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The map label for this gene is pyrC [H]

Identifier: 148259744

GI number: 148259744

Start: 819072

End: 820358

Strand: Reverse

Name: pyrC [H]

Synonym: Acry_0732

Alternate gene names: 148259744

Gene position: 820358-819072 (Counterclockwise)

Preceding gene: 148259745

Following gene: 148259743

Centisome position: 24.2

GC content: 75.06

Gene sequence:

>1287_bases
ATGCATGACACGCCCCCCGACACGCTGATCCGCGGCGCGCGGATCGTCGATCCCGCCACCGGCCACGACGCGGTGGGCGA
CCTGCTGGTCCGCGACGGCGTCATCGCCGATTTCGGCGCCGGTCTCGGCCGGCCGGACGGCGCGGTGATGATCGATGCCG
CCGAGCAGATCCTCTGCCCCGGCCTAGTCGATGCCCGCGCCTCGCTCGGCGAGCCCGGCTACGAATACCGCGAGACCATC
GCCACCGCCGCCGAGGCGGCCAATGCCGCCGGCATCACCACCATCGCCGTACTGCCGGACAATATCCCCGCGACCGACGA
CCCGGCGCTGGTCCGCGCCCTGGCCGGCGCCGGGGCGGCGACCGGGCGGCTCACCATCGCCCCCTACGGCGCGGCGACGC
GCGGCTGCAAGGGCGAGATGATCGCCGAATACGGCCTGCTGCGCGCGGCCGGCGCGGTCGCCTTCTCCGATGGCGCGCGG
GCGATCGGCCCGGCCGGGCTGATGCGCCGCGCCCTGTCCTATGCGCGCGGCTTCGGCGCCATGATCGTCCAGCATCCCGA
GGAGCCGAGCCTCGCCGCCGGCGGTGCGGCGACCGCCGGGGCGCGGGCGACGCTGATGGGCCTGCCCGGAATCCCGGCCT
GCGCCGAGGCGATGATGGTCGCCCGCGACATCCGTCTCGCCGAACTCACCGGCGGCGCGGTGCATTTCGCCCATGTCTCG
ACCGGCGAGGCGCTCGACCTGATCCGTGGCGCGAAACGCCGGGGCCTCGCGATCACCTGCGACACCGCGCCGCCCTATTT
CGACCTCAACGAGAACGCGATCGGCGATTTCCGCACCTATGCGAAGCTCTCGCCGCCGCTGCGCAGCGAGGCCGACCGCC
TCGCCGTCTGCGCCGCCCTCGCCGATGGCACGATCGACGCCGTGGTCTCCGACCACCAGCCGCGCGACGCCGACGACAAG
CGCCTGCCCTTCGCCGAGGCCGCGCCCGGCGGCGCGGGCCTCGCCACGCTGCTCGCGATCACGCTGGCGCAGGTGCAGTC
CGGCGGGCTCGGGCTGATCGCCGCCCTCTCGCTGCTGACCGACCGGCCAGCCCGGCTGTTCGGGCTGGAGGCCGGGCGCA
TCGCCCGCGGTGCGCCGGCCGATCTCTGCCTCTTCGCCCCCGAGCGCCCGTGGCGGATCGAGGCCGGCGCCCTGCCCGGC
AAGGCGCAGAACACGCCCTTCGACGGACGGCCGGTCGAGGGTGTGGTCACCGGCACGTGGAAGGCCGGGCGGCGGGTGCA
CGGATGA

Upstream 100 bases:

>100_bases
GCCGACGACGCCACCCGCTCGGTGATCCGCGAGCAGGTGGAGATGGGCGTCGCCATCCGCATGGCGGTGCTCGACGTGCT
GGCCCGGACGGCGCTCGCCC

Downstream 100 bases:

>100_bases
TCGCGCCCTACGCCCTGCTCGGCTACCTGCTCGGCTCCATCCCGTTCGGCCTGCTGCTCACCCGTGCGGCCGGGCTCGGC
GATGTGCGGCGGATCGGCTC

Product: dihydroorotase, multifunctional complex type

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MHDTPPDTLIRGARIVDPATGHDAVGDLLVRDGVIADFGAGLGRPDGAVMIDAAEQILCPGLVDARASLGEPGYEYRETI
ATAAEAANAAGITTIAVLPDNIPATDDPALVRALAGAGAATGRLTIAPYGAATRGCKGEMIAEYGLLRAAGAVAFSDGAR
AIGPAGLMRRALSYARGFGAMIVQHPEEPSLAAGGAATAGARATLMGLPGIPACAEAMMVARDIRLAELTGGAVHFAHVS
TGEALDLIRGAKRRGLAITCDTAPPYFDLNENAIGDFRTYAKLSPPLRSEADRLAVCAALADGTIDAVVSDHQPRDADDK
RLPFAEAAPGGAGLATLLAITLAQVQSGGLGLIAALSLLTDRPARLFGLEAGRIARGAPADLCLFAPERPWRIEAGALPG
KAQNTPFDGRPVEGVVTGTWKAGRRVHG

Sequences:

>Translated_428_residues
MHDTPPDTLIRGARIVDPATGHDAVGDLLVRDGVIADFGAGLGRPDGAVMIDAAEQILCPGLVDARASLGEPGYEYRETI
ATAAEAANAAGITTIAVLPDNIPATDDPALVRALAGAGAATGRLTIAPYGAATRGCKGEMIAEYGLLRAAGAVAFSDGAR
AIGPAGLMRRALSYARGFGAMIVQHPEEPSLAAGGAATAGARATLMGLPGIPACAEAMMVARDIRLAELTGGAVHFAHVS
TGEALDLIRGAKRRGLAITCDTAPPYFDLNENAIGDFRTYAKLSPPLRSEADRLAVCAALADGTIDAVVSDHQPRDADDK
RLPFAEAAPGGAGLATLLAITLAQVQSGGLGLIAALSLLTDRPARLFGLEAGRIARGAPADLCLFAPERPWRIEAGALPG
KAQNTPFDGRPVEGVVTGTWKAGRRVHG
>Mature_428_residues
MHDTPPDTLIRGARIVDPATGHDAVGDLLVRDGVIADFGAGLGRPDGAVMIDAAEQILCPGLVDARASLGEPGYEYRETI
ATAAEAANAAGITTIAVLPDNIPATDDPALVRALAGAGAATGRLTIAPYGAATRGCKGEMIAEYGLLRAAGAVAFSDGAR
AIGPAGLMRRALSYARGFGAMIVQHPEEPSLAAGGAATAGARATLMGLPGIPACAEAMMVARDIRLAELTGGAVHFAHVS
TGEALDLIRGAKRRGLAITCDTAPPYFDLNENAIGDFRTYAKLSPPLRSEADRLAVCAALADGTIDAVVSDHQPRDADDK
RLPFAEAAPGGAGLATLLAITLAQVQSGGLGLIAALSLLTDRPARLFGLEAGRIARGAPADLCLFAPERPWRIEAGALPG
KAQNTPFDGRPVEGVVTGTWKAGRRVHG

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=366, Percent_Identity=31.6939890710383, Blast_Score=104, Evalue=2e-22,
Organism=Escherichia coli, GI1786722, Length=412, Percent_Identity=29.6116504854369, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI87082175, Length=274, Percent_Identity=29.1970802919708, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI193204318, Length=359, Percent_Identity=26.1838440111421, Blast_Score=95, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6322218, Length=385, Percent_Identity=27.5324675324675, Blast_Score=106, Evalue=7e-24,
Organism=Drosophila melanogaster, GI18859883, Length=418, Percent_Identity=28.2296650717703, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24642586, Length=370, Percent_Identity=25.6756756756757, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 43673; Mature: 43673

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDTPPDTLIRGARIVDPATGHDAVGDLLVRDGVIADFGAGLGRPDGAVMIDAAEQILCP
CCCCCHHHHHCCCEEECCCCCCHHHHHHHHHCCCHHHHCCCCCCCCCEEEEECHHHHHCC
GLVDARASLGEPGYEYRETIATAAEAANAAGITTIAVLPDNIPATDDPALVRALAGAGAA
CHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCC
TGRLTIAPYGAATRGCKGEMIAEYGLLRAAGAVAFSDGARAIGPAGLMRRALSYARGFGA
CCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCEEECCCCCCCCHHHHHHHHHHHHHCCCE
MIVQHPEEPSLAAGGAATAGARATLMGLPGIPACAEAMMVARDIRLAELTGGAVHFAHVS
EEEECCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCEEECCCEEEEEECC
TGEALDLIRGAKRRGLAITCDTAPPYFDLNENAIGDFRTYAKLSPPLRSEADRLAVCAAL
CCHHHHHHHHHHHCCEEEEECCCCCEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHH
ADGTIDAVVSDHQPRDADDKRLPFAEAAPGGAGLATLLAITLAQVQSGGLGLIAALSLLT
HCCCEEEHCCCCCCCCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
DRPARLFGLEAGRIARGAPADLCLFAPERPWRIEAGALPGKAQNTPFDGRPVEGVVTGTW
CCCHHHEECCCCCCCCCCCCCEEEECCCCCCEEECCCCCCCCCCCCCCCCCCCEEEECCH
KAGRRVHG
HCCCCCCC
>Mature Secondary Structure
MHDTPPDTLIRGARIVDPATGHDAVGDLLVRDGVIADFGAGLGRPDGAVMIDAAEQILCP
CCCCCHHHHHCCCEEECCCCCCHHHHHHHHHCCCHHHHCCCCCCCCCEEEEECHHHHHCC
GLVDARASLGEPGYEYRETIATAAEAANAAGITTIAVLPDNIPATDDPALVRALAGAGAA
CHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCC
TGRLTIAPYGAATRGCKGEMIAEYGLLRAAGAVAFSDGARAIGPAGLMRRALSYARGFGA
CCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCEEECCCCCCCCHHHHHHHHHHHHHCCCE
MIVQHPEEPSLAAGGAATAGARATLMGLPGIPACAEAMMVARDIRLAELTGGAVHFAHVS
EEEECCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCEEECCCEEEEEECC
TGEALDLIRGAKRRGLAITCDTAPPYFDLNENAIGDFRTYAKLSPPLRSEADRLAVCAAL
CCHHHHHHHHHHHCCEEEEECCCCCEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHH
ADGTIDAVVSDHQPRDADDKRLPFAEAAPGGAGLATLLAITLAQVQSGGLGLIAALSLLT
HCCCEEEHCCCCCCCCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
DRPARLFGLEAGRIARGAPADLCLFAPERPWRIEAGALPGKAQNTPFDGRPVEGVVTGTW
CCCHHHEECCCCCCCCCCCCCEEEECCCCCCEEECCCCCCCCCCCCCCCCCCCEEEECCH
KAGRRVHG
HCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA