCGCGGATCGTGTTGCTGAAATCGTGGGATGAGGCCGGATTTGTTTTTTATACAAACCTGGAG
AGCCGGAAATCGCTCGAGATCCGCGCGAATCCGGATGTGTCGCTGCTGTTCCACTGGAAGTCGCTGCGCCGGCAGATCCG
CATCGAGGGGCGGTGCCGCGCGGTTTCGGACGACGAGGCGGATGCCTATTTCGACAGCCGGCCGCGGATTTCGCGGCTCG
GGGCCTGGGCCTCGGACCAGTCGCGCCCGCTCGGCGAGCGGGCCGAACTCGAACGGCGGCTCGCTGAGGTGACCGCGCGG
TATGGCGACGGGCCGATCCCGCGCCCGCCGCACTGGTCCGGCTGGCATGTGATGCCCGATTCGATCGAGTTCTGGCAGGA
CCGGGACTTCCGCCTGCACGACCGCGCGGTGTTCACCCGCACCGGCGACGCCTGGTCGGCGACGAGACTGTTCCCGTGA

Upstream 100 bases:

>100_bases
CACGCATCAGCGTGCCGGTCAGCGGGTAGGTCTGTGCGGATTCCTGCATGTCGGGGGCTCCAGTCTGTCGTGTCTCGGCC
GGCCGTGCCGGGGTGGTGGC

Downstream 100 bases:

>100_bases
CGGGCGACCTGCTCATCCGCAACGCGGCGCTGCCGGATGGGCGGCGCGGGGTCGACATCCTGATCCGCGGCGGCGTGATC
GAGACGGTCGGCCCCGGTCT

Product: pyridoxamine 5'-phosphate oxidase

Products: NA

Alternate protein names: PNP/PMP oxidase; PNPOx; Pyridoxal 5'-phosphate synthase

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MRRLGLSNIATRKREQPMIDISADPFQLFAAWMQDAEAAEPNDPNAMTLATATPDGRPSARIVLLKSWDEAGFVFYTNLE
SRKSLEIRANPDVSLLFHWKSLRRQIRIEGRCRAVSDDEADAYFDSRPRISRLGAWASDQSRPLGERAELERRLAEVTAR
YGDGPIPRPPHWSGWHVMPDSIEFWQDRDFRLHDRAVFTRTGDAWSATRLFP

Sequences:

>Translated_212_residues
MRRLGLSNIATRKREQPMIDISADPFQLFAAWMQDAEAAEPNDPNAMTLATATPDGRPSARIVLLKSWDEAGFVFYTNLE
SRKSLEIRANPDVSLLFHWKSLRRQIRIEGRCRAVSDDEADAYFDSRPRISRLGAWASDQSRPLGERAELERRLAEVTAR
YGDGPIPRPPHWSGWHVMPDSIEFWQDRDFRLHDRAVFTRTGDAWSATRLFP
>Mature_212_residues
MRRLGLSNIATRKREQPMIDISADPFQLFAAWMQDAEAAEPNDPNAMTLATATPDGRPSARIVLLKSWDEAGFVFYTNLE
SRKSLEIRANPDVSLLFHWKSLRRQIRIEGRCRAVSDDEADAYFDSRPRISRLGAWASDQSRPLGERAELERRLAEVTAR
YGDGPIPRPPHWSGWHVMPDSIEFWQDRDFRLHDRAVFTRTGDAWSATRLFP

Specific function: Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)

COG id: COG0259

COG function: function code H; Pyridoxamine-phosphate oxidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxamine 5'-phosphate oxidase family

Homologues:

Organism=Homo sapiens, GI8922498, Length=187, Percent_Identity=44.9197860962567, Blast_Score=169, Evalue=1e-42,
Organism=Escherichia coli, GI1787926, Length=193, Percent_Identity=46.6321243523316, Blast_Score=183, Evalue=8e-48,
Organism=Caenorhabditis elegans, GI17553712, Length=197, Percent_Identity=41.6243654822335, Blast_Score=162, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6319509, Length=198, Percent_Identity=41.9191919191919, Blast_Score=149, Evalue=2e-37,
Organism=Drosophila melanogaster, GI45551845, Length=185, Percent_Identity=43.7837837837838, Blast_Score=145, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24644901, Length=185, Percent_Identity=43.7837837837838, Blast_Score=145, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24644903, Length=172, Percent_Identity=30.2325581395349, Blast_Score=77, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXH_ACICJ (A5FWR6)

Other databases:

- EMBL:   CP000697
- RefSeq:   YP_001233967.1
- ProteinModelPortal:   A5FWR6
- SMR:   A5FWR6
- STRING:   A5FWR6
- GeneID:   5161556
- GenomeReviews:   CP000697_GR
- KEGG:   acr:Acry_0829
- eggNOG:   COG0259
- HOGENOM:   HBG327559
- OMA:   FTFFTNY
- ProtClustDB:   PRK05679
- BioCyc:   ACRY349163:ACRY_0829-MONOMER
- HAMAP:   MF_01629
- InterPro:   IPR000659
- InterPro:   IPR019740
- InterPro:   IPR019576
- InterPro:   IPR011576
- InterPro:   IPR012349
- InterPro:   IPR009002
- Gene3D:   G3DSA:2.30.110.10
- PANTHER:   PTHR10851
- PIRSF:   PIRSF000190
- TIGRFAMs:   TIGR00558

Pfam domain/function: PF10590 PNPOx_C; PF01243 Pyridox_oxidase; SSF50475 FMN_binding

EC number: =1.4.3.5

Molecular weight: Translated: 24382; Mature: 24382

Theoretical pI: Translated: 7.68; Mature: 7.68

Prosite motif: PS01064 PYRIDOX_OXIDASE

Important sites: BINDING 61-61 BINDING 64-64 BINDING 66-66 BINDING 83-83 BINDING 123-123 BINDING 127-127 BINDING 131-131

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRLGLSNIATRKREQPMIDISADPFQLFAAWMQDAEAAEPNDPNAMTLATATPDGRPSA
CCCCCCCHHHHHHCCCCEEEECCCHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCE
RIVLLKSWDEAGFVFYTNLESRKSLEIRANPDVSLLFHWKSLRRQIRIEGRCRAVSDDEA
EEEEEECCCCCCEEEEECCCCCCEEEEECCCCEEEEEEEHHHHHHEEECCEEEECCCCCC
DAYFDSRPRISRLGAWASDQSRPLGERAELERRLAEVTARYGDGPIPRPPHWSGWHVMPD
CCEECCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEECCC
SIEFWQDRDFRLHDRAVFTRTGDAWSATRLFP
CHHHHCCCCCEEECEEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MRRLGLSNIATRKREQPMIDISADPFQLFAAWMQDAEAAEPNDPNAMTLATATPDGRPSA
CCCCCCCHHHHHHCCCCEEEECCCHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCE
RIVLLKSWDEAGFVFYTNLESRKSLEIRANPDVSLLFHWKSLRRQIRIEGRCRAVSDDEA
EEEEEECCCCCCEEEEECCCCCCEEEEECCCCEEEEEEEHHHHHHEEECCEEEECCCCCC
DAYFDSRPRISRLGAWASDQSRPLGERAELERRLAEVTARYGDGPIPRPPHWSGWHVMPD
CCEECCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEECCC
SIEFWQDRDFRLHDRAVFTRTGDAWSATRLFP
CHHHHCCCCCEEECEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA