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The map label for this gene is lysA [H]

Identifier: 148259756

GI number: 148259756

Start: 834047

End: 835363

Strand: Reverse

Name: lysA [H]

Synonym: Acry_0744

Alternate gene names: 148259756

Gene position: 835363-834047 (Counterclockwise)

Preceding gene: 148259757

Following gene: 148259755

Centisome position: 24.65

GC content: 73.96

Gene sequence:

>1317_bases
ATGATGAACGCCCTCACCCGCGACCAGGCCTGGCACCGTCTCGTCGCCGCCCGGCCGAACCTTTCGTTCCACGCGATGGA
CGGGCTGTGCCTCGATGACGTGCCGCTCGCGTCCATCGCCGCCGCCCACGGCACGCCCACCTGGGTCTACAGCGCCGCGA
CGATCGAGGGGCGGCTCGCCGCCCTGCGCGCGGCCTTCGCCGGCGAGGGGCTGGCGCCGGCGATCCGCTACGCCGTGAAG
GCGAACGACCACCTCGCGATCCTCGGCCTGGTGCGGGCCGGCGGCGCCGGGGCGGACGTGACCAGTGCCGGCGAATTCGC
CCGCGCCGAGGCCGCCGGGATCGCGCCGGGGGCGATGGTGTTCTCCGGTGTGGGCAAGCGGGAGGACGAGCTGCGCCGCG
CGCTCGCCGCCGGCATCGGCCAGCTCAATGTCGAAAGCGCCGAGGAGCTGGAGATGATCTCCGGCATCGCCGCGGCGATG
GGGGTTGCCGCGCCGGTCGCGCTGCGGGTGAACCCGGATGTCGCCGCCGGCGGGCACGACAAGATCAGCACCGGCCGCAA
GGGCGACAAGTTCGGCATCGGCTTCGATGACGCGGGCGCGCTGTATCGCCGCGCCGCGGCGCTGCCGGGCATCGAGGCGG
TCGGGTTTTCCACCCATATCGGCAGCCAGATCTTCGCGCCCGCCGCCTTCGAGGCGGCTTACCGGCGCGTGCTCGGCCTG
ATCGGGGCGCTGCGCGGCGAGGGGCTCGCGGTGCGCCGCCTCGACCTCGGCGGCGGCTTCGGCATTCCCTATGACGATGG
CACCGCCTTCCCCTTCGCGGCGCAGGCGGCGATGGTCCGCCGCGTGCTCGGCGGCCACGATCTGGAGCTGATCGTCGAAC
CCGGCCGCTGGCTCGTCGGCCCGGCCGGCGTGCTGCTCGCCCGCGTGACGCTCGTCAAGCGCGCCGGAGCGGAACGGTTC
GTCGTGCTCGATGCCGGGATGAACGACCTGATTCGCCCGGCGCTCTATGGCGCGCGGCACGGCATCGTCCCGGTCGGCGC
CGCCGACGCCGCGGGCGCCCCGGCGCCGGCCGAGGTGGTCGGTCCGGTCTGCGAGAGCAGCGACCGTTTCGGCACCCACG
ACCTGCCAGAACTTGCCCCCGGCGCGCTGGTCGCGCTGCTCGATGCCGGGGCCTATGGCGCGACGATGAGCAGCACCTAT
AACGGCCGCCCCTTCGCCGCCCAGGTGATGATCGCCGACGGCGCGCCGCAGCTGATCCGCCGGCGCCAGACGCTGGATGA
ACTCTGGCGCGACGAGATCGTGCCGCCGCGCCGGTAA

Upstream 100 bases:

>100_bases
TGCTCGCCTGCGCCGCTCTCGCCGCCTGCGGCCGGGCCGGCGCGCCCTCGCCGCCCGGCCCGGCGAGCCAGGTGATCTAC
CCGCATCAATATCCCTCCGA

Downstream 100 bases:

>100_bases
TGCCGGCGGCGCGCCTCGCCCGGCTGCGGCGGCGGGCGCGCCGCGTGCTGGCGATCGAGGCCGTCGCCATTGCCGCGATG
CTGCCCGCTTGCGTGATCGC

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MMNALTRDQAWHRLVAARPNLSFHAMDGLCLDDVPLASIAAAHGTPTWVYSAATIEGRLAALRAAFAGEGLAPAIRYAVK
ANDHLAILGLVRAGGAGADVTSAGEFARAEAAGIAPGAMVFSGVGKREDELRRALAAGIGQLNVESAEELEMISGIAAAM
GVAAPVALRVNPDVAAGGHDKISTGRKGDKFGIGFDDAGALYRRAAALPGIEAVGFSTHIGSQIFAPAAFEAAYRRVLGL
IGALRGEGLAVRRLDLGGGFGIPYDDGTAFPFAAQAAMVRRVLGGHDLELIVEPGRWLVGPAGVLLARVTLVKRAGAERF
VVLDAGMNDLIRPALYGARHGIVPVGAADAAGAPAPAEVVGPVCESSDRFGTHDLPELAPGALVALLDAGAYGATMSSTY
NGRPFAAQVMIADGAPQLIRRRQTLDELWRDEIVPPRR

Sequences:

>Translated_438_residues
MMNALTRDQAWHRLVAARPNLSFHAMDGLCLDDVPLASIAAAHGTPTWVYSAATIEGRLAALRAAFAGEGLAPAIRYAVK
ANDHLAILGLVRAGGAGADVTSAGEFARAEAAGIAPGAMVFSGVGKREDELRRALAAGIGQLNVESAEELEMISGIAAAM
GVAAPVALRVNPDVAAGGHDKISTGRKGDKFGIGFDDAGALYRRAAALPGIEAVGFSTHIGSQIFAPAAFEAAYRRVLGL
IGALRGEGLAVRRLDLGGGFGIPYDDGTAFPFAAQAAMVRRVLGGHDLELIVEPGRWLVGPAGVLLARVTLVKRAGAERF
VVLDAGMNDLIRPALYGARHGIVPVGAADAAGAPAPAEVVGPVCESSDRFGTHDLPELAPGALVALLDAGAYGATMSSTY
NGRPFAAQVMIADGAPQLIRRRQTLDELWRDEIVPPRR
>Mature_438_residues
MMNALTRDQAWHRLVAARPNLSFHAMDGLCLDDVPLASIAAAHGTPTWVYSAATIEGRLAALRAAFAGEGLAPAIRYAVK
ANDHLAILGLVRAGGAGADVTSAGEFARAEAAGIAPGAMVFSGVGKREDELRRALAAGIGQLNVESAEELEMISGIAAAM
GVAAPVALRVNPDVAAGGHDKISTGRKGDKFGIGFDDAGALYRRAAALPGIEAVGFSTHIGSQIFAPAAFEAAYRRVLGL
IGALRGEGLAVRRLDLGGGFGIPYDDGTAFPFAAQAAMVRRVLGGHDLELIVEPGRWLVGPAGVLLARVTLVKRAGAERF
VVLDAGMNDLIRPALYGARHGIVPVGAADAAGAPAPAEVVGPVCESSDRFGTHDLPELAPGALVALLDAGAYGATMSSTY
NGRPFAAQVMIADGAPQLIRRRQTLDELWRDEIVPPRR

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=378, Percent_Identity=26.1904761904762, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1789203, Length=422, Percent_Identity=34.1232227488152, Blast_Score=193, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17562780, Length=355, Percent_Identity=24.7887323943662, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24586474, Length=345, Percent_Identity=26.0869565217391, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 45262; Mature: 45262

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMNALTRDQAWHRLVAARPNLSFHAMDGLCLDDVPLASIAAAHGTPTWVYSAATIEGRLA
CCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHCCCCCCEEEEEHHHHHHHH
ALRAAFAGEGLAPAIRYAVKANDHLAILGLVRAGGAGADVTSAGEFARAEAAGIAPGAMV
HHHHHHCCCCCCHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHCCCCCHHHH
FSGVGKREDELRRALAAGIGQLNVESAEELEMISGIAAAMGVAAPVALRVNPDVAAGGHD
HHCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCC
KISTGRKGDKFGIGFDDAGALYRRAAALPGIEAVGFSTHIGSQIFAPAAFEAAYRRVLGL
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHCCCHHHCHHHHHHHHHHHHHH
IGALRGEGLAVRRLDLGGGFGIPYDDGTAFPFAAQAAMVRRVLGGHDLELIVEPGRWLVG
HHHHCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCEEEC
PAGVLLARVTLVKRAGAERFVVLDAGMNDLIRPALYGARHGIVPVGAADAAGAPAPAEVV
HHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHCCCCCCEEECCCCCCCCCCCHHHH
GPVCESSDRFGTHDLPELAPGALVALLDAGAYGATMSSTYNGRPFAAQVMIADGAPQLIR
HHHHCCCCCCCCCCCHHHCCHHEEHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCHHHHH
RRQTLDELWRDEIVPPRR
HHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MMNALTRDQAWHRLVAARPNLSFHAMDGLCLDDVPLASIAAAHGTPTWVYSAATIEGRLA
CCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHCCCCCCEEEEEHHHHHHHH
ALRAAFAGEGLAPAIRYAVKANDHLAILGLVRAGGAGADVTSAGEFARAEAAGIAPGAMV
HHHHHHCCCCCCHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHCCCCCHHHH
FSGVGKREDELRRALAAGIGQLNVESAEELEMISGIAAAMGVAAPVALRVNPDVAAGGHD
HHCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCC
KISTGRKGDKFGIGFDDAGALYRRAAALPGIEAVGFSTHIGSQIFAPAAFEAAYRRVLGL
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHCCCHHHCHHHHHHHHHHHHHH
IGALRGEGLAVRRLDLGGGFGIPYDDGTAFPFAAQAAMVRRVLGGHDLELIVEPGRWLVG
HHHHCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCEEEC
PAGVLLARVTLVKRAGAERFVVLDAGMNDLIRPALYGARHGIVPVGAADAAGAPAPAEVV
HHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHCCCCCCEEECCCCCCCCCCCHHHH
GPVCESSDRFGTHDLPELAPGALVALLDAGAYGATMSSTYNGRPFAAQVMIADGAPQLIR
HHHHCCCCCCCCCCCHHHCCHHEEHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCHHHHH
RRQTLDELWRDEIVPPRR
HHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA