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The map label for this gene is argH

Identifier: 148259757

GI number: 148259757

Start: 835485

End: 836900

Strand: Reverse

Name: argH

Synonym: Acry_0745

Alternate gene names: 148259757

Gene position: 836900-835485 (Counterclockwise)

Preceding gene: 148259762

Following gene: 148259756

Centisome position: 24.69

GC content: 69.49

Gene sequence:

>1416_bases
ATGACGAATTCTGGTGCCGATCAGGCCGGAACGCAACCATCCCGCCTGCAATGGGGCGGACGATTTGCCGCCGGTCCCGC
ATCCGTGATGCAGGCGATCAATGCCTCGATCGGGTTCGATCAGCGGCTCTGGCGGGAGGATATCGAAGGCAGCCTCGCCC
ATGCCGGCATGCTCGCCGCGATGGGAATCATCTCCGCCGAGGACGAGGCGGCGATCCGCGCCGGACTCGCCGAGATCGCC
GAGGCGATCGCCGAGGGGTCGTTCACCTTCGATCCCGCGCTCGAGGACATCCACACCAATATCGAGGCCTGGCTGGTCGC
GCGCATCGGCGAGGCCGGGCGCCGGCTGCACACCGCGCGCAGCCGCAACGACCAGGTGGCGACCGATTTCCGCCTCTGGG
TGCGCAACGCGATCGACAGTCTCGACGGCCAGGTGCGCGAGCTGATGCGCGCGCTGGCCGACCGCGCGGCCGAACACGCG
GCCACCATCATGCCTGGCTTCACCCATCTGCAGACCGCCCAGCCGGTGACGCTCGGGCATCACCTGCTCGCCTATGTCGA
GATGCTGTCGCGCGACCGCGGCCGCCTCGCCGATGCGCGCCGGCGGCTGAACGAATGCCCGCTCGGCGCGGCCGCCCTCG
CCGGCACCACCTTCCCGATCGACCGCAGCATGACCGCCGCCGCCCTCGGCTTCGACCGGCCGACCGCGAATTCGCTCGAT
TCGGTCTCGGACCGCGACTTCGCGCTTGAATTCCTCTCCGCCCTCTCCATCCTCGCGATGCATCTTTCGCGTTTCGCCGA
GGAGATCATCATCTGGACCAGCGCGCCCTATCGCTTCATCCGGCTGTCCGACGCCTATACCACCGGCTCGTCGATCATGC
CGCAGAAGCGCAACCCGGACGCCGCCGAACTCGCCCGCGCCAAGGCCGGGCGGATCTTCGGGGCGCTCACCGGCCTGCTC
GCGGTGATGAAGGGCCTGCCGCTCGCCTATGCGAAGGACATGCAGGAGGACAAGGAGCCGGTGTTCGACGCCGCCGATGC
CGCCGAACTCTGCCTCGCCGCGATGACCGGCATGGTGCGCGACATGATGCCGGACGTGCTGCGGATGCGATCCGTGGCCG
GCGCCGATTTCTCGACCGCGACCGATCTTGCAGACTACCTCGTGCGCGATCTCGGCCTGCCCTTCCGCACCGCCCATCAC
GTCACCGGCCGGATCGTGAGCGAGGCCGAGTCGCGCGGGCTCGAGCTCGTCGCCCTGCCGCTCTCGGTCATGCAGGAGGT
CGAGCCGCGGATCACCGAGGCGGTGTATGATGTGCTGACCATCGAGGCCTCGGTCGCCGCCCGCCGCACCCTCGGCGGCA
CCGCGCCCGACAATGTCGCCCGCGCCGCCGCGCGCTGGCAGGAGACGCTGGCATGA

Upstream 100 bases:

>100_bases
CGAAGTTAAGTCAGGCAGCACAAGACCCGCACCCAGAGCCGCGAACTGCCGCCGAGAAAGCCCGAAACGCATGACCGCCG
ATACCTCTTCCAAACCGAAT

Downstream 100 bases:

>100_bases
CCCGCTCGCTGCTGCTCGTCCTGCTCGCCTGCGCCGCTCTCGCCGCCTGCGGCCGGGCCGGCGCGCCCTCGCCGCCCGGC
CCGGCGAGCCAGGTGATCTA

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MTNSGADQAGTQPSRLQWGGRFAAGPASVMQAINASIGFDQRLWREDIEGSLAHAGMLAAMGIISAEDEAAIRAGLAEIA
EAIAEGSFTFDPALEDIHTNIEAWLVARIGEAGRRLHTARSRNDQVATDFRLWVRNAIDSLDGQVRELMRALADRAAEHA
ATIMPGFTHLQTAQPVTLGHHLLAYVEMLSRDRGRLADARRRLNECPLGAAALAGTTFPIDRSMTAAALGFDRPTANSLD
SVSDRDFALEFLSALSILAMHLSRFAEEIIIWTSAPYRFIRLSDAYTTGSSIMPQKRNPDAAELARAKAGRIFGALTGLL
AVMKGLPLAYAKDMQEDKEPVFDAADAAELCLAAMTGMVRDMMPDVLRMRSVAGADFSTATDLADYLVRDLGLPFRTAHH
VTGRIVSEAESRGLELVALPLSVMQEVEPRITEAVYDVLTIEASVAARRTLGGTAPDNVARAAARWQETLA

Sequences:

>Translated_471_residues
MTNSGADQAGTQPSRLQWGGRFAAGPASVMQAINASIGFDQRLWREDIEGSLAHAGMLAAMGIISAEDEAAIRAGLAEIA
EAIAEGSFTFDPALEDIHTNIEAWLVARIGEAGRRLHTARSRNDQVATDFRLWVRNAIDSLDGQVRELMRALADRAAEHA
ATIMPGFTHLQTAQPVTLGHHLLAYVEMLSRDRGRLADARRRLNECPLGAAALAGTTFPIDRSMTAAALGFDRPTANSLD
SVSDRDFALEFLSALSILAMHLSRFAEEIIIWTSAPYRFIRLSDAYTTGSSIMPQKRNPDAAELARAKAGRIFGALTGLL
AVMKGLPLAYAKDMQEDKEPVFDAADAAELCLAAMTGMVRDMMPDVLRMRSVAGADFSTATDLADYLVRDLGLPFRTAHH
VTGRIVSEAESRGLELVALPLSVMQEVEPRITEAVYDVLTIEASVAARRTLGGTAPDNVARAAARWQETLA
>Mature_470_residues
TNSGADQAGTQPSRLQWGGRFAAGPASVMQAINASIGFDQRLWREDIEGSLAHAGMLAAMGIISAEDEAAIRAGLAEIAE
AIAEGSFTFDPALEDIHTNIEAWLVARIGEAGRRLHTARSRNDQVATDFRLWVRNAIDSLDGQVRELMRALADRAAEHAA
TIMPGFTHLQTAQPVTLGHHLLAYVEMLSRDRGRLADARRRLNECPLGAAALAGTTFPIDRSMTAAALGFDRPTANSLDS
VSDRDFALEFLSALSILAMHLSRFAEEIIIWTSAPYRFIRLSDAYTTGSSIMPQKRNPDAAELARAKAGRIFGALTGLLA
VMKGLPLAYAKDMQEDKEPVFDAADAAELCLAAMTGMVRDMMPDVLRMRSVAGADFSTATDLADYLVRDLGLPFRTAHHV
TGRIVSEAESRGLELVALPLSVMQEVEPRITEAVYDVLTIEASVAARRTLGGTAPDNVARAAARWQETLA

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=450, Percent_Identity=43.3333333333333, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI68303542, Length=450, Percent_Identity=43.3333333333333, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI68303547, Length=450, Percent_Identity=40.8888888888889, Blast_Score=338, Evalue=7e-93,
Organism=Homo sapiens, GI68303549, Length=450, Percent_Identity=40.8888888888889, Blast_Score=337, Evalue=2e-92,
Organism=Escherichia coli, GI1790398, Length=449, Percent_Identity=47.4387527839644, Blast_Score=400, Evalue=1e-113,
Organism=Saccharomyces cerevisiae, GI6321806, Length=447, Percent_Identity=42.2818791946309, Blast_Score=357, Evalue=2e-99,
Organism=Drosophila melanogaster, GI221473854, Length=443, Percent_Identity=40.6320541760722, Blast_Score=343, Evalue=1e-94,
Organism=Drosophila melanogaster, GI78706858, Length=443, Percent_Identity=40.6320541760722, Blast_Score=343, Evalue=1e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_ACICJ (A5FWI3)

Other databases:

- EMBL:   CP000697
- RefSeq:   YP_001233884.1
- ProteinModelPortal:   A5FWI3
- SMR:   A5FWI3
- STRING:   A5FWI3
- GeneID:   5160356
- GenomeReviews:   CP000697_GR
- KEGG:   acr:Acry_0745
- eggNOG:   COG0165
- HOGENOM:   HBG539632
- OMA:   MAEDLIF
- ProtClustDB:   PRK00855
- BioCyc:   ACRY349163:ACRY_0745-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 50854; Mature: 50723

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNSGADQAGTQPSRLQWGGRFAAGPASVMQAINASIGFDQRLWREDIEGSLAHAGMLAA
CCCCCCCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHH
MGIISAEDEAAIRAGLAEIAEAIAEGSFTFDPALEDIHTNIEAWLVARIGEAGRRLHTAR
HHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRNDQVATDFRLWVRNAIDSLDGQVRELMRALADRAAEHAATIMPGFTHLQTAQPVTLGH
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCHHHHH
HLLAYVEMLSRDRGRLADARRRLNECPLGAAALAGTTFPIDRSMTAAALGFDRPTANSLD
HHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCC
SVSDRDFALEFLSALSILAMHLSRFAEEIIIWTSAPYRFIRLSDAYTTGSSIMPQKRNPD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEEEECCCCCCCCCCCCCCCCC
AAELARAKAGRIFGALTGLLAVMKGLPLAYAKDMQEDKEPVFDAADAAELCLAAMTGMVR
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
DMMPDVLRMRSVAGADFSTATDLADYLVRDLGLPFRTAHHVTGRIVSEAESRGLELVALP
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEEHH
LSVMQEVEPRITEAVYDVLTIEASVAARRTLGGTAPDNVARAAARWQETLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TNSGADQAGTQPSRLQWGGRFAAGPASVMQAINASIGFDQRLWREDIEGSLAHAGMLAA
CCCCCCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHH
MGIISAEDEAAIRAGLAEIAEAIAEGSFTFDPALEDIHTNIEAWLVARIGEAGRRLHTAR
HHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRNDQVATDFRLWVRNAIDSLDGQVRELMRALADRAAEHAATIMPGFTHLQTAQPVTLGH
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCHHHHH
HLLAYVEMLSRDRGRLADARRRLNECPLGAAALAGTTFPIDRSMTAAALGFDRPTANSLD
HHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCC
SVSDRDFALEFLSALSILAMHLSRFAEEIIIWTSAPYRFIRLSDAYTTGSSIMPQKRNPD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEEEECCCCCCCCCCCCCCCCC
AAELARAKAGRIFGALTGLLAVMKGLPLAYAKDMQEDKEPVFDAADAAELCLAAMTGMVR
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
DMMPDVLRMRSVAGADFSTATDLADYLVRDLGLPFRTAHHVTGRIVSEAESRGLELVALP
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEEHH
LSVMQEVEPRITEAVYDVLTIEASVAARRTLGGTAPDNVARAAARWQETLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA